{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:07:54Z","timestamp":1789996074124,"version":"4.0.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10096-026-05534-0","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:40:04Z","timestamp":1779090004000},"page":"2705-2720","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analytical performance of Autof MS2600 and Biotyper Sirius for rapid MALDI-TOF MS identification of microorganisms from positive blood cultures"],"prefix":"10.1007","volume":"45","author":[{"given":"D\u00e9laiss\u00e9e Chim\u00e8ne","family":"Nyamessameye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Piron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissatou","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souad","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethel","family":"Seyll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Martiny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"5534_CR1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR et al (2020) Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study. Lancet 395:200\u2013211. https:\/\/doi.org\/10.1016\/S0140-6736(19)32989-7","journal-title":"Lancet"},{"key":"5534_CR2","unstructured":"Sepsis (2025) accessed August 18, n.d. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/sepsis"},{"key":"5534_CR3","doi-asserted-by":"publisher","first-page":"e23119","DOI":"10.1002\/jcla.23119","volume":"34","author":"Y Yuan","year":"2020","unstructured":"Yuan Y, Wang J, Zhang J, Ma B, Gao S, Li Y et al (2020) Evaluation of an optimized method to directly identify bacteria from positive blood cultures using MALDI-TOF mass spectrometry. Clin Lab Anal 34:e23119. https:\/\/doi.org\/10.1002\/jcla.23119","journal-title":"Clin Lab Anal"},{"key":"5534_CR4","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/1469-0691.12195","volume":"19","author":"M Goto","year":"2013","unstructured":"Goto M, Al-Hasan MN (2013) Overall burden of bloodstream infection and nosocomial bloodstream infection in North America and Europe. Clin Microbiol Infect 19:501\u2013509. https:\/\/doi.org\/10.1111\/1469-0691.12195","journal-title":"Clin Microbiol Infect"},{"key":"5534_CR5","doi-asserted-by":"publisher","first-page":"e00355","DOI":"10.1128\/AAC.00355-19","volume":"63","author":"DJ Diekema","year":"2019","unstructured":"Diekema DJ, Hsueh P-R, Mendes RE, Pfaller MA, Rolston KV, Sader HS et al (2019) Microbiology of Bloodstream Infection: 20-Year Trends from the SENTRY Antimicrobial Surveillance ProgramThe. Antimicrob Agents Chemother 63:e00355\u2013e00319. https:\/\/doi.org\/10.1128\/AAC.00355-19","journal-title":"Antimicrob Agents Chemother"},{"key":"5534_CR6","doi-asserted-by":"publisher","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","volume":"24","author":"DW Denning","year":"2024","unstructured":"Denning DW (2024) Global incidence and mortality of severe fungal disease. Lancet Infect Dis 24:e428\u2013e438. https:\/\/doi.org\/10.1016\/S1473-3099(23)00692-8","journal-title":"Lancet Infect Dis"},{"key":"5534_CR7","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s10096-016-2841-3","volume":"36","author":"C Trouv\u00e9","year":"2017","unstructured":"Trouv\u00e9 C, Blot S, Hayette M-P, Jonckheere S, Patteet S, Rodriguez-Villalobos H et al (2017) Epidemiology and reporting of candidaemia in Belgium: a multi-centre study. Eur J Clin Microbiol Infect Dis 36:649\u2013655. https:\/\/doi.org\/10.1007\/s10096-016-2841-3","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"5534_CR8","doi-asserted-by":"publisher","first-page":"646648","DOI":"10.3389\/fcimb.2021.646648","volume":"11","author":"A Cu\u00e9nod","year":"2021","unstructured":"Cu\u00e9nod A, Foucault F, Pfl\u00fcger V, Egli A (2021) Factors Associated With MALDI-TOF Mass Spectral Quality of Species Identification in Clinical Routine Diagnostics. Front Cell Infect Microbiol 11:646648. https:\/\/doi.org\/10.3389\/fcimb.2021.646648","journal-title":"Front Cell Infect Microbiol"},{"key":"5534_CR9","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M