{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:18:04Z","timestamp":1789539484938,"version":"build-2803163510"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s10103-018-2491-z","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T16:50:54Z","timestamp":1526403054000},"page":"1461-1470","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Laser reduction of specific microorganisms in the periodontal pocket using Er:YAG and Nd:YAG lasers: a randomized controlled clinical study"],"prefix":"10.1007","volume":"33","author":[{"given":"K.","family":"Grzech-Le\u015bniak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sculean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8843-8258","authenticated-orcid":false,"given":"Boris","family":"Ga\u0161pirc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"issue":"7","key":"2491_CR1","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1902\/jop.2015.157001","volume":"86","author":"American Academy of Periodontology Task Force","year":"2015","unstructured":"American Academy of Periodontology Task Force (2015) Report on the update to the 1999 classification of periodontal diseases and conditions. J Periodontol 86(7):835\u2013838. \n                    https:\/\/doi.org\/10.1902\/jop.2015.157001","journal-title":"J Periodontol"},{"issue":"1\u20132","key":"2491_CR2","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.jns.2010.07.012","volume":"297","author":"J Slowik","year":"2010","unstructured":"Slowik J, Wnuk MA, Grzech K, Golenia A, Turaj W, Ferens A, Jurczak A, Chomyszyn-Gajewska M, Loster B, Slowik A (2010) Periodontitis affects neurological deficit in acute stroke. J Neurol Sci 297(1\u20132):82\u201384. \n                    https:\/\/doi.org\/10.1016\/j.jns.2010.07.012","journal-title":"J Neurol Sci"},{"key":"2491_CR3","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1600-0757.1997.tb00190.x","volume":"14","author":"RP Darveau","year":"1997","unstructured":"Darveau RP, Tanner A, Page RC (1997) The microbial challenge in periodontitis. Periodontol 2000 14:12\u201332","journal-title":"Periodontol 2000"},{"issue":"Suppl 3","key":"2491_CR4","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1034\/j.1600-051X.29.s3.8.x","volume":"29","author":"D Herrera","year":"2002","unstructured":"Herrera D, Sanz M, Jepsen S, Needleman I, Roldan S (2002) A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients. J Clin Periodontol 29(Suppl 3):136\u2013159 discussion 160-132","journal-title":"J Clin Periodontol"},{"issue":"9","key":"2491_CR5","first-page":"381","volume":"61","author":"PV Patel","year":"2012","unstructured":"Patel PV, Patel A, Kumar S, Holmes JC (2012) Effect of subgingival application of topical ozonated olive oil in the treatment of chronic periodontitis: a randomized, controlled, double blind, clinical and microbiological study. Minerva Stomatol 61(9):381\u2013398","journal-title":"Minerva Stomatol"},{"issue":"1","key":"2491_CR6","doi-asserted-by":"publisher","first-page":"20","DOI":"10.4103\/0975-962X.151697","volume":"6","author":"N Jhinger","year":"2015","unstructured":"Jhinger N, Kapoor D, Jain R (2015) Comparison of Periochip (chlorhexidine gluconate 2.5 mg) and Arestin (Minocycline hydrochloride 1 mg) in the management of chronic periodontitis. Indian J Dent 6(1):20\u201326. \n                    https:\/\/doi.org\/10.4103\/0975-962X.151697","journal-title":"Indian J Dent"},{"issue":"8","key":"2491_CR7","doi-asserted-by":"publisher","first-page":"2175","DOI":"10.1007\/s00784-016-1713-7","volume":"20","author":"O Laugisch","year":"2016","unstructured":"Laugisch O, Ramseier CA, Salvi GE, Hagi TT, Burgin W, Eick S, Sculean A (2016) Effects of two different post-surgical protocols including either 0.05% chlorhexidine herbal extract or 0.1% chlorhexidine on post-surgical plaque control, early wound healing and patient acceptance following standard periodontal surgery and implant placement. Clin Oral Investig 20(8):2175\u20132183. \n                    https:\/\/doi.org\/10.1007\/s00784-016-1713-7","journal-title":"Clin Oral Investig"},{"issue":"6","key":"2491_CR8","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1034\/j.1600-051X.2002.290611.x","volume":"29","author":"GE