{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:00:14Z","timestamp":1791489614722,"version":"4.3.4"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","award":["YSS\/2020\/000048\/PRCYSS"],"award-info":[{"award-number":["YSS\/2020\/000048\/PRCYSS"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["Intramural JE-AES project"],"award-info":[{"award-number":["Intramural JE-AES project"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s10096-024-04817-8","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T09:12:10Z","timestamp":1711962730000},"page":"1205-1212","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular and serological evidence of chikungunya virus infection with high case fatality among pediatric population with acute encephalitis syndrome: first report from Eastern Uttar Pradesh, India"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-0291","authenticated-orcid":false,"given":"Pooja","family":"Bhardwaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamlesh","family":"Sah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzadi","family":"Gulafshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Dhangur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utkarsh","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav Raj","family":"Dwivedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Murhekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupendra","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7597-5601","authenticated-orcid":false,"given":"Rajeev","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"4817_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1080\/22221751.2018.1559708","volume":"8","author":"BMCR Wimalasiri-Yapa","year":"2019","unstructured":"Wimalasiri-Yapa BMCR, Stassen L, Huang X, Hafner LM, Hu W, Devine GJ et al (2019) Chikungunya virus in Asia \u2013 Pacific: a systematic review. Emerg Microbes Infections 8:70\u201379. https:\/\/doi.org\/10.1080\/22221751.2018.1559708","journal-title":"Emerg Microbes Infections"},{"key":"4817_CR2","unstructured":"Chikungunya Facts [Internet] [cited 2023 7] https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chikungunya#:~:text=Chikungunya%20virus%20is%20transmitted%20by,bite%20primarily%20during%20daylight%20hours."},{"key":"4817_CR3","doi-asserted-by":"publisher","first-page":"S153","DOI":"10.4103\/0255-0857.150946","volume":"33","author":"D Taraphdar","year":"2015","unstructured":"Taraphdar D, Roy B, Chatterjee S (2015) Chikungunya virus infection amongst the acute encephalitis syndrome cases in West Bengal, India. Ind J Med Microbiol 33:S153\u2013S156. https:\/\/doi.org\/10.4103\/0255-0857.150946","journal-title":"Ind J Med Microbiol"},{"key":"4817_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.pneurobio.2009.12.006","volume":"91","author":"T Das","year":"2010","unstructured":"Das T, Jaffar-Bandjee MC, Hoarau JJ, Krejbich Trotot P, Denizot M, Lee-Pat-Yuen G et al (2010) Chikungunya fever: CNS infection and pathologies of a re-emerging arbovirus. Prog Neurobiol 91:121\u2013129. https:\/\/doi.org\/10.1016\/j.pneurobio.2009.12.006","journal-title":"Prog Neurobiol"},{"key":"4817_CR5","doi-asserted-by":"publisher","unstructured":"Solomon T A cohort study to assess the new WHO Japanese encephalitis surveillance standards. Bull World Health Organ 2008 1;86:178\u2013186. https:\/\/doi.org\/10.2471\/BLT.07.043307","DOI":"10.2471\/BLT.07.043307"},{"key":"4817_CR6","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s13312-020-1889-4","volume":"15","author":"JWV Thangaraj","year":"2020","unstructured":"Thangaraj JWV, Zaman K, Shete V, Pandey AK, Velusamy S, Deoshatwar A et al (2020) Effectiveness of Presumptive Treatment of Acute Febrile illness with doxycycline or azithromycin in preventing Acute Encephalitis Syndrome in Gorakhpur, India: a Cohort Study. Indian Pediatr 15:57:619\u2013624","journal-title":"Indian