{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:56:22Z","timestamp":1793411782210,"version":"4.5.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82405079"],"award-info":[{"award-number":["82405079"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Guangzhou Science and Technology Bureau","award":["2024A04J3301"],"award-info":[{"award-number":["2024A04J3301"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10096-026-05537-x","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T03:05:14Z","timestamp":1778468714000},"page":"2895-2900","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lessons from a case report of thrombocytopenia-associated multiple organ failure secondary to Streptococcus suis infection: Diagnosis and treatment strategies"],"prefix":"10.1007","volume":"45","author":[{"given":"Miao-En","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Tao","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Ping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"5537_CR1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.medmal.2017.10.001","volume":"48","author":"B Haas","year":"2018","unstructured":"Haas B, Grenier D (2018) Understanding the virulence of Streptococcus suis: A veterinary, medical, and economic challenge. Med Mal Infect 48:159\u2013166","journal-title":"Med Mal Infect"},{"key":"5537_CR2","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.vetmic.2014.08.010","volume":"173","author":"Y Bi","year":"2014","unstructured":"Bi Y, Li J, Yang L, Zhang S, Li Y, Jia X et al (2014) Assessment of the pathogenesis of Streptococcus suis type 2 infection in piglets for understanding streptococcal toxic shock-like syndrome, meningitis, and sequelae. Vet Microbiol 173:299\u2013309","journal-title":"Vet Microbiol"},{"key":"5537_CR3","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1128\/IAI.01317-12","volume":"81","author":"C Lachance","year":"2013","unstructured":"Lachance C, Gottschalk M, Gerber PP, Lemire P, Xu J, Segura M (2013) Exacerbated type II interferon response drives hypervirulence and toxic shock by an emergent epidemic strain of Streptococcus suis. Infect Immun 81:1928\u20131939","journal-title":"Infect Immun"},{"key":"5537_CR4","doi-asserted-by":"crossref","unstructured":"Satoh K, Wada T, Tampo A, Takahashi G, Hoshino K, Matsumoto H, Diagnosis) Study Group (2024) J-STAD (JAPAN Sepsis Treatment and Practical approach to thrombocytopenia in patients with sepsis: a narrative review. Thromb J 22:67","DOI":"10.1186\/s12959-024-00637-0"},{"key":"5537_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1055\/s-0038-1675639","volume":"8","author":"AM Alcamo","year":"2019","unstructured":"Alcamo AM, Pang D, Bashir DA, Carcillo JA, Nguyen TC, Aneja RK (2019) Role of Damage-Associated Molecular Patterns and Uncontrolled Inflammation in Pediatric Sepsis-Induced Multiple Organ Dysfunction Syndrome. J Pediatr Intensive Care 8:25\u201331","journal-title":"J Pediatr Intensive Care"},{"key":"5537_CR6","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ccc.2019.12.010","volume":"36","author":"TC Nguyen","year":"2020","unstructured":"Nguyen TC (2020) Thrombocytopenia-Associated Multiple Organ Failure. Crit Care Clin 36:379\u2013390","journal-title":"Crit Care Clin"},{"key":"5537_CR7","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1055\/s-0037-1616068","volume":"86","author":"FB Taylor Jr","year":"2001","unstructured":"Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M, Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH) (2001) Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 86:1327\u20131330","journal-title":"Thromb Haemost"},{"key":"5537_CR8","doi-asserted-by":"publisher","first-page":"e157","DOI":"10.1016\/S2352-3026(17)30026-1","volume":"4","author":"PK Bendapudi","year":"2017","unstructured":"Bendapudi PK, Hurwitz S, Fry A, Marques MB, Waldo SW, Li A et al (2017) Derivation and external validation of the PLASMIC score for rapid assessment of adults with thrombotic microangiopathies: a cohort study. Lancet Haematol 4:e157\u2013e164","journal-title":"Lancet Haematol"},{"key":"5537_CR9","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.3390\/ijms25094956","volume":"25","author":"S Yamada","year":"2024","unstructured":"Yamada S, Asakura H (2024) How We Interpret Thrombosis with Thrombocytopenia Syndrome? Int J Mol Sci 25:4956","journal-title":"Int J Mol Sci"},{"key":"5537_CR10","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/978-1-0716-3175-1_32","volume":"2663","author":"EJ Favaloro","year":"2023","unstructured":"Favaloro EJ, Chapman K, Mohammed S, Vong R, Pasalic L (2023) Automated and Rapid ADAMTS13 Testing Using Chemiluminescence: Utility for Identification or Exclusion of TTP and Beyond. Methods Mol Biol 2663:487\u2013504","journal-title":"Methods Mol Biol"},{"key":"5537_CR11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12959-018-0174-4","volume":"16","author":"JC Chang","year":"2018","unstructured":"Chang JC (2018) TTP-like syndrome: novel concept and molecular pathogenesis of endotheliopathy-associated vascular microthrombotic disease. Thromb J 16:20","journal-title":"Thromb J"},{"key":"5537_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.trsl.2020.05.006","volume":"225","author":"MA Bray","year":"2020","unstructured":"Bray MA, Sartain SE, Gollamudi J, Rumbaut RE (2020) Microvascular thrombosis: experimental and clinical implications. Transl Res 225:105\u2013130","journal-title":"Transl Res"},{"key":"5537_CR13","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s40560-014-0061-4","volume":"2","author":"S Kurosawa","year":"2014","unstructured":"Kurosawa S, Stearns-Kurosawa DJ (2014) Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care 2:65","journal-title":"J Intensive Care"},{"key":"5537_CR14","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1182\/blood-2005-03-1087","volume":"107","author":"T Ono","year":"2006","unstructured":"Ono T, Mimuro J, Madoiwa S, Soejima K, Kashiwakura Y, Ishiwata A et al (2006) Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure. Blood 107:528\u2013534","journal-title":"Blood"},{"key":"5537_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000528136","volume":"50","author":"C von Heymann","year":"2022","unstructured":"von Heymann C, Lier H, Rosenthal C, Kaufner L (2022) Indications for the Use of Therapeutic Plasma in Adult Patients. Transfus Med Hemother 50:107\u2013115","journal-title":"Transfus Med Hemother"},{"key":"5537_CR16","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s00134-025-07981-3","volume":"51","author":"A Elie","year":"2025","unstructured":"Elie A, Agn\u00e8s V, Spero C, Berangere SJ, Paul K, Lara Z et al (2025) Thrombotic thrombocytopenic purpura: early diagnosis and effective treatment in 2025. Intensive Care Med 51:1225\u20131239","journal-title":"Intensive Care Med"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05537-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-026-05537-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05537-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:34:35Z","timestamp":1789994075000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-026-05537-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["5537"],"URL":"https:\/\/doi.org\/10.1007\/s10096-026-05537-x","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"12 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Written informed consent was obtained from the patient reported in this case report for participation and publication.","order":1,"name":"Ethics","label":"Consent to participate and to publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict-of-interest issue to disclose.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}