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Additionally, we analysed impact of antimicrobial treatment prior to sampling, sampling department, bottle type, sampling time and method, microorganisms isolated as well as patient age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 19.7% of BC bottles were filled with the recommended 8\u201310 mL of blood. The overall pathogen positivity rate of all BC bottles was 6.8%, while 13.3% of the patients had at least one positive BC bottle. Patients &gt;60 years were twice as likely to have a positive blood culture as those aged 18\u201360 years (16.2% vs 8.1%). Recommended filling volumes were positively associated with recovery of microbes, whereas particularly overfilling &gt;14 mL was associated with reduced microbial yield. Overall, bottles with no growth contained a significantly higher mean blood volume than bottles with growth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the gap between established recommendations for BC collection and current practice at our hospital. Preanalytical optimisation of BC collection is needed to improve diagnostic yield in this seriously ill patient population. Overfilling of BC bottles was negatively associated with microbial yield and should be avoided.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10096-026-05568-4","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:19:11Z","timestamp":1782411551000},"page":"3027-3036","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In-depth analysis of sampling practice and yield of blood cultures"],"prefix":"10.1007","volume":"45","author":[{"given":"Thea Kippersund","family":"R\u00f8nningen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frode Width","family":"Gran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Kristian","family":"Dam\u00e5s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Egil","family":"Afset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4233-5725","authenticated-orcid":false,"given":"Birgitta","family":"Ehrnstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"issue":"6","key":"5568_CR1","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/1469-0691.12144","volume":"19","author":"KB Laupland","year":"2013","unstructured":"Laupland KB (2013) Incidence of bloodstream infection: a review of population-based studies. 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The regional ethical committee has assessed the project (527192\/2022). It was categorized as a clinical quality improvement project and not health research. It therefore falls outside of the substantive scope of the Norwegian Health Research Act, cf. Sections 2 and 4 of the Health Research Act, and no ethical approval is required.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}