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Informed consent was waived due to the retrospective nature of the study and the treatment of concealing patient characteristics. Animal experiments were conducted in compliance with the guidelines set forth by the National Institutes of Health (NIH) for the care and use of laboratory animals. All efforts were made to minimize animal discomfort and distress.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}