{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:56:59Z","timestamp":1774353419222,"version":"3.50.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["2009\/01788-5"],"award-info":[{"award-number":["2009\/01788-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["460014\/2014-5"],"award-info":[{"award-number":["460014\/2014-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"crossref","award":["306344\/2017-3"],"award-info":[{"award-number":["306344\/2017-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s10103-019-02887-1","type":"journal-article","created":{"date-parts":[[2019,10,23]],"date-time":"2019-10-23T00:31:50Z","timestamp":1571790710000},"page":"1065-1074","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnosing sickle cell disease and iron deficiency anemia in human blood by Raman spectroscopy"],"prefix":"10.1007","volume":"35","author":[{"given":"Wagner Rafael","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-3334","authenticated-orcid":false,"suffix":"Jr","given":"Landulfo","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-1299","authenticated-orcid":false,"given":"Adriana Barrinha","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"2887_CR1","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","volume":"123","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum NJ, Jasrasaria R, Naghavi M, Wulf SK, Johns N, Lozano R, Regan M, Weatherall D, Chou DP, Eisele TP, Flaxman SR, Pullan RL, Brooker SJ, Murray CJ (2014) A systematic analysis of global anemia burden from 1990 to 2010. Blood 123:615\u2013624. \nhttps:\/\/doi.org\/10.1182\/blood-2013-06-508325","journal-title":"Blood"},{"key":"2887_CR2","unstructured":"World Health Organization, Blood Transfusion Safety (2002) The clinical use of blood in medicine, obstetrics, paediatrics, surgery and anaesthesia, trauma and burns. WHO. \nhttps:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/42397\/a72894.pdf?sequence=1&isAllowed=y\n\n. Accessed 30 Nov 2018"},{"key":"2887_CR3","unstructured":"Benoist B, McLean E, Egli I, Cogswell M (2008) Worldwide prevalence of anaemia 1993-2005: WHO Global Database on Anaemia. WHO. \nhttp:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/43894\/9789241596657_eng.pdf?ua=1\n\n. Accessed 30 Nov 2018"},{"issue":"4","key":"2887_CR4","doi-asserted-by":"publisher","first-page":"279","DOI":"10.2223\/JPED.2005","volume":"86","author":"AP Fernandes","year":"2010","unstructured":"Fernandes AP, Janu\u00e1rio JN, Cangussu CB, Macedo DL, Viana MB (2010) Mortality of children with sickle cell disease: a population study. J Pediatr 86(4):279\u2013284. \nhttps:\/\/doi.org\/10.2223\/JPED.2005","journal-title":"J Pediatr"},{"key":"2887_CR5","unstructured":"U. S. National Institute of Health, U. S. National Library of Medicine (2019) Sickle cell disease. NIH. \nhttps:\/\/ghr.nlm.nih.gov\/condition\/sickle-cell-disease#genes\n\n. Accessed 6 Feb 2019"},{"issue":"6","key":"2887_CR6","doi-asserted-by":"publisher","first-page":"480","DOI":"10.2471\/blt.06.036673","volume":"86","author":"B Modell","year":"2008","unstructured":"Modell B, Darlison M (2008) Global epidemiology of haemoglobin disorders and derived service indicators. Bull World Health Organ 86(6):480\u2013487. \nhttps:\/\/doi.org\/10.2471\/blt.06.036673","journal-title":"Bull World Health Organ"},{"key":"2887_CR7","unstructured":"Brazilian Ministry of Health, Pesquisa Nacional de Demografia e Sa\u00fade da Crian\u00e7a e da Mulher (2006) Anemia e hipovitaminose A. Brazilian Ministry of Health. \nhttp:\/\/bvsms.saude.gov.br\/bvs\/pnds\/anemia.php\n\n. Accessed 2 Dec 2018"},{"issue":"1","key":"2887_CR8","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.bjhh.2016.09.008","volume":"39","author":"GA Arduini","year":"2017","unstructured":"Arduini GA, Rodrigues LP, Trov\u00f3 de Marqui