{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:16:59Z","timestamp":1789190219528,"version":"build-2803163510"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No: 81872517"],"award-info":[{"award-number":["No: 81872517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Zhejiang Basic Public Welfare Research Project","award":["No: LGF18H110001"],"award-info":[{"award-number":["No: LGF18H110001"]}]},{"name":"Hangzhou Science and Technology Bureau Project","award":["No: 20130733Q24"],"award-info":[{"award-number":["No: 20130733Q24"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s10103-018-2658-7","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T17:03:51Z","timestamp":1539104631000},"page":"767-771","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Melanocyte activation and skin barrier disruption induced in melasma patients after 1064\u00a0nm Nd:YAG laser treatment"],"prefix":"10.1007","volume":"34","author":[{"given":"Ya-li","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-xiao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-zhong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-zu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"2658_CR1","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3109\/09546634.2012.735639","volume":"25","author":"S JH","year":"2014","unstructured":"JH S, Park YL, Lee JS, Lee SY et al (2014) Treatment of melasma by low-fluence 1064 nm Q-switched Nd:YAG laser. J Dermatolog Treat 25:212\u2013217","journal-title":"J Dermatolog Treat"},{"key":"2658_CR2","doi-asserted-by":"publisher","first-page":"e847","DOI":"10.1111\/j.1365-2230.2009.03599.x","volume":"34","author":"SB Cho","year":"2009","unstructured":"Cho SB, Kim JS, Kim MJ (2009) Melasma treatment in Korean women using a 1064-nm Q-switched Nd:YAG laser with low pulse energy. Clin Exp Dermatol 34:e847\u2013e850","journal-title":"Clin Exp Dermatol"},{"key":"2658_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1093\/jmicro\/dfq068","volume":"60","author":"JY Mun","year":"2011","unstructured":"Mun JY, Jeong SY, Kim JH, Han SS et al (2011) A low fluence Q-switched Nd:YAG laser modifies the 3D structure of melanocyte and ultrastructure of melanosome by subcellular-selective photothermolysis. J Electron Microsc 60:11\u201318","journal-title":"J Electron Microsc"},{"key":"2658_CR4","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1038\/jid.2011.109","volume":"131","author":"HY Kang","year":"2011","unstructured":"Kang HY, Suzuki I, Lee DJ, Ha J et al (2011) Transcriptional profiling shows altered expression of wnt pathway- and lipid metabolism-related genes as well as melanogenesis-related genes in melasma. J Invest Dermatol 131:1692\u20131700","journal-title":"J Invest Dermatol"},{"key":"2658_CR5","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1038\/jid.2014.187","volume":"134","author":"MQ Man","year":"2014","unstructured":"Man MQ, Lin TK, Santiago JL, Celli A et al (2014) Basis for enhanced barrier function of pigmented skin. J Invest Dermatol 134:2399\u20132407","journal-title":"J Invest Dermatol"},{"key":"2658_CR6","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/pcmr.12404","volume":"28","author":"AY Lee","year":"2015","unstructured":"Lee AY (2015) Recent progress in melasma pathogenesis. Pigment Cell Melanoma Res 28:648\u2013660","journal-title":"Pigment Cell Melanoma Res"},{"key":"2658_CR7","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1002\/lsm.22263","volume":"46","author":"SG Fabi","year":"2014","unstructured":"Fabi SG, Friedmann DP, Niwa Massaki AB, Goldman MP (2014) A randomized, split-face clinical trial of low-fluence Q-switched neodymium-doped yttrium aluminum garnet (1,064\u2009nm) laser versus low-fluence Q-switched alexandrite laser (755\u2009nm) for the treatment of facial melasma. Lasers Surg Med 46:531\u2013537","journal-title":"Lasers Surg Med"},{"key":"2658_CR8","doi-asserted-by":"publisher","first-page":"e228","DOI":"10.1111\/j.1600-0625.2009.01057.x","volume":"19","author":"HY Kang","year":"2010","unstructured":"Kang HY, Bahadoran P, Suzuki I, Zugaj D et al (2010) In vivo reflectance confocal microscopy detects pigmentary changes in melasma at a cellular level resolution. Exp Dermatol 19:e228\u2013e233","journal-title":"Exp Dermatol"},{"key":"2658_CR9","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/jemt.22594","volume":"78","author":"W Xiang","year":"2015","unstructured":"Xiang W, Song X, Peng J, Xu A et al (2015) Real-time in vivo confocal laser scanning microscopy of melanin-containing cells: a promising diagnostic intervention. Microsc Res Tech 78:1121\u20131127","journal-title":"Microsc Res Tech"},{"key":"2658_CR10","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1007\/s10103-013-1498-8","volume":"29","author":"C Longo","year":"2014","unstructured":"Longo C, Pellacani G, Tourlaki A, Galimberti M et al (2014) Melasma and low-energy Q-switched laser: treatment assessment by means of in vivo confocal microscopy. Lasers Med Sci 29:1159\u20131163","journal-title":"Lasers Med Sci"},{"key":"2658_CR11","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3109\/14764172.2011.630084","volume":"13","author":"AS Brown","year":"2011","unstructured":"Brown AS, Hussain M, Goldberg DJ (2011) Treatment of melasma with low fluence, large spot size, 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser for the treatment of melasma in Fitzpatrick skin types II-IV. J Cosmet Laser Ther 13:280\u2013282","journal-title":"J Cosmet Laser Ther"},{"key":"2658_CR12","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1111\/j.1524-4725.2011.02001.x","volume":"37","author":"X Zhou","year":"2011","unstructured":"Zhou X, Gold MH, Lu Z, Li Y (2011) Efficacy and safety of Qswitched 1,064-nm neodymium-doped yttrium aluminum garnet laser treatment of melasma. Dermatol Surg 37:962\u2013970","journal-title":"Dermatol Surg"},{"key":"2658_CR13","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/jdv.13072","volume":"30","author":"HS Song","year":"2016","unstructured":"Song HS, Park JY, Kim SJ, Kang HY (2016) In vivo time-sequential histological study focused on melanocytes: suggestion of golden time for intervention to prevent post-laser pigmentary changes. J Eur Acad Dermatol Venereol 30:306\u2013310","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2658_CR14","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/j.1468-3083.2011.04337.x","volume":"26","author":"DJ Lee","year":"2012","unstructured":"Lee DJ, Lee J, Ha J, Park KC et al (2012) Defective barrier function in melasma skin. J Eur Acad Dermatol Venereol 26:1533\u20131537","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2658_CR15","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1159\/000365080","volume":"229","author":"BY Chung","year":"2014","unstructured":"Chung BY, Noh TK, Yang SH, Kim IH et al (2014) Gene expression profiling in melasma in Korean women. Dermatology 229:333\u2013342","journal-title":"Dermatology"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-018-2658-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10103-018-2658-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-018-2658-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T05:27:52Z","timestamp":1720675672000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10103-018-2658-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["2658"],"URL":"https:\/\/doi.org\/10.1007\/s10103-018-2658-7","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"30 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}