et al (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315:801\u2013810. https:\/\/doi.org\/10.1001\/jama.2016.0287","journal-title":"JAMA"},{"key":"5534_CR10","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.eimc.2017.08.012","volume":"36","author":"J Ruiz-Arag\u00f3n","year":"2018","unstructured":"Ruiz-Arag\u00f3n J, Ballestero-T\u00e9llez M, Guti\u00e9rrez-Guti\u00e9rrez B, De Cueto M, Rodr\u00edguez-Ba\u00f1o J, Pascual \u00c1 (2018) Direct bacterial identification from positive blood cultures using matrix-assisted laser desorption\/ionization time-of-flight (MALDI-TOF) mass spectrometry: A systematic review and meta-analysis. Enfermedades infecciosas y microbiolog\u00eda cl\u00ednica 36:484\u2013492. https:\/\/doi.org\/10.1016\/j.eimc.2017.08.012","journal-title":"Enfermedades infecciosas y microbiolog\u00eda cl\u00ednica"},{"key":"5534_CR11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s10096-023-04725-3","volume":"43","author":"S Cruz","year":"2024","unstructured":"Cruz S, Abreu D, Gomes R, Martins-Oliveira I, Silva-Dias A, Perez-Viso B et al (2024) An improved protocol for bacteria identification by MALDI-TOF MS directly from positive blood cultures. Eur J Clin Microbiol Infect Dis 43:605\u2013610. https:\/\/doi.org\/10.1007\/s10096-023-04725-3","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"5534_CR12","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1007\/s10096-012-1566-1","volume":"31","author":"D Martiny","year":"2012","unstructured":"Martiny D, Dediste A, Vandenberg O (2012) Comparison of an in-house method and the commercial Sepsityper\u2122 kit for bacterial identification directly from positive blood culture broths by matrix-assisted laser desorption-ionisation time-of-flight mass spectrometry. Eur J Clin Microbiol Infect Dis 31:2269\u20132281. https:\/\/doi.org\/10.1007\/s10096-012-1566-1","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"5534_CR13","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s10096-023-04666-x","volume":"42","author":"P Thelen","year":"2023","unstructured":"Thelen P, Graeber S, Schmidt E, Hamprecht A (2023) A side-by-side comparison of the new VITEK MS PRIME and the MALDI Biotyper sirius in the clinical microbiology laboratory. Eur J Clin Microbiol Infect Dis 42:1355\u20131363. https:\/\/doi.org\/10.1007\/s10096-023-04666-x","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"5534_CR14","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3390\/microorganisms12020382","volume":"12","author":"E De Carolis","year":"2024","unstructured":"De Carolis E, Ivagnes V, Magr\u00ec C, Falasca B, Spanu T, Sanguinetti M (2024) Evaluation of Autof MS2600 and MBT Smart MALDI-TOF MS Systems for Routine Identification of Clinical Bacteria and Yeasts. Microorganisms 12:382. https:\/\/doi.org\/10.3390\/microorganisms12020382","journal-title":"Microorganisms"},{"key":"5534_CR15","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/j.1469-0691.2010.03257.x","volume":"17","author":"L Ferreira","year":"2011","unstructured":"Ferreira L, S\u00e1nchez-Juanes F, Porras-Guerra I, Garc\u00eda-Garc\u00eda MI, Garc\u00eda-S\u00e1nchez JE, Gonz\u00e1lez-Buitrago JM et al (2011) Microorganisms direct identification from blood culture by matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry. Clin Microbiol Infect 17:546\u2013551. https:\/\/doi.org\/10.1111\/j.1469-0691.2010.03257.x","journal-title":"Clin Microbiol Infect"},{"key":"5534_CR16","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.fertnstert.2024.01.040","volume":"121","author":"AR Kunselman","year":"2024","unstructured":"Kunselman AR (2024) A brief overview of pilot studies and their sample size justification. Fertil Steril 121:899\u2013901. https:\/\/doi.org\/10.1016\/j.fertnstert.2024.01.040","journal-title":"Fertil Steril"},{"key":"5534_CR17","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1752-8062.2011.00347.x","volume":"4","author":"CG Moore","year":"2011","unstructured":"Moore CG, Carter RE, Nietert PJ, Stewart PW (2011) Recommendations for planning pilot