{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:45:29Z","timestamp":1782513929660,"version":"3.54.5"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001631","name":"University College Dublin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001631","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract\n<\/jats:title><jats:p>Pyelonephritis affects 1\u20132% of pregnant women, and is associated with significant maternal and fetal morbidity. Antenatal pyelonephritis has been associated with PPROM (preterm premature rupture of membranes), preterm labour, low birth weight (LBW) and prematurity. A three-year retrospective dual-centre cohort study of antenatal pyelonephritis cases\u00a0was conducted\u00a0in two neighbouring Irish maternity hospitals\u00a0\u2013 the Rotunda Hospital (RH) and the National Maternity Hospital (NMH). Patient demographics, clinical presentation, investigations, management and maternal\/neonatal outcomes were recorded. A total of 47,676 deliveries (24,768 RH; 22,908 NMH) were assessed. 158 cases of antenatal pyelonephritis were identified (<jats:italic>n<\/jats:italic>\u2009=\u200988 RH, <jats:italic>n<\/jats:italic>\u2009=\u200970 NMH), with an incidence of 0.33%. The median age was 28\u00a0years. The median gestation was 27\u2009+\u20096\u00a0weeks, with 51% presenting before 28\u00a0weeks\u2019 gestation. Risk factors included; obesity (18.4%), diabetes mellitus (13.3%) and self-reported clinical history of recurrent urinary tract infection (28.5%). Rate of relapse with UTI in the same pregnancy was 8.2%. Renal ultrasound was performed in 30.4%. Predominant uropathogens were <jats:italic>Escherichia coli<\/jats:italic> (60%), <jats:italic>Klebsiella pneumoniae<\/jats:italic> (11%) and <jats:italic>Proteus mirabilis<\/jats:italic> (5%). 7.5% of cases had a concurrent bloodstream infection, 13.3% of cases were complicated by sepsis and 1.9% with septic shock. Complications including PPROM (6.3%), preterm delivery\u2009&lt;\u200937\u00a0weeks\u2019 gestation (11%), LBW\u2009&lt;\u20092,500\u00a0g (8.2%) were comparable between sites. Delivery within 72\u00a0hours of diagnosis was noted in 7% (<jats:italic>n<\/jats:italic>\u2009=\u200911) of patients, of which three were preterm and one had LBW. Appropriate and prompt investigation and management of antenatal pyelonephritis is essential given the associated maternal and neonatal morbidity.<\/jats:p>","DOI":"10.1007\/s10096-023-04609-6","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T06:02:06Z","timestamp":1682920926000},"page":"827-833","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antenatal pyelonephritis: a three-year retrospective cohort study of two Irish maternity centres"],"prefix":"10.1007","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1724-4568","authenticated-orcid":false,"given":"Rachel","family":"Barry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Houlihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeve","family":"Eogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Drew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,1]]},"reference":[{"key":"4609_CR1","doi-asserted-by":"crossref","unstructured":"Smaill FM, Vazquez JC (2019) Antibiotics for asymptomatic bacteriuria in pregnancy. 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MMWR Recomm Rep 59(RR-10):1\u201336"},{"issue":"10","key":"4609_CR7","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1093\/jac\/dkt177","volume":"68","author":"N Eliakim-Raz","year":"2013","unstructured":"Eliakim-Raz N, Yahav D, Paul M, Leibovici L (2013) Duration of antibiotic treatment for acute pyelonephritis and septic urinary tract infection\u2013 7 days or less versus longer treatment: systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother 68(10):2183\u20132191","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"4609_CR8","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1155\/S1064744996000567","volume":"4","author":"BC Brost","year":"1996","unstructured":"Brost BC, Campbell B, Stramm S, Eller D, Newman RB (1996) Randomized clinical trial of antibiotic therapy for antenatal pyelonephritis. 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BMC Pregnancy Childbirth 21(1):291","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"4609_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12963-019-0195-7","volume":"17","author":"CS Vilanova","year":"2019","unstructured":"Vilanova CS, Hirakata VN, de Souza Buriol VC, Nunes M, Goldani MZ, da Silva CH (2019) The relationship between the different low birth weight strata of newborns with infant mortality and the influence of the main health determinants in the extreme south of Brazil. 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There are no competing interests to declare. All statements and views expressed in the submitted article are that of the authors and are not an official position of the affiliated institutions.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}