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However, colistin-resistance in clinical isolates is becoming more prevalent. Cinnamaldehyde and baicalin, which are the major active constituents of <jats:italic>Cinnamomum<\/jats:italic> and <jats:italic>Scutellaria<\/jats:italic>, have been reported to exhibit antibacterial properties. The aim of this study was to evaluate the capacity of cinnamaldehyde and baicalin to enhance the antibiotic activity of colistin in <jats:italic>Enterobacterales<\/jats:italic> and <jats:italic>Acinetobacter baumannii<\/jats:italic> strains.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The MICs of colistin were determined with and without fixed concentrations of cinnamaldehyde and baicalin by the broth microdilution method. The FIC indices were also calculated. In addition, time-kill assays were performed with colistin alone and in combination with cinnamaldehyde and baicalin to determine the bactericidal action of the combinations. Similarly, the effects of L-arginine, L-glutamic acid and sucrose on the MICs of colistin combined with cinnamaldehyde and baicalin were studied to evaluate the possible effects of these compounds on the charge of the bacterial cell- wall.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At nontoxic concentrations, cinnamaldehyde and baicalin partially or fully reversed resistance to colistin in <jats:italic>Enterobacterales<\/jats:italic> and <jats:italic>A. baumannii<\/jats:italic>. The combinations of the two compounds with colistin had bactericidal or synergistic effects on the most resistant strains. The ability of these agents to reverse colistin resistance could be associated with bacterial cell wall damage and increased permeability.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Cinnamaldehyde and baicalin are good adjuvants for the antibiotic colistin against <jats:italic>Enterobacterales<\/jats:italic>- and <jats:italic>A. baumannii<\/jats:italic>-resistant strains.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10096-024-04884-x","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T09:01:25Z","timestamp":1722070885000},"page":"1899-1908","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cinnamaldehyde and baicalin reverse colistin resistance in Enterobacterales and Acinetobacter baumannii strains"],"prefix":"10.1007","volume":"43","author":[{"given":"Natalia A.","family":"Mireles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina F.","family":"Malla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-7461","authenticated-orcid":false,"given":"Mar\u00eda M.","family":"Tav\u00edo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"4884_CR1","unstructured":"World Health Organization (2017a) WHO publishes list of bacteria for which new antibiotics are urgently needed. https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed. 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