{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:08:07Z","timestamp":1784902087963,"version":"3.55.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Microbiol Infect Dis"],"DOI":"10.1007\/s10096-026-05600-7","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:38:39Z","timestamp":1784900319000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research trends in COPD\u2013associated invasive pulmonary aspergillosis over the past two decades: a bibliometric and topic modelling analysis"],"prefix":"10.1007","author":[{"given":"Xiaowen","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"5600_CR1","doi-asserted-by":"publisher","unstructured":"Safiri S, Carson-Chahhoud K, Noori M, Nejadghaderi SA, Sullman MJM, Ahmadian Heris J et al Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990\u20132019: results from the Global Burden of Disease Study 2019. BMJ 2022 27;378:e069679. https:\/\/doi.org\/10.1136\/bmj-2021-069679","DOI":"10.1136\/bmj-2021-069679"},{"key":"5600_CR2","doi-asserted-by":"publisher","unstructured":"Christenson SA, Smith BM, Bafadhel M, Putcha N Chronic obstructive pulmonary disease. Lancet 2022 11;399:2227\u20132242. https:\/\/doi.org\/10.1016\/S0140-6736(22)00470-6","DOI":"10.1016\/S0140-6736(22)00470-6"},{"key":"5600_CR3","doi-asserted-by":"publisher","unstructured":"Celli B, Fabbri L, Criner G, Martinez FJ, Mannino D, Vogelmeier C et al Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision. Am J Respir Crit Care Med 2022 1;206:1317\u20131325. https:\/\/doi.org\/10.1164\/rccm.202204-0671PP","DOI":"10.1164\/rccm.202204-0671PP"},{"key":"5600_CR4","doi-asserted-by":"publisher","unstructured":"Confalonieri M, Braga L, Salton F, Ruaro B, Confalonieri P Chronic Obstructive Pulmonary Disease Definition: Is It Time to Incorporate the Concept of Failure of Lung Regeneration? Am J Respir Crit Care Med 2023 1;207:366\u2013367. https:\/\/doi.org\/10.1164\/rccm.202208-1508LE","DOI":"10.1164\/rccm.202208-1508LE"},{"key":"5600_CR5","doi-asserted-by":"publisher","first-page":"1801261","DOI":"10.1183\/13993003.01261-2018","volume":"52","author":"V Kim","year":"2018","unstructured":"Kim V, Aaron SD (2018) What is a COPD exacerbation? Current definitions, pitfalls, challenges and opportunities for improvement. Eur Respir J 52:1801261. https:\/\/doi.org\/10.1183\/13993003.01261-2018","journal-title":"Eur Respir J"},{"key":"5600_CR6","doi-asserted-by":"publisher","unstructured":"Cao Y, Xing Z, Long H, Huang Y, Zeng P, Janssens J-P et al Predictors of mortality in COPD exacerbation cases presenting to the respiratory intensive care unit. Respir Res 2021 4;22:77. https:\/\/doi.org\/10.1186\/s12931-021-01657-4","DOI":"10.1186\/s12931-021-01657-4"},{"key":"5600_CR7","doi-asserted-by":"publisher","unstructured":"Kang Y, Li Q, Ma W, Xu C, Jia W, Wang P Epidemiological characteristics of patients with invasive pulmonary aspergillosis infected with Aspergillus fumigatus from a tertiary hospital in Ningxia, China. Sci Rep 2025 15;15:13036. https:\/\/doi.org\/10.1038\/s41598-025-97587-y","DOI":"10.1038\/s41598-025-97587-y"},{"key":"5600_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.21037\/jtd-2025-1932","volume":"28","author":"L Wu","year":"2026","unstructured":"Wu L, Tang T, Huang X, Xiao Z, Ding J, Zhuang Y et al (2026) Clinical classification of chronic obstructive pulmonary disease with invasive pulmonary aspergillosis: a retrospective study. J Thorac Dis 28:18:79. https:\/\/doi.org\/10.21037\/jtd-2025-1932","journal-title":"J Thorac Dis"},{"key":"5600_CR9","doi-asserted-by":"publisher","unstructured":"Gu Y, Ye X, Wang Y, Shen K, Zhong J, Chen B et al Clinical features and prognostic analysis of patients with Aspergillus isolation during acute exacerbation of chronic