Pediatr"},{"key":"4817_CR7","doi-asserted-by":"publisher","unstructured":"Murhekar M, Vivian Thangaraj JW, Mittal M, Gupta N Acute Encephalitis Syndrome in Eastern Uttar Pradesh, India: changing Etiological understanding. J Med Entomol 2018 4;55:523\u2013526. https:\/\/doi.org\/10.1093\/jme\/tjy042","DOI":"10.1093\/jme\/tjy042"},{"key":"4817_CR8","doi-asserted-by":"publisher","first-page":"527","DOI":"10.4103\/ijmr.IJMR_2303_18","volume":"152","author":"A Ozair","year":"2020","unstructured":"Ozair A, Khan DN, Prakash S, Bhagat A, Verma A, Shukla S et al (2020) Upsurge of chikungunya cases in Uttar Pradesh, India. Indian J Med Res 152:527\u2013530. https:\/\/doi.org\/10.4103\/ijmr.IJMR_2303_18","journal-title":"Indian J Med Res"},{"key":"4817_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4103\/1995-7645.250340","volume":"12","author":"P Dutta","year":"2019","unstructured":"Dutta P, Khan S, Phukan A, Hazarika S, Hazarika N, Chetry S et al (2019) Surveillance of Chikungunya virus activity in some north-eastern states of India. Asian Pac J Trop Med 12:19. https:\/\/doi.org\/10.4103\/1995-7645.250340","journal-title":"Asian Pac J Trop Med"},{"key":"4817_CR10","doi-asserted-by":"publisher","first-page":"104970","DOI":"10.1016\/j.jcv.2021.104970","volume":"144","author":"BV Tandale","year":"2021","unstructured":"Tandale BV, Bondre VP, Sapkal GN, Gopalkrishna V, Gurav YK, Rao RK et al (2021) Childhood encephalitis hospitalizations associated with virus agents in medium-endemic states in India. J Clin Virol 144:104970. https:\/\/doi.org\/10.1016\/j.jcv.2021.104970","journal-title":"J Clin Virol"},{"key":"4817_CR11","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1007\/s10096-020-03933-5","volume":"39","author":"HP Patil","year":"2020","unstructured":"Patil HP, Rane PS, Gosavi M, Mishra AC, Arankalle VA (2020) Standardization of ELISA for anti-chikungunya-IgG antibodies and age-stratified prevalence of anti-chikungunya-IgG antibodies in Pune, India. Eur J Clin Microbiol Infect Dis 39:1925\u20131932. https:\/\/doi.org\/10.1007\/s10096-020-03933-5","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4817_CR12","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/s41390-023-02930-6","volume":"95","author":"BM Liu","year":"2024","unstructured":"Liu BM, Mulkey SB, Campos JM, DeBiasi RL (2024) Laboratory diagnosis of CNS infections in children due to emerging and re-emerging neurotropic viruses. Pediatr Res 95:543\u2013550. https:\/\/doi.org\/10.1038\/s41390-023-02930-6","journal-title":"Pediatr Res"},{"key":"4817_CR13","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s40506-018-0172-x","volume":"10","author":"C Soto-Garita","year":"2018","unstructured":"Soto-Garita C, Carrera J-P, L\u00f3pez-Verg\u00e8s S, Corrales-Aguilar E (2018) Advances in clinical diagnosis and management of Chikungunya Virus infection. Curr Treat Options Infect Dis 10:397\u2013409. https:\/\/doi.org\/10.1007\/s40506-018-0172-x","journal-title":"Curr Treat Options Infect Dis"},{"key":"4817_CR14","doi-asserted-by":"publisher","unstructured":"Shahrtash SA, Ghnim ZS, Ghaheri M, Adabi J, Hassanzadeh MA, Yasamineh S et al Recent advances in the role of different nanoparticles in the various biosensors for the detection of the Chikungunya Virus. Mol Biotechnol [Internet] 2024 23 [cited 2024 18].  