{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T03:31:07Z","timestamp":1770262267325,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-032C"],"award-info":[{"award-number":["TJYXZDXK-3-032C"]}]},{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-032C"],"award-info":[{"award-number":["TJYXZDXK-3-032C"]}]},{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-032C"],"award-info":[{"award-number":["TJYXZDXK-3-032C"]}]},{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-032C"],"award-info":[{"award-number":["TJYXZDXK-3-032C"]}]},{"name":"Tianjin Key Medical Discipline Construction Project","award":["TJYXZDXK-3-032C"],"award-info":[{"award-number":["TJYXZDXK-3-032C"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10096-025-05310-6","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:10:10Z","timestamp":1760447410000},"page":"227-234","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characteristics and outcomes of hospitalized adult patients with respiratory syncytial virus infection in different age groups"],"prefix":"10.1007","volume":"45","author":[{"given":"Xin","family":"Qiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhinan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuechuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songtao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"issue":"1","key":"5310_CR1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08730-x","volume":"23","author":"A Piralla","year":"2023","unstructured":"Piralla A, Chen Z, Zaraket H (2023) An update on respiratory syncytial virus. BMC Infect Dis 23(1):734","journal-title":"BMC Infect Dis"},{"key":"5310_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14030262","author":"KM Contes","year":"2025","unstructured":"Contes KM, Liu BM (2025) Epidemiology, Clinical Significance, and Diagnosis of Respiratory Viruses and Their Co-Infections in the Post-COVID Era. Pathogens. https:\/\/doi.org\/10.3390\/pathogens14030262","journal-title":"Pathogens"},{"issue":"10","key":"5310_CR3","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S2213-2600(24)00255-8","volume":"12","author":"JG Wildenbeest","year":"2024","unstructured":"Wildenbeest JG, Lowe DM, Standing JF, Butler CC (2024) Respiratory syncytial virus infections in adults: a narrative review. Lancet Respir Med 12(10):822\u2013836","journal-title":"Lancet Respir Med"},{"issue":"2","key":"5310_CR4","doi-asserted-by":"publisher","first-page":"134","DOI":"10.37201\/req\/147.2023","volume":"37","author":"J Ruiz-Galiana","year":"2024","unstructured":"Ruiz-Galiana J, Cant\u00f3n R, De Lucas Ramos P et al (2024) Respiratory syncytial virus: a new era. Rev Esp Quimioter 37(2):134\u2013148","journal-title":"Rev Esp Quimioter"},{"issue":"11","key":"5310_CR5","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/S1473-3099(18)30310-4","volume":"18","author":"Estimates of the","year":"2018","unstructured":"Estimates of the (2018) global, regional, and National morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990\u20132016: a systematic analysis for the global burden of disease study 2016. Lancet Infect Dis 18(11):1191\u20131210","journal-title":"Lancet Infect Dis"},{"key":"5310_CR6","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00651-2021","author":"A Descamps","year":"2022","unstructured":"Descamps A, Lenzi N, Galtier F et al (2022) In-hospital and midterm post-discharge complications of adults hospitalised with respiratory syncytial virus infection in France, 2017\u20132019: an observational study. Eur Respir J. https:\/\/doi.org\/10.1183\/13993003.00651-2021","journal-title":"Eur Respir J"},{"issue":"4","key":"5310_CR7","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.cmi.2016.11.014","volume":"23","author":"P Loubet","year":"2017","unstructured":"Loubet P, Lenzi N, Valette M et al (2017) Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France. Clin Microbiol Infect 23(4):253\u2013259","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"5310_CR8","first-page":"Cd015134","volume":"5","author":"EW Phijffer","year":"2024","unstructured":"Phijffer EW, de Bruin O, Ahmadizar F et al (2024) Respiratory syncytial virus vaccination during pregnancy for improving infant outcomes. Cochrane Database Syst Rev 5(5):Cd015134","journal-title":"Cochrane Database Syst Rev"},{"issue":"17","key":"5310_CR9","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1056\/NEJMoa043951","volume":"352","author":"AR Falsey","year":"2005","unstructured":"Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE (2005) Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 352(17):1749\u20131759","journal-title":"N Engl J Med"},{"key":"5310_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jcv.2019.07.001","volume":"117","author":"B Chuaychoo","year":"2019","unstructured":"Chuaychoo B, Ngamwongwan S, Kaewnaphan B et al (2019) Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients. J Clin Virol 117:103\u2013108","journal-title":"J Clin Virol"},{"issue":"8","key":"5310_CR11","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1007\/s10096-021-04217-2","volume":"40","author":"L Chen","year":"2021","unstructured":"Chen L, Han X, Li Y, Zhang C, Xing X (2021) Comparison of clinical