obstructive pulmonary disease. BMC Pulm Med 2021 26;21:69. https:\/\/doi.org\/10.1186\/s12890-021-01427-4","DOI":"10.1186\/s12890-021-01427-4"},{"key":"5600_CR10","doi-asserted-by":"publisher","unstructured":"Chinese Thoracic Society of Chinese Medical Association [Expert consensus on the diagnosis and treatment of pulmonary aspergillosis in patients with chronic obstructive pulmonary disease]. Zhonghua Jie He He Hu Xi Za Zhi 2024 12;47:604\u2013622. https:\/\/doi.org\/10.3760\/cma.j.cn112147-20231228-00399","DOI":"10.3760\/cma.j.cn112147-20231228-00399"},{"key":"5600_CR11","doi-asserted-by":"publisher","unstructured":"Hammond EE, McDonald CS, Vestbo J, Denning DW The global impact of Aspergillus infection on COPD. BMC Pulm Med 2020 11;20:241. https:\/\/doi.org\/10.1186\/s12890-020-01259-8","DOI":"10.1186\/s12890-020-01259-8"},{"key":"5600_CR12","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1183\/09031936.00062206","volume":"30","author":"P Bulpa","year":"2007","unstructured":"Bulpa P, Dive A, Sibille Y (2007) Invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease. Eur Respir J 30:782\u2013800. https:\/\/doi.org\/10.1183\/09031936.00062206","journal-title":"Eur Respir J"},{"key":"5600_CR13","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1055\/s-0040-1702210","volume":"41","author":"P Bulpa","year":"2020","unstructured":"Bulpa P, Duplaquet F, Dimopoulos G, Vogelaers D, Blot S (2020) Invasive Pulmonary Aspergillosis in Chronic Obstructive Pulmonary Disease Exacerbations. Semin Respir Crit Care Med 41:851\u2013861. https:\/\/doi.org\/10.1055\/s-0040-1702210","journal-title":"Semin Respir Crit Care Med"},{"key":"5600_CR14","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-026-04061-0","author":"Y Lan","year":"2026","unstructured":"Lan Y, Li H, Su D, Liao X, Zhang Q, Ma Q (2026) Clinical value of sputum galactomannan testing in the diagnosis of invasive pulmonary aspergillosis among chronic obstructive pulmonary disease patients. Eur J Med Res. https:\/\/doi.org\/10.1186\/s40001-026-04061-0","journal-title":"Eur J Med Res"},{"key":"5600_CR15","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/ppul.22670","volume":"48","author":"M de Mol","year":"2013","unstructured":"de Mol M, de Jongste JC, van Westreenen M, Merkus PJFM, de Vries AHC, Hop WCJ et al (2013) Diagnosis of invasive pulmonary aspergillosis in children with bronchoalveolar lavage galactomannan. Pediatr Pulmonol 48:789\u2013796. https:\/\/doi.org\/10.1002\/ppul.22670","journal-title":"Pediatr Pulmonol"},{"key":"5600_CR16","doi-asserted-by":"publisher","first-page":"1397733","DOI":"10.3389\/fcimb.2024.1397733","volume":"14","author":"S Niu","year":"2024","unstructured":"Niu S, Liu D, Yang Y, Zhao L (2024) Clinical utility of metagenomic next-generation sequencing in the diagnosis of invasive pulmonary aspergillosis in acute exacerbation of chronic obstructive pulmonary disease patients in the intensive care unit. Front Cell Infect Microbiol 14:1397733. https:\/\/doi.org\/10.3389\/fcimb.2024.1397733","journal-title":"Front Cell Infect Microbiol"},{"key":"5600_CR17","doi-asserted-by":"publisher","first-page":"e70132","DOI":"10.1111\/myc.70132","volume":"28","author":"F Lamoth","year":"2025","unstructured":"Lamoth F, Albrich WC, Ragozzino S, Bosetti D, Delaloye J, Khoury CE et al (2025) Management of Invasive Pulmonary Aspergillosis in Intensive Care Units: Guidelines From the Fungal Infection Network of Switzerland (FUNGINOS). Mycoses 28:68:e70132. https:\/\/doi.org\/10.1111\/myc.70132","journal-title":"Mycoses"},{"key":"5600_CR18","doi-asserted-by":"publisher","unstructured":"Chen Y, Zhao J, Wang Y, Ge L, Kwong JS, Lan J et al The efficacy and safety of first-line monotherapies in primary therapy of invasive