Salvi","year":"2002","unstructured":"Salvi GE, Mombelli A, Mayfield L, Rutar A, Suvan J, Garrett S, Lang NP (2002) Local antimicrobial therapy after initial periodontal treatment. J Clin Periodontol 29(6):540\u2013550","journal-title":"J Clin Periodontol"},{"key":"2491_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12903-015-0123-6","volume":"16","author":"D Zandbergen","year":"2016","unstructured":"Zandbergen D, Slot DE, Niederman R, Van der Weijden FA (2016) The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=. BMC Oral Health 16:27. \n                    https:\/\/doi.org\/10.1186\/s12903-015-0123-6","journal-title":"BMC Oral Health"},{"issue":"1","key":"2491_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/prd.12121","volume":"71","author":"K Jepsen","year":"2016","unstructured":"Jepsen K, Jepsen S (2016) Antibiotics\/antimicrobials: systemic and local administration in the therapy of mild to moderately advanced periodontitis. Periodontol 2000 71(1):82\u2013112. \n                    https:\/\/doi.org\/10.1111\/prd.12121","journal-title":"Periodontol 2000"},{"issue":"9","key":"2491_CR11","first-page":"439","volume":"13","author":"A Tamura","year":"2008","unstructured":"Tamura A, Ara T, Imamura Y, Fujii T, Wang PL (2008) The effects of antibiotics on in vitro biofilm model of periodontal disease. Eur J Med Res 13(9):439\u2013445","journal-title":"Eur J Med Res"},{"issue":"4","key":"2491_CR12","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.cden.2015.06.011","volume":"59","author":"J Walters","year":"2015","unstructured":"Walters J, Lai PC (2015) Should antibiotics be prescribed to treat chronic periodontitis? Dent Clin N Am 59(4):919\u2013933. \n                    https:\/\/doi.org\/10.1016\/j.cden.2015.06.011","journal-title":"Dent Clin N Am"},{"issue":"1","key":"2491_CR13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/prd.12080","volume":"68","author":"A Aoki","year":"2015","unstructured":"Aoki A, Mizutani K, Schwarz F, Sculean A, Yukna RA, Takasaki AA, Romanos GE, Taniguchi Y, Sasaki KM, Zeredo JL, Koshy G, Coluzzi DJ, White JM, Abiko Y, Ishikawa I, Izumi Y (2015) Periodontal and peri-implant wound healing following laser therapy. Periodontol 2000 68(1):217\u2013269. \n                    https:\/\/doi.org\/10.1111\/prd.12080","journal-title":"Periodontol 2000"},{"issue":"11","key":"2491_CR14","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1902\/jop.2008.080197","volume":"79","author":"MR Karlsson","year":"2008","unstructured":"Karlsson MR, Diogo Lofgren CI, Jansson HM (2008) The effect of laser therapy as an adjunct to non-surgical periodontal treatment in subjects with chronic periodontitis: a systematic review. J Periodontol 79(11):2021\u20132028. \n                    https:\/\/doi.org\/10.1902\/jop.2008.080197","journal-title":"J Periodontol"},{"issue":"8 Suppl","key":"2491_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1600-051X.2008.01259.x","volume":"35","author":"F Schwarz","year":"2008","unstructured":"Schwarz F, Aoki A, Becker J, Sculean A (2008) Laser application in non-surgical periodontal therapy: a systematic review. J Clin Periodontol 35(8 Suppl):29\u201344. \n                    https:\/\/doi.org\/10.1111\/j.1600-051X.2008.01259.x","journal-title":"J Clin Periodontol"},{"issue":"1","key":"2491_CR16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10103-015-1795-5","volume":"31","author":"Y Cheng","year":"2016","unstructured":"Cheng Y, Chen JW, Ge MK, Zhou ZY, Yin X, Zou SJ (2016) Efficacy of adjunctive laser in non-surgical periodontal treatment: a systematic review and meta-analysis. Lasers Med Sci 31(1):151\u2013163. \n                    https:\/\/doi.org\/10.1007\/s10103-015-1795-5","journal-title":"Lasers Med Sci"},{"key":"2491_CR17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1600-0757.2008.00283.x","volume":"50","author":"I Ishikawa","year":"2009","unstructured":"Ishikawa I, Aoki A, Takasaki AA, Mizutani K, Sasaki KM, Izumi Y (2009) Application of lasers in periodontics: true innovation or myth? Periodontol 2000 50:90\u2013126. \n                    https:\/\/doi.org\/10.1111\/j.1600-0757.2008.00283.x","journal-title":"Periodontol 2000"},{"issue":"4","key":"2491_CR18","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1089\/pho.2011.3172","volume":"30","author":"M