{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:47:29Z","timestamp":1782866849657,"version":"3.54.5"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Tampere University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10096-026-05450-3","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:17:13Z","timestamp":1772497033000},"page":"1675-1682","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of comorbidity burden and skin integrity on clinical presentation and outcomes in Streptococcus dysgalactiae subspecies equisimilis bacteremia"],"prefix":"10.1007","volume":"45","author":[{"given":"Elviira","family":"Haapaniemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viivi","family":"Nevanlinna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Aittoniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reetta","family":"Huttunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiina","family":"Luukkaala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Rantala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"issue":"4","key":"5450_CR1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1084\/jem.57.4.571","volume":"57","author":"RC Lancefield","year":"1933","unstructured":"Lancefield RC (1933) A serological differentiation of human, and other groups of hemolytic streptococci\u00a0J Exp Med 57(4):571\u2013595","journal-title":"J Exp Med"},{"issue":"4","key":"5450_CR2","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1128\/CMR.15.4.613-630.2002","volume":"15","author":"R Facklam","year":"2002","unstructured":"Facklam R (2002) What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin Microbiol Rev 15(4):613\u2013630","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"5450_CR3","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1086\/597035","volume":"48","author":"LN Broyles","year":"2009","unstructured":"Broyles LN, Van Beneden C, Beall B, Facklam R, Shewmaker PL, Malpiedi P et al (2009) Population-based study of invasive disease due to beta-hemolytic streptococci of groups other than A and B. Clin Infect Dis Off Publ Infect Dis Soc Am 48(6):706\u2013712","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"issue":"8","key":"5450_CR4","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/s10096-014-2092-0","volume":"33","author":"S Rantala","year":"2014","unstructured":"Rantala S (2014) Streptococcus dysgalactiae subsp. equisimilis bacteremia: an emerging infection. Eur J Clin Microbiol Infect Dis 33(8):1303\u20131310","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"3","key":"5450_CR5","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1469-0691.2008.02672.x","volume":"15","author":"S Rantala","year":"2009","unstructured":"Rantala S, Vuopio-Varkila J, Vuento R, Huhtala H, Syrj\u00e4nen J (2009) Clinical presentations and epidemiology of \u03b2-haemolytic streptococcal bacteraemia: a population-based study. Clin Microbiol Infect 15(3):286\u2013288","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"5450_CR6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cmi.2014.08.019","volume":"21","author":"O Oppegaard","year":"2015","unstructured":"Oppegaard O, Mylvaganam H, Kittang BR (2015) Beta-haemolytic group A, C and G streptococcal infections in Western Norway: a 15-year retrospective survey. Clin Microbiol Infect 21(2):171\u2013178","journal-title":"Clin Microbiol Infect"},{"key":"5450_CR7","doi-asserted-by":"crossref","unstructured":"Wajima T, Morozumi M, Hanada S, Sunaoshi K, Chiba N, Iwata S et al Molecular Characterization of Invasive Streptococcus dysgalactiae subsp. equisimilis, Japan - Volume 22, Number 2\u2014February 2016 - Emerging Infectious Diseases journal - CDC. 2016 Feb [cited 2025 Oct 30]; Available from: https:\/\/wwwnc.cdc.gov\/eid\/article\/22\/2\/14-1732_article","DOI":"10.3201\/eid2202.141732"},{"key":"5450_CR8","doi-asserted-by":"crossref","unstructured":"Oppegaard O, Glambek M, Skutlaberg DH, Skrede S, Sivertsen A, Kittang BR Streptococcus dysgalactiae Bloodstream Infections, Norway, 1999\u20132021 - Volume 29, Number 2\u2014February 2023 - Emerging Infectious Diseases journal - CDC. 2023 Feb [cited 2025 Oct 30]; Available from: https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/2\/22-1218_article","DOI":"10.3201\/eid2902.221218"},{"key":"5450_CR9","first-page":"211","volume":"28","author":"IS