aspergillosis: a systematic review. Front Pharmacol 2025 15;15:1530999. https:\/\/doi.org\/10.3389\/fphar.2024.1530999","DOI":"10.3389\/fphar.2024.1530999"},{"key":"5600_CR19","doi-asserted-by":"publisher","unstructured":"Cheng J, Han H, Kang W, Cai Z, Zhan P, Lv T Comparison of antifungal drugs in the treatment of invasive pulmonary aspergillosis: a systematic review and network meta-analysis. Front Microbiol 2024 2;15:1504826. https:\/\/doi.org\/10.3389\/fmicb.2024.1504826","DOI":"10.3389\/fmicb.2024.1504826"},{"key":"5600_CR20","doi-asserted-by":"publisher","unstructured":"Daele RV, Wauters J, Vandenbriele C, Lagrou K, Vos R, Debaveye Y et al Interaction between flucloxacillin and azoles: Is isavuconazole next? Mycoses 2021 1;64:1508\u20131511. https:\/\/doi.org\/10.1111\/myc.13373","DOI":"10.1111\/myc.13373"},{"key":"5600_CR21","doi-asserted-by":"publisher","unstructured":"Wang X, Li W, Ma Y, Li Y, Ding S, Shen J et al A serum galactomannan and neutrophil-to-lymphocyte ratio-based nomogram for predicting in-hospital mortality in non-neutropenic invasive pulmonary aspergillosis. Front Cell Infect Microbiol 2025 22;15:1675277. https:\/\/doi.org\/10.3389\/fcimb.2025.1675277","DOI":"10.3389\/fcimb.2025.1675277"},{"key":"5600_CR22","doi-asserted-by":"publisher","first-page":"e0060725","DOI":"10.1128\/spectrum.00607-25","volume":"13","author":"X Wang","year":"2025","unstructured":"Wang X, Lu Y, Sun C, Zhong H, Cai Y, Cao M et al (2025) Development and validation of a machine learning-based diagnostic model for identifying nonneutropenic invasive pulmonary aspergillosis in suspected patients: a multicenter cohort study. Microbiol Spectr 13:e0060725. https:\/\/doi.org\/10.1128\/spectrum.00607-25","journal-title":"Microbiol Spectr"},{"key":"5600_CR23","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/j.1469-0691.2005.01143.x","volume":"11","author":"F Ader","year":"2005","unstructured":"Ader F, Nseir S, Le Berre R, Leroy S, Tillie-Leblond I, Marquette CH et al (2005) Invasive pulmonary aspergillosis in chronic obstructive pulmonary disease: an emerging fungal pathogen. Clin Microbiol Infect 11:427\u2013429. https:\/\/doi.org\/10.1111\/j.1469-0691.2005.01143.x","journal-title":"Clin Microbiol Infect"},{"key":"5600_CR24","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","volume":"84","author":"NJ van Eck","year":"2010","unstructured":"van Eck NJ, Waltman L (2010) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 84:523\u2013538. https:\/\/doi.org\/10.1007\/s11192-009-0146-3","journal-title":"Scientometrics"},{"key":"5600_CR25","first-page":"724","volume":"2005","author":"MB Synnestvedt","year":"2005","unstructured":"Synnestvedt MB, Chen C, Holmes JH (2005) CiteSpace II: visualization and knowledge discovery in bibliographic databases. AMIA Annu Symp Proc 2005:724\u2013728","journal-title":"AMIA Annu Symp Proc"},{"key":"5600_CR26","doi-asserted-by":"publisher","first-page":"e45815","DOI":"10.2196\/45815","volume":"825","author":"J Shi","year":"2023","unstructured":"Shi J, Bendig D, Vollmar HC, Rasche P (2023) Mapping the Bibliometrics Landscape of AI in Medicine: Methodological Study. J Med Internet Res 825:e45815. https:\/\/doi.org\/10.2196\/45815","journal-title":"J Med Internet Res"},{"key":"5600_CR27","doi-asserted-by":"publisher","unstructured":"Yu C, Huang Y, Yan W, Jiang X A comprehensive overview of psoriatic research over the past 20 years: machine learning-based bibliometric analysis. Front Immunol 2023 26;14:1272080. https:\/\/doi.org\/10.3389\/fimmu.2023.1272080","DOI":"10.3389\/fimmu.2023.1272080"},{"key":"5600_CR28","doi-asserted-by":"publisher","first-page":"1077922","DOI":"10.3389\/fonc.2023.1077922","volume":"13","author":"C Yu","year":"2023","unstructured":"Yu