characteristics and outcomes between respiratory syncytial virus and influenza-related pneumonia in China from 2013 to 2019. Eur J Clin Microbiol Infect Dis 40(8):1633\u20131643","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"8","key":"5310_CR12","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1093\/cid\/cit471","volume":"57","author":"N Lee","year":"2013","unstructured":"Lee N, Lui GC, Wong KT et al (2013) High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections. Clin Infect Dis 57(8):1069\u20131077","journal-title":"Clin Infect Dis"},{"issue":"12","key":"5310_CR13","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy316","volume":"5","author":"EA Belongia","year":"2018","unstructured":"Belongia EA, King JP, Kieke BA et al (2018) Clinical features, severity, and incidence of RSV illness during 12 consecutive seasons in a community cohort of adults\u2009\u2265\u200960 years old. Open Forum Infect Dis 5(12):ofy316","journal-title":"Open Forum Infect Dis"},{"issue":"11","key":"5310_CR14","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1093\/infdis\/jiad189","volume":"228","author":"R Osei-Yeboah","year":"2023","unstructured":"Osei-Yeboah R, Spreeuwenberg P, Del Riccio M et al (2023) Estimation of the number of respiratory syncytial virus-associated hospitalizations in adults in the European union. J Infect Dis 228(11):1539\u20131548","journal-title":"J Infect Dis"},{"issue":"2","key":"5310_CR15","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/cid\/ciy991","volume":"69","author":"B Ackerson","year":"2019","unstructured":"Ackerson B, Tseng HF, Sy LS et al (2019) Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults. Clin Infect Dis 69(2):197\u2013203","journal-title":"Clin Infect Dis"},{"issue":"7","key":"5310_CR16","doi-asserted-by":"publisher","first-page":"943.e941","DOI":"10.1016\/j.cmi.2023.03.003","volume":"29","author":"H Celante","year":"2023","unstructured":"Celante H, Oubaya N, Fourati S et al (2023) Prognosis of hospitalised adult patients with respiratory syncytial virus infection: a multicentre retrospective cohort study. Clin Microbiol Infect 29(7):943.e941-943.e948","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"5310_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1080\/14760584.2023.2189459","volume":"22","author":"HY Kim","year":"2023","unstructured":"Kim HY, Yun KW, Cheong HJ, Choi EH, Lee HJ (2023) Respiratory syncytial virus infection and the need for immunization in Korea. Expert Rev Vaccines 22(1):327\u2013340","journal-title":"Expert Rev Vaccines"},{"issue":"5","key":"5310_CR18","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/irv.12258","volume":"8","author":"G Matias","year":"2014","unstructured":"Matias G, Taylor R, Haguinet F, Schuck-Paim C, Lustig R, Shinde V (2014) Estimates of mortality attributable to influenza and RSV in the United States during 1997\u20132009 by influenza type or subtype, age, cause of death, and risk status. Influenza Other Respir Viruses 8(5):507\u2013515","journal-title":"Influenza Other Respir Viruses"},{"issue":"10","key":"5310_CR19","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae513","volume":"11","author":"CL Clausen","year":"2024","unstructured":"Clausen CL, Egeskov-Cavling AM, Hayder N (2024) Clinical manifestations and outcomes in adults hospitalized with respiratory syncytial virus and influenza a\/B: a multicenter observational cohort study. Open Forum Infect Dis 11(10):ofae513","journal-title":"Open Forum Infect Dis"},{"issue":"10383","key":"5310_CR20","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/S0140-6736(23)00341-0","volume":"401","author":"HJ Zar","year":"2023","unstructured":"Zar HJ, Bush A (2023) Early childhood lower respiratory tract infection: a key determinant of premature adult respiratory mortality. Lancet 401(10383):1135\u20131137","journal-title":"Lancet"},{"issue":"1","key":"5310_CR21","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13031","volume":"17","author":"M Savic","year":"2023","unstructured":"Savic M, Penders Y, Shi T, Branche A, Pir\u00e7on JY (2023) Respiratory syncytial virus disease burden in adults aged 60 years and older in high-income countries: a systematic literature review and meta-analysis. Influenza Other Respir Viruses 17(1):e13031","journal-title":"Influenza Other Respir Viruses"},{"issue":"3","key":"5310_CR22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.37201\/req\/006.2024","volume":"37","author":"I Sanz-Mu\u00f1oz","year":"2024","unstructured":"Sanz-Mu\u00f1oz I, S\u00e1nchez-de Prada L, Castrodeza-Sanz J, Eiros JM (2024) Microbiological and epidemiological features of respiratory syncytial virus. Rev Esp Quimioter 37(3):209\u2013220","journal-title":"Rev Esp Quimioter"},{"issue":"6","key":"5310_CR23","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1016\/j.chest.2021.12.670","volume":"161","author":"J Coussement","year":"2022","unstructured":"Coussement J, Zuber B, Garrigues E et al (2022) Characteristics and outcomes of patients in the ICU with respiratory syncytial virus compared with those with influenza infection: A multicenter matched cohort study. Chest 