{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:12:06Z","timestamp":1793859126946,"version":"4.6.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s10096-022-04402-x","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T19:04:11Z","timestamp":1642791851000},"page":"581-588","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study)"],"prefix":"10.1007","volume":"41","author":[{"given":"Cl\u00e9mence","family":"Beauruelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Plouzeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Grillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Isnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Corvec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Degand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Jacquier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marl\u00e8ne","family":"Amara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Mizrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Diedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Piau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Farfour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Bonzon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Le Brun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violaine","family":"Walewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Dortet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Guillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Soismier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Le Guen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Morand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gauthier P\u00e9an","family":"de Ponfilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alban","family":"Le Monnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2089-3825","authenticated-orcid":false,"given":"Genevi\u00e8ve","family":"H\u00e9ry-Arnaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,22]]},"reference":[{"key":"4402_CR1","doi-asserted-by":"publisher","unstructured":"Holt SC. Capnocytophaga. Bergey\u2019s manual of systematics of archaea and bacteria, Wiley, New York, NY; 2015, p. 1\u201313. https:\/\/doi.org\/10.1002\/9781118960608.gbm00299.","DOI":"10.1002\/9781118960608.gbm00299"},{"key":"4402_CR2","doi-asserted-by":"crossref","unstructured":"Brenner DJ, Hollis DG, Fanning GR, Weaver RE. Capnocytophaga canimorsus sp. nov. (formerly CDC group DF-2), a cause of septicemia following dog bite, and C. cynodegmi sp. nov., a cause of localized wound infection following dog bite. J Clin Microbiol 1989;27:231\u20135.","DOI":"10.1128\/jcm.27.2.231-235.1989"},{"key":"4402_CR3","doi-asserted-by":"publisher","unstructured":"Renzi F, Dol M, Raymackers A, Manfredi P, Cornelis GR. Only a subset of C. canimorsus strains is dangerous for humans. Emerg Microbes Infect 2015;4:e48. https:\/\/doi.org\/10.1038\/emi.2015.48.","DOI":"10.1038\/emi.2015.48"},{"key":"4402_CR4","doi-asserted-by":"publisher","first-page":"22919","DOI":"10.1038\/srep22919","volume":"6","author":"S Zangenah","year":"2016","unstructured":"Zangenah S, Abbasi N, Andersson AF, Bergman P (2016) Whole genome sequencing identifies a novel species of the genus Capnocytophaga isolated from dog and cat bite wounds in humans. Sci Rep 6:22919. https:\/\/doi.org\/10.1038\/srep22919","journal-title":"Sci Rep"},{"key":"4402_CR5","doi-asserted-by":"publisher","unstructured":"Suzuki M, Umeda K, Kimura M, Imaoka K, Morikawa S, Maeda K. Capnocytophaga felis sp. nov. isolated from the feline oral cavity. Int J Syst Evol Microbiol 2020;70:3355\u201360. https:\/\/doi.org\/10.1099\/ijsem.0.004176.","DOI":"10.1099\/ijsem.0.004176"},{"key":"4402_CR6","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1007\/s10096-015-2360-7","volume":"34","author":"T Butler","year":"2015","unstructured":"Butler T (2015) Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites. Eur J Clin Microbiol Infect Dis 34:1271\u20131280. https:\/\/doi.org\/10.1007\/s10096-015-2360-7","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4402_CR7","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/bf00144007","volume":"12","author":"C Lion","year":"1996","unstructured":"Lion C, Escande F, Burdin JC (1996) Capnocytophaga canimorsus infections in human: review of the literature and cases report. Eur J Epidemiol 12:521\u2013533. https:\/\/doi.org\/10.1007\/bf00144007","journal-title":"Eur J Epidemiol"},{"key":"4402_CR8","doi-asserted-by":"publisher","unstructured":"Zangenah S, Ozenci V, Bor\u00e4ng S, Bergman P. Identification of blood and wound isolates of C. canimorsus and C. cynodegmi using VITEK2 and MALDI-TOF. Eur J Clin Microbiol Infect Dis 2012;31:2631\u20137. https:\/\/doi.org\/10.1007\/s10096-012-1606-x.","DOI":"10.1007\/s10096-012-1606-x"},{"key":"4402_CR9","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/clinids\/23.1.71","volume":"23","author":"C Pers","year":"1996","unstructured":"Pers C, Gahrn-Hansen B, Frederiksen W (1996) Capnocytophaga canimorsus septicemia in Denmark, 1982\u20131995: review of 39 cases. Clin Infect Dis 23:71\u201375. https:\/\/doi.org\/10.1093\/clinids\/23.1.71","journal-title":"Clin Infect Dis"},{"key":"4402_CR10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.1469-0691.2010.03195.x","volume":"17","author":"AP van Dam","year":"2011","unstructured":"van Dam AP, Jansz A (2011) Capnocytophaga canimorsus infections in the Netherlands: a nationwide survey. Clin Microbiol Infect 17:312\u2013315. https:\/\/doi.org\/10.1111\/j.1469-0691.2010.03195.x","journal-title":"Clin Microbiol Infect"},{"key":"4402_CR11","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3201\/eid1202.050783","volume":"12","author":"JM Janda","year":"2006","unstructured":"Janda JM, Graves MH, Lindquist D, Probert WS (2006) Diagnosing Capnocytophaga canimorsus infections. Emerg Infect Dis 12:340\u2013342. https:\/\/doi.org\/10.3201\/eid1202.050783","journal-title":"Emerg Infect Dis"},{"key":"4402_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.vetmic.2010.01.001","volume":"144","author":"M Suzuki","year":"2010","unstructured":"Suzuki M, Kimura M, Imaoka K, Yamada A (2010) Prevalence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in dogs and cats determined by using a newly established species-specific PCR. Vet Microbiol 144:172\u2013176. https:\/\/doi.org\/10.1016\/j.vetmic.2010.01.001","journal-title":"Vet Microbiol"},{"key":"4402_CR13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.vetmic.2014.03.023","volume":"171","author":"K Umeda","year":"2014","unstructured":"Umeda K, Hatakeyama R, Abe T, Takakura K-I, Wada T, Ogasawara J et al (2014) Distribution of Capnocytophaga canimorsus in dogs and cats with genetic characterization of isolates. Vet Microbiol 171:153\u2013159. https:\/\/doi.org\/10.1016\/j.vetmic.2014.03.023","journal-title":"Vet Microbiol"},{"key":"4402_CR14","doi-asserted-by":"publisher","unstructured":"van Dam AP, van Weert A, Harmanus C, Hovius KE, Claas ECJ, Reubsaet FAG. Molecular characterization of Capnocytophaga canimorsus and other canine Capnocytophaga spp. and assessment by PCR of their frequencies in dogs. J Clin Microbiol 2009;47:3218\u201325. https:\/\/doi.org\/10.1128\/JCM.01246-09.","DOI":"10.1128\/JCM.01246-09"},{"key":"4402_CR15","unstructured":"Plaies aigues en structure d\u2019urgences-R\u00e9f\u00e9rentiel des bonnes pratiques SFMU\/SPILF 2017. https:\/\/www.infectiologie.com\/UserFiles\/File\/spilf\/recos\/2017-rbp-plaies.pdf n.d."},{"key":"4402_CR16","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1111\/aas.12752","volume":"60","author":"J H\u00e4stbacka","year":"2016","unstructured":"H\u00e4stbacka J, Hynninen M, Kolho E (2016) Capnocytophaga canimorsus bacteremia: clinical features and outcomes from a Helsinki ICU cohort. Acta Anaesthesiol Scand 60:1437\u20131443. https:\/\/doi.org\/10.1111\/aas.12752","journal-title":"Acta Anaesthesiol Scand"},{"key":"4402_CR17","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.3201\/eid2412.172060","volume":"24","author":"E Hess","year":"2018","unstructured":"Hess E, Renzi F, Karhunen P, Dol M, Lef\u00e8vre A, Antikainen J et al (2018) Capnocytophaga canimorsus capsular serovar and disease severity, Helsinki Hospital District, Finland, 2000\u20132017. Emerg Infect Dis 24:2195\u20132201. https:\/\/doi.org\/10.3201\/eid2412.172060","journal-title":"Emerg Infect Dis"},{"key":"4402_CR18","doi-asserted-by":"publisher","unstructured":"Chesdachai S, Tai DBG, Yetmar ZA, Misra A, Ough N, Abu Saleh O. The characteristics of Capnocytophaga infection: 10 years of experience. Open Forum Infect Dis 2021;8:ofab175. https:\/\/doi.org\/10.1093\/ofid\/ofab175.","DOI":"10.1093\/ofid\/ofab175"},{"key":"4402_CR19","unstructured":"InVS. Enqu\u00eate sur les facteurs de gravit\u00e9 des morsures de chien 2011. \/maladies-et-traumatismes\/traumatismes\/enquete-sur-les-facteurs-de-gravite-des-morsures-de-chien (accessed January 20, 2020)."},{"key":"4402_CR20","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1128\/JCM.00249-17","volume":"55","author":"E Hess","year":"2017","unstructured":"Hess E, Renzi F, Koudad D, Dol M, Cornelis GR (2017) Identification of virulent Capnocytophaga canimorsus isolates by capsular typing. J Clin Microbiol 55:1902\u20131914. https:\/\/doi.org\/10.1128\/JCM.00249-17","journal-title":"J Clin Microbiol"},{"key":"4402_CR21","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/23744235.2019.1687933","volume":"52","author":"N Mader","year":"2020","unstructured":"Mader N, L\u00fchrs F, Langenbeck M, Herget-Rosenthal S (2020) Capnocytophaga canimorsus - a potent pathogen in immunocompetent humans - systematic review and retrospective observational study of case reports. Infect Dis (Lond) 52:65\u201374. https:\/\/doi.org\/10.1080\/23744235.2019.1687933","journal-title":"Infect Dis (Lond)"},{"key":"4402_CR22","unstructured":"MMWR Morb Mortal Wkly Rep. Nonfatal dog bite-related injuries treated in hospital emergency departments \u2014 United States, 2001. 