{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:18:58Z","timestamp":1773983938425,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2015,7,26]],"date-time":"2015-07-26T00:00:00Z","timestamp":1437868800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s10103-015-1774-x","type":"journal-article","created":{"date-parts":[[2015,7,25]],"date-time":"2015-07-25T10:15:53Z","timestamp":1437819353000},"page":"1941-1948","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["HMME combined with green light-emitting diode irradiation results in efficient apoptosis on human tongue squamous cell carcinoma"],"prefix":"10.1007","volume":"30","author":[{"given":"Xingqiang","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dujuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junchao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,26]]},"reference":[{"key":"1774_CR1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3322\/canjclin.52.4.195","volume":"52","author":"BW Neville","year":"2002","unstructured":"Neville BW, Day TA (2002) Oral cancer and precancerous lesions. CA Cancer J Clin 52:195\u2013215","journal-title":"CA Cancer J Clin"},{"key":"1774_CR2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","volume":"45","author":"S Warnakulasuriya","year":"2009","unstructured":"Warnakulasuriya S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45:309\u2013316","journal-title":"Oral Oncol"},{"key":"1774_CR3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1054\/bjom.1999.0031","volume":"37","author":"S Prince","year":"1999","unstructured":"Prince S, Bailey BM (1999) Squamous carcinoma of the tongue: review. Br J Oral Maxillofac Surg 37:164\u2013174","journal-title":"Br J Oral Maxillofac Surg"},{"key":"1774_CR4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1359-6446(99)01412-9","volume":"4","author":"WM Sharman","year":"1999","unstructured":"Sharman WM, Allen CM, van Lier JE (1999) Photodynamic therapeutics: basic principles and clinical applications. Drug Discov Today 4:507\u2013517","journal-title":"Drug Discov Today"},{"key":"1774_CR5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nrc1071","volume":"3","author":"DE Dolmans","year":"2003","unstructured":"Dolmans DE, Fukumura D, Jain RK (2003) Photodynamic therapy for cancer. Nat Rev Cancer 3:380\u2013387","journal-title":"Nat Rev Cancer"},{"key":"1774_CR6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/jnci\/90.12.889","volume":"90","author":"TJ Dougherty","year":"1998","unstructured":"Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D et al (1998) Photodynamic therapy. J Natl Cancer Inst 90:889\u2013905","journal-title":"J Natl Cancer Inst"},{"key":"1774_CR7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1440-1681.2006.04406.x","volume":"33","author":"S Pervaiz","year":"2006","unstructured":"Pervaiz S, Olivo M (2006) Art and science of photodynamic therapy. Clin Exp Pharmacol Physiol 33:551\u2013556","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"1774_CR8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.canlet.2004.07.005","volume":"216","author":"X Ding","year":"2004","unstructured":"Ding X, Xu Q, Liu F, Zhou P, Gu Y et al (2004) Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation. Cancer Lett 216:43\u201354","journal-title":"Cancer Lett"},{"key":"1774_CR9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bbrc.2005.09.021","volume":"337","author":"K Song","year":"2005","unstructured":"Song K, Kong B, Qu X, Li L, Yang Q (2005) Phototoxicity of hemoporfin to ovarian cancer. Biochem Biophys Res Commun 337:127\u2013132","journal-title":"Biochem Biophys Res Commun"},{"key":"1774_CR10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pdpdt.2007.12.001","volume":"5","author":"KH Yuan","year":"2008","unstructured":"Yuan KH, Li Q, Yu WL, Zeng D, Zhang C et al (2008) Comparison of photodynamic therapy and pulsed dye laser in patients with port wine stain birthmarks: a retrospective analysis. Photodiagnosis Photodyn Ther 5:50\u201357","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"1774_CR11","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.2147\/IJN.S45407","volume":"8","author":"J Shi","year":"2013","unstructured":"Shi J, Ma R, Wang L, Zhang J, Liu R et al (2013) The application of hyaluronic acid-derivatized carbon nanotubes in hematoporphyrin monomethyl ether-based photodynamic therapy for in vivo and in vitro cancer treatment. Int J Nanomedicine 8:2361\u20132373","journal-title":"Int J