{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:33:54Z","timestamp":1783434834405,"version":"3.54.6"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T00:00:00Z","timestamp":1668211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"abstract":"<jats:title>Abstract\u00a0<\/jats:title><jats:p>New Delhi metallo-beta-lactamase (NDM)-producing Klebsiella pneumoniae is increasingly reported worldwide. Clinicians face significant challenges in the treatment of this multidrug-resistant bacterium. The combination of ceftazidime\/avibactam (CAZ\/AVI) and aztreonam (ATM) is currently probably the most effective strategy for the treatment of such infection. We described a patient diagnosed with NK\/T cell lymphoma who underwent autologous hematopoietic stem cell transplantation (ASCT) in the hematology department. The patient developed severe infection after ASCT. Blood and stool cultures showed carbapenem-resistant <jats:italic>K. pneumoniae<\/jats:italic>. Blood sample was detected as NDM-producing <jats:italic>K. pneumoniae<\/jats:italic>. We successfully treated this infection with CAZ\/AVI and ATM.<\/jats:p>","DOI":"10.1007\/s10096-022-04523-3","type":"journal-article","created":{"date-parts":[[2022,11,12]],"date-time":"2022-11-12T22:02:57Z","timestamp":1668290577000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of ceftazidime\/avibactam combined with aztreonam in the NDM-producing Klebsiella pneumoniae bloodstream and intestinal infections in a NK\/T lymphoma patient with agranulocytosis during autologous hematopoietic stem cell transplantation: a case report"],"prefix":"10.1007","author":[{"given":"Shiyi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhi","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huajun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,12]]},"reference":[{"issue":"6","key":"4523_CR1","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S1473-3099(19)30755-8","volume":"20","author":"D van Duin","year":"2020","unstructured":"van Duin D, Arias CA, Komarow L, Chen L, Hanson BM, Weston G, Cober E, Garner OB, Jacob JT, Satlin MJ, Fries BC, Garcia-Diaz J, Doi Y, Dhar S, Kaye KS, Earley M, Hujer AM, Hujer KM, Domitrovic TN, Shropshire WC, Dinh A, Manca C, Luterbach CL, Wang M, Paterson DL, Banerjee R, Patel R, Evans S, Hill C, Arias R, Chambers HF, Fowler VG Jr, Kreiswirth BN, Bonomo RA, Multi-Drug Resistant Organism Network I (2020) Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2) a prospective cohort study. Lancet Infect Dis 20(6):731\u2013741","journal-title":"The Lancet Infectious diseases"},{"issue":"3","key":"4523_CR2","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.cmi.2016.10.005","volume":"23","author":"JA Otter","year":"2017","unstructured":"Otter JA, Burgess P, Davies F, Mookerjee S, Singleton J, Gilchrist M, Parsons D, Brannigan ET, Robotham J, Holmes AH (2017) Counting the cost of an outbreak of carbapenemase-producing Enterobacteriaceae: an economic evaluation from a hospital perspective. Clin Microbiol Infect 23(3):188\u2013196","journal-title":"Clin Microbiol Infect"},{"key":"4523_CR3","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.2147\/IDR.S272217","volume":"13","author":"P Zhang","year":"2020","unstructured":"Zhang P, Wang J, Hu H, Zhang S, Wei J, Yang Q, Qu T (2020) Clinical Characteristics and Risk Factors for Bloodstream Infection Due to Carbapenem-Resistant Klebsiella pneumoniae in Patients with Hematologic Malignancies. Infect Drug Resist 13:3233\u20133242","journal-title":"Infect Drug Resist"},{"issue":"12","key":"4523_CR4","doi-asserted-by":"publisher","first-page":"5046","DOI":"10.1128\/AAC.00774-09","volume":"53","author":"D Yong","year":"2009","unstructured":"Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR (2009) Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother 53(12):5046\u20135054","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"4523_CR5","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1093\/cid\/ciz1159","volume":"71","author":"RK Shields","year":"2020","unstructured":"Shields RK, Doi Y (2020) Aztreonam Combination Therapy: An Answer to Metallo-\u03b2-Lactamase-Producing Gram-Negative Bacteria? Clin Infect Dis\u202f: an Off Publ Infect Dis Soc America 71(4):1099\u20131101","journal-title":"Clin Infect Dis : an