C, Zhou Z, Liu B, Yao D, Huang Y, Wang P et al (2023) Investigation of trends in gut microbiome associated with colorectal cancer using machine learning. Front Oncol 13:1077922. https:\/\/doi.org\/10.3389\/fonc.2023.1077922","journal-title":"Front Oncol"},{"key":"5600_CR29","doi-asserted-by":"publisher","first-page":"205520762614340","DOI":"10.1177\/20552076261434054","volume":"12","author":"R Xiao","year":"2026","unstructured":"Xiao R, Ma S, Lu A, Shi W, Zhang J (2026) Artificial intelligence in telemedicine: Topic modelling and network analysis of patents (1992\u20132024). Digit Health 12:20552076261434054. https:\/\/doi.org\/10.1177\/20552076261434054","journal-title":"Digit Health"},{"key":"5600_CR30","doi-asserted-by":"publisher","unstructured":"Wang W, Chi X, Ji J, Zhang J, Xiang S, Xiong B et al Global status and trends of invasive pulmonary aspergillosis: A bibliometric study. Med (Baltimore) 2025 30;104:e42603. https:\/\/doi.org\/10.1097\/MD.0000000000042603","DOI":"10.1097\/MD.0000000000042603"},{"key":"5600_CR31","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s15010-022-01960-2","volume":"51","author":"A Otu","year":"2023","unstructured":"Otu A, Kosmidis C, Mathioudakis AG, Ibe C, Denning DW (2023) The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease. Infection 51:813\u2013829. https:\/\/doi.org\/10.1007\/s15010-022-01960-2","journal-title":"Infection"},{"key":"5600_CR32","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12931-021-01771-3","volume":"22","author":"Y Gu","year":"2021","unstructured":"Gu Y, Ye X, Liu Y, Wang Y, Shen K, Zhong J et al (2021) A risk-predictive model for invasive pulmonary aspergillosis in patients with acute exacerbation of chronic obstructive pulmonary disease. Respir Res 22:176. https:\/\/doi.org\/10.1186\/s12931-021-01771-3","journal-title":"Respir Res"},{"key":"5600_CR33","doi-asserted-by":"publisher","first-page":"665","DOI":"10.21037\/atm-22-2523","volume":"10","author":"Z Xie","year":"2022","unstructured":"Xie Z, Xia T, Wu D, Che L, Zhang W, Cai X et al (2022) Identification of the key genes in chronic obstructive pulmonary disease by weighted gene co-expression network analysis. Ann Transl Med 10:665. https:\/\/doi.org\/10.21037\/atm-22-2523","journal-title":"Ann Transl Med"},{"key":"5600_CR34","doi-asserted-by":"publisher","unstructured":"Barnes PJ, Burney PGJ, Silverman EK, Celli BR, Vestbo J, Wedzicha JA et al Chronic obstructive pulmonary disease. Nat Rev Dis Primers 2015 3;1:15076. https:\/\/doi.org\/10.1038\/nrdp.2015.76","DOI":"10.1038\/nrdp.2015.76"},{"key":"5600_CR35","doi-asserted-by":"publisher","first-page":"1687790","DOI":"10.3389\/fimmu.2025.1687790","volume":"16","author":"Y Hu","year":"2025","unstructured":"Hu Y, Wang X, Wu H, Deng H, Gao F, Wu Y (2025) Immune markers for pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: a narrative review. Front Immunol 16:1687790. https:\/\/doi.org\/10.3389\/fimmu.2025.1687790","journal-title":"Front Immunol"},{"key":"5600_CR36","doi-asserted-by":"publisher","first-page":"754569","DOI":"10.3389\/fgene.2021.754569","volume":"3","author":"Q Guan","year":"2021","unstructured":"Guan Q, Tian Y, Zhang Z, Zhang L, Zhao P, Li J (2021) Identification of Potential Key Genes in the Pathogenesis of Chronic Obstructive Pulmonary Disease Through Bioinformatics Analysis. Front Genet 3:12:754569. https:\/\/doi.org\/10.3389\/fgene.2021.754569","journal-title":"Front Genet"},{"key":"5600_CR37","doi-asserted-by":"publisher","first-page":"2401976","DOI":"10.1183\/13993003.01976-2024","volume":"64","author":"M Bertuzzi","year":"2024","unstructured":"Bertuzzi M, Denning DW (2024) Are Aspergillus spp. driving COPD exacerbations? Eur Respir J 64:2401976. https:\/\/doi.org\/10.1183\/13993003.01976-2024","journal-title":"Eur