Giannelli","year":"2012","unstructured":"Giannelli M, Bani D, Viti C, Tani A, Lorenzini L, Zecchi-Orlandini S, Formigli L (2012) Comparative evaluation of the effects of different photoablative laser irradiation protocols on the gingiva of periodontopathic patients. Photomed Laser Surg 30(4):222\u2013230. \n                    https:\/\/doi.org\/10.1089\/pho.2011.3172","journal-title":"Photomed Laser Surg"},{"issue":"1","key":"2491_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.11607\/prd.1848","volume":"34","author":"M Nevins","year":"2014","unstructured":"Nevins M, Kim SW, Camelo M, Martin IS, Kim D, Nevins M (2014) A prospective 9-month human clinical evaluation of laser-assisted new attachment procedure (LANAP) therapy. Int J Periodontics Restorative Dent 34(1):21\u201327. \n                    https:\/\/doi.org\/10.11607\/prd.1848","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"4","key":"2491_CR20","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s10103-010-0795-8","volume":"26","author":"C Gomez","year":"2011","unstructured":"Gomez C, Dominguez A, Garcia-Kass AI, Garcia-Nunez JA (2011) Adjunctive Nd:YAG laser application in chronic periodontitis: clinical, immunological, and microbiological aspects. Lasers Med Sci 26(4):453\u2013463. \n                    https:\/\/doi.org\/10.1007\/s10103-010-0795-8","journal-title":"Lasers Med Sci"},{"key":"2491_CR21","doi-asserted-by":"publisher","first-page":"450258","DOI":"10.1155\/2015\/450258","volume":"2015","author":"N Gutknecht","year":"2015","unstructured":"Gutknecht N, Van Betteray C, Ozturan S, Vanweersch L, Franzen R (2015) Laser supported reduction of specific microorganisms in the periodontal pocket with the aid of an Er, Cr:YSGG laser: a pilot study. ScientificWorldJournal 2015:450258. \n                    https:\/\/doi.org\/10.1155\/2015\/450258","journal-title":"ScientificWorldJournal"},{"issue":"5","key":"2491_CR22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/lsm.10179","volume":"32","author":"F Schwarz","year":"2003","unstructured":"Schwarz F, Sculean A, Berakdar M, Szathmari L, Georg T, Becker J (2003) In vivo and in vitro effects of an Er:YAG laser, a GaAlAs diode laser, and scaling and root planing on periodontally diseased root surfaces: a comparative histologic study. Lasers Surg Med 32(5):359\u2013366. \n                    https:\/\/doi.org\/10.1002\/lsm.10179","journal-title":"Lasers Surg Med"},{"issue":"3","key":"2491_CR23","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1007\/s10103-011-0928-8","volume":"27","author":"F Sgolastra","year":"2012","unstructured":"Sgolastra F, Petrucci A, Gatto R, Monaco A (2012) Efficacy of Er:YAG laser in the treatment of chronic periodontitis: systematic review and meta-analysis. Lasers Med Sci 27(3):661\u2013673. \n                    https:\/\/doi.org\/10.1007\/s10103-011-0928-8","journal-title":"Lasers Med Sci"},{"issue":"6","key":"2491_CR24","first-page":"577","volume":"27","author":"RA Yukna","year":"2007","unstructured":"Yukna RA, Carr RL, Evans GH (2007) Histologic evaluation of an Nd:YAG laser-assisted new attachment procedure in humans. Int J Periodontics Restorative Dent 27(6):577\u2013587","journal-title":"Int J Periodontics Restorative Dent"},{"issue":"10","key":"2491_CR25","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1902\/jop.2007.070054","volume":"78","author":"B Gaspirc","year":"2007","unstructured":"Gaspirc B, Skaleric U (2007) Clinical evaluation of periodontal surgical treatment with an Er:YAG laser: 5-year results. J Periodontol 78(10):1864\u20131871. \n                    https:\/\/doi.org\/10.1902\/jop.2007.070054","journal-title":"J Periodontol"},{"issue":"1","key":"2491_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","volume":"4","author":"GC Armitage","year":"1999","unstructured":"Armitage GC (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4(1):1\u20136. \n                    https:\/\/doi.org\/10.1902\/annals.1999.4.1.1","journal-title":"Ann Periodontol"},{"issue":"4","key":"2491_CR27","first-page":"229","volume":"25","author":"J Ainamo","year":"1975","unstructured":"Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25(4):229\u2013235","journal-title":"Int