{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:21:00Z","timestamp":1780590060017,"version":"3.54.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300156"],"award-info":[{"award-number":["32300156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20220493"],"award-info":[{"award-number":["BK20220493"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M731375"],"award-info":[{"award-number":["2023M731375"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004300","name":"Senior Talent Foundation of Jiangsu University","doi-asserted-by":"publisher","award":["No. 5501280007"],"award-info":[{"award-number":["No. 5501280007"]}],"id":[{"id":"10.13039\/501100004300","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Infection Management Special Research Topic of Suzhou Hospital Association","award":["SZSYYXH-2023-ZD7"],"award-info":[{"award-number":["SZSYYXH-2023-ZD7"]}]},{"name":"the Priority Academic Program Development of Jiangsu Higher Education Institutions"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s10096-024-04757-3","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T02:02:30Z","timestamp":1705456950000},"page":"617-622","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Emergence of an ST1934:KL121 hypervirulent Klebsiella pneumoniae carrying a novel virulence-resistance hybrid plasmid with chromosomal integration of ICEKp1"],"prefix":"10.1007","volume":"43","author":[{"given":"Yunbing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6515-4201","authenticated-orcid":false,"given":"Ning","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"issue":"2","key":"4757_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.4161\/viru.22718","volume":"4","author":"AS Shon","year":"2013","unstructured":"Shon AS, Bajwa RPS, Russo TA (2013) Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence 4(2):107\u2013118","journal-title":"Virulence"},{"issue":"11","key":"4757_CR2","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S1473-3099(12)70205-0","volume":"12","author":"LK Siu","year":"2012","unstructured":"Siu LK, Yeh K-M, Lin J-C, Fung C-P, Chang F-Y (2012) Klebsiella pneumoniae liver abscess: a new invasive syndrome. Lancet Infect Dis 12(11):881\u2013887","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"4757_CR3","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1128\/MMBR.00078-15","volume":"80","author":"MK Paczosa","year":"2016","unstructured":"Paczosa MK, Mecsas J (2016) Klebsiella pneumoniae: going on the offense with a strong defense. Microbiol Mol Biol Rev 80(3):629\u2013661","journal-title":"Microbiol Mol Biol Rev"},{"issue":"1","key":"4757_CR4","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1080\/22221751.2021.1906163","volume":"10","author":"Y Yang","year":"2021","unstructured":"Yang Y, Yang Y, Chen G, Lin M, Chen Y, He R, Galv\u00e3o KN, El-Gawad El-Sayed Ahmed MA, Roberts AP, Wu Y, Zhong L-L, Liang X, Qin M, Ding X, Deng W, Huang S, Li H-Y, Dai M, Chen D-Q, Zhang L, Liao K, Xia Y, Tian G-B (2021) Molecular characterization of carbapenem-resistant and virulent plasmids in Klebsiella pneumoniae from patients with bloodstream infections in China. Emerg Microbes Infect 10(1):700\u2013709","journal-title":"Emerg Microbes Infect"},{"issue":"2","key":"4757_CR5","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/jac\/dkz446","volume":"75","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Jin L, Ouyang P, Wang Q, Wang R, Wang J, Gao H, Wang X, Wang H (2020) Evolution of hypervirulence in carbapenem-resistant Klebsiella pneumoniae in China: a multicentre, molecular epidemiological analysis. J Antimicrob Chemother 75(2):327\u2013336","journal-title":"J Antimicrob Chemother"},{"key":"4757_CR6","doi-asserted-by":"publisher","first-page":"103998","DOI":"10.1016\/j.ebiom.2022.103998","volume":"79","author":"N Dong","year":"2022","unstructured":"Dong N, Yang X, Chan EW-C, Zhang R, Chen S (2022) Klebsiella species: Taxonomy, hypervirulence and multidrug resistance. EBioMedicine 79:103998","journal-title":"EBioMedicine"},{"issue":"7","key":"4757_CR7","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1093\/jac\/dkac121","volume":"77","author":"C Liu","year":"2022","unstructured":"Liu C, Dong N, Zeng Y, Lu J, Chen J, Wang Y, Cai C, Chen K, Chen G, Shen Z (2022) Co-transfer of last-line antibiotic resistance and virulence operons by an IncFIBk-FII-X3-ColKP3 hybrid plasmid in Klebsiella pneumoniae. J Antimicrob Chemother 77(7):1856\u20131861","journal-title":"J Antimicrob Chemother"},{"key":"4757_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13073-021-00936-5","volume":"13","author":"Y Xu","year":"2021","unstructured":"Xu Y, Zhang J, Wang M, Liu M, Liu G, Qu H, Liu J, Deng Z, Sun J, Ou H-Y (2021) Mobilization of the nonconjugative virulence plasmid from hypervirulent Klebsiella pneumoniae. Genome Med 13:1\u201315","journal-title":"Genome Med"},{"issue":"1","key":"4757_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-018-05114-7","volume":"9","author":"MM Lam","year":"2018","unstructured":"Lam MM, Wyres KL, Duch\u00eane S, Wick RR, Judd LM, Gan Y-H, Hoh C-H, Archuleta S, Molton JS, Kalimuddin S (2018) Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination. Nat Commun 9(1):1\u201310","journal-title":"Nat Commun"},{"key":"4757_CR10","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1007\/s10096-020-03890-z","volume":"39","author":"G Li","year":"2020","unstructured":"Li G, Shi J, Zhao Y, Xie Y, Tang Y, Jiang X, Lu Y (2020) Identification of