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This study investigates a new ultra-rapid AST system in multiple clinical laboratories, with respect to accuracy, speed and turnaround time in comparison to commonly used AST systems.\u00a0The QuickMIC system is compared to the commonly used automated AST systems BD Phoenix\u2122 (BD, USA), MicroScan WalkAway plus (Beckman Coulter, USA) and VITEK\n                    <jats:sup>\u00ae<\/jats:sup>\n                    2 (bioM\u00e9rieux, France) by concurrent testing of incoming positive blood-cultures with Gram-negative bacteria in four clinical laboratories located in the EU and USA, on the basis of agreement of results, time-to-result (TTR, analysis time) and turnaround time (TAT, time from blood culture positivity or blood culture processing to actionable result).\u00a0A total of 155 patient samples were included, totaling 10 species of Gram-negative bacteria. The overall EA and CA between QuickMIC\n                    <jats:sup>\u00ae<\/jats:sup>\n                    GN and each routine AST system was &gt;\u200995%, while overall bias was within the acceptable range of \u00b1\u200930%. QuickMIC time-to-result was on average 3\u00a0h and 4\u00a0min, compared to 9\u201319 h for the routine systems. The average QuickMIC system turnaround-time ranged from 10 to 11 h 30 min, compared to 22\u201345\u00a0h for the routine systems.\u00a0The QuickMIC system represents a promising rapid AST technology with potential to reduce time-to-result and overall turnaround-time of clinically actionable AST results compared with the most common routinely used automated AST methods, while maintaining good accuracy and quality of results.\n                  <\/jats:p>","DOI":"10.1007\/s10096-025-05298-z","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:44:14Z","timestamp":1760366654000},"page":"185-196","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multicenter evaluation of the QuickMIC\u00ae rapid AST system in clinical practice: impact on turnaround time compared to routine AST systems"],"prefix":"10.1007","volume":"45","author":[{"given":"Anna","family":"Olsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rafeletou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0785-9512","authenticated-orcid":false,"given":"Amanda","family":"\u00c5man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette","family":"Athanasiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1701-2916","authenticated-orcid":false,"given":"Celia","family":"Garc\u00eda-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Gerstbrein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1387-1134","authenticated-orcid":false,"given":"Brian","family":"Mesich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4825-0565","authenticated-orcid":false,"given":"Logan","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Vahturova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-3135","authenticated-orcid":false,"given":"Nicole","family":"VanZeeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ricart-Silvestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Faron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4637-8474","authenticated-orcid":false,"given":"Kevin","family":"Alby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos Rodr\u00edguez","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-2853","authenticated-orcid":false,"given":"Cecilia","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3187-8732","authenticated-orcid":false,"given":"Christer","family":"Malmberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"5298_CR1","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1093\/jac\/dkm279","volume":"60","author":"G Peralta","year":"2007","unstructured":"Peralta G, S\u00e1nchez MB, Garrido JC, De Benito I, Cano ME, Mart\u00ednez-Mart\u00ednez L et al (2007) Impact of antibiotic resistance and of adequate empirical antibiotic treatment in the prognosis of patients with Escherichia coli bacteraemia. 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