Dent J"},{"issue":"1","key":"2491_CR28","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","volume":"43","author":"TJ O\u2019Leary","year":"1972","unstructured":"O\u2019Leary TJ, Drake RB, Naylor JE (1972) The plaque control record. J Periodontol 43(1):38. \n                    https:\/\/doi.org\/10.1902\/jop.1972.43.1.38","journal-title":"J Periodontol"},{"issue":"1","key":"2491_CR29","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s10103-012-1110-7","volume":"28","author":"A Almehdi","year":"2013","unstructured":"Almehdi A, Aoki A, Ichinose S, Taniguchi Y, Sasaki KM, Ejiri K, Sawabe M, Chui C, Katagiri S, Izumi Y (2013) Histological and SEM analysis of root cementum following irradiation with Er:YAG and CO2 lasers. Lasers Med Sci 28(1):203\u2013213. \n                    https:\/\/doi.org\/10.1007\/s10103-012-1110-7","journal-title":"Lasers Med Sci"},{"issue":"7","key":"2491_CR30","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1007\/s10103-014-1691-4","volume":"30","author":"M Ogita","year":"2015","unstructured":"Ogita M, Tsuchida S, Aoki A, Satoh M, Kado S, Sawabe M, Nanbara H, Kobayashi H, Takeuchi Y, Mizutani K, Sasaki Y, Nomura F, Izumi Y (2015) Increased cell proliferation and differential protein expression induced by low-level Er:YAG laser irradiation in human gingival fibroblasts: proteomic analysis. Lasers Med Sci 30(7):1855\u20131866. \n                    https:\/\/doi.org\/10.1007\/s10103-014-1691-4","journal-title":"Lasers Med Sci"},{"key":"2491_CR31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jphotobiol.2017.03.001","volume":"169","author":"T Abduljabbar","year":"2017","unstructured":"Abduljabbar T, Vohra F, Kellesarian SV, Javed F (2017) Efficacy of scaling and root planning with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and gingival crevicular fluid interleukin 1-beta and tumor necrosis factor-alpha levels among patients with periodontal disease: a prospective randomized split-mouth clinical study. J Photochem Photobiol B 169:70\u201374. \n                    https:\/\/doi.org\/10.1016\/j.jphotobiol.2017.03.001","journal-title":"J Photochem Photobiol B"},{"issue":"3","key":"2491_CR32","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10103-011-0939-5","volume":"27","author":"A Eltas","year":"2012","unstructured":"Eltas A, Orbak R (2012) Effect of 1,064-nm Nd:YAG laser therapy on GCF IL-1beta and MMP-8 levels in patients with chronic periodontitis. Lasers Med Sci 27(3):543\u2013550. \n                    https:\/\/doi.org\/10.1007\/s10103-011-0939-5","journal-title":"Lasers Med Sci"},{"issue":"1","key":"2491_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4103\/0972-124X.145819","volume":"19","author":"S Negi","year":"2015","unstructured":"Negi S, Krishnamurthy M, Ganji KK, Pendor S (2015) Modulatory effects by neodymium-doped yttrium aluminum garnet laser on fibroblast attachment to single rooted tooth surfaces following ultrasonic scaling and root planning: an in vitro study. J Indian Soc Periodontol 19(1):25\u201331. \n                    https:\/\/doi.org\/10.4103\/0972-124X.145819","journal-title":"J Indian Soc Periodontol"},{"issue":"8","key":"2491_CR34","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/lsm.22568","volume":"48","author":"DM Harris","year":"2016","unstructured":"Harris DM, Reinisch L (2016) Selective photoantisepsis. Lasers Surg Med 48(8):763\u2013773. \n                    https:\/\/doi.org\/10.1002\/lsm.22568","journal-title":"Lasers Surg Med"},{"issue":"7","key":"2491_CR35","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1902\/jop.2004.75.7.966","volume":"75","author":"A Sculean","year":"2004","unstructured":"Sculean A, Schwarz F, Berakdar M, Romanos GE, Arweiler NB, Becker J (2004) Periodontal treatment with an Er:YAG laser compared to ultrasonic instrumentation: a pilot study. J Periodontol 75(7):966\u2013973. \n                    https:\/\/doi.org\/10.1902\/jop.2004.75.7.966","journal-title":"J Periodontol"},{"issue":"5","key":"2491_CR36","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1902\/jop.2010.090300","volume":"81","author":"BM Lopes","year":"2010","unstructured":"Lopes BM, Theodoro LH, Melo RF, Thompson GM, Marcantonio RA (2010) Clinical