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A <jats:italic>S<\/jats:italic>. 1,4,[5], 12: i: - strain named ST3606 (sequence type 34), isolated from a fecal specimen of a child with acute diarrhea hospitalized in a tertiary hospital in China, was firstly reported to be resistant to carbapenem and ceftazidime-avibactam. The aim of this study was to characterize the whole-genome sequence of <jats:italic>S.<\/jats:italic> 1,4,[5], 12: i: - isolate, ST3606, and explore its antibiotic resistance genes and their genetic environments.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The genomic DNA of <jats:italic>S.<\/jats:italic> 1,4,[5], 12: i: - ST3606 was extracted and performed with single-molecule real-time sequencing. Resistance genes, plasmid replicon type, mobile elements, and multilocus sequence types (STs) of ST3606 were identified by ResFinder 3.2, PlasmidFinder, OriTfinder database, ISfinder database, and MLST 2.0, respectively. The conjugation experiment was utilized to evaluate the conjugation frequency of pST3606-2. Protein expression and enzyme kinetics experiments of CTX-M were performed to analyze hydrolytic activity of a novel CTX-M-261 enzyme toward several antibiotics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Single-molecule real-time sequencing revealed the coexistence of a 109-kb IncI1-I\u03b1 plasmid pST3606-1 and a 70.5-kb IncFII plasmid pST3606-2. The isolate carried resistance genes, including <jats:italic>bla<\/jats:italic><jats:sub>NDM-5<\/jats:sub>, <jats:italic>sul1<\/jats:italic>, <jats:italic>qacE<\/jats:italic>, <jats:italic>aadA2<\/jats:italic>, and\n<jats:italic>dfrA12<\/jats:italic> in pST3606-1, <jats:italic>bla<\/jats:italic><jats:sub>TEM-1B<\/jats:sub>, <jats:italic>aac<\/jats:italic>(3)-<jats:italic>lld<\/jats:italic>, and <jats:italic>bla<\/jats:italic><jats:sub>CTX-M-261<\/jats:sub>, a novel\n<jats:italic>bla<\/jats:italic><jats:sub>CTX-M-1<\/jats:sub> family member, in pST3606-2, and <jats:italic>aac<\/jats:italic>(6')-<jats:italic>Iaa<\/jats:italic> in chromosome. The\n<jats:italic>bla<\/jats:italic><jats:sub>CTX-M-261<\/jats:sub> was derived from <jats:italic>bla<\/jats:italic><jats:sub>CTX-M-55<\/jats:sub> by a single-nucleotide mutation 751G&gt;A leading to amino acid substitution of Val for Met at position 251 (Val251Met), which conferred CTX-M increasing resistance to ceftazidime verified by antibiotics susceptibility testing of transconjugants carrying pST3606-2 and steady-state kinetic parameters of CTX-M-261. pST3606-1 is an IncI1-\u03b1 incompatibility type that shares homology with plasmids of pC-F-164_A-OXA140, pE-T654-NDM-5, p_dm760b_NDM-5, and p_dmcr749c_NDM-5. The conjugation experiment demonstrated that pST3606-2 was successfully transferred to the <jats:italic>Escherichia coli<\/jats:italic> recipient C600 with four modules of OriTfinder.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Plasmid-mediated horizontal transfer plays an important role in <jats:italic>bla<\/jats:italic><jats:sub>NDM-5<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>CTX-M-261<\/jats:sub> dissemination, which increases the threat to public health due to the resistance to most \u03b2-lactam antibiotics. This is the first report of <jats:italic>bla<\/jats:italic><jats:sub>CTX-M-261<\/jats:sub> and <jats:italic>bla<\/jats:italic><jats:sub>NDM-5<\/jats:sub> in <jats:italic>S.<\/jats:italic> 1,4,[5], 12: i: -. The work provides insights into the enzymatic function and demonstrates the ongoing evolution of CTX-M enzymes and confirms urgency to control resistance of <jats:italic>S<\/jats:italic>. 1,4,[5], 12: i: -.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10096-024-04765-3","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T18:02:40Z","timestamp":1708624960000},"page":"829-840","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Emergence of a clinical Salmonella enterica serovar 1,4,[5], 12: i:-isolate, ST3606, in China with susceptibility decrease to ceftazidime-avibactam carrying a novel blaCTX-M-261 variant and a blaNDM-5"],"prefix":"10.1007","volume":"43","author":[{"given":"Jie","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenglan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunhong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YeLin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyi","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoju","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"issue":"10","key":"4765_CR1","doi-asserted-by":"publisher","first-page":"3425","DOI":"10.1128\/JCM.37.10.3425-3425.1999","volume":"37","author":"MA Echeita","year":"1999","unstructured":"Echeita MA, Aladue\u00f1a A, Cruchaga S, Usera MA (1999) Emergence and spread of an atypical Salmonella enterica subsp. enterica serotype 4,5,12:i:- strain in Spain. 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