{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:32:59Z","timestamp":1790371979964,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s10103-019-02736-1","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T06:22:21Z","timestamp":1549002141000},"page":"1325-1332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of 1064-nm Nd:YAG long-pulse laser on polidocanol microfoam injected for varicose vein treatment: a controlled observational study of 404 legs, after 5-year-long treatment"],"prefix":"10.1007","volume":"34","author":[{"given":"Javier","family":"Moreno-Moraga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-9345","authenticated-orcid":false,"given":"Mihail L.","family":"Pascu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justo M.","family":"Alcolea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Smarandache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Royo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fern\u00e1ndez","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario A.","family":"Trelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,1]]},"reference":[{"issue":"3","key":"2736_CR1","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.cps.2011.02.006","volume":"38","author":"MW Mann","year":"2011","unstructured":"Mann MW (2011) Sclerotherapy: it is back and better. Clin Plast Surg 38(3):475\u2013487","journal-title":"Clin Plast Surg"},{"issue":"6","key":"2736_CR2","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1258\/phleb.2009.009050","volume":"24","author":"P Coleridge Smith","year":"2009","unstructured":"Coleridge Smith P (2009) Sclerotherapy and foam sclerotherapy for varicose veins. Phlebology 24(6):260\u2013269","journal-title":"Phlebology"},{"issue":"3","key":"2736_CR3","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1258\/phleb.2009.009043","volume":"25","author":"E Rabe","year":"2010","unstructured":"Rabe E, Schliephake D, Otto J et al (2010) Sclerotherapy of telangiectases and reticular veins: a double-blind randomized, comparative clinical trial of polidocanol, sodium tetradecyl sulphate and isotonic saline (EASI study). Phlebology 25(3):124\u2013131","journal-title":"Phlebology"},{"issue":"1","key":"2736_CR4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.ejvs.2005.08.018","volume":"31","author":"J Al\u00f3s","year":"2006","unstructured":"Al\u00f3s J, Carre\u00f1o P, L\u00f3pez JA et al (2006) Efficacy and safety of sclerotherapy using polidocanol foam: a controlled clinical trial. Eur J Vasc Endovasc 31(1):101\u2013107","journal-title":"Eur J Vasc Endovasc"},{"issue":"5","key":"2736_CR5","first-page":"613","volume":"137","author":"NS Sadick","year":"2001","unstructured":"Sadick NS, Prieto VG, Shea CR et al (2001) Clinical and pathophysiologic correlates of 1064-nm Nd:YAG laser treatment of reticular veins and venulectasias. Arch Dermatol 137(5):613\u2013617","journal-title":"Arch Dermatol"},{"issue":"4","key":"2736_CR6","first-page":"365","volume":"27","author":"NS Sadick","year":"2001","unstructured":"Sadick NS (2001) Long-term results with a multiple synchronized-pulse 1064 nm Nd:YAG laser for the treatment of leg venulectasias and reticular veins. Dermatol Surg 27(4):365\u2013369","journal-title":"Dermatol Surg"},{"issue":"10","key":"2736_CR7","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1177\/0268355513502786","volume":"29","author":"J Moreno-Moraga","year":"2014","unstructured":"Moreno-Moraga J, Smarandache A, Pascu ML et al (2014) 1064 nm Nd:YAG long pulse laser after polidocanol microfoam injection dramatically improves the result of leg vein treatment: a randomized controlled trial on 517 legs with a three-year follow-up. Phlebology 29(10):658\u2013666","journal-title":"Phlebology"},{"issue":"9","key":"2736_CR8","first-page":"1942","volume":"12","author":"A Smarandache","year":"2010","unstructured":"Smarandache A, Trelles M, Pascu ML (2010) Measurement of the modifications of polidocanol absorption spectra after exposure to NIR laser radiation. J Optoelectron Adv Mater 12(9):1942\u20131945","journal-title":"J Optoelectron Adv Mater"},{"issue":"59","key":"2736_CR9","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1089\/pho.2011.3187","volume":"30","author":"A Smarandache","year":"2012","unstructured":"Smarandache A (2012) Laser beams interaction with polidocanol foam: molecular background. Photomed Laser Surg 30(59):262\u2013267","journal-title":"Photomed Laser Surg"},{"issue":"3","key":"2736_CR10","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s10103-012-1180-6","volume":"28","author":"J Moreno-Moraga","year":"2013","unstructured":"Moreno-Moraga J, Hern\u00e1ndez E, Royo J et al (2013) Optimal and safe treatment of spider leg veins measuring less than 1.5 mm on skin type IV patients, using repeated