{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:32:15Z","timestamp":1765233135098,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s10096-021-04290-7","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T05:02:30Z","timestamp":1626325350000},"page":"127-132","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of a 4-year antimicrobial stewardship program implemented in a Greek tertiary hospital"],"prefix":"10.1007","volume":"41","author":[{"given":"Konstantina","family":"Chrysou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olympia","family":"Zarkotou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Kalofolia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiota","family":"Papagiannakopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasiliki","family":"Mamali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Chrysos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katina","family":"Themeli-Digalaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Sypsas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanasios","family":"Tsakris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-9577","authenticated-orcid":false,"given":"Spyros","family":"Pournaras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"4290_CR1","unstructured":"European Centre for Disease Control (ECDC). SURVEILLANCE REPORT Antimicrobial consumption in the EU\/EEA Annual epidemiological report for 2018. https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/Antimicrobial-consumption-EU-EEA.pdf"},{"key":"4290_CR2","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1093\/cid\/ciw118","volume":"62","author":"TF Barlam","year":"2016","unstructured":"Barlam TF, Cosgrove SE, Abbo LM et al (2016) Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 62:e51-77","journal-title":"Clin Infect Dis"},{"key":"4290_CR3","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/2047-2994-2-31","volume":"2","author":"A Huttner","year":"2013","unstructured":"Huttner A, Harbarth S, Carlet J et al (2013) Antimicrobial resistance: a global view from the 2013 World Healthcare-Associated Infections Forum. Antimicrob Resist Infect Control 2:31","journal-title":"Antimicrob Resist Infect Control"},{"key":"4290_CR4","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.2146\/ajhp110603","volume":"69","author":"MA Nowak","year":"2012","unstructured":"Nowak MA, Nelson RE, Breidenbach JL et al (2012) Clinical and economic outcomes of a prospective antimicrobial stewardship program. Am J Health Syst Pharm 69:1500\u20131508","journal-title":"Am J Health Syst Pharm"},{"key":"4290_CR5","first-page":"CD003543","volume":"2","author":"P Davey","year":"2017","unstructured":"Davey P, Marwick CA, Scott CL et al (2017) Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev 2:CD003543","journal-title":"Cochrane Database Syst Rev"},{"key":"4290_CR6","unstructured":"European Centre for Disease Control (ECDC). European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2018. https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/surveillance-antimicrobial-resistance-Europe-2018.pdf"},{"key":"4290_CR7","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s10096-017-3137-y","volume":"37","author":"K Chrysou","year":"2018","unstructured":"Chrysou K, Zarkotou O, Kalofolia S et al (2018) First-year results of an antibiotic stewardship program in a Greek tertiary care hospital. Eur J Clin Microbiol Infect Dis 37:333\u2013337","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4290_CR8","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1093\/jac\/dku046","volume":"69","author":"LM Feazel","year":"2014","unstructured":"Feazel LM, Malhotra A, Perencevich EN et al (2014) Effect of antibiotic stewardship programmes on Clostridium difficile incidence: a systematic review and meta-analysis. J Antimicrob Chemother 69:1748\u20131754","journal-title":"J Antimicrob Chemother"},{"key":"4290_CR9","doi-asserted-by":"publisher","first-page":"2988","DOI":"10.1093\/jac\/dks330","volume":"67","author":"MA Aldeyab","year":"2012","unstructured":"Aldeyab MA, Kearney MP, Scott MG et al (2012) An evaluation of the impact of antibiotic stewardship on reducing the use of high-risk antibiotics and its effect on the incidence of Clostridium difficile infection in hospital settings. J Antimicrob Chemother 67:2988\u20132996","journal-title":"J Antimicrob Chemother"},{"key":"4290_CR10","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1093\/jac\/dkr253","volume":"66","author":"MJ Talpaert","year":"2011","unstructured":"Talpaert MJ, Gopal Rao G, Cooper BS et al (2011) Impact of guidelines and enhanced antibiotic stewardship on reducing broad-spectrum antibiotic usage and its effect on incidence of Clostridium difficile infection. J Antimicrob Chemother 66:2168\u20132174","journal-title":"J Antimicrob Chemother"},{"key":"4290_CR11","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1086\/510393","volume":"44","author":"TH Dellit","year":"2007","unstructured":"Dellit TH, Owens RC, McGowan JE Jr et al (2007) Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis 44:159\u2013177","journal-title":"Clin Infect Dis"},{"key":"4290_CR12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2146\/ajhp120568","volume":"70","author":"DW Bratzler","year":"2013","unstructured":"Bratzler DW, Dellinger EP, Olsen KM et al (2013) Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health Syst Pharm 