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These peculiarities have some overlaps with hidradenitis suppurativa (HS). Our main aim was to assess if <jats:italic>S. aureus<\/jats:italic> producing PVL could have some role in influencing clinical features and\/or course of HS, specifically in the suppuration and recurrence of lesions. This pilot, mono-centric, observational study included all adult subjects affected with HS consecutively referring to our HS clinic over a 3-month period. Clinically evident suppuration and at least 2 weeks wash out from any antibiotic were the main inclusion criteria. Purulent material from HS skin lesions was collected with swabs in order to isolate micro-organisms, with specific regard to <jats:italic>S. aureus.<\/jats:italic> Detection of PVL was performed by real-time quantitative PCR (RT-qPCR). We also analyzed purulent material from suppurative skin lesions other than HS, as a control. Thirty HS patients were included; 29 purulent lesions (96.7%) harbored at least one bacterial species. Five (16.7%) swab samples were positive for <jats:italic>S. aureus<\/jats:italic>, none of which was positive for PVL genes. Among the 30 purulent disorders included as controls, 8 (26.3%) were positive for <jats:italic>S. aureus<\/jats:italic>; of these, 4 strains (50%) expressed LPV. The study results seem to exclude the pathogenetic involvement of <jats:italic>S. aureus<\/jats:italic> producing PVL in HS; as a result, PVL does not seem to represent a potential target in the future development of HS treatments.<\/jats:p>","DOI":"10.1007\/s10096-020-04002-7","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T08:03:28Z","timestamp":1596787408000},"page":"77-83","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Irrelevance of Panton-Valentine leukocidin in hidradenitis suppurativa: results from a pilot, observational study"],"prefix":"10.1007","volume":"40","author":[{"given":"Monica","family":"Corazza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-9691","authenticated-orcid":false,"given":"Alessandro","family":"Borghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Bettoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Pora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Bononi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Mazzola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silva","family":"Saraceni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Maritati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Contini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"4002_CR1","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/jdv.15233","volume":"33","author":"CC Zouboulis","year":"2019","unstructured":"Zouboulis CC, Bechara FG, Dickinson-Blok JL, Gulliver W, Horv\u00e1th B, Hughes R, Kimball AB, Kirby B, Martorell A, Podda M, Prens EP, Ring HC, Tzellos T, van der Zee HH, van Straalen KR, Vossen ARJV, Jemec GBE (2019) Hidradenitis suppurativa\/acne inversa: a practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group. 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