https:\/\/link.springer.com\/https:\/\/doi.org\/10.1007\/s12033-024-01052-6","DOI":"10.1007\/s12033-024-01052-6"},{"key":"4817_CR15","doi-asserted-by":"publisher","first-page":"e00350","DOI":"10.1128\/JCM.00350-19","volume":"57","author":"MS Natrajan","year":"2019","unstructured":"Natrajan MS, Rojas A, Waggoner JJ (2019) Beyond Fever and Pain: diagnostic methods for Chikungunya Virus. J Clin Microbiol 57:e00350\u2013e00319. https:\/\/doi.org\/10.1128\/JCM.00350-19","journal-title":"J Clin Microbiol"},{"key":"4817_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4103\/0019-5359.104781","volume":"65","author":"M Dash","year":"2011","unstructured":"Dash M, Mohanty I, Padhi S (2011) Laboratory diagnosis of Chikungunya virus: do we really need it? Indian J Med Sci 65:83\u201391","journal-title":"Indian J Med Sci"},{"key":"4817_CR17","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1002\/jmv.23406","volume":"84","author":"V Reddy","year":"2012","unstructured":"Reddy V, Ravi V, Desai A, Parida M, Powers AM, Johnson BW (2012) Utility of IgM ELISA, TaqMan real-time PCR, reverse transcription PCR, and RT-LAMP assay for the diagnosis of Chikungunya fever. J Med Virol 84:1771\u20131778. https:\/\/doi.org\/10.1002\/jmv.23406","journal-title":"J Med Virol"},{"key":"4817_CR18","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.actatropica.2016.07.021","volume":"163","author":"EP Calvo","year":"2016","unstructured":"Calvo EP, S\u00e1nchez-Quete F, Dur\u00e1n S, Sandoval I, Castellanos JE (2016) Easy and inexpensive molecular detection of dengue, Chikungunya and zika viruses in febrile patients. Acta Trop 163:32\u201337. https:\/\/doi.org\/10.1016\/j.actatropica.2016.07.021","journal-title":"Acta Trop"},{"key":"4817_CR19","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1128\/jcm.30.3.545-551.1992","volume":"30","author":"RS Lanciotti","year":"1992","unstructured":"Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV (1992) Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30:545\u2013551","journal-title":"J Clin Microbiol"},{"key":"4817_CR20","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1007\/s00203-023-03492-1","volume":"205","author":"P Bhardwaj","year":"2023","unstructured":"Bhardwaj P, Behera SP, Nanaware N, Zaman K, Deval H, Kant R et al (2023) Phylogenetic and immunological investigations of complete TSA56 ORF of Orientia tsutsugamushi present in acute encephalitis syndrome cases from eastern Uttar Pradesh, India. Arch Microbiol 205:178. https:\/\/doi.org\/10.1007\/s00203-023-03492-1","journal-title":"Arch Microbiol"},{"key":"4817_CR21","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1093\/molbev\/msy096","volume":"35","author":"S Kumar","year":"2018","unstructured":"Kumar S, Stecher G, Li M, Knyaz C, Tamura K (2018) MEGA X: Molecular Evolutionary Genetics Analysis across Computing platforms. Mol Biol Evol 35:1547\u20131549. https:\/\/doi.org\/10.1093\/molbev\/msy096","journal-title":"Mol Biol Evol"},{"key":"4817_CR22","doi-asserted-by":"publisher","first-page":"e14504","DOI":"10.7717\/peerj.14504","volume":"11","author":"SP Behera","year":"2023","unstructured":"Behera SP, Bhardwaj P, Deval H, Srivastava N, Singh R, Misra BR et al (2023) Co-circulation of all the four Dengue virus serotypes during 2018\u20132019: first report from Eastern Uttar Pradesh, India. PeerJ 11:e14504. https:\/\/doi.org\/10.7717\/peerj.14504","journal-title":"PeerJ"},{"key":"4817_CR23","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1007\/s10096-017-3061-1","volume":"36","author":"S Mukherjee","year":"2017","unstructured":"Mukherjee S, Dutta SK, Sengupta S, Tripathi A (2017) Evidence of dengue and Chikungunya virus co-infection and circulation of multiple dengue serotypes in a recent Indian outbreak. Eur J Clin Microbiol Infect Dis 36:2273\u20132279. https:\/\/doi.org\/10.1007\/s10096-017-3061-1","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"4817_CR24","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.jinf.2014.08.002","volume":"69","author":"M Kakkar","year":"2014","unstructured":"Kakkar M, Rogawski ET, Abbas SS, Chaturvedi S, Dhole TN, Hossain SS et al (2014) Wishful thinking blurs interpretation of AES data in a high endemic region of India. J Infect 69:520\u2013521. https:\/\/doi.org\/10.1016\/j.jinf.2014.08.002","journal-title":"J Infect"},{"key":"4817_CR25","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4103\/jgid.jgid_179_22","volume":"15","author":"VS