studies in clinical and translational research. Clin Transl Sci 4:332\u2013337. https:\/\/doi.org\/10.1111\/j.1752-8062.2011.00347.x","journal-title":"Clin Transl Sci"},{"key":"5534_CR18","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1128\/CMR.00002-14","volume":"27","author":"KB Laupland","year":"2014","unstructured":"Laupland KB, Church DL (2014) Population-Based Epidemiology and Microbiology of Community-Onset Bloodstream Infections. Clin Microbiol Rev 27:647\u2013664. https:\/\/doi.org\/10.1128\/CMR.00002-14","journal-title":"Clin Microbiol Rev"},{"key":"5534_CR19","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/j.1469-0691.2010.03262.x","volume":"17","author":"J Wilson","year":"2011","unstructured":"Wilson J, Elgohari S, Livermore DM, Cookson B, Johnson A, Lamagni T et al (2011) Trends among pathogens reported as causing bacteraemia in England, 2004\u20132008. Clin Microbiol Infect 17:451\u2013458. https:\/\/doi.org\/10.1111\/j.1469-0691.2010.03262.x","journal-title":"Clin Microbiol Infect"},{"key":"5534_CR20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13756-021-00997-6","volume":"10","author":"F Sch\u00f6neweck","year":"2021","unstructured":"Sch\u00f6neweck F, Schmitz RPH, Ri\u00dfner F, Scherag A, L\u00f6ffler B, Pletz MW et al (2021) The epidemiology of bloodstream infections and antimicrobial susceptibility patterns in Thuringia, Germany: a five-year prospective, state-wide surveillance study (AlertsNet). Antimicrob Resist Infect Control 10:132. https:\/\/doi.org\/10.1186\/s13756-021-00997-6","journal-title":"Antimicrob Resist Infect Control"},{"key":"5534_CR21","unstructured":"sciensano_national_bloodstream_infection_annual_report_2024.pdf n.d. https:\/\/www.sciensano.be\/sites\/default\/files\/sciensano_national_bloodstream_infection_annual_report_2024.pdf Accessed\u00a0 14\u00a0Aug 2025"},{"key":"5534_CR22","doi-asserted-by":"publisher","first-page":"549","DOI":"10.2147\/CLEP.S459600","volume":"16","author":"DJ Bays","year":"2024","unstructured":"Bays DJ, Jenkins EN, Lyman M, Chiller T, Strong N, Ostrosky-Zeichner L et al (2024) Epidemiology of Invasive Candidiasis. Clin Epidemiol 16:549\u2013566. https:\/\/doi.org\/10.2147\/CLEP.S459600","journal-title":"Clin Epidemiol"},{"key":"5534_CR23","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.3390\/life12111744","volume":"12","author":"G Per\u0161e","year":"2022","unstructured":"Per\u0161e G, Samo\u0161\u0107anec I, Bo\u0161njak Z, Budimir A, Kuli\u0161 T, Marekovi\u0107 I (2022) Sepsityper\u00ae Kit versus In-House Method in Rapid Identification of Bacteria from Positive Blood Cultures by MALDI-TOF Mass Spectrometry. Life (Basel) 12:1744. https:\/\/doi.org\/10.3390\/life12111744","journal-title":"Life (Basel)"},{"key":"5534_CR24","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1007\/s10096-019-03654-4","volume":"38","author":"M Kayin","year":"2019","unstructured":"Kayin M, Mert B, Aydemir S, \u00d6zenci V (2019) Comparison of rapid BACpro\u00ae II, Sepsityper\u00ae kit and in-house preparation methods for direct identification of bacteria from blood cultures by MALDI-TOF MS with and without Sepsityper\u00ae module analysis. Eur J Clin Microbiol Infect Dis 38:2133\u20132143. https:\/\/doi.org\/10.1007\/s10096-019-03654-4","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"5534_CR25","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.3390\/diagnostics14151611","volume":"14","author":"S-F Kuo","year":"2024","unstructured":"Kuo S-F, Huang T-Y, Lee C-Y, Lee C-H (2024) Comparison of the Direct Identification and Short-Term Incubation Methods for Positive Blood Cultures via MALDI-TOF Mass Spectrometry. Diagnostics (Basel) 14:1611. https:\/\/doi.org\/10.3390\/diagnostics14151611","journal-title":"Diagnostics (Basel)"},{"key":"5534_CR26","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12879-019-3709-9","volume":"19","author":"M Azrad","year":"2019","unstructured":"Azrad M, Keness Y, Nitzan O, Pastukh N, Tkhawkho L, Freidus V et al (2019) Cheap and rapid in-house method for direct identification of