{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:08:16Z","timestamp":1772842096593,"version":"3.50.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["232300420238"],"award-info":[{"award-number":["232300420238"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["242300421507"],"award-info":[{"award-number":["242300421507"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Henan Province Outstanding Young and Middle-aged Talents Cultivation Project for Health Science and Technology Innovation, China","award":["JORC2023009"],"award-info":[{"award-number":["JORC2023009"]}]},{"name":"Investigator-initiated Clinical Tial and Transformation of Scientific Achievements, Henan CancerHospital","award":["ITTA-2422"],"award-info":[{"award-number":["ITTA-2422"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170151"],"award-info":[{"award-number":["82170151"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10096-025-05280-9","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T16:43:57Z","timestamp":1759164237000},"page":"3047-3055","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy and safety of contezolid in the treatment of Gram-positive bacterial infections in patients with hematological malignancies: a retrospective study"],"prefix":"10.1007","volume":"44","author":[{"given":"Ruihua","family":"Mi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyang","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongbei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3325-0837","authenticated-orcid":false,"given":"Xudong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"5280_CR1","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1093\/cid\/cir492","volume":"53","author":"A Safdar","year":"2011","unstructured":"Safdar A, Armstrong D (2011) Infections in patients with hematologic neoplasms and hematopoietic stem cell transplantation: neutropenia, humoral, and splenic defects. Clin Infect Dis 53:798\u2013806. https:\/\/doi.org\/10.1093\/cid\/cir492","journal-title":"Clin Infect Dis"},{"key":"5280_CR2","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s11912-022-01226-y","volume":"24","author":"F Moreno-Sanchez","year":"2022","unstructured":"Moreno-Sanchez F, Gomez-Gomez B (2022) Antibiotic management of patients with hematologic malignancies: from prophylaxis to unusual infections. Curr Oncol Rep 24:835\u2013842. https:\/\/doi.org\/10.1007\/s11912-022-01226-y","journal-title":"Curr Oncol Rep"},{"key":"5280_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/QCO.0000000000000632","volume":"33","author":"R Ungaro","year":"2020","unstructured":"Ungaro R, Mikulska M (2020) The skin and soft tissue infections in hematological patients. Curr Opin Infect Dis 33:101\u2013109. https:\/\/doi.org\/10.1097\/QCO.0000000000000632","journal-title":"Curr Opin Infect Dis"},{"key":"5280_CR4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41408-020-0323-4","volume":"10","author":"D Pulte","year":"2020","unstructured":"Pulte D, Jansen L, Brenner H (2020) Changes in long term survival after diagnosis with common hematologic malignancies in the early 21st century. Blood Cancer J 10:56. https:\/\/doi.org\/10.1038\/s41408-020-0323-4","journal-title":"Blood Cancer J"},{"key":"5280_CR5","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1038\/s41591-024-03084-6","volume":"30","author":"DM Cordas Dos Santos","year":"2024","unstructured":"Cordas Dos Santos DM, Tix T, Shouval R, Gafter-Gvili A, Alberge J-B, Cliff ERS et al (2024) A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy. Nat Med 30:2667\u20132678. https:\/\/doi.org\/10.1038\/s41591-024-03084-6","journal-title":"Nat Med"},{"key":"5280_CR6","doi-asserted-by":"publisher","first-page":"715","DOI":"10.2147\/IDR.S493670","volume":"18","author":"Y Cui","year":"2025","unstructured":"Cui Y, Liu X, Feng S (2025) Clinical characteristics and optimization of empirical antimicrobial therapy for febrile neutropenia in patients with hematologic malignancies. Infect Drug Resist 18:715\u2013729. https:\/\/doi.org\/10.2147\/IDR.S493670","journal-title":"Infect