{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:16:06Z","timestamp":1740107766791,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,6,13]],"date-time":"2018-06-13T00:00:00Z","timestamp":1528848000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC: 30973908"],"award-info":[{"award-number":["NSFC: 30973908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s10103-018-2479-8","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T20:53:37Z","timestamp":1528836817000},"page":"1279-1286","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Topically applied hypericin exhibits skin penetrability on nude mice"],"prefix":"10.1007","volume":"33","author":[{"given":"Zhuo-heng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai-chun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,6,13]]},"reference":[{"key":"2479_CR1","doi-asserted-by":"publisher","first-page":"22094","DOI":"10.3390\/ijms160922094","volume":"16","author":"TA Debele","year":"2015","unstructured":"Debele TA, Peng S, Tsai H-C (2015) Drug carrier for photodynamic cancer therapy. Int J Mol Sci 16:22094\u201322136","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2479_CR2","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3322\/caac.20114","volume":"61","author":"P Agostinis","year":"2011","unstructured":"Agostinis P, Berg K, Cengel KA et al (2011) Photodynamic therapy of cancer: an update. CA Cancer J Clin 61(4):250\u2013281","journal-title":"CA Cancer J Clin"},{"key":"2479_CR3","doi-asserted-by":"crossref","unstructured":"Huygens A et al (2005) Enhancing the photodynamic effect of hypericin in tumour spheroids by fractionated light delivery in combination with hyperoxygenation. Int J Oncol 26(6):1691\u20131697","DOI":"10.3892\/ijo.26.6.1691"},{"issue":"4","key":"2479_CR4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/j.1751-1097.1999.tb08240.x","volume":"70","author":"RW Redmond","year":"1999","unstructured":"Redmond RW, Gamlin JN (1999) A compilation of singlet oxygen yields from biologically relevant molecules. Photochem Photobiol 70(4):391\u2013475","journal-title":"Photochem Photobiol"},{"issue":"2","key":"2479_CR5","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/S1011-1344(96)07446-5","volume":"38","author":"AL Vandenbogaerde","year":"1997","unstructured":"Vandenbogaerde AL et al (1997) Differential cytotoxic effects induced after photosensitization by hypericin. J Photochem Photobiol B Biol 38(2):136\u2013142","journal-title":"J Photochem Photobiol B Biol"},{"issue":"4","key":"2479_CR6","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s10384-008-0551-9","volume":"52","author":"NA Dewi","year":"2008","unstructured":"Dewi NA et al (2008) Effects of photodynamic therapy on the choriocapillaris and retinal pigment epithelium in the irradiated area. Jpn J Ophthalmol 52(4):277\u2013281","journal-title":"Jpn J Ophthalmol"},{"issue":"4","key":"2479_CR7","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/sj.leu.2404134","volume":"20","author":"C Quiney","year":"2006","unstructured":"Quiney C et al (2006) Hyperforin inhibits MMP-9 secretion by B-CLL cells and microtubule formation by endothelial cells. Leukemia 20(4):583\u2013589","journal-title":"Leukemia"},{"issue":"2","key":"2479_CR8","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1002\/ijc.1324","volume":"93","author":"B Chen","year":"2001","unstructured":"Chen B et al (2001) Efficacy of antitumoral photodynamic therapy with hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model. Int J Cancer 93(2):275\u2013282","journal-title":"Int J Cancer"},{"issue":"3","key":"2479_CR9","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S1357-2725(01)00126-1","volume":"34","author":"P Agostinis","year":"2002","unstructured":"Agostinis P et al (2002) Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol 34(3):221\u2013241","journal-title":"Int J Biochem Cell Biol"},{"key":"2479_CR10","first-page":"017","volume":"10","author":"M Desheng","year":"2010","unstructured":"Desheng M et al (2010) Effect of hypericin injection combined with 525-nm photodynamic therapy on port wine