{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:24:44Z","timestamp":1772119484142,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Belgian Medical-Technical Advisory Board of the National Reference Centers for Human Microbiology"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s10096-024-04900-0","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T07:05:14Z","timestamp":1721718314000},"page":"1919-1926","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Monitoring of Haemophilus influenzae isolated from carriage, lower respiratory tract infections and blood over a six-month period in Belgium"],"prefix":"10.1007","volume":"43","author":[{"given":"Magali","family":"Wautier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sema","family":"Unal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Martiny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"issue":"10","key":"4900_CR1","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1128\/JCM.00492-07","volume":"45","author":"D Mukundan","year":"2007","unstructured":"Mukundan D, Ecevit Z, Patel M, Marrs CF, Gilsdorf JR (2007) Pharyngeal colonization dynamics of Haemophilus influenzae and Haemophilus haemolyticus in healthy adult carriers. J Clin Microbiol 45(10):3207\u20133217. https:\/\/doi.org\/10.1128\/JCM.00492-07","journal-title":"J Clin Microbiol"},{"issue":"1","key":"4900_CR2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/2001-1326-1-10","volume":"1","author":"P King","year":"2012","unstructured":"King P (2012) Haemophilus influenzae and the lung (Haemophilus and the lung). Clin Translational Med 1(1):10. https:\/\/doi.org\/10.1186\/2001-1326-1-10","journal-title":"Clin Translational Med"},{"issue":"6","key":"4900_CR3","doi-asserted-by":"publisher","first-page":"e360","DOI":"10.1016\/S2589-7500(21)00077-7","volume":"3","author":"AB Brueggemann","year":"2021","unstructured":"Brueggemann AB, van Rensburg J, Shaw MJ, McCarthy D, Jolley ND, Maiden KA, van der Linden MCJ, Amin-Chowdhury MPG, Bennett Z, Borrow DE, Brandileone R, Broughton MC, Campbell K, Cao R, Casanova B, Choi C, Chu EH, Clark YW, Claus SA, Coelho H, Zhou J, F (2021) Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the invasive respiratory infection Surveillance Initiative: a prospective analysis of surveillance data. Lancet Digit Health 3(6):e360\u2013e370. https:\/\/doi.org\/10.1016\/S2589-7500(21)00077-7","journal-title":"Lancet Digit Health"},{"key":"4900_CR4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1471-2334-6-130","volume":"6","author":"A Kramer","year":"2006","unstructured":"Kramer A, Schwebke I, Kampf G (2006) How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis 6:130. https:\/\/doi.org\/10.1186\/1471-2334-6-130","journal-title":"BMC Infect Dis"},{"key":"4900_CR5","volume-title":"Surveillance \u00e9pid\u00e9miologique des infections invasives \u00e0 Haemophilus influenzae","author":"S Jacquinet","year":"2022","unstructured":"Jacquinet S, Martiny D, Prevost B, Grammens T (2022) Surveillance \u00e9pid\u00e9miologique des infections invasives \u00e0 Haemophilus influenzae. Sciensano, Brussels"},{"issue":"6","key":"4900_CR6","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1128\/AAC.45.6.1693-1699.2001","volume":"45","author":"K Ubukata","year":"2001","unstructured":"Ubukata K, Shibasaki Y, Yamamoto K, Chiba N, Hasegawa K, Takeuchi Y, Sunakawa K, Inoue M, Konno M (2001) Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother 45(6):1693\u20131699. https:\/\/doi.org\/10.1128\/AAC.45.6.1693-1699.2001","journal-title":"Antimicrob Agents Chemother"},{"key":"4900_CR7","unstructured":"Brussels Environment AMCRAARSIA, CHU Li\u00e8ge; DGZ, EARS-BE; ESAC-Net Study Group, FASFC; FPS Public Health; ISSep; ILVO, NRL-AMR (Sciensano), Salmonella NRC, Mycobacteria (Sciensano); NRC Sexually Transmitted Infections; NRC Staphylococci; Mycology and aerobiology (Sciensano); Sciensano; SPGE; SPW; Statistical analysis and data compilation (Sciensano); TC-MDRO; UGent; Veterinary Epidemiology (Sciensano) BELMAP One Health report on antimicrobial use and resistance in Belgium 2022"},{"key":"4900_CR8","unstructured":"Jacquinet S, Martiny D, Prevost B, Grammens T (2019\u20132021) Surveillance \u00e9pid\u00e9miologique Des infections invasives \u00e0 Haemophilus influenzae. Sciensano, Brussels"},{"key":"4900_CR9","unstructured":"WHO (2024) WHO bacterial priority pathogens list, 2024: Bacterial pathogens of public health importance to guide research, development and strategies to prevent and control antimicrobial resistance https:\/\/www.who.int\/publications\/i\/item\/9789240093461. Accessed 28 May 2024"},{"key":"4900_CR10","unstructured":"Cornaglia G, Courcol R, Hermann J-L, Kahlmeter G, Peigue-Lafeuille H, Vila J (2012) European Manual of Clinical Microbiology (2012) SFM, ESCMID"},{"issue":"11","key":"4900_CR11","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1128\/JCM.01630-15","volume":"53","author":"D Skaare","year":"2015","unstructured":"Skaare D, Lia A, Hannisdal A, Tveten Y, Matuschek E, Kahlmeter G, Kristiansen BE (2015) Haemophilus influenzae with non-beta-lactamase-mediated Beta-lactam resistance: Easy to find but hard to categorize. J Clin Microbiol 53(11):3589\u20133595. https:\/\/doi.org\/10.1128\/JCM.01630-15","journal-title":"J Clin Microbiol"},{"issue":"9","key":"4900_CR12","doi-asserted-by":"publisher","first-page":"2594","DOI":"10.1093\/jac\/dkaa229","volume":"75","author":"SA Fernando","year":"2020","unstructured":"Fernando SA, Pang S, McKew GL, Phan T, Merlino J, Coombs GW, Gottlieb T (2020) Evaluation of the Haemophilus influenzae EUCAST and CLSI disc diffusion methods to recognize Aminopenicillin and amoxicillin\/clavulanate resistance. J Antimicrob Chemother 75(9):2594\u20132598. https:\/\/doi.org\/10.1093\/jac\/dkaa229","journal-title":"J Antimicrob Chemother"},{"issue":"7","key":"4900_CR13","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1128\/AAC.46.7.2208-2218.2002","volume":"46","author":"H Dabernat","year":"2002","unstructured":"Dabernat H, Delmas C, Seguy M, Pelissier R, Faucon G, Bennamani S, Pasquier C (2002) Diversity of beta-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae. Antimicrob Agents Chemother 46(7):2208\u20132218. https:\/\/doi.org\/10.1128\/AAC.46.7.2208-2218.2002","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"4900_CR14","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1128\/jcm.20.4.815-816.1984","volume":"20","author":"FO Sottnek","year":"1984","unstructured":"Sottnek FO, Albritton WL (1984) Haemophilus influenzae biotype VIII. J Clin Microbiol 20(4):815\u2013816. https:\/\/doi.org\/10.1128\/jcm.20.4.815-816.1984","journal-title":"J Clin Microbiol"},{"key":"4900_CR15","doi-asserted-by":"publisher","first-page":"1160073","DOI":"10.3389\/fmicb.2023.1160073","volume":"14","author":"E Ekinci","year":"2023","unstructured":"Ekinci E, Willen L, Rodriguez Ruiz JP, Maertens K, Van Heirstraeten L, Serrano G, Wautier M, Deplano A, Goossens H, Van Damme P, Beutels P, Malhotra-Kumar S, Martiny D, Theeten H (2023) Haemophilus influenzae carriage and antibiotic resistance profile in Belgian infants over a three-year period (2016\u20132018). Front Microbiol 14:1160073. https:\/\/doi.org\/10.3389\/fmicb.2023.1160073","journal-title":"Front Microbiol"},{"issue":"12","key":"4900_CR16","doi-asserted-by":"publisher","first-page":"000723","DOI":"10.1099\/mgen.0.000723","volume":"7","author":"A Carrera-Salinas","year":"2021","unstructured":"Carrera-Salinas A, Gonz\u00e1lez-D\u00edaz A, Calatayud L, Mercado-Maza J, Puig C, Berbel