positive blood cultures by MALDI-TOF MS technology. BMC Infect Dis 19:72. https:\/\/doi.org\/10.1186\/s12879-019-3709-9","journal-title":"BMC Infect Dis"},{"key":"5534_CR27","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1186\/s12879-025-11129-5","volume":"25","author":"MM Ashmawy","year":"2025","unstructured":"Ashmawy MM, Khairat SM, Reda NM, Abdelhalim MM (2025) Rapid and cost-effective identification of microorganisms from positive blood cultures using MALDI-TOF MS. BMC Infect Dis 25:736. https:\/\/doi.org\/10.1186\/s12879-025-11129-5","journal-title":"BMC Infect Dis"},{"key":"5534_CR28","doi-asserted-by":"publisher","first-page":"e8041","DOI":"10.1371\/journal.pone.0008041","volume":"4","author":"B La Scola","year":"2009","unstructured":"La Scola B, Raoult D (2009) Direct identification of bacteria in positive blood culture bottles by matrix-assisted laser desorption ionisation time-of-flight mass spectrometry. PLoS ONE 4:e8041. https:\/\/doi.org\/10.1371\/journal.pone.0008041","journal-title":"PLoS ONE"},{"key":"5534_CR29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ijid.2016.09.014","volume":"52","author":"S Yonetani","year":"2016","unstructured":"Yonetani S, Ohnishi H, Ohkusu K, Matsumoto T, Watanabe T (2016) Direct identification of microorganisms from positive blood cultures by MALDI-TOF MS using an in-house saponin method. Int J Infect Dis 52:37\u201342. https:\/\/doi.org\/10.1016\/j.ijid.2016.09.014","journal-title":"Int J Infect Dis"},{"key":"5534_CR30","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.bjid.2017.03.007","volume":"21","author":"MG Barberino","year":"2017","unstructured":"Barberino MG, Silva M, de O, Arraes ACP, Correia LC, Mendes AV (2017) Direct identification from positive blood broth culture by matrix-assisted laser desorption-ionization time-of-flight mass spectrometry (MALDI-TOF MS). Braz J Infect Dis 21:339\u2013342. https:\/\/doi.org\/10.1016\/j.bjid.2017.03.007","journal-title":"Braz J Infect Dis"},{"key":"5534_CR31","doi-asserted-by":"publisher","unstructured":"Karada\u011f D, Ergon MC Investigation of different methods in rapid microbial identification directly from positive blood culture bottles by MALDI-TOF MS. Microbiology Spectrum 2024. https:\/\/doi.org\/10.1128\/spectrum.00638-24","DOI":"10.1128\/spectrum.00638-24"},{"key":"5534_CR32","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.jhsa.2024.01.006","volume":"49","author":"BM Derksen","year":"2024","unstructured":"Derksen BM, Bruinsma W, Goslings JC, Schep NWL (2024) The Kappa Paradox Explained. J Hand Surg Am 49:482\u2013485. https:\/\/doi.org\/10.1016\/j.jhsa.2024.01.006","journal-title":"J Hand Surg Am"},{"key":"5534_CR33","doi-asserted-by":"publisher","first-page":"100618","DOI":"10.1016\/j.jtocrr.2023.100618","volume":"5","author":"KS Tan","year":"2024","unstructured":"Tan KS, Yeh Y-C, Adusumilli PS, Travis WD (2024) Quantifying Interrater Agreement and Reliability Between Thoracic Pathologists: Paradoxical Behavior of Cohen\u2019s Kappa in the Presence of a High Prevalence of the Histopathologic Feature in Lung Cancer. JTO Clin Res Rep 5:100618. https:\/\/doi.org\/10.1016\/j.jtocrr.2023.100618","journal-title":"JTO Clin Res Rep"},{"key":"5534_CR34","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1002\/sim.9341","volume":"41","author":"A Vanacore","year":"2022","unstructured":"Vanacore A, Pellegrino MS (2022) Robustness of \u03ba -type coefficients for clinical agreement. Stat Med 41:1986\u20132004. https:\/\/doi.org\/10.1002\/sim.9341","journal-title":"Stat Med"},{"key":"5534_CR35","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3343\/alm.2017.37.6.475","volume":"37","author":"A van Belkum","year":"2017","unstructured":"van Belkum A, Welker M, Pincus D, Charrier JP, Girard V (2017) Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry in Clinical Microbiology: What Are the Current Issues? Ann Lab Med 37:475\u2013483. https:\/\/doi.org\/10.3343\/alm.2017.37.6.475","journal-title":"Ann Lab Med"},{"key":"5534_CR36","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1128\/JCM.02399-13","volume":"52","author":"B