low-fluence Nd:YAG laser pulses after polidocanol injection. Lasers Med Sci 28(3):925\u2013933","journal-title":"Lasers Med Sci"},{"issue":"2","key":"2736_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/lsm.20141","volume":"36","author":"EV Ross","year":"2005","unstructured":"Ross EV, Domankevitz Y (2005) Laser treatment of leg veins: physical mechanisms and theoretical considerations. Lasers Surg Med 36(2):105\u2013116","journal-title":"Lasers Surg Med"},{"issue":"Suppl 1","key":"2736_CR12","first-page":"54","volume":"20","author":"L Tessari","year":"2001","unstructured":"Tessari L (2001) Extemporary sclerosing foam according to personal method: experimental clinical data and catheter usage. Int Angiol 20(Suppl 1):54","journal-title":"Int Angiol"},{"issue":"1","key":"2736_CR13","first-page":"58","volume":"27","author":"L Tessari","year":"2001","unstructured":"Tessari L, Cavezzi A, Frullini A (2001) Preliminary experience with a new sclerosing foam in the treatment of varicose veins. Dermatol Surg 27(1):58\u201360","journal-title":"Dermatol Surg"},{"issue":"1","key":"2736_CR14","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/BF02667958","volume":"17","author":"A Cavezzi","year":"2002","unstructured":"Cavezzi A, Frullini A, Ricci S et al (2002) Treatment of varicose veins by foam sclerotherapy: two clinical series. Phlebology 17(1):13\u201318","journal-title":"Phlebology"},{"issue":"4","key":"2736_CR15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.sder.2005.10.005","volume":"24","author":"P Redondo","year":"2005","unstructured":"Redondo P, Cabrera J (2005) Microfoam sclerotherapy. Semin Cutan Med Surg 24(4):175\u2013183","journal-title":"Semin Cutan Med Surg"},{"issue":"2","key":"2736_CR16","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.jaad.2005.09.009","volume":"54","author":"MA Trelles","year":"2006","unstructured":"Trelles MA, Allones I, Alvarez J et al (2006) The 800-nm diode laser in the treatment of leg veins: assessment at 6 months. J Am Acad Dermatol 54(2):282\u2013289","journal-title":"J Am Acad Dermatol"},{"issue":"9","key":"2736_CR17","first-page":"916","volume":"29","author":"N Sadick","year":"2003","unstructured":"Sadick N (2003) Laser treatment with a 1064-nm laser for lower extremity class I-III veins employing variable spots and pulse width parameters. Dermatol Surg 29(9):916\u2013919","journal-title":"Dermatol Surg"},{"issue":"2","key":"2736_CR18","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/lsm.10135","volume":"32","author":"S Mordon","year":"2003","unstructured":"Mordon S, Brisot D, Fournier N (2003) Using a \u201cnon-uniform pulse sequence\u201d can improve selective coagulation with a Nd:YAG laser (1.06 microm) thanks to met-hemoglobin absorption: a clinical study on blue leg veins. Lasers Surg Med 32(2):160\u2013170","journal-title":"Lasers Surg Med"},{"issue":"3","key":"2736_CR19","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/lsm.20010","volume":"34","author":"J Levy","year":"2004","unstructured":"Levy J, Elbahr C, Jouve E, Mordon S (2004) Comparison and sequential study of long pulsed Nd:YAG 1064 nm laser and sclerotherapy in leg telangiectasias treatment. Lasers Surg Med 34(3):273\u2013276","journal-title":"Lasers Surg Med"},{"issue":"2","key":"2736_CR20","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1160\/TH04-05-0291","volume":"93","author":"M Heger","year":"2005","unstructured":"Heger M, Beek JF, Moldovan NI et al (2005) Towards optimization of selective photothermolysis: prothrombotic pharmaceutical agents as potential adjuvants in laser treatment of port wine stains: a theoretical study. Thromb Haemost 93(2):242\u2013256","journal-title":"Thromb Haemost"},{"issue":"4","key":"2736_CR21","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/j.1524-4725.1995.tb00184.x","volume":"21","author":"P Conrad","year":"1995","unstructured":"Conrad P, Malouf GM, Stacey MC (1995) The Australian polidocanol (aethoxyskclerol) study. Results at 2 years. Dermatol Surg 21(4):334\u2013336 discussion 337-8","journal-title":"Dermatol Surg"},{"issue":"3","key":"2736_CR22","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/jdv.12627","volume":"29","author":"B Parlar","year":"2015","unstructured":"Parlar B, Blazek C, Cazzaniga S et al (2015) Treatment of lower extremity telangiectasias in women by foam sclerotherapy vs. Nd:YAG laser: a prospective, comparative, randomized, open-label trial. J Eur Acad Dermatol Venereol 29(3):549\u2013554","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"5","key":"2736_CR23","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1002\/lsm.1136","volume":"29","author":"GB Altshuler","year":"2001","unstructured":"Altshuler GB, Anderson RR, Manstein D, Zenzie HH, Smirnov MZ (2001) Extended theory of selective photothermolysis. Lasers