Schwartz","year":"2014","unstructured":"Schwartz IS, Keynan Y, Gilmour MW, Dufault B, Lagac\u00e9-Wiens P (2014) Changing trends in \u03b2-hemolytic streptococcal bacteremia in Manitoba, Canada: 2007\u20132012. Int J Infect Dis IJID Off Publ Int Soc Infect Dis 28:211\u2013213","journal-title":"Int J Infect Dis IJID Off Publ Int Soc Infect Dis"},{"key":"5450_CR10","doi-asserted-by":"crossref","unstructured":"Shinohara K, Murase K, Tsuchido Y, Noguchi T, Yukawa S, Yamamoto M et al Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005\u20132021 - Volume 29, Number 3\u2014March 2023 - Emerging Infectious Diseases journal - CDC. 2023 Mar [cited 2025 Oct 31]; Available from: https:\/\/wwwnc.cdc.gov\/eid\/article\/29\/3\/22-1060_article","DOI":"10.3201\/eid2903.221060"},{"issue":"3","key":"5450_CR11","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1111\/j.1469-0691.2010.03253.x","volume":"17","author":"BR Kittang","year":"2011","unstructured":"Kittang BR, Bruun T, Langeland N, Mylvaganam H, Glambek M, Skrede S (2011) Invasive group A, C and G streptococcal disease in western Norway: virulence gene profiles, clinical features and outcomes. Clin Microbiol Infect 17(3):358\u2013364","journal-title":"Clin Microbiol Infect"},{"issue":"8","key":"5450_CR12","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1111\/j.1469-0691.2009.03047.x","volume":"16","author":"T Takahashi","year":"2010","unstructured":"Takahashi T, Sunaoshi K, Sunakawa K, Fujishima S, Watanabe H, Ubukata K (2010) Clinical aspects of invasive infections with Streptococcus dysgalactiae ssp. equisimilis in Japan: differences with respect to Streptococcus pyogenes and Streptococcus agalactiae infections. Clin Microbiol Infect 16(8):1097\u2013103","journal-title":"Clin Microbiol Infect"},{"issue":"7","key":"5450_CR13","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.1469-0691.2005.01169.x","volume":"11","author":"K Ekelund","year":"2005","unstructured":"Ekelund K, Skinh\u00f8j P, Madsen J, Konradsen HB (2005) Invasive group A, B, C and G streptococcal infections in Denmark 1999\u20132002: epidemiological and clinical aspects. Clin Microbiol Infect 11(7):569\u2013576","journal-title":"Clin Microbiol Infect"},{"issue":"3","key":"5450_CR14","doi-asserted-by":"publisher","first-page":"e0211786","DOI":"10.1371\/journal.pone.0211786","volume":"14","author":"Y Fujiya","year":"2019","unstructured":"Fujiya Y, Hayakawa K, Gu Y, Yamamoto K, Mawatari M, Kutsuna S et al (2019) Age-related differences in clinical characteristics of invasive group G streptococcal infection: Comparison with group A and group B streptococcal infections. PLoS ONE 14(3):e0211786","journal-title":"PLoS ONE"},{"issue":"10","key":"5450_CR15","doi-asserted-by":"publisher","first-page":"e0206289","DOI":"10.1371\/journal.pone.0206289","volume":"13","author":"A Couture-Cossette","year":"2018","unstructured":"Couture-Cossette A, Carignan A, Mercier A, Desruisseaux C, Valiquette L, P\u00e9pin J (2018) Secular trends in incidence of invasive beta-hemolytic streptococci and efficacy of adjunctive therapy in Quebec, Canada, 1996\u20132016. PLoS ONE 13(10):e0206289","journal-title":"PLoS ONE"},{"issue":"6","key":"5450_CR16","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s15010-019-01356-9","volume":"47","author":"KB Laupland","year":"2019","unstructured":"Laupland KB, Pasquill K, Parfitt EC, Steele L (2019) Bloodstream infection due to \u03b2-hemolytic streptococci: a population-based comparative analysis. Infection 47(6):1021\u20131025","journal-title":"Infection"},{"issue":"5","key":"5450_CR17","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1080\/23744235.2023.2182910","volume":"55","author":"A Bl\u00e4ckberg","year":"2023","unstructured":"Bl\u00e4ckberg A, Lundberg K, Svedevall S, Nilson B, Rasmussen M (2023) Time to positivity of blood cultures in bloodstream infections with Streptococcus dysgalactiae and association with outcome. Infect Dis 55(5):333\u2013339","journal-title":"Infect Dis"},{"issue":"4","key":"5450_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jinf.2009.01.015","volume":"58","author":"S Rantala","year":"2009","unstructured":"Rantala S, Vuopio-Varkila J, Vuento R, Huhtala H, Syrj\u00e4nen J (2009) Predictors