{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:37:10Z","timestamp":1792658230292,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s10103-012-1104-5","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T08:37:41Z","timestamp":1335775061000},"page":"157-166","source":"Crossref","is-referenced-by-count":49,"title":["Short-term clinical and osteoimmunological effects of scaling and root planing complemented by simple or repeated laser phototherapy in chronic periodontitis"],"prefix":"10.1007","volume":"28","author":[{"given":"Saray","family":"Calder\u00edn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Antonio","family":"Garc\u00eda-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"1104_CR1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/10454411010120020301","volume":"12","author":"MA Taubman","year":"2001","unstructured":"Taubman MA, Kawai T (2001) Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit Rev Oral Biol Med 12:125\u2013135","journal-title":"Crit Rev Oral Biol Med"},{"key":"1104_CR2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1034\/j.1600-0765.2003.00615.x","volume":"38","author":"T Crotti","year":"2003","unstructured":"Crotti T, Smith MD, Hirsch R et al (2003) Receptor activator NF kappaB ligand (RANKL) and osteoprotegerin (OPG) protein expression in periodontitis. J Periodontal Res 38:380\u2013387","journal-title":"J Periodontal Res"},{"key":"1104_CR3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/pho.2008.2446","volume":"28","author":"PV Peplow","year":"2010","unstructured":"Peplow PV, Chung TY, Baxter GD (2010) Laser photobiomodulation of wound healing: a review of experimental studies in mouse and rat animal models. Photomed Laser Surg 28:291\u2013325","journal-title":"Photomed Laser Surg"},{"key":"1104_CR4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10103-003-0260-z","volume":"18","author":"RA Nicola","year":"2003","unstructured":"Nicola RA, Jorgetti V, Rigau J, Pacheco MT, dos Reis LM, Z\u00e2ngaro RA (2003) Effect of low-power GaAlAs laser (660\u00a0nm) on bone structure and cell activity: an experimental animal study. Lasers Med Sci 18:89\u201394","journal-title":"Lasers Med Sci"},{"key":"1104_CR5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1089\/pho.2007.2218","volume":"26","author":"S Benedicenti","year":"2008","unstructured":"Benedicenti S, Pepe IM, Angiero F, Benedicenti A (2008) Intracellular ATP level increases in lymphocytes irradiated with infrared laser light of wavelength 904\u00a0nm. Photomed Laser Surg 26:451\u2013453","journal-title":"Photomed Laser Surg"},{"key":"1104_CR6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0304-3940(02)00159-3","volume":"323","author":"N Mochizuki-Oda","year":"2002","unstructured":"Mochizuki-Oda N, Kataoka Y, Cui Y, Yamada H, Heya M, Awazu K (2002) Effects of near-infra-red laser irradiation on adenosine triphosphate and adenosine diphosphate contents of rat brain tissue. Neurosci Lett 323:207\u2013210","journal-title":"Neurosci Lett"},{"key":"1104_CR7","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1600-051X.2005.00749.x","volume":"32","author":"T Qadri","year":"2005","unstructured":"Qadri T, Miranda L, Tuner J, Gustafsson A (2005) The short-term effects of low-level lasers as adjunct therapy in the treatment of periodontal inflammation. J Clin Periodontol 32:714\u2013719","journal-title":"J Clin Periodontol"},{"key":"1104_CR8","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0765.2010.01316.x","volume":"46","author":"J Lui","year":"2011","unstructured":"Lui J, Corbet EF, Jin L (2011) Combined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis. J Periodontal Res 46:89\u201396","journal-title":"J Periodontal Res"},{"key":"1104_CR9","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1902\/jop.2010.100195","volume":"82","author":"G Aykol","year":"2011","unstructured":"Aykol G, Baser U, Maden I et al (2011) The effect of low-level laser therapy as an adjunct to non-surgical periodontal treatment. J Periodontol 82:481\u2013488","journal-title":"J Periodontol"},{"key":"1104_CR10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1600-0765.1999.tb02226.x","volume":"34","author":"ILC Chapple","year":"1999","unstructured":"Chapple ILC, Landini G, Griffiths GS, Patel NC, Ward RSN (1999) Calibration of the Periotron 8000\u00ae and 6000\u00ae by polynomial regression. J Periodontol Res 34:79\u201386","journal-title":"J Periodontol Res"},{"key":"1104_CR11","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1600-0757.2004.03675.x","volume":"36","author":"M Umeda","year":"2004","unstructured":"Umeda M, Takeuchi Y, Noguchi K, Huang Y, Koshy G, Ishikawa I (2004) Effects of nonsurgical periodontal therapy on the microbiota. Periodontol 