{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:08:37Z","timestamp":1790518117714,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10096-025-05200-x","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T10:03:14Z","timestamp":1752228194000},"page":"2465-2474","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Lab efficiency and improvements in the management of bloodstream infections: a before and after study"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1976-4660","authenticated-orcid":false,"given":"Maxime","family":"Paluch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0815-973X","authenticated-orcid":false,"given":"Nicolas","family":"Ettahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7943-6737","authenticated-orcid":false,"given":"Benjamin","family":"Lagraulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-2415","authenticated-orcid":false,"given":"Christian","family":"Cattoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rethore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Dubrulle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0159-7121","authenticated-orcid":false,"given":"L\u00e9lia","family":"Abad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Canis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-499X","authenticated-orcid":false,"given":"Laura","family":"Wayenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Lambiotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7422-2972","authenticated-orcid":false,"given":"Gis\u00e8le","family":"Dewulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"issue":"1","key":"5200_CR1","doi-asserted-by":"publisher","first-page":"6839","DOI":"10.4081\/idr.2017.6839","volume":"9","author":"FP Maurer","year":"2017","unstructured":"Maurer FP, Christner M, Hentschke M, Rohde H (2017) Advances in rapid identification and susceptibility testing of Bacteria in the clinical microbiology laboratory: implications for patient care and antimicrobial stewardship programs. Infect Dis Rep 9(1):6839. https:\/\/doi.org\/10.4081\/idr.2017.6839","journal-title":"Infect Dis Rep"},{"issue":"2","key":"5200_CR2","doi-asserted-by":"publisher","first-page":"e0215323","DOI":"10.1128\/spectrum.02153-23","volume":"12","author":"G Trigueiro","year":"2024","unstructured":"Trigueiro G, Oliveira C, Rodrigues A, Seabra S, Pinto R, Bala Y, Gutierrez Granado M, Vallejo S, Gonzalez V, Cardoso C (2024) Conversion of a classical microbiology laboratory to a total automation laboratory enhanced by the application of lean principles. Microbiol Spectr 12(2):e0215323. https:\/\/doi.org\/10.1128\/spectrum.02153-23","journal-title":"Microbiol Spectr"},{"issue":"1","key":"5200_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.eimce.2021.08.014","volume":"40","author":"G Bou","year":"2022","unstructured":"Bou G, Calbo E, Crespo M, Canton R, Alvarez de Luna FF, Garcia Rodriguez J, Angel Goenaga M, Gonzalez-Garcia J, Gonzalez J, Larrosa N, Martinez-Martinez L, Navarro D, Ramon Pano J, Rivero A, Carlos Rodriguez J, Tomas M, Vilaj J (2022) Justification for 24\/7 clinical microbiology services. Enferm Infecc Microbiol Clin (Engl Ed) 40(1):1\u20134. https:\/\/doi.org\/10.1016\/j.eimce.2021.08.014","journal-title":"Enferm Infecc Microbiol Clin (Engl Ed)"},{"key":"5200_CR4","unstructured":"SPILF (2022) Actualisation de la liste des antibiotiques critiques disponibles en France pour l\u2019exercice lib\u00e9ral ET en \u00e9tablissements de sant\u00e9, https:\/\/www.infectiologie.com\/UserFiles\/File\/spilf\/recos\/saisine-dgs-atb-critique-9-fev-22-v3.pdf"},{"key":"5200_CR5","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1186\/1471-2288-11-144","volume":"11","author":"GN Brock","year":"2011","unstructured":"Brock GN, Barnes C, Ramirez JA, Myers J (2011) How to handle mortality when investigating length of hospital stay and time to clinical stability. BMC Med Res Methodol 11:144. https:\/\/doi.org\/10.1186\/1471-2288-11-144","journal-title":"BMC