{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:30:58Z","timestamp":1787679058047,"version":"build-2784847793"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T00:00:00Z","timestamp":1620864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cryptococcosis is a fungal infection that is rarely reported in patients without human immunodeficiency virus (HIV) infection, especially when the central nervous system (CNS) or pulmonary system is not involved. We report a case of isolated colonic cryptococcosis without disseminated disease in a 64-year-old immunocompetent woman without HIV infection who presented with chronic diarrhea and no episodes of fever or weight loss. The diagnosis was based on histopathology examination. Furthermore, we performed a literature review showing that few reports have been published so far and in the case of colonic cryptococcal infection, the prognosis is favorable among HIV-uninfected patients.<\/jats:p>","DOI":"10.1007\/s10096-021-04268-5","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T17:03:10Z","timestamp":1620925390000},"page":"2623-2626","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cryptococcal infection of the colon in a patient without concurrent human immunodeficiency infection: a case report and literature review"],"prefix":"10.1007","volume":"40","author":[{"given":"Alvaro","family":"Quincho-Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3667-9719","authenticated-orcid":false,"given":"Noah","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Nesemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogger","family":"Verona-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Carayhua-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"4268_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrmicro.2015.6","volume":"14","author":"RC May","year":"2016","unstructured":"May RC, Stone NRH, Wiesner DL, Bicanic T, Nielsen K (2016) Cryptococcus: from environmental saprophyte to global pathogen. Nat Rev Microbiol 14:106\u2013117","journal-title":"Nat Rev Microbiol"},{"key":"4268_CR2","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.idc.2015.10.006","volume":"30","author":"EK Maziarz","year":"2016","unstructured":"Maziarz EK, Perfect JR (2016) Cryptococcosis. Infect Dis Clin N Am 30:179\u2013206","journal-title":"Infect Dis Clin N Am"},{"key":"4268_CR3","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1128\/CVI.00446-12","volume":"19","author":"MJ Binnicker","year":"2012","unstructured":"Binnicker MJ, Jespersen DJ, Bestrom JE, Rollins LO (2012) Comparison of four assays for the detection of cryptococcal antigen. Clin Vaccine Immunol 19:1988\u20131990","journal-title":"Clin Vaccine Immunol"},{"key":"4268_CR4","first-page":"1","volume":"10","author":"HR Huang","year":"2015","unstructured":"Huang HR, Fan LC, Rajbanshi B, Xu JF (2015) Evaluation of a new cryptococcal antigen lateral flow immunoassay in serum, cerebrospinal fluid and urine for the diagnosis of cryptococcosis: a meta-analysis and systematic review. PLoS One 10:1\u201310","journal-title":"PLoS One"},{"key":"4268_CR5","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/0002-9343(51)90098-8","volume":"11","author":"S Zelman","year":"1951","unstructured":"Zelman S, O\u2019Neil R, Plaut A (1951) Disseminated visceral torulosis without nervous system involvement with clinical appearance of granulocytic leukemia. Am J Med 11:658\u2013664","journal-title":"Am J Med"},{"key":"4268_CR6","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1136\/bmj.2.5211.1501","volume":"2","author":"E Unat","year":"1960","unstructured":"Unat E, Pars B, Kosyak J (1960) A case of cryptococcosis of the colon. Br Med J 2:1501\u20131502","journal-title":"Br Med J"},{"key":"4268_CR7","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/0016-5085(88)90257-0","volume":"94","author":"JO Hutto","year":"1988","unstructured":"Hutto JO, Bryan CS, Greene FL, White CJ, Gallin JI (1988) Cryptococcosis of the colon resembling Crohn\u2019s disease in a patient with the hyperimmunoglobulinemia E-recurrent infection (Job\u2019s) syndrome. Gastroenterology 94:808\u2013812","journal-title":"Gastroenterology"},{"key":"4268_CR8","first-page":"1421","volume":"85","author":"J Daly","year":"1990","unstructured":"Daly J, Porter K, Chong F, Robillard R (1990) Disseminated, nonmeningeal gastrointestinal