AB (2017) Mortality by sickle cell disease in Brazil. Rev Bras Hematol Hemoter 39(1):52\u201356. \nhttps:\/\/doi.org\/10.1016\/j.bjhh.2016.09.008","journal-title":"Rev Bras Hematol Hemoter"},{"key":"2887_CR9","unstructured":"Brazilian Ministry of Health, Secretaria de Aten\u00e7\u00e3o \u00e0 Sa\u00fade, Departamento de Aten\u00e7\u00e3o Especializada (2012) Doen\u00e7a falciforme: condutas b\u00e1sicas para tratamento. Brazilian Ministry of Health. \nhttp:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/doenca_falciforme_condutas_basicas.pdf\n\n. Accessed 2 Dec 2018"},{"issue":"2","key":"2887_CR10","doi-asserted-by":"publisher","first-page":"604S","DOI":"10.1093\/jn\/131.2.604S","volume":"131","author":"BJ Brabin","year":"2001","unstructured":"Brabin BJ, Hakimi M, Pelletier D (2001) An analysis of anemia and pregnancy-related maternal mortality. J Nutr 131(2):604S\u2013614S. \nhttps:\/\/doi.org\/10.1093\/jn\/131.2.604S","journal-title":"J Nutr"},{"issue":"2","key":"2887_CR11","doi-asserted-by":"publisher","first-page":"676S","DOI":"10.1093\/jn\/131.2.676S","volume":"131","author":"JD Haas","year":"2001","unstructured":"Haas JD, Brownlie T IV (2001) Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr 131(2):676S\u2013690S. \nhttps:\/\/doi.org\/10.1093\/jn\/131.2.676S","journal-title":"J Nutr"},{"key":"2887_CR12","unstructured":"World Health Organization Regional Office for Europe, UNICEF Regional Office for Central and Eastern Europe the Commonwealth of Independence States and the Baltic States (1999) Prevention and control of iron-deficiency anaemia in women and children. UNICEF\/WHO. \nhttp:\/\/www.who.int\/nutrition\/publications\/micronutrients\/anaemia_iron_deficiency\/e73102\/en\/\n\n. Accessed 2 Dec 2018"},{"issue":"14","key":"2887_CR13","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1056\/NEJM197810052991405","volume":"299","author":"J Dean","year":"1978","unstructured":"Dean J, Schechter AN (1978) Sickle-cell anemia: molecular and cellular bases of therapeutic approaches. N Engl J Med 299(14):752\u2013763. \nhttps:\/\/doi.org\/10.1056\/NEJM197810052991405","journal-title":"N Engl J Med"},{"issue":"2","key":"2887_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.hoc.2012.02.008","volume":"26","author":"LJ Bryan","year":"2012","unstructured":"Bryan LJ, Zakai NA (2012) Why is my patient anemic? Hematol Oncol Clin North Am 26(2):205\u2013230. \nhttps:\/\/doi.org\/10.1016\/j.hoc.2012.02.008","journal-title":"Hematol Oncol Clin North Am"},{"issue":"5","key":"2887_CR15","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3109\/10408363.2015.1038744","volume":"52","author":"NM Archer","year":"2015","unstructured":"Archer NM, Brugnara C (2015) Diagnosis of iron-deficient states. Crit Rev Clin Lab Sci 52(5):256\u2013272. \nhttps:\/\/doi.org\/10.3109\/10408363.2015.1038744","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"3","key":"2887_CR16","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1177\/1756283X11398736","volume":"4","author":"TD Johnson-Wimbley","year":"2011","unstructured":"Johnson-Wimbley TD, Graham DY (2011) Diagnosis and management of iron deficiency anemia in the 21st century. Ther Adv Gastroenterol 4(3):177\u2013184. \nhttps:\/\/doi.org\/10.1177\/1756283X11398736","journal-title":"Ther Adv Gastroenterol"},{"issue":"8","key":"2887_CR17","first-page":"945","volume":"118","author":"MA Ali","year":"1978","unstructured":"Ali MA, Luxton AW, Walker WH (1978) Serum ferritin concentration and bone marrow iron stores: a prospective study. Can Med Assoc J 118(8):945\u2013946","journal-title":"Can Med Assoc J"},{"issue":"2","key":"2887_CR18","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/ajcp\/93.2.240","volume":"93","author":"ER Burns","year":"1990","unstructured":"Burns ER, Goldberg SN, Lawrence C, Wenz B (1990) Clinical