stains. Acta Acad Med Milit Tertiae 10:017","journal-title":"Acta Acad Med Milit Tertiae"},{"issue":"6","key":"2479_CR11","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1111\/php.12323","volume":"90","author":"Zh Li","year":"2014","unstructured":"Li Zh et al (2014) Hypericin damages the ectatic capillaries in a Roman cockscomb model and inhibits the growth of human endothelial cells more potently than hematoporphyrin does through induction of apoptosis. Photochem Photobiol 90(6):1368\u20131375","journal-title":"Photochem Photobiol"},{"key":"2479_CR12","volume-title":"Capillary (port-wine) and other telangiectatic stains. Vascular birthmarks, hemangiomas, and malformations","author":"JB Mulliken","year":"1988","unstructured":"Mulliken JB (1988) Capillary (port-wine) and other telangiectatic stains. Vascular birthmarks, hemangiomas, and malformations. WB Saunders, Philadelphia"},{"issue":"7","key":"2479_CR13","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1001\/archderm.1994.01690070073011","volume":"130","author":"R Neumann","year":"1994","unstructured":"Neumann R et al (1994) Immunohistochemistry of port-wine stains and normal skin with endothelium-specific antibodies PAL-E, anti-ICAM-1, anti-ELAM-1, and anti-factor VIIIrAg. Arch Dermatol 130(7):879\u2013883","journal-title":"Arch Dermatol"},{"issue":"3","key":"2479_CR14","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/1523-1747.ep12535052","volume":"74","author":"SH Barsky","year":"1980","unstructured":"Barsky SH et al (1980) The nature and evolution of port wine stains: a computer-assisted study. J Investig Dermatol 74(3):154\u2013157","journal-title":"J Investig Dermatol"},{"issue":"1","key":"2479_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1524-4725.1991.tb01597.x","volume":"17","author":"RG GERONEMUS","year":"1991","unstructured":"GERONEMUS RG, Ashinoff R (1991) The medical necessity of evaluation and treatment of port-wine stains. J Dermatol Surg Oncol 17(1):76\u201379","journal-title":"J Dermatol Surg Oncol"},{"issue":"2","key":"2479_CR16","first-page":"138","volume":"111","author":"J Lan","year":"1998","unstructured":"Lan J et al (1998) Changes of skin perfusion after photodynamic therapy for port wine stain. Chin Med J 111(2):138\u2013138","journal-title":"Chin Med J"},{"issue":"3","key":"2479_CR17","first-page":"163","volume":"14","author":"T Ouyang","year":"1998","unstructured":"Ouyang T, Cheng Y, Xing X (1998) Clinical application of photodynamic therapy combined with non-coherent light (red light) for treatment of port-wine stains. Chin J Plast Surg Burns 14(3):163\u2013165","journal-title":"Chin J Plast Surg Burns"},{"issue":"2","key":"2479_CR18","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1258\/ebm.2009.009294","volume":"235","author":"Y Wang","year":"2010","unstructured":"Wang Y et al (2010) Fluorescence monitoring of a photosensitizer and prediction of the therapeutic effect of photodynamic therapy for port wine stains. Exp Biol Med 235(2):175\u2013180","journal-title":"Exp Biol Med"},{"issue":"5","key":"2479_CR19","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1089\/pho.2007.2117","volume":"26","author":"AHA Machado","year":"2008","unstructured":"Machado AHA et al (2008) Cytotoxicity of octal-bromide zinc phthalocyanine after photodynamic therapy with different light sources. Photomed Laser Surg 26(5):455\u2013459","journal-title":"Photomed Laser Surg"},{"issue":"1","key":"2479_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jaad.2006.06.006","volume":"56","author":"LR Braathen","year":"2007","unstructured":"Braathen LR et al (2007) Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. J Am Acad Dermatol 56(1):125\u2013143","journal-title":"J Am Acad Dermatol"},{"issue":"7","key":"2479_CR21","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1097\/00006534-199706000-00004","volume":"99","author":"L Xiao-Xi","year":"1997","unstructured":"Xiao-Xi L et al (1997) Treatment of capillary vascular malformation (port-wine stains) with photochemotherapy. Plast Reconstr Surg 99(7):1826\u20131830","journal-title":"Plast Reconstr