Med Res Methodol"},{"issue":"7","key":"5200_CR6","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1093\/cid\/ciy211","volume":"67","author":"CM Keene","year":"2018","unstructured":"Keene CM, Dondorp A, Crawley J, Ohuma EO, Mukaka M (2018) A Competing-Risk approach for modeling length of stay in severe malaria patients in South-East Asia and the implications for planning of hospital services. Clin Infect Dis 67(7):1053\u20131062. https:\/\/doi.org\/10.1093\/cid\/ciy211","journal-title":"Clin Infect Dis"},{"issue":"1","key":"5200_CR7","doi-asserted-by":"publisher","first-page":"e0837","DOI":"10.1097\/CCE.0000000000000837","volume":"5","author":"Y Mishima","year":"2023","unstructured":"Mishima Y, Nawa N, Asada M, Nagashima M, Aiso Y, Nukui Y, Fujiwara T, Shigemitsu H (2023) Impact of antibiotic Time-Outs in multidisciplinary ICU rounds for antimicrobial stewardship program on patient survival: A controlled Before-and-After study. Crit Care Explor 5(1):e0837. https:\/\/doi.org\/10.1097\/CCE.0000000000000837","journal-title":"Crit Care Explor"},{"issue":"8","key":"5200_CR8","doi-asserted-by":"publisher","first-page":"e0024122","DOI":"10.1128\/jcm.00241-22","volume":"60","author":"AL Leber","year":"2022","unstructured":"Leber AL, Peterson E, Dien Bard J, Personnel S, Workforce Subcommittee ASM (2022) The hidden crisis in the times of COVID-19: critical shortages of medical laboratory professionals in clinical microbiology. J Clin Microbiol 60(8):e0024122. https:\/\/doi.org\/10.1128\/jcm.00241-22","journal-title":"J Clin Microbiol"},{"issue":"9","key":"5200_CR9","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1007\/s10096-018-3309-4","volume":"37","author":"B Van den Poel","year":"2018","unstructured":"Van den Poel B, Klak A, Desmet S, Verhaegen J (2018) How small modifications in laboratory workflow of blood cultures can have a significant impact on time to results. Eur J Clin Microbiol Infect Dis 37(9):1753\u20131760. https:\/\/doi.org\/10.1007\/s10096-018-3309-4","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"5200_CR10","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1515\/cclm-2022-0667","volume":"61","author":"D Chirio","year":"2023","unstructured":"Chirio D, Demonchy E, Le Marechal M, Gaudart A, Lotte R, Carles M, Ruimy R (2023) 24\/7 workflow for bloodstream infection diagnostics in microbiology laboratories: the first step to improve clinical management. Clin Chem Lab Med 61(2):349\u2013355. https:\/\/doi.org\/10.1515\/cclm-2022-0667","journal-title":"Clin Chem Lab Med"},{"issue":"3","key":"5200_CR11","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1093\/cid\/ciac727","volume":"76","author":"J Van Heuverswyn","year":"2023","unstructured":"Van Heuverswyn J, Valik JK, van der Desiree S, Hedberg P, Giske C, Naucler P (2023) Association between time to appropriate antimicrobial treatment and 30-day mortality in patients with bloodstream infections: A retrospective cohort study. Clin Infect Dis 76(3):469\u2013478. https:\/\/doi.org\/10.1093\/cid\/ciac727","journal-title":"Clin Infect Dis"},{"issue":"2","key":"5200_CR12","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/labmed\/lmad057","volume":"55","author":"YW Tsai","year":"2024","unstructured":"Tsai YW, Zhang B, Chou HY, Chen HJ, Hsu YC, Shiue YL (2024) Clinical impacts of the rapid diagnostic method on positive blood cultures. Lab Med 55(2):179\u2013184. https:\/\/doi.org\/10.1093\/labmed\/lmad057","journal-title":"Lab Med"},{"key":"5200_CR13","doi-asserted-by":"publisher","unstructured":"Tjandra KC, Ram-Mohan N, Abe R, Hashemi MM, Lee JH, Chin SM, Roshardt MA, Liao JC, Wong PK, Yang S (2022) Diagnosis of bloodstream infections: an evolution of technologies towards accurate and rapid identification and antibiotic susceptibility testing. Antibiot (Basel) 11(4). https:\/\/doi.org\/10.3390\/antibiotics11040511","DOI":"10.3390\/antibiotics11040511"},{"key":"5200_CR14","unstructured":"SFM (2022) Observatoire national du diagnostic