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In this study, onychomycosis agents including dermatophytes (\n                    <jats:italic>Trichophyton<\/jats:italic>\n                    spp.,\n                    <jats:italic>Microsporum<\/jats:italic>\n                    spp.,\n                    <jats:italic>Candida<\/jats:italic>\n                    spp.) and secondary agents such as\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    and\n                    <jats:italic>Fusarium solani<\/jats:italic>\n                    were cultured on Sabouraud dextrose agar (SDA). Species identification was confirmed using MALDI-TOF MS. The minimum inhibitory concentration (MIC) values of OCT-D, HOCl, and terbinafine for dermatophytes grown on culture plates were determined using the agar dilution method and the broth microdilution (tube dilution) method in accordance with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines. Following MIC determination, the minimum fungicidal concentration (MFC) was assessed. Based on the MFC results, flow cytometry analysis was performed using SYTO 9 and propidium iodide (PI) dyes to investigate the fungicidal effects of OCT-D, HOCl, and terbinafine.\n                  <\/jats:p>\n                  <jats:p>As a result of antifungal susceptibility testing of onychomycosis agents, approximate MIC values obtained by the agar dilution method were 250\u00a0mg\/L for OCT-D, 128\u00a0mg\/L for HOCl, and 0.064\u00a0mg\/L for terbinafine. Using the tube dilution method, approximate MIC values were 62.5\u00a0mg\/L, 64\u00a0mg\/L, and 0.032\u00a0mg\/L for OCT-D, HOCl, and terbinafine, respectively. Flow cytometry-based viability analyses showed that the results obtained using the tube dilution method were more consistent. Since OCT-D and HOCl demonstrated MIC values far below their commercially available concentrations and exhibited high fungicidal activity, further studies suggest that these agents may be strong alternatives for topical treatment.<\/jats:p>","DOI":"10.1007\/s10096-026-05477-6","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:06:54Z","timestamp":1776406014000},"page":"2345-2354","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determination of the susceptibility of onychomycosis agents isolated in Sakarya to octenidine dihydrochloride and hypochlorous acid"],"prefix":"10.1007","volume":"45","author":[{"given":"Merve","family":"G\u00fcl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsan Hakk\u0131","family":"\u00c7iftci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fclay","family":"Erman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Can","family":"Ya\u011fmur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130mdat","family":"K\u0131lba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"K\u00f6ro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"5477_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.52403\/gijhsr.20220701","volume":"7","author":"PK Gupta","year":"2023","unstructured":"Gupta PK, Ranjan S (2023) A case study of onychomycosis caused by Aspergillus fumigatus. 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