Kumar","year":"2023","unstructured":"Kumar VS, Sivasubramanian S, Padmanabhan P, Anupama CP, Ramesh K, Gunasekaran P et al (2023) Etiological Profile and Clinico epidemiological patterns of Acute Encephalitis Syndrome in Tamil Nadu, India. J Global Infect Dis 15:52\u201358. https:\/\/doi.org\/10.4103\/jgid.jgid_179_22","journal-title":"J Global Infect Dis"},{"key":"4817_CR26","doi-asserted-by":"publisher","unstructured":"Dubey RS, Kalyan S, Pathak B (2023) Impacts of urbanization and climate change on Habitat Destruction and Emergence of Zoonotic species [Internet]. In: Pathak B, Dubey RS (eds) Climate Change and Urban Environment Sustainability. Springer Nature Singapore, Singapore, pp 303\u2013322. [cited 2024 4] https:\/\/link.springer.com\/https:\/\/doi.org\/10.1007\/978-981-19-7618-6_17","DOI":"10.1007\/978-981-19-7618-6_17"},{"key":"4817_CR27","doi-asserted-by":"publisher","first-page":"6613564","DOI":"10.1155\/2021\/6613564","volume":"2021","author":"S Pathak","year":"2021","unstructured":"Pathak S, Chaudhary N, Dhakal P, Yadav SR, Gupta BK, Kurmi OP (2021) Comparative study of Chikungunya only and Chikungunya-Scrub Typhus Coinfection in Children: findings from a hospital-based observational study from Central Nepal. Int J Pediatr 2021:6613564. https:\/\/doi.org\/10.1155\/2021\/6613564","journal-title":"Int J Pediatr"},{"key":"4817_CR28","doi-asserted-by":"publisher","unstructured":"Chatterjee RP, Chatterjee S, Sikdar S, Das B, Ray Ghosh R Prevalence of Chikungunya and Scrub Typhus Coinfection among Dengue negative patients in Kolkata, India-A Newly Emerging Public Health Hazard. EJMED 2023 5;5:5\u201311. https:\/\/doi.org\/10.24018\/ejmed.2023.5.2.1598","DOI":"10.24018\/ejmed.2023.5.2.1598"},{"key":"4817_CR29","doi-asserted-by":"publisher","first-page":"e1978","DOI":"10.1002\/rmv.1978","volume":"28","author":"R Mehta","year":"2018","unstructured":"Mehta R, Gerardin P, De Brito CAA, Soares CN, Ferreira MLB, Solomon T (2018) The neurological complications of Chikungunya virus: a systematic review. Rev Med Virol 28:e1978. https:\/\/doi.org\/10.1002\/rmv.1978","journal-title":"Rev Med Virol"},{"key":"4817_CR30","first-page":"151","volume":"43","author":"C Lahariya","year":"2006","unstructured":"Lahariya C, Pradhan SK (2006) Emergence of Chikungunya virus in Indian subcontinent after 32 years: a review. J Vector Borne Dis 43:151\u2013160","journal-title":"J Vector Borne Dis"},{"key":"4817_CR31","doi-asserted-by":"publisher","unstructured":"Simon F, Caumes E, Jelinek T, Lopez-Velez R, Steffen R, Chen LH Chikungunya: risks for travellers. J Travel Med 2023 5;30:taad008. https:\/\/doi.org\/10.1093\/jtm\/taad008","DOI":"10.1093\/jtm\/taad008"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-024-04817-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-024-04817-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-024-04817-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T14:10:35Z","timestamp":1718374235000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-024-04817-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,1]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["4817"],"URL":"https:\/\/doi.org\/10.1007\/s10096-024-04817-8","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,1]]},"assertion":[{"value":"1 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in line with the guidelines established and approved by the Institutional Human Ethics Committee of ICMR-Regional Medical Research Centre, Gorakhpur for studies involving humans by letter no. RMRCGKP\/EC\/2022\/3.17. The IEC (human), RMRC, Gorakhpur adheres to the 2006 ethical principles for biomedical research involving human subjects issued by the Indian Council of Medical Research (ICMR), New Delhi. All Biosafety criteria were rigorously observed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}