{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T02:38:00Z","timestamp":1776825480839,"version":"3.51.2"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/12317-9"],"award-info":[{"award-number":["2013\/12317-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/21670-1"],"award-info":[{"award-number":["2012\/21670-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s10103-016-2068-7","type":"journal-article","created":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T01:18:13Z","timestamp":1475284693000},"page":"1899-1905","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A randomized placebo-blind study of the effect of low power laser on pain caused by irreversible pulpitis"],"prefix":"10.1007","volume":"31","author":[{"given":"Karen M\u00fcller","family":"Ramalho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1rissa Marcondes Paladini","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Peixoto","family":"Tortamano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"Adde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney Garcia","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"de Paula Eduardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"2068_CR1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0030-4220(63)90201-9","volume":"16","author":"S Seltzer","year":"1963","unstructured":"Seltzer S, Bender IB, Ziontz M (1963) The dynamics of pulp inflammation: correlations between diagnostic data and actual histologic findings in the pulp. Oral Surg Oral Med Oral Pathol 16:969\u2013977","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"8","key":"2068_CR2","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/AJP.0b013e3181f09713","volume":"26","author":"AM Fulop","year":"2010","unstructured":"Fulop AM, Dhimmer S, Deluca JR, Johanson DD, Lenz RV, Patel KB, Douris PC, Enwemeka CS (2010) A meta-analysis of the efficacy of laser phototherapy on pain relief. The clinical journal of pain 26(8):729\u2013736. doi: 10.1097\/AJP.0b013e3181f09713","journal-title":"The clinical journal of pain"},{"issue":"4","key":"2068_CR3","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1089\/1549541041797841","volume":"22","author":"CS Enwemeka","year":"2004","unstructured":"Enwemeka CS, Parker JC, Dowdy DS, Harkness EE, Sanford LE, Woodruff LD (2004) The efficacy of low-power lasers in tissue repair and pain control: a meta-analysis study. Photomed Laser Surg 22(4):323\u2013329. doi: 10.1089\/1549541041797841","journal-title":"Photomed Laser Surg"},{"key":"2068_CR4","doi-asserted-by":"crossref","unstructured":"Tsuchiya K, Kawatani M, Takeshige C, Sato T, Matsumoto I (1993) Diode laser irradiation selectively diminishes slow component of axonal volleys to dorsal roots from the saphenous nerve in the rat. Neurosci Lett 161 (1):65-68. doi:0304-3940(93)90141-7","DOI":"10.1016\/0304-3940(93)90141-7"},{"issue":"2","key":"2068_CR5","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1089\/pho.2005.23.177","volume":"23","author":"DM Ferreira","year":"2005","unstructured":"Ferreira DM, Zangaro RA, Villaverde AB, Cury Y, Frigo L, Picolo G, Longo I, Barbosa DG (2005) Analgesic effect of He-Ne (632.8 nm) low-level laser therapy on acute inflammatory pain. Photomed Laser Surg 23(2):177\u2013181. doi: 10.1089\/pho.2005.23.177","journal-title":"Photomed Laser Surg"},{"issue":"4","key":"2068_CR6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/lsm.1900130411","volume":"13","author":"A Honmura","year":"1993","unstructured":"Honmura A, Ishii A, Yanase M, Obata J, Haruki E (1993) Analgesic effect of Ga-Al-As diode laser irradiation on hyperalgesia in carrageenin-induced inflammation. Lasers Surg Med 13(4):463\u2013469","journal-title":"Lasers Surg Med"},{"issue":"1","key":"2068_CR7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1034\/j.1600-0722.2000.00783.x","volume":"108","author":"Y Sakurai","year":"2000","unstructured":"Sakurai Y, Yamaguchi M, Abiko Y (2000) Inhibitory effect of low-level laser irradiation on LPS-stimulated prostaglandin E2 production and cyclooxygenase-2 in human gingival fibroblasts. Eur J Oral Sci 108(1):29\u201334","journal-title":"Eur J Oral Sci"},{"key":"2068_CR8","doi-asserted-by":"publisher","unstructured":"Sousa LR, Cavalcanti BN, Marques MM (2009) Effect of laser phototherapy on the release of TNF-alpha and MMP-1 by endodontic sealer-stimulated macrophages. Photomed Laser Surg 27 (1):37-42. doi: 