{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:08:14Z","timestamp":1789996094517,"version":"4.0.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10096-026-05531-3","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:33:28Z","timestamp":1778920408000},"page":"2695-2704","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of hepatitis A virus with periodontitis: a cross-sectional and genetic analysis"],"prefix":"10.1007","volume":"45","author":[{"given":"Ziyang","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"5531_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","volume":"75","author":"J Slots","year":"2017","unstructured":"Slots J (2017) Periodontitis: facts, fallacies and the future. Periodontol 2000 75:7\u201323. https:\/\/doi.org\/10.1111\/prd.12221","journal-title":"Periodontol 2000"},{"key":"5531_CR2","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.adaj.2018.04.023","volume":"149","author":"PI Eke","year":"2018","unstructured":"Eke PI, Thornton-Evans GO, Wei L, Borgnakke WS, Dye BA, Genco RJ (2018) Periodontitis in US adults: National Health and Nutrition Examination Survey 2009\u20132014. J Am Dent Assoc 149:576-588.e6. https:\/\/doi.org\/10.1016\/j.adaj.2018.04.023","journal-title":"J Am Dent Assoc"},{"key":"5531_CR3","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/jcpe.13506","volume":"48","author":"MX Chen","year":"2021","unstructured":"Chen MX, Zhong YJ, Dong QQ, Wong HM, Wen YF (2021) Global, regional, and national burden of severe periodontitis, 1990\u20132019: an analysis of the Global Burden of Disease Study 2019. J Clin Periodontol 48:1165\u20131188. https:\/\/doi.org\/10.1111\/jcpe.13506","journal-title":"J Clin Periodontol"},{"key":"5531_CR4","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","volume":"21","author":"G Hajishengallis","year":"2021","unstructured":"Hajishengallis G, Chavakis T (2021) Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol 21:426\u201340. https:\/\/doi.org\/10.1038\/s41577-020-00488-6","journal-title":"Nat Rev Immunol"},{"key":"5531_CR5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/prd.12268","volume":"82","author":"DM Proctor","year":"2020","unstructured":"Proctor DM, Shelef KM, Gonzalez A, Davis CL, Dethlefsen L, Burns AR et al (2020) Microbial biogeography and ecology of the mouth and implications for periodontal diseases. Periodontol 2000 82:26\u201341. https:\/\/doi.org\/10.1111\/prd.12268","journal-title":"Periodontol 2000"},{"key":"5531_CR6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41579-023-00963-6","volume":"22","author":"JL Baker","year":"2024","unstructured":"Baker JL, Mark Welch JL, Kauffman KM, McLean JS, He X (2024) The oral microbiome: diversity, biogeography and human health. Nat Rev Microbiol 22:89\u2013104. https:\/\/doi.org\/10.1038\/s41579-023-00963-6","journal-title":"Nat Rev Microbiol"},{"key":"5531_CR7","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/prd.12435","volume":"89","author":"F Teles","year":"2022","unstructured":"Teles F, Collman RG, Mominkhan D, Wang Y (2022) Viruses, periodontitis, and comorbidities. Periodontol 2000 89:190\u2013206. https:\/\/doi.org\/10.1111\/prd.12435","journal-title":"Periodontol 2000"},{"key":"5531_CR8","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/prd.12112","volume":"70","author":"PLAM Corstjens","year":"2016","unstructured":"Corstjens PLAM, Abrams WR, Malamud D (2016) Saliva and viral infections. Periodontol 2000 70:93\u2013110. https:\/\/doi.org\/10.1111\/prd.12112","journal-title":"Periodontol 2000"},{"key":"5531_CR9","doi-asserted-by":"publisher","first-page":"414","DOI":"10.12688\/f1000research.52624.2","volume":"10","author":"C Maulani","year":"2021","unstructured":"Maulani C, Masulili C, Santoso SL, Soedarsono WD, Kusdhany N, Auerkari L (2021) Association of subgingival Epstein-Barr virus and periodontitis. F1000Res 