{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:44:58Z","timestamp":1761864298523,"version":"3.37.3"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s10096-021-04287-2","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T12:10:09Z","timestamp":1623067809000},"page":"2651-2656","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China"],"prefix":"10.1007","volume":"40","author":[{"given":"Ye","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangkuo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaihang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaiyu","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunquan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2171-4710","authenticated-orcid":false,"given":"Tieli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"4287_CR1","doi-asserted-by":"crossref","unstructured":"Hooper DC, Jacoby GA. Topoisomerase inhibitors: fluoroquinolone mechanisms of action and resistance. Cold Spring Harb Perspect Med. 2016;6.","DOI":"10.1101\/cshperspect.a025320"},{"key":"4287_CR2","first-page":"32","volume":"2019","author":"J Ruiz","year":"1998","unstructured":"Ruiz J, Transferable mechanisms of quinolone resistance from, (1998) Onward. Clin Microbiol Rev 2019:32","journal-title":"Clin Microbiol Rev"},{"key":"4287_CR3","doi-asserted-by":"crossref","unstructured":"Ch\u00e1vez-Jacobo VM, Hern\u00e1ndez-Ram\u00edrez KC, Romo-Rodr\u00edguez P, P\u00e9rez-Gallardo RV, Campos-Garc\u00eda J, Guti\u00e9rrez-Corona JF, et al. CrpP is a novel ciprofloxacin-modifying enzyme encoded by the Pseudomonas aeruginosa pUM505 plasmid. Antimicrob Agents Chemother. 2018;62.","DOI":"10.1128\/AAC.02629-17"},{"key":"4287_CR4","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1093\/jac\/dky562","volume":"74","author":"VM Ch\u00e1vez-Jacobo","year":"2019","unstructured":"Ch\u00e1vez-Jacobo VM, Hern\u00e1ndez-Ram\u00edrez KC, Silva-S\u00e1nchez J, Garza-Ramos U, Barrios-Camacho H, Ortiz-Alvarado R et al (2019) Prevalence of the crpP gene conferring decreased ciprofloxacin susceptibility in enterobacterial clinical isolates from Mexican hospitals. J Antimicrob Chemother 74:1253\u20131259","journal-title":"J Antimicrob Chemother"},{"key":"4287_CR5","doi-asserted-by":"crossref","unstructured":"Ortiz de la Rosa JM, Nordmann P, Poirel L. Pathogenicity genomic island-associated CrpP-Like fluoroquinolone-modifying enzymes among Pseudomonas aeruginosa clinical isolates in Europe. Antimicrob Agents Chemother. 2020;64.","DOI":"10.1128\/AAC.00489-20"},{"key":"4287_CR6","doi-asserted-by":"crossref","unstructured":"Wang LJ, Chen EZ, Yang L, Feng DH, Xu Z, Chen DQ. Emergence of clinical Pseudomonas aeruginosa isolate Guangzhou-PaeC79 carrying crpP, blaGES-5, and blaKPC-2 in Guangzhou of China. Microb Drug Resist. 2021","DOI":"10.1089\/mdr.2020.0420"},{"key":"4287_CR7","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.2147\/IDR.S249475","volume":"13","author":"Y Xu","year":"2020","unstructured":"Xu Y, Zheng X, Zeng W, Chen T, Liao W, Qian J et al (2020) Mechanisms of heteroresistance and resistance to imipenem in Pseudomonas aeruginosa. Infect Drug Resist 13:1419\u20131428","journal-title":"Infect Drug Resist"},{"key":"4287_CR8","unstructured":"CLSI. Performance standards for antimicrobial susceptibility testing. 29th ed. CLSI supplement M100. Wayne, PA: Clin Lab Standards Inst; 2019."},{"key":"4287_CR9","doi-asserted-by":"crossref","unstructured":"Ortiz de la Rosa JM, Nordmann P, Poirel L. ESBLs and resistance to ceftazidime\/avibactam and ceftolozane\/tazobactam combinations in Escherichia coli and Pseudomonas aeruginosa. J Antimicrob Chemother. 2019;74:1934\u20139.","DOI":"10.1093\/jac\/dkz149"},{"key":"4287_CR10","doi-asserted-by":"publisher","first-page":"4783","DOI":"10.1128\/AAC.00574-09","volume":"53","author":"JM Rodriguez-Martinez","year":"2009","unstructured":"Rodriguez-Martinez JM, Poirel L, Nordmann P (2009) Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother 53:4783\u20134788","journal-title":"Antimicrob Agents Chemother"},{"key":"4287_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/j.1574-6968.2007.00997.x","volume":"279","author":"A Ikonomidis","year":"2008","unstructured":"Ikonomidis A, Tsakris A, Kantzanou M, Spanakis N, Maniatis AN, Pournaras S (2008) Efflux system overexpression and decreased OprD contribute to the carbapenem heterogeneity in Pseudomonas aeruginosa. FEMS Microbiol Lett 279:36\u201339","journal-title":"FEMS Microbiol Lett"},{"key":"4287_CR12","doi-asserted-by":"crossref","unstructured":"Botelho J, Grosso F, Peixe L. ICEs are the main reservoirs of the ciprofloxacin-modifying crpP Gene in Pseudomonas aeruginosa. Genes. 2020;11.","DOI":"10.1101\/2020.03.13.991208"},{"key":"4287_CR13","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.1093\/jac\/dkz316","volume":"74","author":"J Ruiz","year":"2019","unstructured":"Ruiz J (2019) CrpP, a passenger or a hidden stowaway in the Pseudomonas aeruginosa genome? J Antimicrob Chemother 74:3397\u20133399","journal-title":"J Antimicrob Chemother"},{"key":"4287_CR14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s13100-018-0141-4","volume":"9","author":"J Botelho","year":"2018","unstructured":"Botelho J, Roberts AP, Le\u00f3n-Sampedro R, Grosso F, Peixe L (2018) Carbapenemases on the move: it\u2019s good to be on ICEs. Mob DNA 9:37","journal-title":"Mob DNA"},{"key":"4287_CR15","doi-asserted-by":"crossref","unstructured":"Guglielmini J, Quintais L, Garcill\u00e1n-Barcia MP, de la Cruz F, Rocha EP. The repertoire of ICE in prokaryotes underscores the unity, diversity, and ubiquity of conjugation. PLoS Genet. 2011;7:e1002222.","DOI":"10.1371\/journal.pgen.1002222"},{"key":"4287_CR16","doi-asserted-by":"crossref","unstructured":"Zubyk HL, Wright GD. CrpP is not a fluoroquinolone inactivating enzyme. Antimicrob Agents Chemother. 2021.","DOI":"10.1128\/AAC.00773-21"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-021-04287-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-021-04287-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-021-04287-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T13:04:01Z","timestamp":1636808641000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-021-04287-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,7]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["4287"],"URL":"https:\/\/doi.org\/10.1007\/s10096-021-04287-2","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"type":"print","value":"0934-9723"},{"type":"electronic","value":"1435-4373"}],"subject":[],"published":{"date-parts":[[2021,6,7]]},"assertion":[{"value":"1 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}