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Time to blood culture positivity (TTP) has been suggested as a marker of disease severity. This study investigated the clinical characteristics of\n                      <jats:italic>S. agalactiae<\/jats:italic>\n                      bacteraemia and the association between TTP and outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective population-based study included adult episodes of\n                      <jats:italic>S. agalactiae<\/jats:italic>\n                      bacteraemia in southern Sweden, from 2016 to 2023. Medical records were reviewed. Information on TTP was obtained from the Department of Clinical Microbiology in Sk\u00e5ne. The primary outcome was 30-day mortality rate. Secondary outcomes were infective endocarditis (IE), development of sepsis and clinical deterioration within 48\u00a0h of blood culture collection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 463 patients were included. Median age was 72 years (interquartile range (IQR 62\u201382). Skin and soft tissue were the most common focus of infection. IE occurred in 23 patients. 30-day mortality was 9% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). TTP analysis included 411 patients. There was no statistically significant difference in levels of TTP between patients with 30-day mortality and survivors, 8.6\u00a0h (IQR 7.6\u201310.1) vs. 9.1\u00a0h (IQR 7.8\u201310.4),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.4. Patients with IE had statistically significantly lower levels of TTP compared to patients without IE, 7.5\u00a0h (IQR 5.9\u20138.8) vs. 9.1\u00a0h (IQR 7.9\u201310.5),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>S. agalactiae<\/jats:italic>\n                      bacteraemia occurs in elderly patients, predominantly male, with a relatively high mortality. Shorter TTP was associated with the presence of IE, but not with mortality or sepsis, suggesting a potential role in identifying patients at risk for IE in\n                      <jats:italic>S. agalactiae<\/jats:italic>\n                      bacteraemia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10096-026-05411-w","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:01:49Z","timestamp":1769169709000},"page":"1275-1283","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bacteraemia with Streptococcus agalactiae \u2013 an observational study on clinical aspects and time to blood culture positivity"],"prefix":"10.1007","volume":"45","author":[{"given":"Torgny","family":"Sunnerhagen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Mnajed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"T\u00f6rngren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2778-5314","authenticated-orcid":false,"given":"Anna","family":"Bl\u00e4ckberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"issue":"suppl2","key":"5411_CR1","doi-asserted-by":"publisher","first-page":"S200","DOI":"10.1093\/cid\/cix664","volume":"65","author":"AC Seale","year":"2017","unstructured":"Seale AC, Bianchi-Jassir F, Russell NJ, Kohli-Lynch M, Tann CJ, Hall J et al (2017) Estimates of the burden of group B Streptococcal disease worldwide for pregnant Women, Stillbirths, and children. 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