D, C\u00e0mara J, Tubau F, Grau I, Dom\u00ednguez M\u00c1, Ardanuy C, Mart\u00ed S (2021) Epidemiology and population structure of Haemophilus influenzae causing invasive disease. Microb Genomics 7(12):000723. https:\/\/doi.org\/10.1099\/mgen.0.000723","journal-title":"Microb Genomics"},{"issue":"12","key":"4900_CR17","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1007\/s10096-020-03971-z","volume":"39","author":"M McElligott","year":"2020","unstructured":"McElligott M, Meyler K, Bennett D, Mulhall R, Drew RJ, Cunney R (2020) Epidemiology of Haemophilus influenzae in the Republic of Ireland, 2010\u20132018. Eur J Clin Microbiol Infect Diseases: Official Publication Eur Soc Clin Microbiol 39(12):2335\u20132344. https:\/\/doi.org\/10.1007\/s10096-020-03971-z","journal-title":"Eur J Clin Microbiol Infect Diseases: Official Publication Eur Soc Clin Microbiol"},{"issue":"10","key":"4900_CR18","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/S1473-3099(23)00204-9","volume":"23","author":"EC Wall","year":"2023","unstructured":"Wall EC, Taha MK (2023) Haemophilus influenzae is fighting back: is serotype a an emerging threat? Lancet Infect Dis 23(10):1106\u20131108. https:\/\/doi.org\/10.1016\/S1473-3099(23)00204-9","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"4900_CR19","doi-asserted-by":"publisher","first-page":"e0002821","DOI":"10.1128\/CMR.00028-21","volume":"34","author":"MPE Slack","year":"2021","unstructured":"Slack MPE, Cripps AW, Grimwood K, Mackenzie GA, Ulanova M (2021) Invasive Haemophilus influenzae infections after 3 decades of hib protein Conjugate Vaccine Use. Clin Microbiol Rev 34(3):e0002821. https:\/\/doi.org\/10.1128\/CMR.00028-21","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"4900_CR20","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1007\/s10096-022-04457-w","volume":"41","author":"M Kiedrowska","year":"2022","unstructured":"Kiedrowska M, Fory\u015b WJ, Go\u0142\u0119biewska A, Wa\u015bko I, Ronkiewicz P, Kuch A, Wr\u00f3bel-Pawelczyk I, Wroczy\u0144ski M, Hryniewicz W, Skoczy\u0144ska A (2022) Antimicrobial resistance among Haemophilus influenzae isolates responsible for lower respiratory tract infections in Poland, 2005\u20132019. Eur J Clin Microbiol Infect Diseases: Official Publication Eur Soc Clin Microbiol 41(6):961\u2013969. https:\/\/doi.org\/10.1007\/s10096-022-04457-w","journal-title":"Eur J Clin Microbiol Infect Diseases: Official Publication Eur Soc Clin Microbiol"},{"issue":"2","key":"4900_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3390\/microorganisms11020315","volume":"11","author":"M Giufr\u00e8","year":"2023","unstructured":"Giufr\u00e8 M, Cardines R, Marra M, Carollo M, Cerquetti M, Stefanelli P (2023) Antibiotic susceptibility and molecular typing of invasive Haemophilus influenzae isolates, with emergence of Ciprofloxacin Resistance, 2017\u20132021, Italy. Microorganisms 11(2):315. https:\/\/doi.org\/10.3390\/microorganisms11020315","journal-title":"Microorganisms"},{"issue":"4","key":"4900_CR22","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1093\/jac\/dkaa557","volume":"76","author":"S N\u00fcrnberg","year":"2021","unstructured":"N\u00fcrnberg S, Claus H, Krone M, Vogel U, L\u00e2m TT (2021) Cefotaxime resistance in invasive Haemophilus influenzae isolates in Germany 2016-19: prevalence, epidemiology and relevance of PBP3 substitutions. J Antimicrob Chemother 76(4):920\u2013929. https:\/\/doi.org\/10.1093\/jac\/dkaa557","journal-title":"J Antimicrob Chemother"},{"key":"4900_CR23","doi-asserted-by":"publisher","first-page":"973257","DOI":"10.3389\/fmicb.2022.973257","volume":"13","author":"R T\u00f8nnessen","year":"2022","unstructured":"T\u00f8nnessen R, Garc\u00eda I, Debech N, Lindstr\u00f8m JC, Wester AL, Skaare D (2022) Molecular