2000 36:98\u2013120","journal-title":"Periodontol 2000"},{"key":"1104_CR12","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1902\/jop.2006.050087","volume":"77","author":"L Machion","year":"2006","unstructured":"Machion L, Andia DC, Lecio G et al (2006) Locally delivered doxycycline as an adjunctive therapy to scaling and root planing in the treatment of smokers: a 2-year follow-up. J Periodontol 77:606\u2013613","journal-title":"J Periodontol"},{"key":"1104_CR13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/lsm.10010","volume":"30","author":"S Yilmaz","year":"2002","unstructured":"Yilmaz S, Kuru B, Kuru L, Noyan U, Argun D, Kadir T (2002) Effect of gallium arsenide diode laser on human periodontal disease: a microbiological and clinical study. Lasers Surg Med 30:60\u201366","journal-title":"Lasers Surg Med"},{"key":"1104_CR14","volume-title":"Ten lectures on basic science of laser phototherapy","author":"T Karu","year":"2007","unstructured":"Karu T (2007) Ten lectures on basic science of laser phototherapy. Prima Books AB, Gr\u00e4ngesberg, Sweden"},{"key":"1104_CR15","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1902\/jop.2001.72.10.1312","volume":"72","author":"M Kreisler","year":"2001","unstructured":"Kreisler M, Meyer C, Stender E, Daubl\u00e4nder M, Willershausen-Z\u00f6nnchen B, d\u2019Hoedt B (2001) Effect of diode laser irradiation on the attachment rate of periodontal ligament cells: an in vitro study. J Periodontol 72:1312\u20131317","journal-title":"J Periodontol"},{"key":"1104_CR16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/lsm.20252","volume":"37","author":"M Kreisler","year":"2005","unstructured":"Kreisler M, Al Haj H, d\u2019Hoedt B (2005) Clinical efficacy of semiconductor laser application as an adjunct to conventional scaling and root planing. Lasers Surg Med 37:350\u2013355","journal-title":"Lasers Surg Med"},{"key":"1104_CR17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1089\/pho.2006.2067","volume":"25","author":"M Assaf","year":"2007","unstructured":"Assaf M, Yilmaz S, Kuru B, Ipci SD, Noyun V, Kadir T (2007) Effect of diode laser on bacteremia associated with dental ultrasonic scaling: a microbiological study. Photomed Laser Surg 25:250\u2013256","journal-title":"Photomed Laser Surg"},{"key":"1104_CR18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/pho.2008.2301","volume":"28","author":"A Pejcic","year":"2010","unstructured":"Pejcic A, Kojovic D, Kesic L, Obradovic R (2010) The effects of low level laser irradiation on gingival inflammation. Photomed Laser Surg 28:69\u201374","journal-title":"Photomed Laser Surg"},{"key":"1104_CR19","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10103-009-0753-5","volume":"26","author":"G Micheli De","year":"2011","unstructured":"De Micheli G, de Andrade AK, Alves VT, Seto M, Pannuti CM, Cai S (2011) Efficacy of high intensity diode laser as an adjunct to non-surgical periodontal treatment: a randomized controlled trial. Lasers Med Sci 26:43\u201348","journal-title":"Lasers Med Sci"},{"key":"1104_CR20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1113\/jphysiol.2003.057216","volume":"556","author":"T Nedreb\u00f8","year":"2004","unstructured":"Nedreb\u00f8 T, Reed RK, Jonsson R, Berg A, Wiig H (2004) Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats. J Physiol 556:193\u2013202","journal-title":"J Physiol"},{"key":"1104_CR21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2210-4-25","volume":"4","author":"N Garbacki","year":"2004","unstructured":"Garbacki N, Tits M, Angenot L, Damas J (2004) Inhibitory effects of proanthocyanidins from Ribes nigrum leaves on carrageenin acute inflammatory reactions induced in rats. BMC Pharmacol 4:25","journal-title":"BMC Pharmacol"},{"key":"1104_CR22","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1177\/00220345950740071001","volume":"74","author":"N Shimizu","year":"1995","unstructured":"Shimizu N, Yamaguchi M, Goseki T et al (1995) Inhibition of prostaglandin E2 and interleukin 1-beta production by low-power laser irradiation in stretched human periodontal ligament cells. J Dent Res 74:1382\u20131388","journal-title":"J Dent Res"},{"key":"1104_CR23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/PL00011358","volume":"16","author":"K Nomura","year":"2001","unstructured":"Nomura K, Yamaguchi M, Abiko Y (2001) Inhibition of interleukin-1beta production and gene expresion in human gingival fibroblasts by low-energy laser irradiation. Laser Med Sci 16:218\u2013223","journal-title":"Laser Med Sci"},{"key":"1104_CR24","doi-asserted-by":"crossref","unstructured":"Giannopoulou C, Cappuyns I, Cancela J, Cionca N, Mombelli A (2012) Effect of photodynamic therapy, diode laser and deep scaling