Drug Resist"},{"key":"5280_CR7","unstructured":"Carss Big Data Query Platform (2025) \u2013 Homepage n.d. https:\/\/data.carss.cn\/home\/index"},{"key":"5280_CR8","doi-asserted-by":"publisher","first-page":"996","DOI":"10.3760\/cma.j.issn.0253-2727.2020.12.005","volume":"41","author":"Y Yuezhuo Chu","year":"2020","unstructured":"Yuezhuo Chu Y, Guo N, Liu M, Liu S, Xiao Y, Zhang et al (2020) Epidemiological analysis of pathogenic bacteria in bloodstream infections in the department of hematology in Guangdong region. Chin J Hematol 41:996. https:\/\/doi.org\/10.3760\/cma.j.issn.0253-2727.2020.12.005","journal-title":"Chin J Hematol"},{"key":"5280_CR9","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1097\/MCC.0000000000000657","volume":"25","author":"R Wanchoo","year":"2019","unstructured":"Wanchoo R, Stotter BR, Bayer RL, Jhaveri KD (2019) Acute kidney injury in hematopoietic stem cell transplantation. Curr Opin Crit Care 25:531\u2013538. https:\/\/doi.org\/10.1097\/MCC.0000000000000657","journal-title":"Curr Opin Crit Care"},{"key":"5280_CR10","doi-asserted-by":"publisher","first-page":"500","DOI":"10.3760\/cma.j.issn.1001-0939.2016.07.002","volume":"39","author":"Expert consensus working group on teicoplanin clinical dosage","year":"2016","unstructured":"Expert consensus working group on teicoplanin clinical dosage (2016) Expert consensus on the clinical dosage of Teicoplanin. Zhonghua Jie He He Hu Xi Za Zhi 39:500\u2013508. https:\/\/doi.org\/10.3760\/cma.j.issn.1001-0939.2016.07.002","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"5280_CR11","doi-asserted-by":"publisher","first-page":"989","DOI":"10.12138\/j.issn.1671-9638.20195182","volume":"18","author":"Expert panel for compiling expert opinion on clinical application of daptomycin, professional committee of evidence-based and transformation of infectious diseases, chinese research hospital association","year":"2019","unstructured":"Expert panel for compiling expert opinion on clinical application of daptomycin, professional committee of evidence-based and transformation of infectious diseases, chinese research hospital association (2019) Expert opinion on clinical application of daptomycin. Chin J Infect Control 18:989\u20131003. https:\/\/doi.org\/10.12138\/j.issn.1671-9638.20195182","journal-title":"Chin J Infect Control"},{"key":"5280_CR12","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/17512433.2023.2181160","volume":"16","author":"JE Dario Cattaneo, Deborah","year":"2023","unstructured":"Dario Cattaneo, Deborah JE, Marriott C, Gervasoni (2023) Hematological toxicities associated with linezolid therapy in adults: key findings and clinical considerations. Expert Rev Clin Phar 16:219\u2013230. https:\/\/doi.org\/10.1080\/17512433.2023.2181160","journal-title":"Expert Rev Clin Phar"},{"key":"5280_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8030137","volume":"8","author":"S-H Lan","year":"2019","unstructured":"Lan S-H, Lin W-T, Chang S-P, Lu L-C, Chao C-M, Lai C-C et al (2019) Tedizolid versus linezolid for the treatment of acute bacterial skin and skin structure infection: a systematic review and meta-analysis. Antibiotics 8:137. https:\/\/doi.org\/10.3390\/antibiotics8030137","journal-title":"Antibiotics"},{"key":"5280_CR14","doi-asserted-by":"publisher","unstructured":"Cecilia G, Carvalhaes LR, Duncan, Wen Wang, Helio S Sader (2020) In Vitro Activity and Potency of the Novel Oxazolidinone Contezolid (MRX-I) Tested against Gram-Positive Clinical Isolates from the United States and Europe. Antimicrob Agents Ch ;64:e01195-20. https:\/\/doi.org\/10.1128\/aac.01195-20","DOI":"10.1128\/aac.01195-20"},{"key":"5280_CR15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.16718\/j.1009-7708.2021.02.001","volume":"21","author":"D Zhu","year":"2021","unstructured":"Zhu D, Ye X, Hu F, Wu S, Guo Y, Wu P (2021) In vitro antibacterial activity study of contezolid. Chin J Infect Chemother 21:121\u2013135. https:\/\/doi.org\/10.16718\/j.1009-7708.2021.02.001","journal-title":"Chin J Infect