10.1089\/pho.2007.2220","DOI":"10.1089\/pho.2007.2220"},{"key":"2068_CR9","doi-asserted-by":"crossref","unstructured":"Hagiwara S, Iwasaka H, Hasegawa A, Noguchi T (2008) Pre-Irradiation of blood by gallium aluminum arsenide (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. Anesth Analg 107 (3):1058-1063. doi:107\/3\/1058","DOI":"10.1213\/ane.0b013e31817ee43e"},{"issue":"1","key":"2068_CR10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/lsm.1900090111","volume":"9","author":"B Braverman","year":"1989","unstructured":"Braverman B, McCarthy RJ, Ivankovich AD, Forde DE, Overfield M, Bapna MS (1989) Effect of helium-neon and infrared laser irradiation on wound healing in rabbits. Lasers Surg Med 9(1):50\u201358","journal-title":"Lasers Surg Med"},{"key":"2068_CR11","doi-asserted-by":"crossref","unstructured":"Mester E, Spiry T, Szende B, Tota JG (1971) Effect of laser rays on wound healing. Am J Surg 122 (4):532-535. doi:0002-9610(71)90482-X","DOI":"10.1016\/0002-9610(71)90482-X"},{"issue":"5","key":"2068_CR12","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/1096-9101(2000)27:5<427::AID-LSM1004>3.0.CO;2-A","volume":"27","author":"Y Maegawa","year":"2000","unstructured":"Maegawa Y, Itoh T, Hosokawa T, Yaegashi K, Nishi M (2000) Effects of near-infrared low-level laser irradiation on microcirculation. Lasers Surg Med 27(5):427\u2013437. doi: 10.1002\/1096-9101(2000)27:5<427::AID-LSM1004>3.0.CO;2-A","journal-title":"Lasers Surg Med"},{"key":"2068_CR13","unstructured":"Urbaniak GC, Plous S (2013) Research Randomizer (Version 4.0) [Computer software]. Retrieved on June 22, 2013, from http:\/\/www.randomizer.org\/"},{"key":"2068_CR14","doi-asserted-by":"crossref","unstructured":"Yoo YJ, Shon WJ, Baek SH, Kang MK, Kim HC, Lee W (2014) Effect of 1440-nanometer neodymium:yttrium-aluminum-garnet laser irradiation on pain and neuropeptide reduction: a randomized prospective clinical trial. J Endod 40 (1):28-32","DOI":"10.1016\/j.joen.2013.07.011"},{"key":"2068_CR15","doi-asserted-by":"crossref","unstructured":"Schulz KF, Altman DG, Moher D (2010) CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. J Clin Epidemiol 63 (8):834-840","DOI":"10.1016\/j.jclinepi.2010.02.005"},{"issue":"2","key":"2068_CR16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1089\/pho.2006.24.158","volume":"24","author":"JM Bjordal","year":"2006","unstructured":"Bjordal JM, Johnson MI, Iversen V, Aimbire F, Lopes-Martins RA (2006) Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials. Photomed Laser Surg 24(2):158\u2013168. doi: 10.1089\/pho.2006.24.158","journal-title":"Photomed Laser Surg"},{"key":"2068_CR17","unstructured":"Li C, Yang X, Ma X, Li L, Shi Z (2012) Preoperative oral nonsteroidal anti-inflammatory drugs for the success of the inferior alveolar nerve block in irreversible pulpitis treatment: a systematic review and meta-analysis based on randomized controlled trials. Quintessence Int 43 (3):209-219. doi:22758"},{"issue":"1","key":"2068_CR18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1034\/j.1601-1546.2002.10103.x","volume":"1","author":"KM Hargreaves","year":"2002","unstructured":"Hargreaves KM, Keiser K (2002) Local anesthetic failure in endodontics: mechanisms and management. Endod Top 1(1):26\u201333","journal-title":"Endod Top"},{"key":"2068_CR19","doi-asserted-by":"crossref","unstructured":"Bigby J, Reader A, Nusstein J, Beck M (2007) Anesthetic efficacy of lidocaine\/meperidine for inferior alveolar nerve blocks in patients with irreversible pulpitis. J Endod 33 (1):7-10. doi:S0099-2399(06)00810-7","DOI":"10.1016\/j.joen.2006.09.006"},{"key":"2068_CR20","doi-asserted-by":"crossref","unstructured":"Claffey E, Reader A, Nusstein J, Beck M, Weaver J (2004) Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis. J Endod 30 (8):568-571. doi:00004770-200408000-00002","DOI":"10.1097\/01.DON.0000125317.21892.8F"},{"key":"2068_CR21","doi-asserted-by":"crossref","unstructured":"Cohen HP, Cha BY, Spangberg LS (1993) Endodontic anesthesia in mandibular molars: a clinical study. J Endod 19 (7):370-373. doi:S0099-2399(06)81366-X","DOI":"10.1016\/S0099-2399(06)81366-X"},{"issue":"10","key":"2068_CR22","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.joen.2008.07.013","volume":"34","author":"M Lindemann","year":"2008","unstructured":"Lindemann M, Reader A, Nusstein J, Drum M, Beck M (2008) Effect of sublingual triazolam on the success of inferior alveolar nerve block in patients with irreversible pulpitis. Journal of endodontics 