Surg Med 29(5):416\u2013432","journal-title":"Lasers Surg Med"},{"issue":"2","key":"2736_CR24","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1365-2133.2006.07314.x","volume":"155","author":"W B\u00e4umler","year":"2006","unstructured":"B\u00e4umler W, Ulrich H, Hartl A, Landthaler M, Shafirstein G (2006) Optimal parameters for the treatment of leg veins using Nd:YAG lasers at 1064 nm. Brit J Dermatol 155(2):364\u2013371","journal-title":"Brit J Dermatol"},{"issue":"2","key":"2736_CR25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/lsm.20245","volume":"38","author":"EC Parlette","year":"2006","unstructured":"Parlette EC, Groff WF, Kinshella MJ et al (2006) Optimal pulse durations for the treatment of leg telangiectasias with a neodymium YAG laser. Lasers Surg Med 38(2):98\u2013105","journal-title":"Lasers Surg Med"},{"issue":"3","key":"2736_CR26","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1007\/s10103-013-1445-8","volume":"29","author":"MJ Murphy","year":"2014","unstructured":"Murphy MJ, Torstensson PA (2014) Thermal relaxation times: an outdated concept in photothermal treatments. Lasers Surg Med 29(3):973\u2013978","journal-title":"Lasers Surg Med"},{"issue":"12","key":"2736_CR27","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1517\/13543780903376163","volume":"18","author":"DM Eckmann","year":"2009","unstructured":"Eckmann DM (2009) Polidocanol for endovenous microfoam sclerosant therapy. Expert Opin Investig Drugs 18(12):1919\u20131927","journal-title":"Expert Opin Investig Drugs"},{"key":"2736_CR28","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3109\/10731199.2010.516262","volume":"39","author":"AP Sommer","year":"2011","unstructured":"Sommer AP, Zhu D, Mester AR, F\u00f6rsterling H-D (2011) Pulsed laser light forces cancer cells to absorb anticancer drugs--the role of water in nanomedicine. Artif Cells Blood Substit Immobil Biotechnol 39:169\u2013173","journal-title":"Artif Cells Blood Substit Immobil Biotechnol"},{"issue":"3","key":"2736_CR29","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1021\/la7032737","volume":"24","author":"AP Sommer","year":"2008","unstructured":"Sommer AP, Caron A, Fecht HJ (2008) Tuning nanoscopic water layers on hydrophobic and hydrophilic surfaces with laser light. Langmuir 24(3):635\u2013636","journal-title":"Langmuir"},{"key":"2736_CR30","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1089\/pho.2011.3073","volume":"30","author":"AP Sommer","year":"2012","unstructured":"Sommer AP, Bieschke J, Friedrich RP, Zhu D, Wanker EE, Fecht HJ, Mereles D, Hunstein W (2012) 670\u2009nm laser light and EGCG complementarily reduce amyloid-\u03b2 aggregates in human neuroblastoma cells: basis for treatment of Alzheimer\u2019s disease? Photomed. Laser Surg 30:54\u201360","journal-title":"Laser Surg"},{"key":"2736_CR31","doi-asserted-by":"publisher","first-page":"12029","DOI":"10.1038\/srep12029","volume":"5","author":"AP Sommer","year":"2015","unstructured":"Sommer AP, Haddad MK, Fecht HJ (2015) Light effect on water viscosity: implication for ATP biosynthesis. Sci Rep 5:12029","journal-title":"Sci Rep"},{"key":"2736_CR32","first-page":"303","volume-title":"Laser optofluidics in fighting multiple drug resistance","author":"V Nastasa","year":"2016","unstructured":"Nastasa V, Boni M, Stoicu A, Dinache A, Smarandache A, Pascu ML (2016) Lasers in foams and emulsions studies. In: Pascu ML (ed) Laser optofluidics in fighting multiple drug resistance. Bentham Science Publishers, Sharjah, pp 303\u2013350"},{"issue":"4","key":"2736_CR33","first-page":"1480","volume":"67","author":"A Smarandache","year":"2015","unstructured":"Smarandache A, Staicu A, Nastasa V, Moreno-Moraga J, Royo de la Torre J, Trelles M, Pirvulescu R, Pascu ML (2015) Physical properties of laser irradiated sclerosing foams. Rom Rep Phys 67(4):1480\u20131490","journal-title":"Rom Rep Phys"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10103-019-02736-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-019-02736-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-019-02736-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T19:25:45Z","timestamp":1580498745000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10103-019-02736-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["2736"],"URL":"https:\/\/doi.org\/10.1007\/s10103-019-02736-1","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,1]]},"assertion":[{"value":"20 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The interview and study methodology were approved by the Ethics Committee of the Fundaci\u00f3n Antoni de Gimbernat, and all patients who agreed to participate at control visit for evaluation of the results signed an informed consent form.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}