Respir J"},{"key":"5600_CR38","doi-asserted-by":"publisher","unstructured":"Sengupta A, Ray A, Upadhyay AD, Izumikawa K, Tashiro M, Kimura Y et al Mortality in chronic pulmonary aspergillosis: a systematic review and individual patient data meta-analysis. Lancet Infect Dis 2025 1;25:312\u2013324. https:\/\/doi.org\/10.1016\/S1473-3099(24)00567-X","DOI":"10.1016\/S1473-3099(24)00567-X"},{"key":"5600_CR39","doi-asserted-by":"publisher","unstructured":"Denning DW Global incidence and mortality of severe fungal disease. The Lancet Infectious Diseases 2024 1;24:e428\u201338. https:\/\/doi.org\/10.1016\/S1473-3099(23)00692-8","DOI":"10.1016\/S1473-3099(23)00692-8"},{"key":"5600_CR40","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.3760\/cma.j.issn.0366-6999.2012.17.003","volume":"125","author":"H He","year":"2012","unstructured":"He H, Chang S, Ding L, Sun B, Li F, Zhan Q (2012) Significance ofAspergillus spp.isolation from lower respiratory tract samples for the diagnosis and prognosis of invasive pulmonary aspergillosis in chronic obstructive pulmonary disease. Chin Med J 125:2973. https:\/\/doi.org\/10.3760\/cma.j.issn.0366-6999.2012.17.003","journal-title":"Chin Med J"},{"key":"5600_CR41","doi-asserted-by":"publisher","first-page":"1700532","DOI":"10.1183\/13993003.00532-2017","volume":"50","author":"P Bulpa","year":"2017","unstructured":"Bulpa P, Bihin B, Dimopoulos G, Taccone FS, Van den Abeele A-M, Misset B et al (2017) Which algorithm diagnoses invasive pulmonary aspergillosis best in ICU patients with COPD? Eur Respir J 50:1700532. https:\/\/doi.org\/10.1183\/13993003.00532-2017","journal-title":"Eur Respir J"},{"key":"5600_CR42","doi-asserted-by":"publisher","unstructured":"Huang L, He H, Jin J, Zhan Q Is Bulpa criteria suitable for the diagnosis of probable invasive pulmonary Aspergillosis in critically ill patients with chronic obstructive pulmonary disease? A comparative study with EORTC\/ MSG and ICU criteria. BMC Infect Dis 2017 14;17:209. https:\/\/doi.org\/10.1186\/s12879-017-2307-y","DOI":"10.1186\/s12879-017-2307-y"},{"key":"5600_CR43","doi-asserted-by":"publisher","unstructured":"Sedik S, Aerts R, Lagrou K, Vanbiervliet Y, Maertens JA, White PL et al Mucorales PCR Testing in Respiratory and Biopsy Samples From Immunocompromised Patients With Invasive Pulmonary Aspergillosis and Other Mold Infections: Results From a Multicenter ECMM Study. Open Forum Infect Dis 2025 30;13:ofaf801. https:\/\/doi.org\/10.1093\/ofid\/ofaf801","DOI":"10.1093\/ofid\/ofaf801"},{"key":"5600_CR44","doi-asserted-by":"publisher","unstructured":"Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE et al Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis 2019 5;71:1367\u20131376. https:\/\/doi.org\/10.1093\/cid\/ciz1008","DOI":"10.1093\/cid\/ciz1008"},{"key":"5600_CR45","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s00134-024-07341-7","volume":"50","author":"M Bassetti","year":"2024","unstructured":"Bassetti M, Giacobbe DR, Agvald-Ohman C, Akova M, Alastruey-Izquierdo A, Arikan-Akdagli S et al (2024) Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM. Intensive Care Med 50:502\u2013515. https:\/\/doi.org\/10.1007\/s00134-024-07341-7","journal-title":"Intensive Care Med"},{"key":"5600_CR46","doi-asserted-by":"publisher","first-page":"640289","DOI":"10.3389\/fmed.2021.640289","volume":"4","author":"Y Wu","year":"2021","unstructured":"Wu Y, Zuo Y, Cheng Q, Huang Y, Bao Z, Jin X et al (2021) Respiratory Aspergillus Colonization Was Associated With Relapse of Acute Exacerbation in Patients With Chronic Obstructive Pulmonary Disease: Analysis of Data From A Retrospective Cohort Study. Front Med (Lausanne) 4:8:640289. https:\/\/doi.org\/10.3389\/fmed.2021.640289","journal-title":"Front