Off Publ Infect Dis Soc America"},{"issue":"4","key":"4523_CR6","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1128\/AAC.00826-13","volume":"58","author":"SM Drawz","year":"2014","unstructured":"Drawz SM, Papp-Wallace KM, Bonomo RA (2014) New \u03b2-lactamase inhibitors: a therapeutic renaissance in an MDR world. Antimicrob Agents Chemother 58(4):1835\u20131846","journal-title":"Antimicrob Agents Chemother"},{"key":"4523_CR7","doi-asserted-by":"crossref","unstructured":"Marshall S, Hujer AM, Rojas LJ, Papp-Wallace KM, Humphries RM, Spellberg B, Hujer KM, Marshall EK, Rudin SD, Perez F, Wilson BM, Wasserman RB, Chikowski L, Paterson DL, Vila AJ, van Duin D, Kreiswirth BN, Chambers HF, Fowler VG Jr, Jacobs MR, Bonomo RA (2017) Can ceftazidime-avibactam and aztreonam overcome \u03b2-lactam resistance conferred by metallo-\u03b2-lactamases in enterobacteriaceae?. Antimicrobial agents and chemotherapy 61(4):e02243\u201316","DOI":"10.1128\/AAC.02243-16"},{"issue":"8","key":"4523_CR8","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1007\/s10096-021-04197-3","volume":"40","author":"S Maraki","year":"2021","unstructured":"Maraki S, Mavromanolaki VE, Moraitis P, Stafylaki D, Kasimati A, Magkafouraki E, Scoulica E (2021) Ceftazidime-avibactam, meropenen-vaborbactam, and imipenem-relebactam in combination with aztreonam against multidrug-resistant, metallo-beta-lactamase-producing Klebsiella pneumoniae. Eur J Clin Microbiol Infect Dis 40(8):1755\u20131759","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"4523_CR9","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1093\/jac\/dkx393","volume":"73","author":"A Jayol","year":"2018","unstructured":"Jayol A, Nordmann P, Poirel L, Dubois V (2018) Ceftazidime\/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae. J Antimicrob Chemother 73(2):542\u2013544","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"4523_CR10","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1093\/cid\/ciaa586","volume":"72","author":"M Falcone","year":"2021","unstructured":"Falcone M, Daikos GL, Tiseo G, Bassoulis D, Giordano C, Galfo V, Leonildi A, Tagliaferri E, Barnini S, Sani S, Farcomeni A, Ghiadoni L, Menichetti F (2021) Efficacy of Ceftazidime-avibactam Plus Aztreonam in Patients With Bloodstream Infections Caused by Metallo-beta-lactamase-Producing Enterobacterales. Clin Infect Dis 72(11):1871\u20131878","journal-title":"Clin Infect Dis"},{"key":"4523_CR11","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.jgar.2020.10.019","volume":"23","author":"P Bocanegra-Ibarias","year":"2020","unstructured":"Bocanegra-Ibarias P, Camacho-Ortiz A, Garza-Gonzalez E, Flores-Trevino S, Kim H, Perez-Alba E (2020) Aztreonam plus ceftazidime-avibactam as treatment of NDM-1-producing Klebsiella pneumoniae bacteraemia in a neutropenic patient: Last resort therapy? J Glob Antimicrob Resist 23:417\u2013419","journal-title":"J Glob Antimicrob Resist"},{"key":"4523_CR12","doi-asserted-by":"crossref","unstructured":"Perrotta F, Perrini MP (2021) Successful treatment of klebsiella pneumoniae NDM sepsis and intestinal decolonization with ceftazidime\/avibactam plus aztreonam combination in a patient with TTP complicated by SARSCoV-2 nosocomial infection. Medicina (Kaunas, Lithuania) 57(5):424","DOI":"10.3390\/medicina57050424"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-022-04523-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-022-04523-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-022-04523-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T15:05:54Z","timestamp":1668351954000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-022-04523-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":12,"alternative-id":["4523"],"URL":"https:\/\/doi.org\/10.1007\/s10096-022-04523-3","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,12]]},"assertion":[{"value":"29 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval for this study was waived by the local ethics committee at Hospital of Ningbo University because it is a single-case study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the patient.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The participant has consented to the submission of the case report to the journal.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}