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This study aims to evaluate the clinical outcomes of patients treated with short courses (4\u201310 days) compared to those receiving longer regimens (11\u201318 days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study was conducted at the Lausanne University Hospital, Switzerland (January 2015-June 2024) and included adult patients with uncomplicated enterococcal bacteremia. Primary outcome was a composite of mortality, recurrence of bacteremia by the same enterococcal species and development of bone and joint infection within 120 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the study period, 331 episodes of uncomplicated enterococcal bacteremia were included. The median duration of antimicrobial treatment was 12 days (interquartile range: 8\u201315); 138 (42%) and 193 (58%) episodes received a short (4\u201310 days) and long (11\u201318 days) duration of antimicrobial treatment, respectively. The primary endpoint was observed in 77 (23%) episodes; 120-day mortality was 21% (69 episodes), recurrence of bacteremia was 4% (12 episodes), and bone and joint infection was 0.6% (2 episodes). No difference in primary endpoint was observed between episodes receiving short and long courses of antimicrobial treatment (23%\n                      <jats:italic>versus<\/jats:italic>\n                      23%;\n                      <jats:italic>P\u2009=<\/jats:italic>\n                      \u20091.000). The Cox multivariable regression model found that malignancy (aHR 2.00, 95% CI 1.24\u20133.22), immunosuppression (1.78, 1.09\u20132.90), cirrhosis (2.53, 1.42\u20134.51), and sepsis or septic shock (2.48, 1.52\u20134.03) were associated with primary endpoint; a short course of antimicrobial treatment was not associated with primary endpoint (1.03, 0.65\u20131.62).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Among uncomplicated enterococcal bacteremia giving a short duration of antimicrobial treatment is reasonable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10096-025-05348-6","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:06:07Z","timestamp":1762520767000},"page":"557-565","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Short course of antimicrobial treatment for uncomplicated enterococcal bacteremia"],"prefix":"10.1007","volume":"45","author":[{"given":"Virgile","family":"Zimmermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Fourr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Senn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Guery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-5105","authenticated-orcid":false,"given":"Matthaios","family":"Papadimitriou-Olivgeris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"5348_CR1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jinf.2014.08.012","volume":"70","author":"SL Nielsen","year":"2015","unstructured":"Nielsen SL, Lassen AT, Gradel KO, Jensen TG, Kolmos HJ, Hallas J et al (2015) Bacteremia is associated with excess long-term mortality: a 12-year population-based cohort study. 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