Nanomedicine"},{"key":"1774_CR12","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/6848d2aa-d15f-4632-9074-727b25958da3","volume":"8","author":"H Zeng","year":"2013","unstructured":"Zeng H, Sun M, Zhou C, Yin F, Wang Z et al (2013) Hematoporphyrin monomethyl ether-mediated photodynamic therapy selectively kills sarcomas by inducing apoptosis. PLoS One 8, e77727","journal-title":"PLoS One"},{"key":"1774_CR13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s101030200027","volume":"17","author":"L Brancaleon","year":"2002","unstructured":"Brancaleon L, Moseley H (2002) Laser and non-laser light sources for photodynamic therapy. Lasers Med Sci 17:173\u2013186","journal-title":"Lasers Med Sci"},{"key":"1774_CR14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10103-004-0314-x","volume":"19","author":"A Juzeniene","year":"2004","unstructured":"Juzeniene A, Juzenas P, Ma LW, Iani V, Moan J (2004) Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy. Lasers Med Sci 19:139\u2013149","journal-title":"Lasers Med Sci"},{"key":"1774_CR15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tvjl.2010.05.013","volume":"188","author":"Y Liu","year":"2011","unstructured":"Liu Y, Ma XQ, Jin P, Li HT, Zhang RR et al (2011) Apoptosis induced by hematoporphyrin monomethyl ether combined with He-Ne laser irradiation in vitro on canine breast cancer cells. Vet J 188:325\u2013330","journal-title":"Vet J"},{"key":"1774_CR16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.pdpdt.2011.04.002","volume":"8","author":"Q Zhan","year":"2011","unstructured":"Zhan Q, Yue W, Hu S (2011) Effect of photodynamic therapy and endostatin on human glioma xenografts in nude mice. Photodiagn Photodyn Ther 8:314\u2013320","journal-title":"Photodiagn Photodyn Ther"},{"key":"1774_CR17","first-page":"902","volume":"22","author":"BH Li","year":"2002","unstructured":"Li BH, Xie SS, Lu ZK (2002) Spectral properties of new photosensitizers for photodynamic diagnosis and therapy. Guang Pu Xue Yu Guang Pu Fen Xi 22:902\u2013904","journal-title":"Guang Pu Xue Yu Guang Pu Fen Xi"},{"key":"1774_CR18","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.2147\/IJN.S33261","volume":"7","author":"H Xu","year":"2012","unstructured":"Xu H, Liu C, Mei J, Yao C, Wang S et al (2012) Effects of light irradiation upon photodynamic therapy based on 5-aminolevulinic acid-gold nanoparticle conjugates in K562 cells via singlet oxygen generation. Int J Nanomedicine 7:5029\u20135038","journal-title":"Int J Nanomedicine"},{"key":"1774_CR19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jss.2013.05.048","volume":"185","author":"H Hino","year":"2013","unstructured":"Hino H, Murayama Y, Nakanishi M, Inoue K, Nakajima M et al (2013) 5-Aminolevulinic acid-mediated photodynamic therapy using light-emitting diodes of different wavelengths in a mouse model of peritoneally disseminated gastric cancer. J Surg Res 185:119\u2013126","journal-title":"J Surg Res"},{"key":"1774_CR20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02133211","volume":"11","author":"H Moseley","year":"1996","unstructured":"Moseley H (1996) Total effective fluence: a useful concept in photodynamic therapy. Lasers Med Sci 11:139\u2013143","journal-title":"Lasers Med Sci"},{"key":"1774_CR21","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1039\/b315237e","volume":"3","author":"P Agostinis","year":"2004","unstructured":"Agostinis P, Buytaert E, Breyssens H, Hendrickx N (2004) Regulatory pathways in photodynamic therapy induced apoptosis. Photochem Photobiol Sci 3:721\u2013729","journal-title":"Photochem Photobiol Sci"},{"key":"1774_CR22","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1054\/bjoc.2001.1795","volume":"84","author":"L Wyld","year":"2001","unstructured":"Wyld L, Reed MW, Brown NJ (2001) Differential cell death response to photodynamic therapy is dependent on dose and cell type. Br J Cancer 84:1384\u20131386","journal-title":"Br J Cancer"},{"key":"1774_CR23","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0076-6879(00)19034-2","volume":"319","author":"N Ahmad","year":"2000","unstructured":"Ahmad N, Mukhtar H (2000) Mechanism of photodynamic therapy-induced cell death. Methods Enzymol 319:342\u2013358","journal-title":"Methods Enzymol"},{"key":"1774_CR24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1751-1097.1999.tb08150.x","volume":"70","author":"J Dahle","year":"1999","unstructured":"Dahle J, Steen HB, Moan J (1999) The mode of cell death induced by photodynamic treatment depends on cell