{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:41:54Z","timestamp":1790440914405,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:00:00Z","timestamp":1597363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s10096-020-04006-3","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T00:02:26Z","timestamp":1597363346000},"page":"111-121","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Characterization of 16S rRNA methylase genes in Enterobacterales and Pseudomonas aeruginosa in Athens Metropolitan area, 2015\u20132016"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0612-8518","authenticated-orcid":false,"given":"Konstantina","family":"Nafplioti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-4534","authenticated-orcid":false,"given":"Maria","family":"Souli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Adamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Moraitou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Giannopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Chra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Damala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Vogiatzakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Trikka-Graphakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Baka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Prifti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0991-9198","authenticated-orcid":false,"given":"Anastasia","family":"Antoniadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6455-9848","authenticated-orcid":false,"given":"Irene","family":"Galani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"4006_CR1","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.idc.2016.02.011","volume":"30","author":"Y Doi","year":"2016","unstructured":"Doi Y, Wachino JI, Arakawa Y (2016) Aminoglycoside resistance: the emergence of acquired 16S ribosomal RNA methyltransferases. Infect Dis Clin N Am 30:523\u2013537. https:\/\/doi.org\/10.1016\/j.idc.2016.02.011","journal-title":"Infect Dis Clin N Am"},{"key":"4006_CR2","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1086\/518605","volume":"45","author":"Y Doi","year":"2007","unstructured":"Doi Y, Arakawa Y (2007) 16S ribosomal RNA methylation: emerging resistance mechanism against aminoglycosides. Clin Infect Dis 45:88\u201394. https:\/\/doi.org\/10.1086\/518605","journal-title":"Clin Infect Dis"},{"key":"4006_CR3","doi-asserted-by":"publisher","first-page":"E52","DOI":"10.1111\/j.1469-0691.2011.03738.x","volume":"18","author":"I Galani","year":"2012","unstructured":"Galani I, Souli M, Panagea T, Poulakou G, Kanellakopoulou K, Giamarellou H (2012) Prevalence of 16S rRNA methylase genes in Enterobacteriaceae isolates from a Greek university hospital. Clin Microbiol Infect 18:E52\u2013E54. https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03738.x","journal-title":"Clin Microbiol Infect"},{"key":"4006_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jgar.2013.03.006","volume":"1","author":"L Galani","year":"2013","unstructured":"Galani L, Galani I, Souli M, Karaiskos I, Katsouda E, Patrozou E, Baziaka F, Paskalis C, Giamarellou H (2013) Nosocomial dissemination of Providencia stuartii isolates producing extended-spectrum \u03b2-lactamases VEB-1 and SHV-5, metallo-\u03b2-lactamase VIM-1, and RNA methylase RmtB. J Glob Antimicrob Resist 1:115\u2013116. https:\/\/doi.org\/10.1016\/j.jgar.2013.03.006","journal-title":"J Glob Antimicrob Resist"},{"key":"4006_CR5","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.cmi.2016.08.002","volume":"22","author":"I Galani","year":"2016","unstructured":"Galani I, Anagnostoulis G, Chatzikonstantinou M, Petrikkos G, Souli M (2016) Emergence of Klebsiella pneumoniae co-producing OXA-48, CTX-M-15, and ArmA in Greece. Clin Microbiol Infect 22:898\u2013899. https:\/\/doi.org\/10.1016\/j.cmi.2016.08.002","journal-title":"Clin Microbiol Infect"},{"key":"4006_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12879-019-3801-1","volume":"19","author":"I Galani","year":"2019","unstructured":"Galani I, Nafplioti K, Adamou P, Karaiskos I, Giamarellou H, Souli M, Study Collaborators (2019) Nationwide epidemiology of carbapenem resistant Klebsiella pneumoniae isolates from Greek hospitals, with regards to plazomicin and aminoglycoside resistance. BMC Infect Dis 19:167. https:\/\/doi.org\/10.1186\/s12879-019-3801-1","journal-title":"BMC Infect Dis"},{"key":"4006_CR7","unstructured":"Clinical and Laboratory Standards Institute (2015) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard\u2014tenth edition. CLSI document M07-A10. Wayne, PA: CLSI; 2015."