10:414. https:\/\/doi.org\/10.12688\/f1000research.52624.2","journal-title":"F1000Res"},{"key":"5531_CR10","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/1744666X.2018.1459571","volume":"14","author":"TLS P\u00f3lvora","year":"2018","unstructured":"P\u00f3lvora TLS, Nobre \u00c1VV, Tirapelli C, Taba M, de Macedo LD, Santana RC et al (2018) Relationship between human immunodeficiency virus (HIV-1) infection and chronic periodontitis. Expert Rev Clin Immunol 14:315\u2013327. https:\/\/doi.org\/10.1080\/1744666X.2018.1459571","journal-title":"Expert Rev Clin Immunol"},{"key":"5531_CR11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/prd.12434","volume":"89","author":"F Tamimi","year":"2022","unstructured":"Tamimi F, Altigani S, Sanz M (2022) Periodontitis and coronavirus disease 2019. Periodontol 2000 89:207\u2013214. https:\/\/doi.org\/10.1111\/prd.12434","journal-title":"Periodontol 2000"},{"key":"5531_CR12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1186\/s12903-023-03416-x","volume":"23","author":"Y Song","year":"2023","unstructured":"Song Y, Liu N, Gao L, Yang D, Liu J, Xie L et al (2023) Association between human herpes simplex virus and periodontitis: results from the continuous National Health and Nutrition Examination Survey 2009\u20132014. BMC Oral Health 23:675. https:\/\/doi.org\/10.1186\/s12903-023-03416-x","journal-title":"BMC Oral Health"},{"key":"5531_CR13","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1186\/s12903-024-04489-y","volume":"24","author":"X Chen","year":"2024","unstructured":"Chen X, Song J, Sun J, Zhang J, Chen X, Zeng C et al (2024) Hepatitis B infection is associated with periodontitis: the national health and nutrition examination survey (2009\u20132014). BMC Oral Health 24:815. https:\/\/doi.org\/10.1186\/s12903-024-04489-y","journal-title":"BMC Oral Health"},{"key":"5531_CR14","doi-asserted-by":"publisher","first-page":"e29784","DOI":"10.1002\/jmv.29784","volume":"96","author":"T Fang","year":"2024","unstructured":"Fang T, Liu L, Mao S, Jiang Z, Cao Y, Pan J (2024) Association between virus infection and periodontitis: Evidence from the National Health and Nutrition Examination Survey 2009\u20132014. J Med Virol 96:e29784. https:\/\/doi.org\/10.1002\/jmv.29784","journal-title":"J Med Virol"},{"key":"5531_CR15","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1002\/jmv.21822","volume":"82","author":"YM Jung","year":"2010","unstructured":"Jung YM, Park SJ, Kim JS, Jang J-H, Lee SH, Kim J-W et al (2010) Atypical manifestations of hepatitis A infection: a prospective, multicenter study in Korea. J Med Virol 82:1318\u20131326. https:\/\/doi.org\/10.1002\/jmv.21822","journal-title":"J Med Virol"},{"key":"5531_CR16","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1001\/jama.2017.17244","volume":"318","author":"KA Linder","year":"2017","unstructured":"Linder KA, Malani PN, Hepatitis A (2017) JAMA 318:2393. https:\/\/doi.org\/10.1001\/jama.2017.17244","journal-title":"JAMA"},{"key":"5531_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1365-2613.2009.00699.x","volume":"91","author":"LA Amado","year":"2010","unstructured":"Amado LA, Marchevsky RS, de Paula VS, Hooper C, Freire M, Gaspar AMC et al (2010) Experimental Hepatitis A virus (HAV) infection in cynomolgus monkeys (Macaca fascicularis): Evidence of active extrahepatic site of HAV replication. Int J Exp Path 91:87\u201397. https:\/\/doi.org\/10.1111\/j.1365-2613.2009.00699.x","journal-title":"Int J Exp Path"},{"key":"5531_CR18","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1111\/j.1600-0714.2011.01123.x","volume":"41","author":"N Mahboobi","year":"2012","unstructured":"Mahboobi N, Porter SR, Karayiannis P, Alavian SM (2012) Oral fluid and hepatitis a, B and C: a literature review. J Oral Pathol Med 41:505\u2013516. https:\/\/doi.org\/10.1111\/j.1600-0714.2011.01123.x","journal-title":"J Oral Pathol