density. Photochem Photobiol 70:363\u2013367","journal-title":"Photochem Photobiol"},{"key":"1774_CR25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/01913129609016306","volume":"20","author":"Q Peng","year":"1996","unstructured":"Peng Q, Moan J, Nesland JM (1996) Correlation of subcellular and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy. Ultrastruct Pathol 20:109\u2013129","journal-title":"Ultrastruct Pathol"},{"key":"1774_CR26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0169-409X(01)00126-0","volume":"49","author":"J Morgan","year":"2001","unstructured":"Morgan J, Oseroff AR (2001) Mitochondria-based photodynamic anti-cancer therapy. Adv Drug Deliv Rev 49:71\u201386","journal-title":"Adv Drug Deliv Rev"},{"key":"1774_CR27","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1751-1097.1997.tb08581.x","volume":"65","author":"D Kessel","year":"1997","unstructured":"Kessel D, Luo Y, Deng Y, Chang CK (1997) The role of subcellular localization in initiation of apoptosis by photodynamic therapy. Photochem Photobiol 65:422\u2013426","journal-title":"Photochem Photobiol"},{"key":"1774_CR28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/jcp.10273","volume":"194","author":"YJ Hsieh","year":"2003","unstructured":"Hsieh YJ, Wu CC, Chang CJ, Yu JS (2003) Subcellular localization of Photofrin determines the death phenotype of human epidermoid carcinoma A431 cells triggered by photodynamic therapy: when plasma membranes are the main targets. J Cell Physiol 194:363\u2013375","journal-title":"J Cell Physiol"},{"key":"1774_CR29","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1111\/j.1349-7006.2007.00628.x","volume":"98","author":"K Song","year":"2007","unstructured":"Song K, Kong B, Li L, Yang Q, Wei Y et al (2007) Intraperitoneal photodynamic therapy for an ovarian cancer ascite model in Fischer 344 rat using hematoporphyrin monomethyl ether. Cancer Sci 98:1959\u20131964","journal-title":"Cancer Sci"},{"key":"1774_CR30","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1158\/0008-5472.CAN-03-1670","volume":"64","author":"K Ito","year":"2004","unstructured":"Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T et al (2004) Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res 64:1071\u20131078","journal-title":"Cancer Res"},{"key":"1774_CR31","doi-asserted-by":"crossref","first-page":"19911","DOI":"10.1074\/jbc.M412443200","volume":"280","author":"SV Singh","year":"2005","unstructured":"Singh SV, Srivastava SK, Choi S, Lew KL, Antosiewicz J et al (2005) Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. J Biol Chem 280:19911\u201319924","journal-title":"J Biol Chem"},{"key":"1774_CR32","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.2307\/3579816","volume":"150","author":"NL Oleinick","year":"1998","unstructured":"Oleinick NL, Evans HH (1998) The photobiology of photodynamic therapy: cellular targets and mechanisms. Radiat Res 150:S146\u2013S156","journal-title":"Radiat Res"},{"key":"1774_CR33","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/bies.10329","volume":"25","author":"A Lawen","year":"2003","unstructured":"Lawen A (2003) Apoptosis-an introduction. Bioessays 25:888\u2013896","journal-title":"Bioessays"},{"key":"1774_CR34","first-page":"777","volume":"36","author":"T Liu","year":"2010","unstructured":"Liu T, Wu LY, Choi JK, Berkman CE (2010) Targeted photodynamic therapy for prostate cancer: inducing apoptosis via activation of the caspase-8\/-3 cascade pathway. Int J Oncol 36:777\u2013784","journal-title":"Int J Oncol"},{"key":"1774_CR35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jphotobiol.2010.06.005","volume":"101","author":"J Cheng","year":"2010","unstructured":"Cheng J, Liang H, Li Q, Peng C, Li Z et al (2010) Hematoporphyrin monomethyl ether-mediated photodynamic effects on THP-1 cell-derived macrophages. J Photochem Photobiol B 101:9\u201315","journal-title":"J Photochem Photobiol B"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-015-1774-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10103-015-1774-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-015-1774-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T18:27:28Z","timestamp":1567016848000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10103-015-1774-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,26]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["1774"],"URL":"https:\/\/doi.org\/10.1007\/s10103-015-1774-x","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,26]]}}}