Surg"},{"issue":"1\u20132","key":"2479_CR22","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.ijpharm.2011.07.027","volume":"419","author":"SH Nam","year":"2011","unstructured":"Nam SH et al (2011) Ion pairs of risedronate for transdermal delivery and enhanced permeation rate on hairless mouse skin. Int J Pharm 419(1\u20132):114\u2013120","journal-title":"Int J Pharm"},{"issue":"1\u20133","key":"2479_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jphotobiol.2003.08.008","volume":"72","author":"AB Uzdensky","year":"2003","unstructured":"Uzdensky AB et al (2003) Photodynamic effect of hypericin and a water-soluble derivative on isolated crayfish neuron and surrounding glial cells. J Photochem Photobiol B 72(1\u20133):27\u201333","journal-title":"J Photochem Photobiol B"},{"issue":"6","key":"2479_CR24","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/j.1751-1097.1986.tb05646.x","volume":"43","author":"N Duran","year":"1986","unstructured":"Duran N, Song PS (1986) Hypericin and its photodynamic action. Photochem Photobiol 43(6):677\u2013680","journal-title":"Photochem Photobiol"},{"issue":"2","key":"2479_CR25","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/med.2610150203","volume":"15","author":"G Lavie","year":"1995","unstructured":"Lavie G et al (1995) The chemical and biological properties of hypericin\u2014a compound with a broad spectrum of biological activities. Med Res Rev 15(2):111\u2013119","journal-title":"Med Res Rev"},{"issue":"2","key":"2479_CR26","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0022-5347(05)67357-0","volume":"164","author":"MA D'Hallewin","year":"2000","unstructured":"D'Hallewin MA et al (2000) Fluorescence detection of flat bladder carcinoma in situ after intravesical instillation of hypericin. J Urol 164(2):349\u2013351","journal-title":"J Urol"},{"key":"2479_CR27","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.addr.2012.09.032","volume":"64","author":"AC Williams","year":"2012","unstructured":"Williams AC, Barry BW (2012) Penetration enhancers. Adv Drug Deliv Rev 64:128\u2013137","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"2479_CR28","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/10717540590931936","volume":"12","author":"RJ Babu","year":"2005","unstructured":"Babu RJ, Pandit JK (2005) Effect of penetration enhancers on the transdermal delivery of bupranolol through rat skin. Drug Deliv 12(3):165\u2013169","journal-title":"Drug Deliv"},{"issue":"2","key":"2479_CR29","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0168-3659(98)00187-4","volume":"59","author":"T Marjukka Suhonen","year":"1999","unstructured":"Marjukka Suhonen T, Bouwstra JA, Urtti A (1999) Chemical enhancement of percutaneous absorption in relation to stratum corneum structural alterations. J Control Release 59(2):149\u2013161","journal-title":"J Control Release"},{"issue":"1","key":"2479_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1172\/JCI119129","volume":"99","author":"PJ Newman","year":"1997","unstructured":"Newman PJ (1997) The biology of PECAM-1. J Clin Investig 99(1):3","journal-title":"J Clin Investig"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10103-018-2479-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-018-2479-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-018-2479-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T19:14:41Z","timestamp":1560366881000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10103-018-2479-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,13]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["2479"],"URL":"https:\/\/doi.org\/10.1007\/s10103-018-2479-8","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"type":"print","value":"0268-8921"},{"type":"electronic","value":"1435-604X"}],"subject":[],"published":{"date-parts":[[2018,6,13]]},"assertion":[{"value":"29 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Studies involving animals were approved by the Ethical Committee of 3rd Military Medical University (the protocol number is NO.00003362).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}