Schulthess","year":"2014","unstructured":"Schulthess B, Bloemberg GV, Zbinden R, B\u00f6ttger EC, Hombach M (2014) Evaluation of the Bruker MALDI Biotyper for Identification of Gram-Positive Rods: Development of a Diagnostic Algorithm for the Clinical Laboratory. J Clin Microbiol 52:1089\u20131097. https:\/\/doi.org\/10.1128\/JCM.02399-13","journal-title":"J Clin Microbiol"},{"key":"5534_CR37","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13059-023-03096-4","volume":"24","author":"Y Sekiguchi","year":"2023","unstructured":"Sekiguchi Y, Teramoto K, Tourlousse DM, Ohashi A, Hamajima M, Miura D et al (2023) A large-scale genomically predicted protein mass database enables rapid and broad-spectrum identification of bacterial and archaeal isolates by mass spectrometry. Genome Biol 24:257. https:\/\/doi.org\/10.1186\/s13059-023-03096-4","journal-title":"Genome Biol"},{"key":"5534_CR38","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1186\/s12866-020-02005-0","volume":"20","author":"Q Ma","year":"2020","unstructured":"Ma Q, Zhang Q, Yuan Y, Yan W, Wang S, Xu J et al (2020) Evaluation of the Autof MS1000 mass spectrometer in the identification of clinical isolates. BMC Microbiol 20:318. https:\/\/doi.org\/10.1186\/s12866-020-02005-0","journal-title":"BMC Microbiol"},{"key":"5534_CR39","doi-asserted-by":"publisher","first-page":"e0169332","DOI":"10.1371\/journal.pone.0169332","volume":"11","author":"K French","year":"2016","unstructured":"French K, Evans J, Tanner H, Gossain S, Hussain A (2016) The Clinical Impact of Rapid, Direct MALDI-ToF Identification of Bacteria from Positive Blood Cultures. PLoS ONE 11:e0169332. https:\/\/doi.org\/10.1371\/journal.pone.0169332","journal-title":"PLoS ONE"},{"key":"5534_CR40","doi-asserted-by":"publisher","first-page":"2788","DOI":"10.1128\/JCM.00957-15","volume":"53","author":"SA Cunningham","year":"2015","unstructured":"Cunningham SA, Patel R (2015) Standard Matrix-Assisted Laser Desorption Ionization\u2013Time of Flight Mass Spectrometry Reagents May Inactivate Potentially Hazardous Bacteria. J Clin Microbiol 53:2788\u20132789. https:\/\/doi.org\/10.1128\/JCM.00957-15","journal-title":"J Clin Microbiol"},{"key":"5534_CR41","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1128\/JCM.02654-12","volume":"51","author":"B Schulthess","year":"2013","unstructured":"Schulthess B, Brodner K, Bloemberg GV, Zbinden R, B\u00f6ttger EC, Hombach M (2013) Identification of Gram-Positive Cocci by Use of Matrix-Assisted Laser Desorption Ionization\u2013Time of Flight Mass Spectrometry: Comparison of Different Preparation Methods and Implementation of a Practical Algorithm for Routine Diagnostics. J Clin Microbiol 51:1834\u20131840. https:\/\/doi.org\/10.1128\/JCM.02654-12","journal-title":"J Clin Microbiol"},{"key":"5534_CR42","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.jmoldx.2011.07.004","volume":"13","author":"S Schubert","year":"2011","unstructured":"Schubert S, Weinert K, Wagner C, Gunzl B, Wieser A, Maier T et al (2011) Novel, improved sample preparation for rapid, direct identification from positive blood cultures using matrix-assisted laser desorption\/ionization time-of-flight (MALDI-TOF) mass spectrometry. J Mol Diagn 13:701\u2013706. https:\/\/doi.org\/10.1016\/j.jmoldx.2011.07.004","journal-title":"J Mol Diagn"},{"key":"5534_CR43","doi-asserted-by":"publisher","first-page":"e0142398","DOI":"10.1371\/journal.pone.0142398","volume":"10","author":"M Almuhayawi","year":"2015","unstructured":"Almuhayawi M, Altun O, Abdulmajeed AD, Ullberg M, \u00d6zenci V (2015) The Performance of the Four Anaerobic Blood Culture Bottles BacT\/ALERT-FN, -FN Plus, BACTEC-Plus and -Lytic in Detection of Anaerobic Bacteria and Identification by Direct MALDI-TOF MS. PLoS ONE 10:e0142398. https:\/\/doi.org\/10.1371\/journal.pone.0142398","journal-title":"PLoS ONE"},{"key":"5534_CR44","doi-asserted-by":"publisher","first-page":"e0156299","DOI":"10.1371\/journal.pone.0156299","volume":"11","author":"A Verroken","year":"2016","unstructured":"Verroken