2003. https:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm5226a1.htm (accessed January 20, 2020)."},{"key":"4402_CR23","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1097\/00006454-199112000-00013","volume":"10","author":"JR Campbell","year":"1991","unstructured":"Campbell JR, Edwards MS (1991) Capnocytophaga species infections in children. Pediatr Infect Dis J 10:944\u2013948. https:\/\/doi.org\/10.1097\/00006454-199112000-00013","journal-title":"Pediatr Infect Dis J"},{"key":"4402_CR24","doi-asserted-by":"publisher","unstructured":"Renzi F, Ittig SJ, Sadovskaya I, Hess E, Lauber F, Dol M, et al. Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus. Scientific Reports 2016;6. https:\/\/doi.org\/10.1038\/srep38914.","DOI":"10.1038\/srep38914"},{"key":"4402_CR25","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.micinf.2009.02.005","volume":"11","author":"M Mally","year":"2009","unstructured":"Mally M, Paroz C, Shin H, Meyer S, Soussoula LV, Schmiediger U et al (2009) Prevalence of Capnocytophaga canimorsus in dogs and occurrence of potential virulence factors. Microbes Infect 11:509\u2013514. https:\/\/doi.org\/10.1016\/j.micinf.2009.02.005","journal-title":"Microbes Infect"},{"key":"4402_CR26","doi-asserted-by":"publisher","unstructured":"Meyers B, Schoeman JP, Goddard A, Picard J. The bacteriology and antimicrobial susceptibility of infected and non-infected dog bite wounds: fifty cases. Veterinary Microbiology 2008;127:360\u20138. \/https:\/\/doi.org\/10.1016\/j.vetmic.2007.09.004.","DOI":"10.1016\/j.vetmic.2007.09.004"},{"key":"4402_CR27","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.vetmic.2006.07.002","volume":"118","author":"E van Duijkeren","year":"2006","unstructured":"van Duijkeren E, van Mourik C, Broekhuizen M, Leuven M, Gaastra W, Houwers D (2006) First documented Capnocytophaga canimorsus infection in a species other than humans. Vet Microbiol 118:148\u2013150. https:\/\/doi.org\/10.1016\/j.vetmic.2006.07.002","journal-title":"Vet Microbiol"},{"key":"4402_CR28","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1128\/IAI.01324-08","volume":"77","author":"H Shin","year":"2009","unstructured":"Shin H, Mally M, Meyer S, Fiechter C, Paroz C, Zaehringer U et al (2009) Resistance of Capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes. Infect Immun 77:2262\u20132271. https:\/\/doi.org\/10.1128\/IAI.01324-08","journal-title":"Infect Immun"},{"key":"4402_CR29","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.imbio.2008.07.019","volume":"213","author":"S Meyer","year":"2008","unstructured":"Meyer S, Shin H, Cornelis GR (2008) Capnocytophaga canimorsus resists phagocytosis by macrophages and blocks the ability of macrophages to kill other bacteria. Immunobiology 213:805\u2013814. https:\/\/doi.org\/10.1016\/j.imbio.2008.07.019","journal-title":"Immunobiology"},{"key":"4402_CR30","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s10096-016-2842-2","volume":"36","author":"S Zangenah","year":"2017","unstructured":"Zangenah S, Andersson AF, \u00d6zenci V, Bergman P (2017) Genomic analysis reveals the presence of a class D beta-lactamase with broad substrate specificity in animal bite associated Capnocytophaga species. Eur J Clin Microbiol Infect Dis 36:657\u2013662. https:\/\/doi.org\/10.1007\/s10096-016-2842-2","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4402_CR31","doi-asserted-by":"publisher","first-page":"e130","DOI":"10.1016\/s0828-282x(09)70076-5","volume":"25","author":"O Hayani","year":"2009","unstructured":"Hayani O, Higginson LAJ, Toye B, Burwash IG (2009) Man\u2019s best friend? Infective endocarditis due to Capnocytophaga canimorsus. Can J Cardiol 25:e130-132. https:\/\/doi.org\/10.1016\/s0828-282x(09)70076-5","journal-title":"Can J Cardiol"},{"key":"4402_CR32","first-page":"90","volume":"148","author":"RE Perez","year":"1988","unstructured":"Perez RE (1988) Dysgonic fermenter-2 infections. West J Med 148:90\u201392","journal-title":"West J Med"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-022-04402-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-022-04402-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-022-04402-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T07:06:52Z","timestamp":1647673612000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-022-04402-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,22]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["4402"],"URL":"https:\/\/doi.org\/10.1007\/s10096-022-04402-x","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,22]]},"assertion":[{"value":"28 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethics committee in human research of the university hospital of Brest (Brest, France; 29BRC19.0251). All experiments were performed in accordance with relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all participants and\/or their legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}