{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:07:25Z","timestamp":1789225645553,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005632","name":"Narodowe Centrum Bada\u0144 i Rozwoju","doi-asserted-by":"publisher","award":["POIR.01.01.01-00-1346\/15"],"award-info":[{"award-number":["POIR.01.01.01-00-1346\/15"]}],"id":[{"id":"10.13039\/501100005632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s10096-026-05418-3","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T03:10:12Z","timestamp":1770001812000},"page":"1349-1364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["In vitro activity of furazidin and comparator agents against bacterial isolates from urinary tract infections"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1606-8299","authenticated-orcid":false,"given":"Justyna","family":"Maszkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Denkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0126-1782","authenticated-orcid":false,"given":"Mariana","family":"Castanheira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7022-6644","authenticated-orcid":false,"given":"Helio S.","family":"Sader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Pawelec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"issue":"5","key":"5418_CR1","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/nrmicro3432","volume":"13","author":"AL Flores-Mireles","year":"2015","unstructured":"Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ (2015) Urinary tract infections: epidemiology, mechanisms of infection, and treatment options. Nat Rev Microbiol 13(5):269\u2013284. https:\/\/doi.org\/10.1038\/nrmicro3432","journal-title":"Nat Rev Microbiol"},{"key":"5418_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89240-5","volume":"15","author":"Y He","year":"2025","unstructured":"He Y, Zhao J, Wang L et al (2025) Epidemiological trends and predictions of urinary tract infections in the global burden of disease study 2021. Sci Rep 15:4702. https:\/\/doi.org\/10.1038\/s41598-025-89240-5","journal-title":"Sci Rep"},{"issue":"1","key":"5418_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/QCO.0000000000000228","volume":"29","author":"Z Tandogdu","year":"2016","unstructured":"Tandogdu Z, Wagenlehner FM (2016) Global epidemiology of urinary tract infections. Curr Opin Infect Dis 29(1):73\u201379. https:\/\/doi.org\/10.1097\/QCO.0000000000000228","journal-title":"Curr Opin Infect Dis"},{"issue":"1A","key":"5418_CR4","doi-asserted-by":"publisher","first-page":"5S","DOI":"10.1016\/S0002-9343(02)01054-9","volume":"113","author":"B Foxman","year":"2002","unstructured":"Foxman B (2002) Epidemiology of urinary tract infections: incidence, morbidity, and economic costs. Am J Med 113(1A):5S\u201313S. https:\/\/doi.org\/10.1016\/S0002-9343(02)01054-9","journal-title":"Am J Med"},{"key":"5418_CR5","unstructured":"WHO Regional Office for Europe and European Centre for Disease Prevention and Control (ECDC) (2022) Surveillance of antimicrobial resistance in Europe, 2022 data. Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Available at: https:\/\/www.ecdc.europa.eu. Accessed June 2025"},{"key":"5418_CR6","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jgar.2021.11.008","volume":"28","author":"F Wagenlehner","year":"2022","unstructured":"Wagenlehner F, Nicolle L, Bartoletti R et al (2022) A global perspective on improving patient care in uncomplicated urinary tract infection: expert consensus and practical guidance. J Glob Antimicrob Resist 28:18\u201329. https:\/\/doi.org\/10.1016\/j.jgar.2021.11.008","journal-title":"J Glob Antimicrob Resist"},{"issue":"15","key":"5418_CR7","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s40265-019-01180-3","volume":"79","author":"G Peirano","year":"2019","unstructured":"Peirano G, Pitout JD (2019) Extended-spectrum \u03b2-lactamase-producing enterobacteriaceae: update on molecular epidemiology and treatment options. Drugs 79(15):1529\u20131541. https:\/\/doi.org\/10.1007\/s40265-019-01180-3","journal-title":"Drugs"},{"issue":"16","key":"5418_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12165166","volume":"12","author":"F Bielec","year":"2023","unstructured":"Bielec F, Brauncajs M, Pastuszak-Lewandoska D (2023) Nitrofuran derivatives cross-resistance evidence-uropathogenic Escherichia coli nitrofurantoin and furazidin in vitro susceptibility testing. J Clin Med 12(16):5166. https:\/\/doi.org\/10.3390\/jcm12165166","journal-title":"J Clin Med"},{"issue":"4","key":"5418_CR9","doi-asserted-by":"publisher","first-page":"403","DOI":"10.33073\/pjm-2019-048","volume":"68","author":"B Kot","year":"2019","unstructured":"Kot B (2019) Antibiotic Resistance Among Uropathogenic Escherichia coli. Pol J Microbiol 68(4):403\u201315. https:\/\/doi.org\/10.33073\/pjm-2019-048","journal-title":"Pol J Microbiol"},{"key":"5418_CR10","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.15284","author":"E Jura\u0142owicz","year":"2020","unstructured":"Jura\u0142owicz E, Bartoszko-Tyczkowska A, Tyczkowska-Siero\u0144 E, Kurnatowska I (2020) Etiology and bacterial susceptibility to antibiotics in patients with recurrent lower urinary tract infections. Pol Arch Intern Med. https:\/\/doi.org\/10.20452\/pamw.15284","journal-title":"Pol Arch Intern Med"},{"issue":"5","key":"5418_CR11","doi-asserted-by":"publisher","first-page":"e103","DOI":"10.1093\/cid\/ciq257","volume":"52","author":"K Gupta","year":"2011","unstructured":"Gupta K, Hooton TM, Naber KG et al (2011) International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52(5):e103\u2013e120. https:\/\/doi.org\/10.1093\/cid\/ciq257","journal-title":"Clin Infect Dis"},{"key":"5418_CR12","unstructured":"Bonkat G, Kranz J, Cai T et al (2025) EAU Guidelines on Urological Infections, presented at the EAU Annual Congress Madrid, Spain 2025. ISBN 978-94-92671-29-5 Available at: http:\/\/uroweb.org\/guideline\/urological-infections\/. Accessed June 2025"},{"issue":"3","key":"5418_CR13","first-page":"803","volume":"75","author":"K Klesiewicz","year":"2018","unstructured":"Klesiewicz K, Karczewska E, Nowak P et al (2018) Comparative in vitro studies of Furazidin and Nitrofurantoin activities against common uropathogens including multidrug-resistant strains of E. coli and S. aureus. Acta Pol Pharm \u2013 Drug Res 75(3):803\u2013812","journal-title":"Acta Pol Pharm \u2013 Drug Res"},{"key":"5418_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/ph11020054","volume":"11","author":"D Olender","year":"2018","unstructured":"Olender D, Zwawiak J, Zaprutko L (2018) Multidirectional efficacy of biologically active nitro compounds included in medicines. Pharmaceuticals 11:54. https:\/\/doi.org\/10.3390\/ph11020054","journal-title":"Pharmaceuticals"},{"key":"5418_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drup.2019.03.001","volume":"43","author":"RA Wijma","year":"2019","unstructured":"Wijma RA, Fransen F, Muller AE, Mouton JW (2019) Optimizing dosing of nitrofurantoin from a PK\/PD point of view: what do we need to know? Drug Resist Updat 43:1\u20139. https:\/\/doi.org\/10.1016\/j.drup.2019.03.001","journal-title":"Drug Resist Updat"},{"key":"5418_CR16","first-page":"264","volume":"17","author":"P M\u00e4nnist\u04e7","year":"1979","unstructured":"M\u00e4nnist\u04e7 P, Karttunen P (1979) Pharmacokinetics offuragin, a new nitrofurantoin congener, on human volunteers. Int J Clin Pharmacol Biopharm 17:264\u2013270","journal-title":"Int J Clin Pharmacol Biopharm"},{"issue":"4","key":"5418_CR17","first-page":"280","volume":"14","author":"IS Palagin","year":"2012","unstructured":"Palagin IS, Sukhorukova MV, Dekhnich AV et al (2012) Current state of antibiotic resistance of pathogens causing Community-Acquired urinary tract infections in russia: \u00abDARMIS\u00bb study (2010\u20132011), clin. Microbiol Antimicrob Chemother 14(4):280\u2013302","journal-title":"Microbiol Antimicrob Chemother"},{"issue":"2","key":"5418_CR18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.36488\/cmac.2019.2.134-146","volume":"21","author":"IS Palagin","year":"2019","unstructured":"Palagin IS, Sukhorukova MV, Dekhnich AV et al (2019) Antimicrobial resistance of pathogens causing community-acquired urinary tract infections in russia: results of the multicenter study DARMIS-2018. Clin Microbiol Antimicrob Chemother 21(2):134\u2013146","journal-title":"Clin Microbiol Antimicrob Chemother"},{"key":"5418_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.18565\/urology.2020.1.19-31","volume":"1","author":"IS Palagin","year":"2020","unstructured":"Palagin IS, Sukhorukova MV, Dekhnich AV et al (2020) Current state of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia, Belarus and Kazakhstan: results of the international multicenter study Darmis-2018. Urology 1:19\u201331. https:\/\/doi.org\/10.18565\/urology.2020.1.19-31","journal-title":"Urology"},{"key":"5418_CR20","unstructured":"ISO 20776-1 (2019) Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices - Part 1: Broth micro-dilution reference method for testing the in vitro activity of antimicrobial agents against rapidly growing aerobic bacteria involved in infectious diseases"},{"key":"5418_CR21","unstructured":"CLSI. M100Ed33 (2023) Performance standards for antimicrobial susceptibility testing: 33nd informational supplement. Wayne, PA, Clinical