cryptococcal infection in an HIV-negative patient. Am J Gastroenterol 85:1421\u20131424","journal-title":"Am J Gastroenterol"},{"key":"4268_CR9","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1111\/j.1572-0241.1998.00492.x","volume":"93","author":"M Melato","year":"1998","unstructured":"Melato M, Gorji N (1998) Primary intestinal cryptococcosis mimicking adenomatous polyp in an HIV-negative patient. Am J Gastroenterol 93:1592\u20131593","journal-title":"Am J Gastroenterol"},{"key":"4268_CR10","first-page":"255","volume":"52","author":"JC Song","year":"2008","unstructured":"Song JC, Kim SK, Kim ES, Jung IS (2008) A case of colonic cryptococcosis. Korean J Gastroenterol 52:255\u2013260","journal-title":"Korean J Gastroenterol"},{"key":"4268_CR11","doi-asserted-by":"publisher","first-page":"e436","DOI":"10.1016\/j.ijid.2009.05.019","volume":"14","author":"R Osawa","year":"2010","unstructured":"Osawa R, Singh N (2010) Colitis as a manifestation of infliximab-associated disseminated cryptococcosis. Int J Infect Dis 14:e436\u2013e440","journal-title":"Int J Infect Dis"},{"key":"4268_CR12","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.crohns.2010.08.003","volume":"5","author":"G Sciaudone","year":"2011","unstructured":"Sciaudone G, Pellino G, Guadagni I, Somma A, D\u2019Armiento FP, Selvaggi F (2011) Disseminated Cryptococcus neoformans infection and Crohn\u2019s disease in an immunocompetent patient. J Crohn's Colitis 5:60\u201363","journal-title":"J Crohn's Colitis"},{"key":"4268_CR13","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.1016\/j.transproceed.2015.09.041","volume":"47","author":"F Cicora","year":"2015","unstructured":"Cicora F, Petroni J, Roberti J (2015) Cryptococcosis presenting as a colonic ulcer in a kidney transplant recipient: a case report. Transplant Proc 47:2786\u20132787","journal-title":"Transplant Proc"},{"key":"4268_CR14","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1053\/j.gastro.2016.11.009","volume":"152","author":"MA T\u00falio","year":"2017","unstructured":"T\u00falio MA, Figueiredo P, Cassis J (2017) Rare cause for a colonic ulcerated stricture. Gastroenterology 152:e5\u2013e6","journal-title":"Gastroenterology"},{"key":"4268_CR15","first-page":"1","volume":"3","author":"N Chavapradit","year":"2018","unstructured":"Chavapradit N, Angkasekwinai N (2018) Disseminated cryptococcosis in Crohn\u2019s disease: a case report. BMC Infect Dis 3:1\u20135","journal-title":"BMC Infect Dis"},{"key":"4268_CR16","first-page":"288","volume":"39","author":"J Medina Alvarez","year":"2019","unstructured":"Medina Alvarez J, Tanta Chipana C, Ar\u00e9valo Suarez F (2019) Proctocolitis by cryptococcus in an immunocompetent patient: first report in Peru. Rev Gastroenterol Peru 39:288\u2013291","journal-title":"Rev Gastroenterol Peru"},{"key":"4268_CR17","doi-asserted-by":"publisher","first-page":"415","DOI":"10.2147\/CEG.S67776","volume":"7","author":"S Praneenararat","year":"2014","unstructured":"Praneenararat S (2014) Fungal infection of the colon. Clin Exp Gastroenterol 7:415\u2013426","journal-title":"Clin Exp Gastroenterol"},{"key":"4268_CR18","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1086\/649858","volume":"50","author":"JR Perfect","year":"2010","unstructured":"Perfect JR et al (2010) Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 50:291\u2013322","journal-title":"Clin Infect Dis"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-021-04268-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-021-04268-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-021-04268-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T13:03:44Z","timestamp":1636808624000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-021-04268-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,13]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4268"],"URL":"https:\/\/doi.org\/10.1007\/s10096-021-04268-5","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,13]]},"assertion":[{"value":"27 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval for this study was waived by the local ethics committee at Universidad Nacional Mayor de San Marcos because it is a single-case study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The participant has consented to the submission of the case report to the journal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}