{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:31:38Z","timestamp":1791491498353,"version":"4.3.4"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100032753","name":"Universidad Alfonso X El Sabio","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100032753","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Recurrent urinary tract infections (rUTIs) are a global problem due to their high prevalence and because are caused by antibiotic-resistant strains. The hypothesis of our study is that a fecal microbiota transplant (FMT) might reduce the presence of uropathogenic\n                    <jats:italic>E. coli<\/jats:italic>\n                    in the intestinal microbiota, thereby leading to a decrease in the rUTIs. The objective of this study was to assess the efficacy of a single FMT intervention for the treatment rUTIs. A total of 22 postmenopausal women received a 3-day course of oral rifaximin to reduce their commensal microbiota, followed by a 2-day washout period, and then an oral FMT using lyophilized fecal capsules equivalent to 100\u00a0g of freeze-dried fecal matter from a single certificated fecal donor. The results demonstrated that over a period of six months, there was a 68.1% reduction in urinary infectious episodes, with minimal adverse effects. In addition, eradication of fecal colonization of urinary pathogens that were resistant to multiple antibiotics was achieved. The findings of this pilot study indicate that FMT is a promising and safe alternative for the treatment of rUTIs, particularly those caused by multidrug-resistant bacteria.\n                  <\/jats:p>","DOI":"10.1007\/s10096-025-05202-9","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T10:35:44Z","timestamp":1751452544000},"page":"2549-2554","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fecal microbiota transplant as treatment for recurrent urinary tract infections: a proof-of-concept study"],"prefix":"10.1007","volume":"44","author":[{"given":"Ver\u00f3nica","family":"Rico-Caballero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Romero-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Moreno-Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Aira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Climent","family":"Casals-Pascual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Rodr\u00edguez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Quereda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Soriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-7923","authenticated-orcid":false,"given":"Rosa","family":"del Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"5202_CR1","doi-asserted-by":"publisher","unstructured":"Aira A, Rubio E, G\u00f3mez AV, Feh\u00e9r C, Casals-Pascual C, Gonz\u00e1lez B et al (2021) rUTI resolution after FMT for Clostridioides difficile infection: a case report. Infect Disesases Therapy 10:1065\u20131071. https:\/\/doi.org\/10.1007\/s40121-020-00365-8","DOI":"10.1007\/s40121-020-00365-8"},{"key":"5202_CR2","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/s41385-022-00549-0","volume":"15","author":"L Deltourbe","year":"2022","unstructured":"Deltourbe L, Mariano LL, Hreha TN, Hunstad DA, Ingersoll MA (2022) The impact of biological sex on diseases of the urinary tract. Mucosal Immunol 15:857\u2013866. https:\/\/doi.org\/10.1038\/s41385-022-00549-0","journal-title":"Mucosal Immunol"},{"key":"5202_CR3","doi-asserted-by":"publisher","unstructured":"Gupta V, Mastromarino P, Garg R (2023) Effectiveness of prophylactic oral and\/or vaginal probiotic supplementation in the prevention of recurrent urinary tract infections: A randomized, Double-Blind, Placebo-Controlled trial. Clin Infect Dis ciad766. https:\/\/doi.org\/10.1093\/cid\/ciad766","DOI":"10.1093\/cid\/ciad766"},{"key":"5202_CR4","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41385-020-00372-5","volume":"14","author":"B Jones-Freeman","year":"2021","unstructured":"Jones-Freeman B, Chonwerawong M, Marcelino VR, Deshpande AV, Forster SC, Starkey MR (2021) The Microbiome and host mucosal interactions in urinary tract diseases. Mucosal Immunol 14:779\u2013792. https:\/\/doi.org\/10.1038\/s41385-020-00372-5","journal-title":"Mucosal Immunol"},{"key":"5202_CR5","doi-asserted-by":"publisher","first-page":"5521","DOI":"10.1038\/s41467-019-13467-w","volume":"10","author":"M Magruder","year":"2019","unstructured":"Magruder M, Sholi AN, Gong C, Zhang L, Edusei E, Huang J et al (2019) Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection. Nat Commun 10:5521. https:\/\/doi.org\/10.1038\/s41467-019-13467-w","journal-title":"Nat Commun"},{"key":"5202_CR6","doi-asserted-by":"publisher","unstructured":"Minkoff NZ, Aslam S, Medina M, Tanner-Smith EE, Zackular JP, Acra S et al (2023) Fecal microbiota transplantation for the treatment of recurrent Clostridioides difficile (Clostridium difficile). Cochrane Database Syst Rev CD013871. https:\/\/doi.org\/10.1002\/14651858.cd013871.pub2","DOI":"10.1002\/14651858.cd013871.pub2"},{"key":"5202_CR7","doi-asserted-by":"publisher","first-page":"ofae471","DOI":"10.1093\/ofid\/ofae471","volume":"11","author":"A Naji","year":"2024","unstructured":"Naji A, Siskin D, Woodworth MH, Lee JR, Kraft CS, Mehta N (2024) The role of the gut, urine, and vaginal Microbiomes in the pathogenesis of urinary tract infection in women and consideration of Microbiome therapeutics. Open Forum Infect Dis 11:ofae471. https:\/\/doi.org\/10.1093\/ofid\/ofae471","journal-title":"Open Forum Infect Dis"},{"key":"5202_CR8","doi-asserted-by":"publisher","first-page":"e20180119","DOI":"10.1542\/peds.2018-0119","volume":"142","author":"RE Selekman","year":"2018","unstructured":"Selekman RE, Shapiro DJ, Boscardin J, Williams G, Craig JC, Brandstr\u00f6m P et al (2018) Uropathogen resistance and antibiotic prophylaxis: a meta-analysis. Pediatrics 142:e20180119. https:\/\/doi.org\/10.1542\/peds.2018-0119","journal-title":"Pediatrics"},{"key":"5202_CR9","doi-asserted-by":"publisher","unstructured":"Tariq R, Pardi DS, Tosh PK, Walker RC, Razonable RR, Khanna S (2017) Fecal microbiota transplantation for recurrent Clostridium difficile infection reduces recurrent urinary tract infection frequency. 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