161(6):1475\u20131484","journal-title":"Chest"},{"issue":"6","key":"5310_CR24","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s40266-024-01118-9","volume":"41","author":"F Alfano","year":"2024","unstructured":"Alfano F, Bigoni T, Caggiano FP, Papi A (2024) Respiratory syncytial virus infection in older adults: an update. Drugs Aging 41(6):487\u2013505","journal-title":"Drugs Aging"},{"issue":"1","key":"5310_CR25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s10096-018-3407-3","volume":"38","author":"M Jeanno\u00ebl","year":"2019","unstructured":"Jeanno\u00ebl M, Lina G, Rasigade JP, Lina B, Morfin F, Casalegno JS (2019) Microorganisms associated with respiratory syncytial virus pneumonia in the adult population. Eur J Clin Microbiol Infect Dis 38(1):157\u2013160","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"4","key":"5310_CR26","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.jmii.2025.03.005","volume":"58","author":"YC Fu","year":"2025","unstructured":"Fu YC, Lai TW, Su YH et al (2025) High bacterial coinfection rates and associated mortality among hospitalized older adults with laboratory-confirmed respiratory syncytial virus infection. J Microbiol Immunol Infect 58(4):422\u2013428","journal-title":"J Microbiol Immunol Infect"},{"issue":"4","key":"5310_CR27","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/irv.12971","volume":"16","author":"P Wongsurakiat","year":"2022","unstructured":"Wongsurakiat P, Sunhapanit S, Muangman N (2022) Respiratory syncytial virus-associated acute respiratory illness in adult non-immunocompromised patients: outcomes, determinants of outcomes, and the effect of oral ribavirin treatment. Influenza Other Respir Viruses 16(4):767\u2013779","journal-title":"Influenza Other Respir Viruses"},{"issue":"3","key":"5310_CR28","doi-asserted-by":"publisher","first-page":"R191","DOI":"10.1186\/cc3488","volume":"9","author":"J Garnacho-Montero","year":"2005","unstructured":"Garnacho-Montero J, Amaya-Villar R, Ortiz-Leyba C et al (2005) Isolation of Aspergillus spp. From the respiratory tract in critically ill patients: risk factors, clinical presentation and outcome. Crit Care 9(3):R191\u2013199","journal-title":"Crit Care"},{"issue":"1","key":"5310_CR29","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1183\/09031936.99.14614549","volume":"13","author":"JP Janssens","year":"1999","unstructured":"Janssens JP, Pache JC, Nicod LP (1999) Physiological changes in respiratory function associated with ageing. Eur Respir J 13(1):197\u2013205","journal-title":"Eur Respir J"},{"key":"5310_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02152","volume":"10","author":"JJ Carvajal","year":"2019","unstructured":"Carvajal JJ, Avellaneda AM, Salazar-Ardiles C, Maya JE, Kalergis AM, Lay MK (2019) Host components contributing to respiratory syncytial virus pathogenesis. Front Immunol 10:2152","journal-title":"Front Immunol"},{"issue":"3","key":"5310_CR31","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1007\/s12325-020-01230-3","volume":"37","author":"V Wyffels","year":"2020","unstructured":"Wyffels V, Kariburyo F, Gavart S, Fleischhackl R, Yuce H (2020) A real-world analysis of patient characteristics and predictors of hospitalization among US medicare beneficiaries with respiratory syncytial virus infection. Adv Ther 37(3):1203\u20131217","journal-title":"Adv Ther"},{"issue":"1","key":"5310_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1517-9","volume":"20","author":"G Voiriot","year":"2016","unstructured":"Voiriot G, Visseaux B, Cohen J et al (2016) Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia. Crit Care 20(1):375","journal-title":"Crit Care"},{"key":"5310_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101422","volume":"71","author":"A Santoro","year":"2021","unstructured":"Santoro A, Bientinesi E, Monti D (2021) Immunosenescence and inflammaging in the aging process: age-related diseases or longevity? Ageing Res Rev 71:101422","journal-title":"Ageing Res Rev"},{"issue":"5","key":"5310_CR34","doi-asserted-by":"publisher","first-page":"e330","DOI":"10.1016\/S2666-5247(23)00031-9","volume":"4","author":"YN Liu","year":"2023","unstructured":"Liu YN, Zhang YF, Xu Q (2023) Infection and co-infection patterns of community-acquired pneumonia in patients of different ages in China from 2009 to 2020: a national surveillance study. Lancet Microbe 4(5):e330\u2013e339","journal-title":"Lancet Microbe"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-025-05310-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-025-05310-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-025-05310-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T13:19:37Z","timestamp":1770211177000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-025-05310-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5310"],"URL":"https:\/\/doi.org\/10.1007\/s10096-025-05310-6","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"assertion":[{"value":"25 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and has been approved by the ethics committees of Tianjin Chest Hospital (2024LW-011). Informed consent was waived because of retrospective nature and patient information was de-identified and anonymized throughout the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}