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There are microbiological and clinical differences between\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      and\n                      <jats:italic>E. faecium<\/jats:italic>\n                      infections. The aim of this study was to investigate differences in predisposing factors for\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      and\n                      <jats:italic>E. faecium<\/jats:italic>\n                      BSI and to explore prognostic factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study was a post-hoc analysis of PROBAC, a Spanish prospective, multicenter, cohort in 2016\u20132017. Patients with\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      or\n                      <jats:italic>E. faecium<\/jats:italic>\n                      BSI were eligible. Independent predictors for BSI development in polymicrobial and monomicrobial BSI and in-hospital mortality in the monomicrobial group were identified by logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 431 patients were included. Independent factors associated with\n                      <jats:italic>E. faecium<\/jats:italic>\n                      BSI were previous use of penicillins (aOR 1.99 (95% CI 1.20\u20133.32)) or carbapenems (2.35 (1.12\u20134.93)), hospital-acquired BSI (2.58 (1.61\u20134.12)), and biliary tract source (3.36 (1.84\u20136.13)), while congestive heart failure (0.51 (0.27\u20130.97)), cerebrovascular disease (0.45 (0.21\u20130.98)), and urinary tract source (0.49 (0.26\u20130.92)) were associated with\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      BSI. Independent prognostic factors for in-hospital mortality in\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      BSI were Charlson Comorbidity Index (1.27 (1.08\u20131.51)), SOFA score (1.47 (1.24\u20131.73)), age (1.06 (1.02\u20131.10)), and urinary\/biliary source (0.29 (0.09\u20130.90)). For\n                      <jats:italic>E. faecium<\/jats:italic>\n                      BSI, only SOFA score (1.34 (1.14\u20131.58) was associated with in-hospital mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The factors associated with\n                      <jats:italic>E. faecium<\/jats:italic>\n                      and\n                      <jats:italic>E. faecalis<\/jats:italic>\n                      BSI are different. These variables may be helpful in the suspicion of one or other species for empiric therapeutic decisions and provide valuable information on prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10096-024-04917-5","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:02:06Z","timestamp":1723068126000},"page":"2011-2022","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Clinical characteristics, predisposing factors and outcomes for Enterococcus faecalis versus Enterococcus faecium bloodstream infections: a prospective multicentre cohort study"],"prefix":"10.1007","volume":"43","author":[{"given":"Fenna","family":"Scharloo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cogliati 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