{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:16:37Z","timestamp":1791389797502,"version":"4.3.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Eastern Finland (UEF) including Kuopio University Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Polymerase chain reaction (PCR)-based diagnostics for <jats:italic>Mycoplasma pneumoniae<\/jats:italic> (<jats:italic>M. pneumoniae<\/jats:italic>) from the respiratory tract has become widely available, but the interpretation of the results remains unclear. <jats:italic>M. pneumoniae<\/jats:italic> has been suggested to cause mainly mild and self-limiting infections or asymptomatic carriage. However, systematic analyses of the association between PCR results and clinical findings are scarce. This study aimed to clarify the clinical features of PCR-positive <jats:italic>M. pneumoniae<\/jats:italic> infections in a hospital setting. We reviewed 103 PCR-positive patients cared for in a university hospital during a 3-year period. Data on age, sex, health condition, acute symptoms, other pathogens found, laboratory and X-ray results and treatments were collected. Over 85% of the patients had a triad of typical symptoms: fever, cough and shortness of breath. Symptoms in the upper respiratory tract were rare. In 91% of the cases, <jats:italic>M. pneumoniae<\/jats:italic> was the only pathogen found. The highest incidence was found in the age group of 30\u201340 years, and 68% of the patients did not have any underlying diseases. Most patients were initially empirically treated with beta-lactam antibiotics and needed 2\u20134 changes in their treatment. Only 6% were discharged without an antibiotic effective against <jats:italic>M. pneumoniae<\/jats:italic>. This study shows that <jats:italic>M. pneumoniae<\/jats:italic> often led to hospitalisation and that patients needed appropriate antimicrobial treatment to recover. Mixed infections were rare, and situations that could be interpreted as carriage did not occur.<\/jats:p>","DOI":"10.1007\/s10096-021-04171-z","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T03:08:40Z","timestamp":1612321720000},"page":"1427-1431","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Mycoplasma pneumoniae may cause dyspnoea and hospitalisations in young healthy adults"],"prefix":"10.1007","volume":"40","author":[{"given":"Riku","family":"Mets\u00e4l\u00e4","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solja","family":"Ala-Korpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Rannikko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja","family":"Helminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0507-4773","authenticated-orcid":false,"given":"Marjo","family":"Renko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"issue":"3","key":"4171_CR1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/QCO.0000000000000063","volume":"27","author":"P Meyer Sauteur","year":"2014","unstructured":"Meyer Sauteur P, van Rossum A, Vink C (2014) Mycoplasma pneumoniae in children: carriage, pathogenesis, and antibiotic resistance. 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