microbiologique des bact\u00e9ri\u00e9mies. https:\/\/www.sfm-microbiologie.org\/actualites\/observatoire-national-du-diagnostic-microbiologique-des-bacteriemies\/. Cited 2\/09\/2024"},{"key":"5200_CR15","volume-title":"Restitution de l\u2019observatoire National des bact\u00e9ri\u00e9mies. Microbes 2022 17e congres","author":"C Cattoen","year":"2022","unstructured":"Cattoen C, Lamy B (2022) Restitution de l\u2019observatoire National des bact\u00e9ri\u00e9mies. Microbes 2022 17e congres. National de la SFM, Montpellier"},{"issue":"1","key":"5200_CR16","doi-asserted-by":"publisher","first-page":"e39","DOI":"10.1093\/cid\/ciaa528","volume":"73","author":"R Banerjee","year":"2021","unstructured":"Banerjee R, Komarow L, Virk A, Rajapakse N, Schuetz AN, Dylla B, Earley M, Lok J, Kohner P, Ihde S, Cole N, Hines L, Reed K, Garner OB, Chandrasekaran S, de St Maurice A, Kanatani M, Curello J, Arias R, Swearingen W, Doernberg SB, Patel R (2021) Randomized trial evaluating clinical impact of rapid identification and susceptibility testing for Gram-negative bacteremia: RAPIDS-GN. Clin Infect Dis 73(1):e39\u2013e46. https:\/\/doi.org\/10.1093\/cid\/ciaa528","journal-title":"Clin Infect Dis"},{"issue":"7","key":"5200_CR17","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1093\/cid\/civ447","volume":"61","author":"R Banerjee","year":"2015","unstructured":"Banerjee R, Teng CB, Cunningham SA, Ihde SM, Steckelberg JM, Moriarty JP, Shah ND, Mandrekar JN, Patel R (2015) Randomized trial of rapid multiplex polymerase chain Reaction-Based blood culture identification and susceptibility testing. Clin Infect Dis 61(7):1071\u20131080. https:\/\/doi.org\/10.1093\/cid\/civ447","journal-title":"Clin Infect Dis"},{"key":"5200_CR18","doi-asserted-by":"publisher","unstructured":"Lopez-Pintor JM, Sanchez-Lopez J, Navarro-San Francisco C, Sanchez-Diaz AM, Loza E, Canton R (2021) Real life clinical impact of antimicrobial stewardship actions on the blood culture workflow from a microbiology laboratory. Antibiot (Basel) 10(12). https:\/\/doi.org\/10.3390\/antibiotics10121511","DOI":"10.3390\/antibiotics10121511"},{"issue":"6","key":"5200_CR19","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1093\/cid\/ciad744","volume":"78","author":"D Morquin","year":"2024","unstructured":"Morquin D, Lejeune J, Agostini C, Godreuil S, Reynes J, Le Moing V, Lamy B (2024) Time is of the essence: achieving prompt and effective antimicrobial therapy of bloodstream infection with advanced hospital information systems. Clin Infect Dis 78(6):1434\u20131442. https:\/\/doi.org\/10.1093\/cid\/ciad744","journal-title":"Clin Infect Dis"},{"issue":"2","key":"5200_CR20","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.cmi.2019.11.017","volume":"26","author":"B Lamy","year":"2020","unstructured":"Lamy B, Sundqvist M, Idelevich EA (2020) Bloodstream infections - Standard and progress in pathogen diagnostics. Clin Microbiol Infect 26(2):142\u2013150. https:\/\/doi.org\/10.1016\/j.cmi.2019.11.017","journal-title":"Clin Microbiol Infect"},{"key":"5200_CR21","doi-asserted-by":"publisher","first-page":"869822","DOI":"10.3389\/fmed.2022.869822","volume":"9","author":"YP Hung","year":"2022","unstructured":"Hung YP, Lee CC, Ko WC (2022) Effects of inappropriate administration of empirical antibiotics on mortality in adults with bacteraemia: systematic review and Meta-Analysis. Front Med (Lausanne) 9:869822. https:\/\/doi.org\/10.3389\/fmed.2022.869822","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"5200_CR22","doi-asserted-by":"publisher","first-page":"e202899","DOI":"10.1001\/jamanetworkopen.2020.2899","volume":"3","author":"C Rhee","year":"2020","unstructured":"Rhee C, Kadri SS, Dekker JP, Danner RL, Chen HC, Fram D, Zhang F, Wang R, Klompas M, Program CDCPE (2020) Prevalence of antibiotic-Resistant pathogens in Culture-Proven Sepsis and outcomes associated with inadequate and Broad-Spectrum empiric antibiotic use. JAMA Netw Open 