34(10):1167\u20131170. doi: 10.1016\/j.joen.2008.07.013","journal-title":"Journal of endodontics"},{"key":"2068_CR23","doi-asserted-by":"crossref","unstructured":"Sampaio RM, Carnaval TG, Lanfredi CB, Horliana AC, Rocha RG, Tortamano IP (2012) Comparison of the anesthetic efficacy between bupivacaine and lidocaine in patients with irreversible pulpitis of mandibular molar. J Endod 38 (5):594-597","DOI":"10.1016\/j.joen.2012.01.008"},{"key":"2068_CR24","doi-asserted-by":"crossref","unstructured":"Tortamano IP, Siviero M, Costa CG, Buscariolo IA, Armonia PL (2009) A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis. J Endod 35 (2):165-168","DOI":"10.1016\/j.joen.2008.10.020"},{"key":"2068_CR25","doi-asserted-by":"crossref","unstructured":"Jeske AH (2002) Selecting new drugs for pain control: evidence-based decisions or clinical impressions? J Am Dent Assoc 133 (8):1052-1056; quiz 1093-1054","DOI":"10.14219\/jada.archive.2002.0328"},{"issue":"8","key":"2068_CR26","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0099-2399(85)80039-X","volume":"11","author":"JS Cohen","year":"1985","unstructured":"Cohen JS, Reader A, Fertel R, Beck M, Meyers WJ (1985) A radioimmunoassay determination of the concentrations of prostaglandins E2 and F2alpha in painful and asymptomatic human dental pulps. J Endod 11(8):330\u2013335","journal-title":"J Endod"},{"issue":"2-3","key":"2068_CR27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0304-3940(83)90211-2","volume":"43","author":"J Walker","year":"1983","unstructured":"Walker J (1983) Relief from chronic pain by low power laser irradiation. Neurosci Lett 43(2-3):339\u2013344","journal-title":"Neurosci Lett"},{"issue":"2","key":"2068_CR28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3109\/03091909309008351","volume":"17","author":"KF Gibson","year":"1993","unstructured":"Gibson KF, Kernohan WG (1993) Lasers in medicine\u2014a review. J Med Eng Technol 17(2):51\u201357","journal-title":"J Med Eng Technol"},{"key":"2068_CR29","doi-asserted-by":"crossref","unstructured":"Aggarwal V, Singla M, Kabi D (2010) Comparative evaluation of effect of preoperative oral medication of ibuprofen and ketorolac on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical trial. J Endod 36 (3):375-378","DOI":"10.1016\/j.joen.2009.11.010"},{"key":"2068_CR30","doi-asserted-by":"crossref","unstructured":"Vase L, Riley JL, 3rd, Price DD (2002) A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia. Pain 99 (3):443-452","DOI":"10.1016\/S0304-3959(02)00205-1"},{"key":"2068_CR31","doi-asserted-by":"crossref","unstructured":"Price DD, Milling LS, Kirsch I, Duff A, Montgomery GH, Nicholls SS (1999) An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain 83 (2):147-156","DOI":"10.1016\/S0304-3959(99)00081-0"},{"issue":"17","key":"2068_CR32","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1001\/jama.1955.02960340022006","volume":"159","author":"HK Beecher","year":"1955","unstructured":"Beecher HK (1955) The powerful placebo. J Am Med Assoc 159(17):1602\u20131606","journal-title":"J Am Med Assoc"},{"issue":"6","key":"2068_CR33","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1089\/pho.2008.2430","volume":"28","author":"MH Aras","year":"2010","unstructured":"Aras MH, Omezli MM, Gungormus M (2010) Does low-level laser therapy have an antianesthetic effect? A review. Photomed Laser Surg 28(6):719\u2013722. doi: 10.1089\/pho.2008.2430","journal-title":"Photomed Laser Surg"},{"key":"2068_CR34","doi-asserted-by":"publisher","unstructured":"Yamaguchi H, Kobayashi K, Sato Y, Osada R, Sakuraba E, Nomura T, Arai T, Nakamura J, Cox CF (2000) Nd:YAG laser irradiation of the human dental pulp: implications as a predictor of pulp hemodynamics. Lasers Surg Med 26 (3):270-276. doi: 10.1002\/(SICI)1096-9101(2000)26:3<270::AID-LSM4>3.0.CO;2-9","DOI":"10.1002\/(SICI)1096-9101(2000)26:3%3C270::AID-LSM4%3E3.0.CO;2-9"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-016-2068-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10103-016-2068-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-016-2068-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T01:30:38Z","timestamp":1568424638000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10103-016-2068-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,1]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["2068"],"URL":"https:\/\/doi.org\/10.1007\/s10103-016-2068-7","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,1]]}}}