{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:15:35Z","timestamp":1789103735712,"version":"build-2803163510"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Although [18F]-FDG-PET\/CT scanning (PET\/CT) is recommended for managing <jats:italic>Staphylococcus aureus<\/jats:italic> bacteremia (SAB), its added value remains debated. This study investigated the clinical revenues of selective PET\/CT use in SAB by considering three consequence-categories: detection of new infection foci, performance of new interventions, and alterations in antimicrobial therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>All adult patients with \u2265\u20091 blood culture (BC) positive with <jats:italic>Staphylococcus aureus<\/jats:italic> admitted in a Dutch academic center between 2017<jats:sup>11<\/jats:sup> and 2023<jats:sup>11<\/jats:sup> were identified. Standard practice was to order PET\/CT for patients with community acquired SAB and\/or positive BCs after \u2265\u200948\u00a0h of treatment, or if multiple foci, or persistent fever, or endocarditis were present. Clinical- and laboratory data were obtained from electronic health records. Numbers-needed-to-scan (NNT-scan) were calculated for each consequence-category. Regression analyses were performed to identify variables correlated with consequence-bearing PET\/CT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Of 397 SAB patients, 143 (36%) underwent PET\/CT. This led to detection of new foci in 73\/143 patients (NNT-scan\u2009\u2248\u20092), new interventions in 33\/143 patients (NNT-scan\u2009\u2248\u20094), and a change in antimicrobial therapy in 44\/143 patients (NNT-scan\u2009\u2248\u20093). A CRP\u2009&gt;\u2009200\u00a0mg\/L at presentation and positive follow-up BCs at 48\u00a0h were independently associated with interventions following PET\/CT (adjusted OR and 95%CI 3.2 (1.2\u20138.3) and 2.6 (1.0-6.7) respectively). PET\/CT results instigated changes in antimicrobial therapy predominantly in patients\u2009&lt;\u200965 years and those with a CRP\u2009&lt;\u2009100 at presentation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Selective PET\/CT ordering in real-life practice resulted in a relatively low NNT-scan across all consequence-categories. Further research is warranted to optimize patient selection for PET\/CT using clinical parameters or profiles.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10096-025-05052-5","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T11:15:46Z","timestamp":1739013346000},"page":"895-904","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical revenues of selective use of [18F]-FDG-PET\/CT scanning in the management of Staphylococcus aureus bacteremia"],"prefix":"10.1007","volume":"44","author":[{"given":"Dewi","family":"Verkaik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette C.","family":"Westgeest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim C. 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