Chemother"},{"key":"5280_CR16","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1093\/jac\/dkac073","volume":"77","author":"X Zhao","year":"2022","unstructured":"Zhao X, Huang H, Yuan H, Yuan Z, Zhang Y (2022) A phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections. J Antimicrob Chemother 77:1762\u20131769. https:\/\/doi.org\/10.1093\/jac\/dkac073","journal-title":"J Antimicrob Chemother"},{"key":"5280_CR17","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s15010-024-02287-w","volume":"52","author":"G Zhang","year":"2024","unstructured":"Zhang G, Liu T, Ren A, Liang W, Yin H, Cai Y (2024) Advances in contezolid: novel oxazolidinone antibacterial in gram-positive treatment. Infection 52:787\u2013800. https:\/\/doi.org\/10.1007\/s15010-024-02287-w","journal-title":"Infection"},{"key":"5280_CR18","doi-asserted-by":"publisher","first-page":"3167","DOI":"10.3760\/cma.j.cn112137-20220628-01433","volume":"102","author":"Anemia Working Group, Hematology Society of Chinese Medical Association","year":"2022","unstructured":"Anemia Working Group, Hematology Society of Chinese Medical Association (2022) Chinese expert consensus on diagnosis and treatment of neutropenia. Chin Med J 102:3167\u20133173. https:\/\/doi.org\/10.3760\/cma.j.cn112137-20220628-01433","journal-title":"Chin Med J"},{"key":"5280_CR19","unstructured":"National Antimicrobial Resistance Surveillance Network \u2013\u20092023 National Antimicrobial Resistance Surveillance Report (2025) (Brief Version) n.d. https:\/\/www.carss.cn\/Report\/Details?aId=978"},{"key":"5280_CR20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.12435\/j.issn.2095-5227.2024.001","volume":"45","author":"P Na","year":"2024","unstructured":"Na P, Liu T, Yuan Y, Wu J, Wang C, Fang X et al (2024) Efficacy comparison between contezolid and linezolid in elderly patients over 70 years with severe hospital-acquired pneumonia. J Chin PLA Med Sch 45:239\u2013244251. https:\/\/doi.org\/10.12435\/j.issn.2095-5227.2024.001","journal-title":"J Chin PLA Med Sch"},{"key":"5280_CR21","unstructured":"Wu H, Cheng Z, Ding F, Hua J, Wang H, Meng X et al (2025) Pharmacokinetics of contezolid in plasma and pulmonary epithelial lining fluid of patients with community-acquired pneumonia [Internet]. ESCMID Global 2025.\u00a0https:\/\/online.escmid.org\/container-detail.php?id=808"},{"key":"5280_CR22","doi-asserted-by":"publisher","first-page":"4487","DOI":"10.1021\/jm401931e","volume":"57","author":"MF Gordeev","year":"2014","unstructured":"Gordeev MF, Yuan ZY (2014) New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile. J Med Chem 57:4487\u20134497. https:\/\/doi.org\/10.1021\/jm401931e","journal-title":"J Med Chem"},{"key":"5280_CR23","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1124\/dmd.114.061747","volume":"43","author":"J Meng","year":"2015","unstructured":"Meng J, Zhong D, Li L, Yuan Z, Yuan H, Xie C et al (2015) Metabolism of MRX-I, a novel antibacterial oxazolidinone, in humans: the oxidative ring opening of 2,3-dihydropyridin-4-one catalyzed by non-p450 enzymes. Drug Metab Dispos 43:646\u2013659. https:\/\/doi.org\/10.1124\/dmd.114.061747","journal-title":"Drug Metab Dispos"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-025-05280-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-025-05280-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-025-05280-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T10:45:48Z","timestamp":1767091548000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-025-05280-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["5280"],"URL":"https:\/\/doi.org\/10.1007\/s10096-025-05280-9","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"13 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the declaration of Helsinki and approved by the Ethics Committee of Henan Cancer Hospital (Approval number: 2022-548-001).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was provided by the patient to allow the case details and any accompanying images to be published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}