},{"key":"4006_CR8","unstructured":"The European Committee on Antimicrobial Susceptibility Testing (2019) Breakpoint tables for interpretation of MICs and zone diameters. Version 9.0. Vaxjo: EUCAST; Available from; http:\/\/www.eucast.org"},{"key":"4006_CR9","unstructured":"Centers for Disease Control and Prevention (2003) National antimicrobial resistance monitoring system for enteric bacteria (NARMS): 2001 annual report. Atlanta, Georgia: U.S. Department of Health and Human Services, CDC, 2003"},{"key":"4006_CR10","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","volume":"18","author":"AP Magiorakos","year":"2012","unstructured":"Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL (2012) Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 18:268\u2013281. https:\/\/doi.org\/10.1111\/j.1469-0691.2011.03570.x","journal-title":"Clin Microbiol Infect"},{"key":"4006_CR11","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.ijantimicag.2014.02.003","volume":"43","author":"LL Corr\u00eaa","year":"2014","unstructured":"Corr\u00eaa LL, Montezzi LF, Bonelli RR, Moreira BM, Pic\u00e3o RC (2014) Revised and updated multiplex PCR, targeting acquired 16S rRNA methyltransferases. Int J Antimicrob Agents 43:479\u2013481. https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.02.003","journal-title":"Int J Antimicrob Agents"},{"issue":"6","key":"4006_CR12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2807\/1560-7917.ES.2018.23.6.17-00672","volume":"23","author":"AR Rebelo","year":"2018","unstructured":"Rebelo AR, Bortolaia V, Kjeldgaard JS, Pedersen SK, Leekitcharoenphon P, Hansen IM, Guerra B, Malorny B, Borowiak M, Hammerl JA, Battisti A, Franco A, Alba P, Perrin-Guyomard A, Granier SA, De Frutos EC, Malhotra-Kumar S, Villa L, Carattoli A, Hendriksen RS (2018) Multiplex PCR for detection of plasmid-mediated colistin resistance determinants, mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5 for surveillance purposes. Euro Surveill 23(6):17\u201300672. https:\/\/doi.org\/10.2807\/1560-7917.ES.2018.23.6.17-00672","journal-title":"Euro Surveill"},{"key":"4006_CR13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.mimet.2005.03.018","volume":"63","author":"A Carattoli","year":"2005","unstructured":"Carattoli A, Bertini A, Villa L, Falbo V, Hopkins KL, Threlfall EJ (2005) Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 63:219\u2013228. https:\/\/doi.org\/10.1016\/j.mimet.2005.03.018","journal-title":"J Microbiol Methods"},{"key":"4006_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1006\/abio.1995.1220","volume":"226","author":"BM Barton","year":"1995","unstructured":"Barton BM, Harding GP, Zuccarelli AJ (1995) A general method for detecting and sizing large plasmids. Anal Biochem 226:235\u2013240. https:\/\/doi.org\/10.1006\/abio.1995.1220","journal-title":"Anal Biochem"},{"key":"4006_CR15","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s10096-019-03517-y","volume":"38","author":"I Galani","year":"2019","unstructured":"Galani I, Souli M, Nafplioti K, Adamou P, Karaiskos I, Giamarellou H, Antoniadou A, Study Collaborators (2019) In vitro activity of imipenem-relebactam against non-MBL carbapenemase-producing Klebsiella pneumoniae isolated in Greek hospitals in 2015-2016. Eur J Clin Microbiol Infect Dis 38:1143\u20131150. https:\/\/doi.org\/10.1007\/s10096-019-03517-y","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4006_CR16","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.plasmid.2018.02.002","volume":"96-97","author":"SJ Ambrose","year":"2018","unstructured":"Ambrose SJ, Harmer CJ, Hall RM (2018) Compatibility and entry exclusion of IncA and IncC plasmids revisited: IncA and IncC plasmids are compatible. Plasmid 96-97:7\u201312. https:\/\/doi.org\/10.1016\/j.plasmid.2018.02.002","journal-title":"Plasmid"},{"key":"4006_CR17","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3201\/eid1305.061293","volume":"13","author":"L Poirel","year":"2007","unstructured":"Poirel L, Villa L, Bertini A, Pitout JD, Nordmann P, Carattoli A (2007) Expanded-spectrum \u03b2-lactamase and plasmid-mediated quinolone resistance. Emerg Infect Dis 13:803\u2013805. https:\/\/doi.org\/10.3201\/eid1305.061293","journal-title":"Emerg Infect Dis"},{"key":"4006_CR18","doi-asserted-by":"publisher","first-page":"e01740","DOI":"10.1128\/AAC.01740-16","volume":"61","author":"SJ Hancock","year":"2017","unstructured":"Hancock SJ, Phan MD, Peters KM, Forde BM, Chong TM, Yin WF, Chan KG, Paterson DL, Walsh TR, Beatson SA, Schembri MA (2017) Identification of IncA\/C plasmid replication and maintenance genes and