Med (Lausanne)"},{"key":"5600_CR47","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1007\/s11596-019-2074-7","volume":"1","author":"X Guo","year":"2019","unstructured":"Guo X, Deng N, Chen Q, Yu H, Ding X, Hu S et al (2019) Application of Inflammatory Markers in Induced Sputum in Stable Chronic Obstructive Pulmonary Disease Patients with Positive Bronchodilation Tests. CURR MED SCI 1:39:560\u2013567. https:\/\/doi.org\/10.1007\/s11596-019-2074-7","journal-title":"CURR MED SCI"},{"key":"5600_CR48","doi-asserted-by":"publisher","unstructured":"Fang L, Wang X, Zhang M, Khan P, Tamm M, Roth M MicroRNA-101-3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell Degeneration in COPD. Can Respiratory J 2022 5;2022:5933324. https:\/\/doi.org\/10.1155\/2022\/5933324","DOI":"10.1155\/2022\/5933324"},{"key":"5600_CR49","doi-asserted-by":"publisher","unstructured":"Liu C, Liu C, Liu H, Lin S Characteristics of pathogenic microorganisms in COPD-related infections: prognostic correlations and implications. Front Cell Infect Microbiol 2026 19;15:1739849. https:\/\/doi.org\/10.3389\/fcimb.2025.1739849","DOI":"10.3389\/fcimb.2025.1739849"},{"issue":"3","key":"5600_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032955","volume":"24","author":"PY Tiew","year":"2023","unstructured":"Tiew PY, Meldrum OW, Chotirmall SH (2023) Applying next-generation sequencing and multi-omics in chronic obstructive pulmonary disease. Int J Mol Sci 24(3):2955. https:\/\/doi.org\/10.3390\/ijms24032955","journal-title":"Int J Mol Sci"},{"key":"5600_CR51","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1128\/JCM.00942-12","volume":"50","author":"T Avni","year":"2012","unstructured":"Avni T, Levy I, Sprecher H, Yahav D, Leibovici L, Paul M (2012) Diagnostic Accuracy of PCR Alone Compared to Galactomannan in Bronchoalveolar Lavage Fluid for Diagnosis of Invasive Pulmonary Aspergillosis: a Systematic Review. J Clin Microbiol 50:3652\u20133658. https:\/\/doi.org\/10.1128\/JCM.00942-12","journal-title":"J Clin Microbiol"},{"key":"5600_CR52","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-1125-y","volume":"20","author":"Q Yu","year":"2020","unstructured":"Yu Q, He J, Xing B, Li X, Qian H, Zhang H et al (2020) Potential value of serum Aspergillus IgG antibody detection in the diagnosis of invasive and chronic pulmonary aspergillosis in non-agranulocytic patients. BMC Pulm Med 20:89. https:\/\/doi.org\/10.1186\/s12890-020-1125-y","journal-title":"BMC Pulm Med"},{"key":"5600_CR53","doi-asserted-by":"publisher","unstructured":"Li Z, Zong Y, Chen D, Ma J, Zhang P, Cao L Efficacy and safety of voriconazole and caspofungin for the treatment of invasive pulmonary aspergillosis in critically ill patients in China. Front Cell Infect Microbiol 2025 21;15:1584950. https:\/\/doi.org\/10.3389\/fcimb.2025.1584950","DOI":"10.3389\/fcimb.2025.1584950"},{"key":"5600_CR54","doi-asserted-by":"publisher","unstructured":"Maertens JA, Rahav G, Lee D-G, Ponce-de-Le\u00f3n A, Ram\u00edrez S\u00e1nchez IC, Klimko N et al Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial. Lancet 2021 6;397:499\u2013509. https:\/\/doi.org\/10.1016\/S0140-6736(21)00219-1","DOI":"10.1016\/S0140-6736(21)00219-1"},{"key":"5600_CR55","doi-asserted-by":"publisher","first-page":"ofaf709","DOI":"10.1093\/ofid\/ofaf709","volume":"12","author":"S Hatzl","year":"2025","unstructured":"Hatzl S, Geiger C, Kriegl L, Reinisch A, Keldorfer M, W\u00f6lfler A et al (2025) Triazoles Versus Echinocandins for the First-Line Treatment of Invasive Pulmonary Aspergillosis: A Propensity Score-Weighted Multicenter Study. Open Forum Infect Dis 12:ofaf709. https:\/\/doi.org\/10.1093\/ofid\/ofaf709","journal-title":"Open Forum Infect