Med"},{"key":"5531_CR19","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/prd.12387","volume":"87","author":"R Kuraji","year":"2021","unstructured":"Kuraji R, Sekino S, Kapila Y, Numabe Y (2021) Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an emerging concept of oral-liver axis. Periodontol 2000 87:204\u2013240. https:\/\/doi.org\/10.1111\/prd.12387","journal-title":"Periodontol 2000"},{"key":"5531_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/srep17098","volume":"5","author":"Z Ling","year":"2015","unstructured":"Ling Z, Liu X, Cheng Y, Jiang X, Jiang H, Wang Y et al (2015) Decreased diversity of the oral microbiota of patients with Hepatitis B virus-induced chronic liver disease: a pilot project. Sci Rep 5:17098. https:\/\/doi.org\/10.1038\/srep17098","journal-title":"Sci Rep"},{"key":"5531_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane DF, Stathopoulou PG, Papapanou PN (2017) Periodontal diseases. Nat Rev Dis Primers 3:17038. https:\/\/doi.org\/10.1038\/nrdp.2017.38","journal-title":"Nat Rev Dis Primers"},{"key":"5531_CR22","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7139a1","author":"MA Foster","year":"2022","unstructured":"Foster MA (2022) Widespread Hepatitis A outbreaks associated with person-to-person transmission\u2014United States, 2016\u20132020. MMWR Morb Mortal Wkly Rep. https:\/\/doi.org\/10.15585\/mmwr.mm7139a1","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"5531_CR23","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1902\/jop.2012.110664","volume":"83","author":"PI Eke","year":"2012","unstructured":"Eke PI, Page RC, Wei L, Thornton-Evans G, Genco RJ (2012) Update of the case definitions for population\u2010based surveillance of periodontitis. J Periodontol 83:1449\u201354. https:\/\/doi.org\/10.1902\/jop.2012.110664","journal-title":"J Periodontol"},{"issue":"6","key":"5531_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2025.01.009","volume":"134","author":"Z Zheng","year":"2025","unstructured":"Zheng Z, Xu M, Wang L, Deng Y, Liu Q, Yu K (2025) Masticatory function and cognition in older adults: A population-based study. J Prosthet Dent S0022391325000435. https:\/\/doi.org\/10.1016\/j.prosdent.2025.01.009","journal-title":"J Prosthet Dent"},{"key":"5531_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00257-5","volume":"8","author":"C Tian","year":"2017","unstructured":"Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY et al (2017) Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nat Commun 8:599","journal-title":"Nat Commun"},{"key":"5531_CR26","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1093\/bioinformatics\/btv402","volume":"31","author":"MJ Machiela","year":"2015","unstructured":"Machiela MJ, Chanock SJ (2015) LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants. Bioinformatics 31:3555\u20133557. https:\/\/doi.org\/10.1093\/bioinformatics\/btv402","journal-title":"Bioinformatics"},{"key":"5531_CR27","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf BA, Yarmolinsky J, Davies NM, Swanson SA et al (2021) Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. JAMA 326:1614\u20131621","journal-title":"JAMA"},{"key":"5531_CR28","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/jmv.22045","volume":"83","author":"LA Amado","year":"2011","unstructured":"Amado LA, Villar LM, De Paula VS, Pinto MA, Gaspar AMC (2011) Exposure to multiple subgenotypes of hepatitis a virus during an outbreak using matched serum and saliva specimens. J Med Virol 83:768\u2013775. https:\/\/doi.org\/10.1002\/jmv.22045","journal-title":"J Med Virol"},{"key":"5531_CR29","doi-asserted-by":"publisher","first-page":"8720101","DOI":"10.1155\/2018\/8720101","volume":"2018","author":"DN Gheorghe","year":"2018","unstructured":"Gheorghe DN, Foia L, Toma V, Surdu A, Herascu E, Popescu DM et al (2018) Hepatitis C Infection and Periodontal Disease: Is there a Common Immunological Link? J Immunol Res 