3(4):e202899. https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.2899","journal-title":"JAMA Netw Open"},{"key":"5200_CR23","doi-asserted-by":"publisher","unstructured":"Babowicz F, LaPlante R, Mitchell C, O\u2019Donnell JN, Tobin E, George M, Carreno JJ (2021) Impact of accelerate pheno and bact\/alert virtuo on clinical processes and outcomes in patients with Sepsis and concurrent Gram-Negative bacteremia. Antimicrob Agents Chemother 65(6). https:\/\/doi.org\/10.1128\/AAC.02364-20","DOI":"10.1128\/AAC.02364-20"},{"issue":"Supplement1","key":"5200_CR24","doi-asserted-by":"publisher","first-page":"i13","DOI":"10.1093\/jac\/dkae282","volume":"79","author":"SH MacVane","year":"2024","unstructured":"MacVane SH, Dwivedi HP (2024) Evaluating the impact of rapid antimicrobial susceptibility testing for bloodstream infections: a review of actionability, antibiotic use and patient outcome metrics. J Antimicrob Chemother 79(Supplement1):i13\u2013i25. https:\/\/doi.org\/10.1093\/jac\/dkae282","journal-title":"J Antimicrob Chemother"},{"issue":"12","key":"5200_CR25","doi-asserted-by":"publisher","first-page":"e2451633","DOI":"10.1001\/jamanetworkopen.2024.51633","volume":"7","author":"RC Moon","year":"2024","unstructured":"Moon RC, MacVane SH, David J, Morton JB, Rosenthal N, Claeys KC (2024) Clinical outcomes of early Phenotype-Desirable antimicrobial therapy for enterobacterales bacteremia. JAMA Netw Open 7(12):e2451633. https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.51633","journal-title":"JAMA Netw Open"},{"key":"5200_CR26","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2334-14-13","volume":"14","author":"BG Bell","year":"2014","unstructured":"Bell BG, Schellevis F, Stobberingh E, Goossens H, Pringle M (2014) A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect Dis 14:13. https:\/\/doi.org\/10.1186\/1471-2334-14-13","journal-title":"BMC Infect Dis"},{"issue":"4","key":"5200_CR27","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1093\/cid\/ciae253","volume":"79","author":"BF Teshome","year":"2024","unstructured":"Teshome BF, Park T, Arackal J, Hampton N, Kollef MH, Micek ST (2024) Preventing new Gram-negative resistance through Beta-lactam De-escalation in hospitalized patients with sepsis: A retrospective cohort study. Clin Infect Dis 79(4):826\u2013833. https:\/\/doi.org\/10.1093\/cid\/ciae253","journal-title":"Clin Infect Dis"},{"issue":"24","key":"5200_CR28","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1001\/jama.270.24.2957","volume":"270","author":"JR Le Gall","year":"1993","unstructured":"Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a european\/north American multicenter study. JAMA 270(24):2957\u20132963. https:\/\/doi.org\/10.1001\/jama.270.24.2957","journal-title":"JAMA"},{"key":"5200_CR29","unstructured":"CASFM (2024) Comit\u00e9 de l\u2019antibiogramme de la Soci\u00e9t\u00e9 Fran\u00e7aise de Microbiologie Recommandations 2024 V.1.0 Juin, https:\/\/www.sfm-microbiologie.org\/wp-content\/uploads\/2024\/06\/CASFM2024_V1.0.pdf. Cited 2\/09\/2024"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-025-05200-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-025-05200-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-025-05200-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T13:45:25Z","timestamp":1759239925000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-025-05200-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["5200"],"URL":"https:\/\/doi.org\/10.1007\/s10096-025-05200-x","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]},"assertion":[{"value":"21 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Clinical Research Ethics Commission (CERCI) of the Valenciennes Hospital (24\/03\/2022\/No CHV-2022-008).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human ethics and consent to participate"}},{"value":"Eric Rethore, Arnaud Dubrulle and L\u00e9lia Abad are employees of bioM\u00e9rieux. The remaining authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}