and microbiologic follow-up evaluations after non-surgical periodontal treatment with erbium:YAG laser and scaling and root planing. J Periodontol 81(5):682\u2013691. \n                    https:\/\/doi.org\/10.1902\/jop.2010.090300","journal-title":"J Periodontol"},{"issue":"7","key":"2491_CR37","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1902\/jop.2007.060460","volume":"78","author":"R Crespi","year":"2007","unstructured":"Crespi R, Cappare P, Toscanelli I, Gherlone E, Romanos GE (2007) Effects of Er:YAG laser compared to ultrasonic scaler in periodontal treatment: a 2-year follow-up split-mouth clinical study. J Periodontol 78(7):1195\u20131200. \n                    https:\/\/doi.org\/10.1902\/jop.2007.060460","journal-title":"J Periodontol"},{"issue":"7","key":"2491_CR38","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1007\/s10103-014-1692-3","volume":"30","author":"M Yan","year":"2015","unstructured":"Yan M, Liu M, Wang M, Yin F, Xia H (2015) The effects of Er:YAG on the treatment of peri-implantitis: a meta-analysis of randomized controlled trials. Lasers Med Sci 30(7):1843\u20131853. \n                    https:\/\/doi.org\/10.1007\/s10103-014-1692-3","journal-title":"Lasers Med Sci"},{"issue":"1","key":"2491_CR39","doi-asserted-by":"publisher","first-page":"e0171086","DOI":"10.1371\/journal.pone.0171086","volume":"12","author":"S Eick","year":"2017","unstructured":"Eick S, Meier I, Spoerle F, Bender P, Aoki A, Izumi Y, Salvi GE, Sculean A (2017) In vitro-activity of Er:YAG laser in comparison with other treatment modalities on biofilm ablation from implant and tooth surfaces. PLoS One 12(1):e0171086. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0171086","journal-title":"PLoS One"},{"issue":"2","key":"2491_CR40","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s10103-010-0763-3","volume":"26","author":"F Akiyama","year":"2011","unstructured":"Akiyama F, Aoki A, Miura-Uchiyama M, Sasaki KM, Ichinose S, Umeda M, Ishikawa I, Izumi Y (2011) In vitro studies of the ablation mechanism of periodontopathic bacteria and decontamination effect on periodontally diseased root surfaces by erbium:yttrium-aluminum-garnet laser. Lasers Med Sci 26(2):193\u2013204. \n                    https:\/\/doi.org\/10.1007\/s10103-010-0763-3","journal-title":"Lasers Med Sci"},{"issue":"1","key":"2491_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1601-5037.2009.00375.x","volume":"8","author":"A Kranendonk","year":"2010","unstructured":"Kranendonk A, van der Reijden W, van Winkelhoff A, van der Weijden G (2010) The bactericidal effect of a Genius Nd:YAG laser. Int J Dent Hyg 8(1):63\u201367. \n                    https:\/\/doi.org\/10.1111\/j.1601-5037.2009.00375.x","journal-title":"Int J Dent Hyg"},{"issue":"6","key":"2491_CR42","doi-asserted-by":"publisher","first-page":"489","DOI":"10.3290\/j.qi.a31803","volume":"45","author":"B Yaneva","year":"2014","unstructured":"Yaneva B, Firkova E, Karaslavova E, Romanos GE (2014) Bactericidal effects of using a fiber-less Er:YAG laser system for treatment of moderate chronic periodontitis: preliminary results. Quintessence Int 45(6):489\u2013497. \n                    https:\/\/doi.org\/10.3290\/j.qi.a31803","journal-title":"Quintessence Int"},{"key":"2491_CR43","doi-asserted-by":"publisher","unstructured":"Saglam M, Koseoglu S, Tasdemir I, Erbak Yilmaz H, Savran L, Sutcu R (2017) Combined application of Er:YAG and Nd:YAG lasers in treatment of chronic periodontitis. A split-mouth, single-blind, randomized controlled trial. J Periodontal Res. \n                    https:\/\/doi.org\/10.1111\/jre.12454","DOI":"10.1111\/jre.12454"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10103-018-2491-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-018-2491-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-018-2491-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T20:10:17Z","timestamp":1557864617000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10103-018-2491-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["2491"],"URL":"https:\/\/doi.org\/10.1007\/s10103-018-2491-z","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"assertion":[{"value":"20 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}