of mortality in beta-hemolytic streptococcal bacteremia: a population-based study. J Infect 58(4):266\u2013272","journal-title":"J Infect"},{"issue":"7","key":"5450_CR19","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.3201\/eid2307.161259","volume":"23","author":"SA Lother","year":"2017","unstructured":"Lother SA, Demczuk W, Martin I, Mulvey M, Dufault B, Lagac\u00e9-Wiens P et al (2017) Clonal Clusters and Virulence Factors of Group C and G Streptococcus Causing Severe Infections, Manitoba, Canada, 2012\u20132014. Emerg Infect Dis 23(7):1079\u201388","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"5450_CR20","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1128\/JCM.01262-13","volume":"51","author":"J Loubinoux","year":"2013","unstructured":"Loubinoux J, Plainvert C, Collobert G, Touak G, Bouvet A, Poyart C (2013) Adult invasive and noninvasive infections due to Streptococcus dysgalactiae subsp. equisimilis in France from 2006 to 2010. J Clin Microbiol 51(8):2724\u20137","journal-title":"J Clin Microbiol"},{"issue":"7","key":"5450_CR21","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s10096-023-04607-8","volume":"42","author":"V Nevanlinna","year":"2023","unstructured":"Nevanlinna V, Huttunen R, Aittoniemi J, Luukkaala T, Rantala S (2023) Incidence, seasonal pattern, and clinical manifestations of Streptococcus dysgalactiae subspecies equisimilis bacteremia; a population-based study. Eur J Clin Microbiol Infect Dis 42(7):819\u2013825","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"5","key":"5450_CR22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373\u2013383","journal-title":"J Chronic Dis"},{"issue":"6","key":"5450_CR23","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1093\/aje\/kwq433","volume":"173","author":"H Quan","year":"2011","unstructured":"Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P et al (2011) Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol 173(6):676\u2013682","journal-title":"Am J Epidemiol"},{"issue":"1","key":"5450_CR24","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","volume":"143","author":"JA Hanley","year":"1982","unstructured":"Hanley JA, McNeil BJ (1982) The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 143(1):29\u201336","journal-title":"Radiology"},{"issue":"1","key":"5450_CR25","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1186\/s12879-025-10966-8","volume":"25","author":"M Saukkosaari","year":"2025","unstructured":"Saukkosaari M, Aittoniemi J, Huttunen R, Luukkaala T, Rantala S (2025) Predictors of severe disease in Streptococcus dysgalactiae subsp. equisimilis bacteremia: a population-based study. BMC Infect Dis 25(1):582","journal-title":"BMC Infect Dis"},{"issue":"6","key":"5450_CR26","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1080\/23744235.2023.2192287","volume":"55","author":"V Kailankangas","year":"2023","unstructured":"Kailankangas V, Vilhonen J, Gr\u00f6ndahl-Yli-Hannuksela K, Rantakokko-Jalava K, Seiskari T, Auranen K et al (2023) Presence of Streptococcus pyogenes in the throat in invasive Group A Streptococcal disease: a prospective two-year study in two health districts, Finland. Infect Dis 55(6):405\u201314","journal-title":"Infect Dis"},{"issue":"2","key":"5450_CR27","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jacc.2015.10.065","volume":"67","author":"F Delahaye","year":"2016","unstructured":"Delahaye F, M\u2019Hammedi A, Guerpillon B, de Gevigney G, Boibieux A, Dauwalder O et al (2016) Systematic Search for Present and Potential Portals of Entry for Infective Endocarditis. J Am Coll Cardiol 67(2):151\u2013158","journal-title":"J Am Coll Cardiol"}],"container-title":["European Journal of Clinical Microbiology &amp; Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05450-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-026-05450-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05450-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:53:23Z","timestamp":1782863603000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-026-05450-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["5450"],"URL":"https:\/\/doi.org\/10.1007\/s10096-026-05450-3","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"15 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}