A, Defourny L, le Polain de Waroux O, Belkhir L, Laterre P-F, Delm\u00e9e M et al (2016) Clinical Impact of MALDI-TOF MS Identification and Rapid Susceptibility Testing on Adequate Antimicrobial Treatment in Sepsis with Positive Blood Cultures. PLoS ONE 11:e0156299. https:\/\/doi.org\/10.1371\/journal.pone.0156299","journal-title":"PLoS ONE"},{"key":"5534_CR45","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.cmi.2016.08.009","volume":"23","author":"M Osthoff","year":"2017","unstructured":"Osthoff M, G\u00fcrtler N, Bassetti S, Balestra G, Marsch S, Pargger H et al (2017) Impact of MALDI-TOF-MS-based identification directly from positive blood cultures on patient management: a controlled clinical trial. Clin Microbiol Infect 23:78\u201385. https:\/\/doi.org\/10.1016\/j.cmi.2016.08.009","journal-title":"Clin Microbiol Infect"},{"key":"5534_CR46","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1128\/CMR.00053-14","volume":"29","author":"SS Buehler","year":"2016","unstructured":"Buehler SS, Madison B, Snyder SR, Derzon JH, Cornish NE, Saubolle MA et al (2016) Effectiveness of Practices To Increase Timeliness of Providing Targeted Therapy for Inpatients with Bloodstream Infections: a Laboratory Medicine Best Practices Systematic Review and Meta-analysis. Clin Microbiol Rev 29:59\u2013103. https:\/\/doi.org\/10.1128\/CMR.00053-14","journal-title":"Clin Microbiol Rev"},{"key":"5534_CR47","doi-asserted-by":"publisher","first-page":"e328","DOI":"10.1016\/S1470-2045(16)30206-6","volume":"17","author":"S Kumar","year":"2016","unstructured":"Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P et al (2016) International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol 17:e328\u2013e346. https:\/\/doi.org\/10.1016\/S1470-2045(16)30206-6","journal-title":"Lancet Oncol"},{"key":"5534_CR48","unstructured":"Lennon D Practicalities of maldi-tof* n.d"},{"key":"5534_CR49","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1086\/504810","volume":"43","author":"KW Garey","year":"2006","unstructured":"Garey KW, Rege M, Pai MP, Mingo DE, Suda KJ, Turpin RS et al (2006) Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. Clin Infect Dis 43:25\u201331. https:\/\/doi.org\/10.1086\/504810","journal-title":"Clin Infect Dis"},{"key":"5534_CR50","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1093\/cid\/ciae234","volume":"79","author":"AM Peri","year":"2024","unstructured":"Peri AM, Chatfield MD, Ling W, Furuya-Kanamori L, Harris PNA, Paterson DL (2024) Rapid Diagnostic Tests and Antimicrobial Stewardship Programs for the Management of Bloodstream Infection: What Is Their Relative Contribution to Improving Clinical Outcomes? A Systematic Review and Network Meta-analysis. Clin Infect Dis 79:502\u2013515. https:\/\/doi.org\/10.1093\/cid\/ciae234","journal-title":"Clin Infect Dis"},{"key":"5534_CR51","doi-asserted-by":"publisher","first-page":"E568","DOI":"10.1111\/1469-0691.12282","volume":"19","author":"D Martiny","year":"2013","unstructured":"Martiny D, Debaugnies F, Gateff D, G\u00e9rard M, Aoun M, Martin C et al (2013) Impact of rapid microbial identification directly from positive blood cultures using matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry on patient management. Clin Microbiol Infect 19:E568\u2013581. https:\/\/doi.org\/10.1111\/1469-0691.12282","journal-title":"Clin Microbiol Infect"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05534-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-026-05534-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05534-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:34:33Z","timestamp":1789994073000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-026-05534-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5534"],"URL":"https:\/\/doi.org\/10.1007\/s10096-026-05534-0","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"31 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was not required for this study.","order":1,"name":"Ethics","label":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}