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HEV infection manifest asymptomatically or progress to fulminant hepatitis, liver failure, and extrahepatic manifestations such as neurological disorders and renal damage. MicroRNAs are non-coding RNA molecules that play a key role in diseases and viral pathogenesis, influencing viral replication and immune evasion through their interaction with host factors.<\/jats:p>\n            <jats:p>In this review, we discuss the role of microRNAs described to date in hepatitis E infection, highlighting their impact on acute, chronic, and pregnancy-related clinical outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>miR-122, miR-214, miR-221, and miR-222 participate in the HEV replication and immune evasion, while specific miRNA profiles distinguish acute and chronic hepatitis E. HEV poses severe risks in pregnancy, with miR-431, miR-654, and miR-1468 related to self-limiting infection, and miR-450b to acute liver failure. Studying these miRNAs lead to biomarkers and therapies for hepatitis E.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10096-025-05207-4","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T15:55:49Z","timestamp":1752508549000},"page":"2303-2321","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential miRNA signatures in Hepatitis E Virus Infection: Insights into acute, chronic, and pregnancy-related outcomes"],"prefix":"10.1007","volume":"44","author":[{"given":"Nancy","family":"Le\u00f3n-Janampa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Marlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"issue":"1","key":"5207_CR1","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1128\/CMR.00057-13","volume":"27","author":"N Kamar","year":"2014","unstructured":"Kamar N, Dalton HR, Abravanel F, Izopet J (2014) Hepatitis E Virus Infection. 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