and Laboratory Standards Institute"},{"key":"5418_CR22","unstructured":"CLSI. M07Ed11 (2018) Methods for dilution antimicrobial susceptibilty tests for bacteria that grow aerobically; approved standard - eleventh edition. Wayne, PA, Clinical and Laboratory Standards Institute"},{"key":"5418_CR23","unstructured":"CLSI. M26-A (2011) Methods for determining bactericidal activity of antimicrobial agents. Wayne, PA, Clinical and Laboratory Standards Institute"},{"key":"5418_CR24","volume-title":"Clinical microbiology procedures handbook","author":"AL Leber","year":"2016","unstructured":"Leber AL (2016) Chap. 5.14. In: Leber AL (ed) Clinical microbiology procedures handbook, 4th edn. ASM, Washington, D. C.5.14In","edition":"4"},{"issue":"6","key":"5418_CR25","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1086\/381972","volume":"38","author":"GA Pankey","year":"2004","unstructured":"Pankey GA, Sabath LD (2004) Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of Gram-positive bacterial infections. Clin Infect Dis 38(6):864\u2013870. https:\/\/doi.org\/10.1086\/381972","journal-title":"Clin Infect Dis"},{"key":"5418_CR26","unstructured":"EUCAST (2023) Breakpoint tables for interpretation of MIC\u2019s and zone diameters. Version 13.1, June 2023. Available at http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/v_13.1_Breakpoint_Tables.pdf. Accessed October 2023"},{"key":"5418_CR27","unstructured":"United States Food and Drug Administration (2023) Antibacterial susceptibility test interpretive criteria. Available at https:\/\/www.fda.gov\/drugs\/development-resources\/antibacterial-susceptibility-test-interpretive-criteria Accessed June"},{"key":"5418_CR28","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s10096-016-2673-1","volume":"35","author":"E Stefaniuk","year":"2016","unstructured":"Stefaniuk E, Suchocka U, Bosacka K, Hryniewicz W (2016) Etiology and antibiotic susceptibility of bacterial pathogens responsible for community-acquired urinary tract infections in Poland. Eur J Clin Microbiol Infect Dis 35:1363\u20131369. https:\/\/doi.org\/10.1007\/s10096-016-2673-1","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"5418_CR29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jgar.2018.11.004","volume":"17","author":"S Ny","year":"2019","unstructured":"Ny S, Edquist P, Dumpis U et al (2019) Antimicrobial resistance of Escherichia coli isolates from outpatient urinary tract infections in women in six European countries including Russia. J Glob Antimicrob Resist 17:25\u201334. https:\/\/doi.org\/10.1016\/j.jgar.2018.11.004","journal-title":"J Glob Antimicrob Resist"},{"key":"5418_CR30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s40121-015-0095-5","volume":"4","author":"G Kahlmeter","year":"2015","unstructured":"Kahlmeter G, \u00c5hman J, Matuschek E (2015) Antimicrobial resistance of Escherichia coli causing uncomplicated urinary tract infections: a European update for 2014 and comparison with 2000 and 2008. Infect Dis Ther 4:417\u2013423. https:\/\/doi.org\/10.1007\/s40121-015-0095-5","journal-title":"Infect Dis Ther"},{"key":"5418_CR31","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/jac\/dkg028","volume":"51","author":"G Kahlmeter","year":"2003","unstructured":"Kahlmeter G (2003) An international survey of the antimicrobial susceptibility of pathogens from uncomplicated urinary tract infections: the ECO\u00b7SENS project. J Antimicrob Chemother 51:69\u201376. https:\/\/doi.org\/10.1093\/jac\/dkg028","journal-title":"J Antimicrob Chemother"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05418-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-026-05418-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05418-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T08:04:09Z","timestamp":1780128249000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-026-05418-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["5418"],"URL":"https:\/\/doi.org\/10.1007\/s10096-026-05418-3","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]},"assertion":[{"value":"2 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Element (JMI Laboratories) was contracted to perform these studies by Adamed Pharma S.A. company. Helio S. Sader and Mariana Castanheira are employees of Element (JMI Laboratories). Justyna Maszkowska, Agnieszka Denkis and Dariusz Pawelec are employees of Adamed Pharma S.A.\u00a0JMI Laboratories are Clinical Laboratory Improvement Amendments certified and adhere to good laboratory practice guidelines when performing studies related to antimicrobial susceptibility testing.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}