hypervirulent Klebsiella pneumoniae isolates using the string test in combination with Galleria mellonella infectivity. Eur J Clin Microbiol Infect Dis 39:1673\u20131679","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"4757_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1471-2334-14-31","volume":"14","author":"MM McLaughlin","year":"2014","unstructured":"McLaughlin MM, Advincula MR, Malczynski M, Barajas G, Qi C, Scheetz MH (2014) Quantifying the clinical virulence of Klebsiella pneumoniae producing carbapenemase Klebsiella pneumoniae with a Galleria mellonella model and a pilot study to translate to patient outcomes. BMC Infect Dis 14(1):31","journal-title":"BMC Infect Dis"},{"issue":"3","key":"4757_CR12","doi-asserted-by":"publisher","first-page":"e02528","DOI":"10.1128\/spectrum.02528-21","volume":"10","author":"H Wang","year":"2022","unstructured":"Wang H, Xu Q, Chen K, Chan BKW, Ye L, Yang X, Xie M, Liu X, Ni H, Chan EWC (2022) A Siderophore-encoding plasmid encodes high-level virulence in Escherichia coli. Microbiology Spectrum 10(3):e02528-e2521","journal-title":"Microbiology Spectrum"},{"issue":"12","key":"4757_CR13","first-page":"3317","volume":"73","author":"N Dong","year":"2018","unstructured":"Dong N, Lin D, Zhang R, Chan EW-C, Chen S (2018) Carriage of bla KPC-2 by a virulence plasmid in hypervirulent Klebsiella pneumoniae. J Antimicrob Chemother 73(12):3317\u20133321","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"4757_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-24448-3","volume":"12","author":"M Lam","year":"2021","unstructured":"Lam M, Wick RR, Watts SC, Cerdeira LT, Wyres KL, Holt KE (2021) A genomic surveillance framework and genotyping tool for Klebsiella pneumoniae and its related species complex. Nat Commun 12(1):1\u201316","journal-title":"Nat Commun"},{"issue":"5","key":"4757_CR15","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1128\/AAC.19.5.831","volume":"19","author":"DE Taylor","year":"1981","unstructured":"Taylor DE, De Grandis SA, Karmali MA, Fleming PC (1981) Transmissible plasmids from Campylobacter jejuni. Antimicrob Agents Chemother 19(5):831\u2013835","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"4757_CR16","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S1473-3099(17)30489-9","volume":"18","author":"D Gu","year":"2018","unstructured":"Gu D, Dong N, Zheng Z, Lin D, Huang M, Wang L, Chan EW-C, Shu L, Yu J, Zhang R (2018) A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis 18(1):37\u201346","journal-title":"Lancet Infect Dis"},{"key":"4757_CR17","unstructured":"Xi J, Xu Y, Guo Y (2020) Virulence gene detection and homology analysis of Klebsiella pneumoniae inducing liver abscess. J Clin Hepatol 1072\u20131076"},{"key":"4757_CR18","doi-asserted-by":"publisher","first-page":"105014","DOI":"10.1016\/j.micpath.2021.105014","volume":"158","author":"P Lan","year":"2021","unstructured":"Lan P, Yan R, Lu Y, Zhao D, Shi Q, Jiang Y, Yu Y, Zhou J (2021) Genetic diversity of siderophores and hypermucoviscosity phenotype in Klebsiella pneumoniae. Microb Pathog 158:105014","journal-title":"Microb Pathog"},{"issue":"1","key":"4757_CR19","first-page":"10","volume":"64","author":"Z Shen","year":"2020","unstructured":"Shen Z, Gao Q, Qin J, Liu Y, Li M (2020) Emergence of an NDM-5-producing hypervirulent Klebsiella pneumoniae sequence type 35 strain with chromosomal integration of an integrative and conjugative element, ICEKp1. Antimicrob Agents Chemother 64(1):10\u20131128","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"4757_CR20","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1128\/JB.01219-07","volume":"190","author":"T-L Lin","year":"2008","unstructured":"Lin T-L, Lee C-Z, Hsieh P-F, Tsai S-F, Wang J-T (2008) Characterization of integrative and conjugative element ICE Kp1-associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscess. J Bacteriol 190(2):515\u2013526","journal-title":"J Bacteriol"},{"key":"4757_CR21","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.mib.2019.06.004","volume":"51","author":"SJ Dunn","year":"2019","unstructured":"Dunn SJ, Connor C, McNally A (2019) The evolution and transmission of multi-drug resistant Escherichia coli and Klebsiella pneumoniae: the complexity of clones and plasmids. Curr Opin Microbiol 51:51\u201356","journal-title":"Curr Opin Microbiol"},{"key":"4757_CR22","doi-asserted-by":"publisher","first-page":"581543","DOI":"10.3389\/fmicb.2020.581543","volume":"11","author":"M Tang","year":"2020","unstructured":"Tang M, Kong X, Hao J, Liu J (2020) Epidemiological characteristics and formation mechanisms of multidrug-resistant hypervirulent Klebsiella pneumoniae. Front Microbiol 11:581543","journal-title":"Front Microbiol"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-024-04757-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-024-04757-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-024-04757-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T14:12:46Z","timestamp":1709734366000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-024-04757-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["4757"],"URL":"https:\/\/doi.org\/10.1007\/s10096-024-04757-3","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]},"assertion":[{"value":"26 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by an independent ethics committee and the Institutional Review Board of the Children\u2019s Hospital of Soochow University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}