2018:8720101. https:\/\/doi.org\/10.1155\/2018\/8720101","journal-title":"J Immunol Res"},{"key":"5531_CR30","doi-asserted-by":"publisher","first-page":"2381","DOI":"10.3892\/etm.2020.8906","volume":"20","author":"P Surlin","year":"2020","unstructured":"Surlin P, Gheorghe DN, Popescu DM, Martu AM, Solomon S, Roman A et al (2020) Interleukin-1\u03b1 and \u2013\u20091\u03b2 assessment in the gingival crevicular fluid of periodontal patients with chronic hepatitis C. Exp Ther Med 20:2381\u20132386. https:\/\/doi.org\/10.3892\/etm.2020.8906","journal-title":"Exp Ther Med"},{"key":"5531_CR31","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.jiac.2020.10.028","volume":"27","author":"H Kamimura","year":"2021","unstructured":"Kamimura H, Watanabe J, Sugano T, Kohisa J, Abe H, Kamimura K et al (2021) Relationship between detection of hepatitis B virus in saliva and periodontal disease in hepatitis B virus carriers in Japan. J Infect Chemother 27:492\u2013496. https:\/\/doi.org\/10.1016\/j.jiac.2020.10.028","journal-title":"J Infect Chemother"},{"key":"5531_CR32","first-page":"53","volume":"91","author":"AA Sorokina","year":"2013","unstructured":"Sorokina AA, Bogomolov BP (2013) The state of oral cavity in patients with hepatitis A. Klin Med 91:53\u201356","journal-title":"Klin Med"},{"key":"5531_CR33","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1503\/cmaj.1040752","volume":"172","author":"EG Giannini","year":"2005","unstructured":"Giannini EG, Testa R, Savarino V (2005) Liver enzyme alteration: a guide for clinicians. CMAJ 172:367\u2013379","journal-title":"CMAJ"},{"key":"5531_CR34","doi-asserted-by":"publisher","first-page":"1189417","DOI":"10.3389\/fcimb.2023.1189417","volume":"13","author":"J Yang","year":"2023","unstructured":"Yang J, Wang D, Li Y, Wang H, Hu Q, Wang Y (2023) Metabolomics in viral hepatitis: advances and review. Front Cell Infect Microbiol 13:1189417. https:\/\/doi.org\/10.3389\/fcimb.2023.1189417","journal-title":"Front Cell Infect Microbiol"},{"key":"5531_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/jper.70029","author":"X Ye","year":"2025","unstructured":"Ye X, Liu B, Liu Z, Zheng T, Fan Y, Ni J et al (2025) Genetic susceptibility and metabolic pathways linking oral health to metabolic dysfunction-associated steatotic liver disease. J Periodontol. https:\/\/doi.org\/10.1002\/jper.70029","journal-title":"J Periodontol"},{"key":"5531_CR36","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/prd.12427","volume":"89","author":"E Albuquerque-Souza","year":"2022","unstructured":"Albuquerque-Souza E, Sahingur SE (2022) Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis. Periodontol 2000 89:125\u201341. https:\/\/doi.org\/10.1111\/prd.12427","journal-title":"Periodontol 2000"},{"key":"5531_CR37","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1080\/07399332.2021.1961775","volume":"43","author":"AR Ahmadinia","year":"2022","unstructured":"Ahmadinia AR, Pakkhesal M, Vakili MA (2022) Evaluation of serum alanine aminotransferase and aspartate aminotransferase enzyme levels in women patients with chronic periodontitis. Health Care Women Int 43:367\u2013375. https:\/\/doi.org\/10.1080\/07399332.2021.1961775","journal-title":"Health Care Women Int"},{"key":"5531_CR38","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/odi.14364","volume":"30","author":"F Zhang","year":"2024","unstructured":"Zhang F, Zhao D, Xu X, Wen P, Li H, Yu R et al (2024) Periodontitis links to concurrent metabolic disorders and abnormal liver function in pregnant women. Oral Dis 30:697\u2013709. https:\/\/doi.org\/10.1111\/odi.14364","journal-title":"Oral Dis"},{"key":"5531_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/00016350903291913","volume":"68","author":"M Furuta","year":"2010","unstructured":"Furuta M, Ekuni D, Yamamoto T, Irie K, Koyama R, Sanbe T et al (2010) Relationship between periodontitis and hepatic abnormalities in young adults. Acta