Dis"},{"key":"5600_CR56","doi-asserted-by":"publisher","unstructured":"Henry SS, Duong KE, Duong TQ Long-term impact of SARS-CoV-2 on recurrent COPD exacerbations. EBioMedicine 2026 17;126:106212. https:\/\/doi.org\/10.1016\/j.ebiom.2026.106212","DOI":"10.1016\/j.ebiom.2026.106212"},{"key":"5600_CR57","doi-asserted-by":"publisher","first-page":"57","DOI":"10.7774\/cevr.2026.15.e1","volume":"15","author":"SS Karabulut","year":"2026","unstructured":"Karabulut SS, Nemli A, Ko\u00e7yi\u011fit Y (2026) Survival after primary and booster COVID-19 vaccination in patients with COPD. Clin Exp Vaccine Res 15:57\u201362. https:\/\/doi.org\/10.7774\/cevr.2026.15.e1","journal-title":"Clin Exp Vaccine Res"},{"key":"5600_CR58","first-page":"2532","volume":"11","author":"B-C He","year":"2019","unstructured":"He B-C, Liu L-L, Chen B-L, Zhang F, Su X (2019) The application of next-generation sequencing in diagnosing invasive pulmonary aspergillosis: three case reports. Am J Transl Res 11:2532\u20132539","journal-title":"Am J Transl Res"},{"key":"5600_CR59","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.2169\/internalmedicine.53.2381","volume":"53","author":"X Cai","year":"2014","unstructured":"Cai X, Ni W, Wei C, Cui J (2014) Diagnostic value of the serum galactomannan and (1, 3)-\u03b2-D-glucan assays for invasive pulmonary aspergillosis in non-neutropenic patients. Intern Med 53:2433\u20132437. https:\/\/doi.org\/10.2169\/internalmedicine.53.2381","journal-title":"Intern Med"},{"key":"5600_CR60","doi-asserted-by":"publisher","unstructured":"Castro-Fuentes CA, Cabrera-Guerrero JP, Duarte-Escalante E, Silva GH, Herrera AC, Reyes-Montes M (2026) 21;12:229 del R. Aspergillosis: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment. Journal of Fungi https:\/\/doi.org\/10.3390\/jof12030229","DOI":"10.3390\/jof12030229"},{"key":"5600_CR61","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.101764","volume":"18","author":"U Ilhan","year":"2026","unstructured":"Ilhan U, \u00d6zden \u015e, Tepetam FM, Aydogar B, Cetinkaya E (2026) Fluorodeoxyglucose (FDG)-avid upper-lobe mass mimicking malignancy in an elderly patient with allergic bronchopulmonary aspergillosis: a case report. Cureus 18:e101764. https:\/\/doi.org\/10.7759\/cureus.101764","journal-title":"Cureus"},{"key":"5600_CR62","doi-asserted-by":"publisher","first-page":"dkag055","DOI":"10.1093\/jac\/dkag055","volume":"281","author":"DB Chastain","year":"2026","unstructured":"Chastain DB, Anderson DT, Eudy J, Henao-Mart\u00ednez AF, Cluck DB (2026) Precision dosing of systemic antifungals in adults: therapeutic drug monitoring, empiric dose optimization and barriers to implementation. J Antimicrob Chemother 281:dkag055. https:\/\/doi.org\/10.1093\/jac\/dkag055","journal-title":"J Antimicrob Chemother"},{"key":"5600_CR63","doi-asserted-by":"publisher","first-page":"e70177","DOI":"10.1111\/eci.70177","volume":"56","author":"C Bartalucci","year":"2026","unstructured":"Bartalucci C, Mezzogori L, Schiavoni R, Vena A, Giacobbe DR, Bassetti M (2026) Antifungal treatment strategies in intensive care unit patients. Eur J Clin Invest 56:e70177. https:\/\/doi.org\/10.1111\/eci.70177","journal-title":"Eur J Clin Invest"},{"key":"5600_CR64","doi-asserted-by":"publisher","first-page":"1718019","DOI":"10.3389\/fphar.2025.1718019","volume":"16","author":"W Jia","year":"2025","unstructured":"Jia W, Wang T, Wang J (2025) Pharmacovigilance insights: safety profiles of antifungal agents for invasive aspergillosis. Front Pharmacol 16:1718019. https:\/\/doi.org\/10.3389\/fphar.2025.1718019","journal-title":"Front Pharmacol"},{"key":"5600_CR65","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.cmi.2022.02.026","volume":"28","author":"H Lamberink","year":"2022","unstructured":"Lamberink