development of a plasmid multilocus sequence typing scheme. Antimicrob Agents Chemother 61:e01740\u2013e01716. https:\/\/doi.org\/10.1128\/AAC.01740-16","journal-title":"Antimicrob Agents Chemother"},{"key":"4006_CR19","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1128\/AAC.47.1.395-397.2003","volume":"47","author":"V Miriagou","year":"2003","unstructured":"Miriagou V, Tzelepi E, Gianneli D, Tzouvelekis LS (2003) Escherichia coli with a self-transferable, multiresistant plasmid coding for metallo-beta-lactamase VIM-1. Antimicrob Agents Chemother 47:395\u2013397. https:\/\/doi.org\/10.1128\/AAC.47.1.395-397.2003","journal-title":"Antimicrob Agents Chemother"},{"key":"4006_CR20","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1128\/AAC.49.2.479-487.2005","volume":"49","author":"K Poole","year":"2005","unstructured":"Poole K (2005) Aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 49:479\u2013487. https:\/\/doi.org\/10.1128\/AAC.49.2.479-487.2005","journal-title":"Antimicrob Agents Chemother"},{"key":"4006_CR21","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1128\/AAC.05116-11","volume":"56","author":"A Carattoli","year":"2012","unstructured":"Carattoli A, Villa L, Poirel L, Bonnin RA, Nordmann P (2012) Evolution of IncA\/C blaCMY-2-carrying plasmids by acquisition of the blaNDM-1 carbapenemase gene. Antimicrob Agents Chemother 56:783\u2013786. https:\/\/doi.org\/10.1128\/AAC.05116-11","journal-title":"Antimicrob Agents Chemother"},{"key":"4006_CR22","doi-asserted-by":"publisher","first-page":"3346","DOI":"10.1093\/jac\/dky344","volume":"73","author":"M Castanheira","year":"2018","unstructured":"Castanheira M, Deshpande LM, Woosley LN, Serio AW, Krause KM, Flamm RK (2018) Activity of plazomicin compared with other aminoglycosides against isolates from European and adjacent countries, including Enterobacteriaceae molecularly characterized for aminoglycoside-modifying enzymes and other resistance mechanisms. J Antimicrob Chemother 73:3346\u20133354. https:\/\/doi.org\/10.1093\/jac\/dky344","journal-title":"J Antimicrob Chemother"},{"key":"4006_CR23","doi-asserted-by":"publisher","first-page":"4024","DOI":"10.1128\/AAC.00470-12","volume":"56","author":"CC Papagiannitsis","year":"2012","unstructured":"Papagiannitsis CC, Miriagou V, Kotsakis SD, Tzelepi E, Vatopoulos AC, Petinaki E, Tzouvelekis LS (2012) Characterization of a transmissible plasmid encoding VEB-1 and VIM-1 in Proteus mirabilis. Antimicrob Agents Chemother 56:4024\u20134025. https:\/\/doi.org\/10.1128\/AAC.00470-12","journal-title":"Antimicrob Agents Chemother"},{"key":"4006_CR24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.diagmicrobio.2015.02.009","volume":"82","author":"P Giakkoupi","year":"2015","unstructured":"Giakkoupi P, Tryfinopoulou K, Polemis M, Pappa O, Miriagou V, Vatopoulos A (2015) Circulation of a multiresistant, conjugative, IncA\/C plasmid within the nosocomial Providencia stuartii population in the Athens area. Diagn Microbiol Infect Dis 82:62\u201364. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2015.02.009","journal-title":"Diagn Microbiol Infect Dis"},{"key":"4006_CR25","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/jac\/dks367","volume":"68","author":"L Drieux","year":"2013","unstructured":"Drieux L, Decr\u00e9 D, Frangeul L, Arlet G, Jarlier V, Sougakoff W (2013) Complete nucleotide sequence of the large conjugative pTC2 multireplicon plasmid encoding the VIM-1 metallo-\u03b2-lactamase. J Antimicrob Chemother 68:97\u2013100. https:\/\/doi.org\/10.1093\/jac\/dks367","journal-title":"J Antimicrob Chemother"},{"key":"4006_CR26","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1089\/mdr.2015.0215","volume":"22","author":"O Oikonomou","year":"2016","unstructured":"Oikonomou O, Liakopoulos A, Phee LM, Betts J, Mevius D, Wareham DW (2016) Providencia stuartii isolates from Greece: co-carriage of cephalosporin (blaSHV-5, blaVEB-1), carbapenem (blaVIM-1), and aminoglycoside (rmtB) resistance determinants by a multidrug-resistant outbreak clone. Microb Drug Resist 22:379\u2013386. https:\/\/doi.org\/10.1089\/mdr.2015.0215","journal-title":"Microb Drug Resist"},{"key":"4006_CR27","doi-asserted-by":"publisher","unstructured":"Galani I, Karaiskos I, Souli M, Papoutsaki V, Galani L, Gkoufa A, Antoniadou A, Giamarellou H (2020). Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019. Euro Surveill; 25: pii = 2000028. https:\/\/doi.org\/10.2807\/1560-7917.ES.2020.25.3.2000028","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000028"},{"key":"4006_CR28","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ijantimicag.2016.10.002","volume":"49","author":"F Morel","year":"2017","unstructured":"Morel F, Decousser JW, Kumanski S, Cambau E, Denamur E, Ber\u00e7ot B (2017) Association of the 16S rRNA methylase gene rmtB with a novel insertion sequence element belonging to the ISL3 family. Int J Antimicrob Agents 49:117\u2013118. https:\/\/doi.org\/10.1016\/j.ijantimicag.2016.10.002","journal-title":"Int J Antimicrob Agents"},{"key":"4006_CR29","doi-asserted-by":"publisher","first-page":"4526","DOI":"10.1128\/AAC.00882-08","volume":"52","author":"B Ber\u00e7ot","year":"2008","unstructured":"Ber\u00e7ot B, Poirel L, Nordmann P (2008) Plasmid-mediated 16S rRNA methylases among extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae isolates. Antimicrob Agents Chemother 52:4526\u20134527. https:\/\/doi.org\/10.1128\/AAC.00882-08","journal-title":"Antimicrob Agents Chemother"},{"key":"4006_CR30","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/jac\/dkq408","volume":"66","author":"DM Livermore","year":"2011","unstructured":"Livermore DM, Mushtaq S, Warner M, Zhang JC, Maharjan S, Doumith M, Woodford N (2011) Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates. J Antimicrob Chemother 66:48\u201353. https:\/\/doi.org\/10.1093\/jac\/dkq408","journal-title":"J Antimicrob Chemother"},{"key":"4006_CR31","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.diagmicrobio.2016.09.002","volume":"86","author":"KP Smith","year":"2016","unstructured":"Smith KP, Kirby JE (2016) Evaluation of apramycin activity against carbapenem resistant and -susceptible strains of Enterobacteriaceae. Diagn Microbiol Infect Dis 86:439\u2013441. https:\/\/doi.org\/10.1016\/j.diagmicrobio.2016.09.002","journal-title":"Diagn Microbiol Infect Dis"},{"key":"4006_CR32","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.3389\/fmicb.2017.02275","volume":"8","author":"Y Hu","year":"2017","unstructured":"Hu Y, Liu L, Zhang X, Feng Y, Zong Z (2017) In vitro activity of neomycin, streptomycin, paromomycin and apramycin against carbapenem-resistant Enterobacteriaceae clinical strains. Front Microbiol 8:2275. https:\/\/doi.org\/10.3389\/fmicb.2017.02275","journal-title":"Front Microbiol"},{"key":"4006_CR33","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1093\/jac\/dky546","volume":"74","author":"M Juhas","year":"2019","unstructured":"Juhas M, Widlake E, Teo J, Huseby DL, Tyrrell JM, Polikanov YS, Ercan O, Petersson A, Cao S, Aboklaish AF, Rominski A, Crich D, B\u00f6ttger EC, Walsh TR, Hughes D, Hobbie SN (2019) In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. J Antimicrob Chemother 74:944\u2013952. https:\/\/doi.org\/10.1093\/jac\/dky546","journal-title":"J Antimicrob Chemother"},{"key":"4006_CR34","doi-asserted-by":"publisher","first-page":"10984","DOI":"10.1073\/pnas.1204073109","volume":"109","author":"T Matt","year":"2012","unstructured":"Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, B\u00f6ttger EC (2012) Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin. Proc Natl Acad Sci U S A 109:10984\u201310989. https:\/\/doi.org\/10.1073\/pnas.1204073109","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4006_CR35","doi-asserted-by":"publisher","first-page":"1900766","DOI":"10.2807\/1560-7917.ES.2020.25.2.1900766","volume":"25","author":"E Voulgari","year":"2020","unstructured":"Voulgari E, Kotsakis SD, Giannopoulou P, Perivolioti E, Tzouvelekis LS, Miriagou V (2020) Detection in two hospitals of transferable ceftazidime-avibactam resistance in Klebsiella pneumoniae due to a novel VEB \u03b2-lactamase variant with a Lys234Arg substitution, Greece, 2019. Euro Surveill 25:1900766. https:\/\/doi.org\/10.2807\/1560-7917.ES.2020.25.2.1900766","journal-title":"Euro Surveill"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-020-04006-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-020-04006-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-020-04006-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T23:46:20Z","timestamp":1628898380000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-020-04006-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,14]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["4006"],"URL":"https:\/\/doi.org\/10.1007\/s10096-020-04006-3","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,14]]},"assertion":[{"value":"29 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors. The study was approved by the Ethical Committee (5\/06-07-2016) and the Scientific Committee (16\/06-07-2016) of University General Hospital Attikon (E\u0392\u03941614\/13-6-2016).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}