70:195\u2013283","journal-title":"Am J Health Syst Pharm"},{"key":"4290_CR13","first-page":"537","volume":"64","author":"PD Tamma","year":"2017","unstructured":"Tamma PD, Avdic E, Keenan JF et al (2017) What is the more effective antibiotic stewardship intervention: preprescription authorization or postprescription review with feedback? Clin Infect Dis 64:537\u2013543","journal-title":"Clin Infect Dis"},{"key":"4290_CR14","unstructured":"European Centre for Disease Control (ECDC). Proposals for EU guidelines on the pudent use of antimicrobials in humans. https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/media\/en\/publications\/Publications\/EU-guidelines-prudent-use-antimicrobials.pdf"},{"key":"4290_CR15","unstructured":"World Health Organization Collaborating Centre for Drug Statistics Methodology. ATC Index with DDDs. https:\/\/www.whocc.no\/atc_ddd_index\/; Last updated: 2020-12-17"},{"key":"4290_CR16","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.ijantimicag.2017.01.028","volume":"49","author":"S Pournaras","year":"2017","unstructured":"Pournaras S, Dafopoulou K, Del Franco M et al (2017) Predominance of international clone 2 OXA-23-producing-Acinetobacter baumannii clinical isolates in Greece, 2015: results of a nationwide study. Int J Antimicrob Agents 49:749\u2013753","journal-title":"Int J Antimicrob Agents"},{"key":"4290_CR17","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST). Recommendations for MIC determination of colistin (polymyxin E) as recommended by the joint CLSI-EUCAST Polymyxin Breakpoints Working Group.\u00a0https:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/General_documents\/Recommendations_for_MIC_determination_of_colistin_March_2016.pdf, Published on www.eucast.org; 22 March 2016"},{"key":"4290_CR18","unstructured":"Centers for Disease Control and Prevention. Antibiotic prescribing and use in hospitals and long-term care. http:\/\/www.cdc.gov\/getsmart\/healthcare\/. Accessed 12 May 2020"},{"key":"4290_CR19","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1128\/CMR.00066-16","volume":"30","author":"P Morency-Potvin","year":"2017","unstructured":"Morency-Potvin P, Schwartz DN, Weinstein RA (2017) Antimicrobial stewardship: how the microbiology laboratory can right the ship. Clin Microbiol Rev 30:381\u2013407","journal-title":"Clin Microbiol Rev"},{"key":"4290_CR20","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1086\/664909","volume":"33","author":"HC Standiford","year":"2012","unstructured":"Standiford HC, Chan S, Tripoli M et al (2012) Antimicrobial stewardship at a large tertiary care academic medical center: cost analysis before, during, and after a 7-year program. Infect Control Hosp Epidemiol 33:338\u2013345","journal-title":"Infect Control Hosp Epidemiol"},{"key":"4290_CR21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1086\/664922","volume":"33","author":"JR Beardsley","year":"2012","unstructured":"Beardsley JR, Williamson JC, Johnson JW et al (2012) Show me the money: long-term financial impact of an antimicrobial stewardship program. Infect Control Hosp Epidemiol 33:398\u2013400","journal-title":"Infect Control Hosp Epidemiol"},{"key":"4290_CR22","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s13756-017-0259-z","volume":"6","author":"AP Magiorakos","year":"2017","unstructured":"Magiorakos AP, Burns K, Rodriguez Bano J et al (2017) Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control. Antimicrob Resist Infect Control 6:113","journal-title":"Antimicrob Resist Infect Control"},{"key":"4290_CR23","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.cmi.2017.07.013","volume":"23","author":"C Pulcini","year":"2017","unstructured":"Pulcini C, Morel CM, Tacconelli E et al (2017) Human resources estimates and funding for antibiotic stewardship teams are urgently needed. Clin Microbiol Infect 23:785\u2013787","journal-title":"Clin Microbiol Infect"},{"key":"4290_CR24","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/s15010-020-01421-8","volume":"48","author":"H Stocker","year":"2020","unstructured":"Stocker H, Mehlhorn C, Jordan K et al (2020) Clinical and economic effects of an antimicrobial stewardship intervention in a surgical intensive care unit. Infection 48:509\u2013519","journal-title":"Infection"},{"key":"4290_CR25","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1001\/jamainternmed.2014.8273","volume":"175","author":"K Brown","year":"2015","unstructured":"Brown K, Valenta K, Fisman D et al (2015) Hospital ward antibiotic prescribing and the risks of Clostridium difficile infection. JAMA Intern Med 175:626\u2013633","journal-title":"JAMA Intern Med"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-021-04290-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-021-04290-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-021-04290-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T14:21:28Z","timestamp":1641392488000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-021-04290-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,15]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["4290"],"URL":"https:\/\/doi.org\/10.1007\/s10096-021-04290-7","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"type":"print","value":"0934-9723"},{"type":"electronic","value":"1435-4373"}],"subject":[],"published":{"date-parts":[[2021,7,15]]},"assertion":[{"value":"16 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}