H, Wagemakers A, Sigaloff KCE, van Houdt R, de Jonge NA, van Dijk K (2022) The impact of the updated EORTC\/MSG criteria on the classification of hematological patients with suspected invasive pulmonary aspergillosis. Clin Microbiol Infect 28:1120\u20131125. https:\/\/doi.org\/10.1016\/j.cmi.2022.02.026","journal-title":"Clin Microbiol Infect"},{"key":"5600_CR66","doi-asserted-by":"publisher","unstructured":"Denning DW, Rogers TR, Takazono T, Su X, Lagrou K, White PL et al Diagnostic criteria for invasive pulmonary aspergillosis in COPD patients. Am J Respir Crit Care Med 2026 1aamag310. https:\/\/doi.org\/10.1093\/ajrccm\/aamag310","DOI":"10.1093\/ajrccm\/aamag310"},{"key":"5600_CR67","doi-asserted-by":"publisher","first-page":"102790","DOI":"10.1016\/j.jiph.2025.102790","volume":"18","author":"S Asadi Shahi Sarae","year":"2025","unstructured":"Asadi Shahi Sarae S, Aliyali M, Mortezaee V, Jamaati H, Asgarian Omran H, Abedi S et al (2025) Galactomannan detection in sputum samples of patients with chronic obstructive pulmonary disease: A promising marker for diagnosis of chronic pulmonary aspergillosis? J Infect Public Health 18:102790. https:\/\/doi.org\/10.1016\/j.jiph.2025.102790","journal-title":"J Infect Public Health"},{"key":"5600_CR68","doi-asserted-by":"publisher","unstructured":"Mercier T, Dunbar A, Veldhuizen V, Holtappels M, Schauwvlieghe A, Maertens J et al Point of care aspergillus testing in intensive care patients. Crit Care 2020 10;24:642. https:\/\/doi.org\/10.1186\/s13054-020-03367-7","DOI":"10.1186\/s13054-020-03367-7"},{"key":"5600_CR69","doi-asserted-by":"publisher","first-page":"579990","DOI":"10.2147\/IDR.S579990","volume":"19","author":"Z Wu","year":"2026","unstructured":"Wu Z, Lin Z, Jiang L (2026) Current Evidence on Voriconazole Exposure and Individualized Therapy for Aspergillosis. Infect Drug Resist 19:579990. https:\/\/doi.org\/10.2147\/IDR.S579990","journal-title":"Infect Drug Resist"},{"key":"5600_CR70","doi-asserted-by":"publisher","first-page":"1739837","DOI":"10.3389\/fcimb.2026.1739837","volume":"16","author":"F Liu","year":"2026","unstructured":"Liu F, Liu B, Wang J, Wang Z, Zhou W, Yang Y et al (2026) Integrative diagnosis of invasive pulmonary aspergillosis in non-neutropenic patients using BALF-tNGS-derived Aspergillus load and host risk factors: a multicenter study. Front Cell Infect Microbiol 16:1739837. https:\/\/doi.org\/10.3389\/fcimb.2026.1739837","journal-title":"Front Cell Infect Microbiol"},{"key":"5600_CR71","doi-asserted-by":"publisher","first-page":"1856761","DOI":"10.3389\/fcimb.2026.1856761","volume":"16","author":"Y Qu","year":"2026","unstructured":"Qu Y, Du R, Liu P, Pan Y, Zhi L, Gao Y et al (2026) Animal models of fungus-related allergic airway disease: exposures, readouts, mechanisms, and translational gaps. Front Cell Infect Microbiol 16:1856761. https:\/\/doi.org\/10.3389\/fcimb.2026.1856761","journal-title":"Front Cell Infect Microbiol"}],"container-title":["European Journal of Clinical Microbiology & Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05600-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10096-026-05600-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10096-026-05600-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:38:43Z","timestamp":1784900323000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10096-026-05600-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":71,"alternative-id":["5600"],"URL":"https:\/\/doi.org\/10.1007\/s10096-026-05600-7","relation":{},"ISSN":["0934-9723","1435-4373"],"issn-type":[{"value":"0934-9723","type":"print"},{"value":"1435-4373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"19 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}