epidemiology and antibiotic resistance profiles of invasive Haemophilus influenzae from Norway 2017\u20132021. Front Microbiol 13:973257. https:\/\/doi.org\/10.3389\/fmicb.2022.973257","journal-title":"Front Microbiol"},{"issue":"3","key":"4900_CR24","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/jac\/dkg107","volume":"51","author":"K Straker","year":"2003","unstructured":"Straker K, Wootton M, Simm AM, Bennett PM, MacGowan AP, Walsh TR (2003) Cefuroxime resistance in non-beta-lactamase Haemophilus influenzae is linked to mutations in ftsI. J Antimicrob Chemother 51(3):523\u2013530. https:\/\/doi.org\/10.1093\/jac\/dkg107","journal-title":"J Antimicrob Chemother"},{"issue":"11","key":"4900_CR25","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.3390\/life11111260","volume":"11","author":"V Jakubu","year":"2021","unstructured":"Jakubu V, Malisova L, Musilek M, Pomorska K, Zemlickova H (2021) Characterization of Haemophilus influenzae strains with non-enzymatic resistance to \u03b2-Lactam antibiotics caused by mutations in the PBP3 gene in the Czech Republic in 2010\u20132018. Life (Basel Switzerland) 11(11):1260. https:\/\/doi.org\/10.3390\/life11111260","journal-title":"Life (Basel Switzerland)"},{"issue":"1","key":"4900_CR26","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12866-023-02926-6","volume":"23","author":"PY Su","year":"2023","unstructured":"Su PY, Cheng WH, Ho CH (2023) Molecular characterization of multidrug-resistant non-typeable Haemophilus influenzae with high-level resistance to cefuroxime, levofloxacin, and trimethoprim-sulfamethoxazole. BMC Microbiol 23(1):178. https:\/\/doi.org\/10.1186\/s12866-023-02926-6","journal-title":"BMC Microbiol"},{"issue":"1","key":"4900_CR27","doi-asserted-by":"publisher","first-page":"e00969","DOI":"10.1128\/mSphere.00969-19","volume":"5","author":"K Hegstad","year":"2020","unstructured":"Hegstad K, Mylvaganam H, Janice J, Josefsen E, Sivertsen A, Skaare D (2020) Role of horizontal gene transfer in the development of Multidrug Resistance in Haemophilus influenzae. mSphere 5(1):e00969\u2013e00919. https:\/\/doi.org\/10.1128\/mSphere.00969-19","journal-title":"mSphere"},{"issue":"7","key":"4900_CR28","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1111\/j.1558-5646.2009.00658.x","volume":"63","author":"H Maughan","year":"2009","unstructured":"Maughan H, Redfield RJ (2009) Extensive variation in natural competence in Haemophilus influenzae. Evolution 63(7):1852\u20131866. https:\/\/doi.org\/10.1111\/j.1558-5646.2009.00658.x","journal-title":"Evolution"},{"issue":"2","key":"4900_CR29","doi-asserted-by":"publisher","first-page":"000649v3","DOI":"10.1099\/acmi.0.000649.v3","volume":"6","author":"C Michel","year":"2024","unstructured":"Michel C, Argud\u00edn MA, Wautier M, Echahidi F, Prevost B, Vandenberg O, Martiny D, Hallin M (2024) Multiple interspecies recombination events documented by whole-genome sequencing in multidrug-resistant Haemophilus influenzae clinical isolates. Access Microbiol 6(2):000649v3. https:\/\/doi.org\/10.1099\/acmi.0.000649.v3","journal-title":"Access Microbiol"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-024-04900-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-024-04900-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-024-04900-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T08:36:00Z","timestamp":1726648560000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-024-04900-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4900"],"URL":"https:\/\/doi.org\/10.1007\/s10096-024-04900-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4312104\/v1","asserted-by":"object"}]},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]},"assertion":[{"value":"23 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}