Odontol Scand 68:27\u201333. https:\/\/doi.org\/10.3109\/00016350903291913","journal-title":"Acta Odontol Scand"},{"key":"5531_CR40","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.94416","volume":"2","author":"C Acharya","year":"2017","unstructured":"Acharya C, Sahingur SE, Bajaj JS (2017) Microbiota, cirrhosis, and the emerging oral-gut-liver axis. JCI Insight 2:e94416. https:\/\/doi.org\/10.1172\/jci.insight.94416","journal-title":"JCI Insight"},{"key":"5531_CR41","doi-asserted-by":"crossref","unstructured":"Fierro NA, Castro-Garcia FP, Panduro A (2013) Rethinking cytokine function during hepatitis A and hepatitis C infections","DOI":"10.4236\/abb.2013.47A1003"},{"key":"5531_CR42","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41368-019-0064-z","volume":"11","author":"W Pan","year":"2019","unstructured":"Pan W, Wang Q, Chen Q (2019) The cytokine network involved in the host immune response to periodontitis. Int J Oral Sci 11:30. https:\/\/doi.org\/10.1038\/s41368-019-0064-z","journal-title":"Int J Oral Sci"},{"key":"5531_CR43","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.92895","volume":"12","author":"X Ye","year":"2024","unstructured":"Ye X, Bai Y, Li M, Ye Y, Chen Y, Liu B et al (2024) Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care. Elife 12:RP92895. https:\/\/doi.org\/10.7554\/eLife.92895","journal-title":"Elife"},{"key":"5531_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020395","volume":"20","author":"I Milosevic","year":"2019","unstructured":"Milosevic I, Vujovic A, Barac A, Djelic M, Korac M, Radovanovic Spurnic A et al (2019) Gut-liver axis, gut microbiota, and its modulation in the management of liver diseases: a review of the literature. Int J Mol Sci 20:395. https:\/\/doi.org\/10.3390\/ijms20020395","journal-title":"Int J Mol Sci"},{"key":"5531_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04559-9","volume":"21","author":"X Ye","year":"2023","unstructured":"Ye X, Liu B, Bai Y, Cao Y, Lin S, Lyu L et al (2023) Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: Insights from a two-sample Mendelian randomization study. J Transl Med 21:674. https:\/\/doi.org\/10.1186\/s12967-023-04559-9","journal-title":"J Transl Med"},{"key":"5531_CR46","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031823","volume":"9","author":"SM Lemon","year":"2019","unstructured":"Lemon SM, Walker CM (2019) Hepatitis A Virus and Hepatitis E Virus: Emerging and re-emerging enterically transmitted hepatitis viruses. Cold Spring Harb Perspect Med 9:a031823. https:\/\/doi.org\/10.1101\/cshperspect.a031823","journal-title":"Cold Spring Harb Perspect Med"},{"key":"5531_CR47","doi-asserted-by":"publisher","unstructured":"Hofmeister MG, Yin S, Nelson NP, Weng MK, Gupta N (2023) Trends and opportunities: hepatitis A virus infection, seroprevalence, and vaccination coverage\u2014United States, 1976\u20132020. Public Health Rep 00333549231184007. https:\/\/doi.org\/10.1177\/00333549231184007","DOI":"10.1177\/00333549231184007"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05531-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-026-05531-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05531-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:34:28Z","timestamp":1789994068000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-026-05531-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5531"],"URL":"https:\/\/doi.org\/10.1007\/s10096-026-05531-3","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,16]]},"assertion":[{"value":"10 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All information from the NHANES program and GWAS data are available and free for public, so the agreement of the medical ethics committee board and written inform consent was not necessary.","order":1,"name":"Ethics","label":"Ethics approval\u00a0statement and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}