on cytokine and acute-phase protein levels in gingival crevicular fluid of residual periodontal pockets. J Periodontol. doi: 10.1902\/jop.2011.110281 .","DOI":"10.1902\/jop.2011.110281"},{"key":"1104_CR25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1146\/annurev.bi.59.070190.004031","volume":"59","author":"KI Arai","year":"1990","unstructured":"Arai KI, Lee F, Miyajima A, Miyatakes S, Arai N, Yokota T (1990) Cytoquines: coordinators of immune and inflammatory responses. Ann Rev Biochem 59:783\u2013836","journal-title":"Ann Rev Biochem"},{"key":"1104_CR26","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-0765.2004.00722.x","volume":"39","author":"N Yoshinari","year":"2004","unstructured":"Yoshinari N, Kawase H, Mitani A et al (2004) Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues. J Periodontal Res 39:158\u2013167","journal-title":"J Periodontal Res"},{"key":"1104_CR27","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.0105-2896.2005.00337.x","volume":"208","author":"H Takayanagi","year":"2005","unstructured":"Takayanagi H, Sato K, Takaoka A, Taniguchi T (2005) Interplay between interferon and other cytokine systems in bone metabolism. Immunol Rev 208:181\u2013193","journal-title":"Immunol Rev"},{"key":"1104_CR28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/er.20.3.345","volume":"20","author":"T Suda","year":"1999","unstructured":"Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999) Modulation of osteoclast differentiation and function by the new members of the tumour necrosis factor receptor and ligand families. Endocr Rev 20:345\u2013357","journal-title":"Endocr Rev"},{"key":"1104_CR29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0757.2006.00185.x","volume":"43","author":"T Nagasawa","year":"2000","unstructured":"Nagasawa T, Kiji M, Yashiro R et al (2007) Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and disease. Periodontol 2000 43:65\u201384","journal-title":"Periodontol 2000"},{"key":"1104_CR30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey DL, Timms E, Tan H-L et al (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclat differentiation and activation. Cell 93:165\u2013176","journal-title":"Cell"},{"key":"1104_CR31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1600-051X.2007.01061.x","volume":"34","author":"N Bostanci","year":"2007","unstructured":"Bostanci N, Ilgenli T, Emingil G et al (2007) Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio. J Clin Periodontol 34:370\u2013376","journal-title":"J Clin Periodontol"},{"key":"1104_CR32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1600-0765.2006.00883.x","volume":"41","author":"H-K Lu","year":"2006","unstructured":"Lu H-K, Chen Y-L, Chang H-C, Li C-L, Kuo MY-P (2006) Identification of the osteoprotegerin\/receptor activator of nuclear factor-kappa B ligand system in gingival crevicular fluid and tissue of patients with chronic periodontitis. J Periodontal Res 41:354\u2013360","journal-title":"J Periodontal Res"},{"key":"1104_CR33","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1600-051X.2011.01701.x","volume":"38","author":"N Bostanci","year":"2011","unstructured":"Bostanci N, Saygan B, Emingil G, Atilla G, Belibasakis GN (2011) Effect of periodontal treatment on receptor activator of NF-kB ligand and osteoprotegerin levels and relative ratio in gingival crevicular fluid. J Clin Periodontol 38:428\u2013433","journal-title":"J Clin Periodontol"},{"key":"1104_CR34","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1902\/jop.2010.100125","volume":"81","author":"VR Santos","year":"2010","unstructured":"Santos VR, Lima JA, Gon\u00e7alves TE et al (2010) Receptor activator of nuclear factor-kappaB ligand\/osteoprotegerin ratio in sites of chronic periodontitis of poorly-controlled and well controlled type 2 diabetes. J Periodontol 81:1455\u20131465","journal-title":"J Periodontol"},{"key":"1104_CR35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1600-051X.2005.00785.x","volume":"32","author":"GE Salvi","year":"2005","unstructured":"Salvi GE, Lang NP (2005) Host response modulation in the management of periodontal diseases. J Clin Periodontol 32:108\u2013129","journal-title":"J Clin Periodontol"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-012-1104-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10103-012-1104-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-012-1104-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T09:50:43Z","timestamp":1559123443000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10103-012-1104-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["1104"],"URL":"https:\/\/doi.org\/10.1007\/s10103-012-1104-5","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,1]]}}}