utility of serum tests for iron deficiency in hospitalized patients. Am J Clin Pathol 93(2):240\u2013245. \nhttps:\/\/doi.org\/10.1093\/ajcp\/93.2.240","journal-title":"Am J Clin Pathol"},{"issue":"3","key":"2887_CR19","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0002-9343(90)90143-2","volume":"88","author":"GH Guyatt","year":"1990","unstructured":"Guyatt GH, Patterson C, Ali M, Singer J, Levine M, Turpie I, Meyer R (1990) Diagnosis of iron-deficiency anemia in the elderly. Am J Med 88(3):205\u2013209. \nhttps:\/\/doi.org\/10.1016\/0002-9343(90)90143-2","journal-title":"Am J Med"},{"issue":"4","key":"2887_CR20","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1111\/j.1365-2141.1995.tb05395.x","volume":"91","author":"S Baumann Kurer","year":"1995","unstructured":"Baumann Kurer S, Seifert B, Michel B, Ruegg R, Fehr J (1995) Prediction of iron deficiency in chronic inflammatory rheumatic disease anaemia. Brit J Haematol 91(4):820\u2013826. \nhttps:\/\/doi.org\/10.1111\/j.1365-2141.1995.tb05395.x","journal-title":"Brit J Haematol"},{"issue":"1","key":"2887_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/clinchem\/44.1.45","volume":"44","author":"AE Mast","year":"1998","unstructured":"Mast AE, Blinder MA, Gronowski AM, Chumley C, Scott MG (1998) Clinical utility of the soluble transferrin receptor and comparison with serum ferritin in several populations. Clin Chem 44(1):45\u201351","journal-title":"Clin Chem"},{"issue":"3","key":"2887_CR22","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1309\/21XVW414MQRTKH14","volume":"35","author":"HO Ogedegbe","year":"2004","unstructured":"Ogedegbe HO, Csury L, Simmons BH (2004) Anemias: a clinical laboratory perspective. Lab Med 35(3):177\u2013185. \nhttps:\/\/doi.org\/10.1309\/21XVW414MQRTKH14","journal-title":"Lab Med"},{"issue":"10","key":"2887_CR23","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1590\/S0100-879X2003001000001","volume":"36","author":"MS Gon\u00e7alves","year":"2003","unstructured":"Gon\u00e7alves MS, Bomfim GC, Maciel E, Cerqueira I, Lyra I, Zanette A, Bomfim G, Adorno EV, Albuquerque AL, Pontes A, Dupuit MF, Fernandes GB, dos Reis MG (2003) \u03b2S-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil. Braz J Med Biol Res 36(10):1283\u20131288. \nhttps:\/\/doi.org\/10.1590\/S0100-879X2003001000001","journal-title":"Braz J Med Biol Res"},{"issue":"2","key":"2887_CR24","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1088\/0031-9155\/45\/2\/201","volume":"45","author":"EB Hanlon","year":"2000","unstructured":"Hanlon EB, Manoharan R, Koo TW, Shafer KE, Motz JT, Fitzmaurice M, Kramer JR, Itzkan I, Dasari RR, Feld MS (2000) Prospects for in vivo Raman spectroscopy. Phys Med Biol 45(2):R1\u2013R59. \nhttps:\/\/doi.org\/10.1088\/0031-9155\/45\/2\/201","journal-title":"Phys Med Biol"},{"issue":"7","key":"2887_CR25","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s10103-016-2003-y","volume":"31","author":"ML de Almeida","year":"2016","unstructured":"de Almeida ML, Saatkamp CJ, Fernandes AB, Pinheiro AL, Silveira L (2016) Estimating the concentration of urea and creatinine in the human serum of normal and dialysis patients through Raman spectroscopy. Lasers Med Sci 31(7):1415\u20131423. \nhttps:\/\/doi.org\/10.1007\/s10103-016-2003-y","journal-title":"Lasers Med Sci"},{"issue":"4","key":"2887_CR26","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s10103-017-2173-2","volume":"32","author":"L Silveira","year":"2017","unstructured":"Silveira L, Borges RCF, Navarro RS, Giana HE, Z\u00e2ngaro RA, Pacheco MTT, Fernandes AB (2017) Quantifying glucose and lipid components in human serum by Raman spectroscopy and multivariate statistics. Lasers Med Sci 32(4):787\u2013795. \nhttps:\/\/doi.org\/10.1007\/s10103-017-2173-2","journal-title":"Lasers Med Sci"},{"issue":"1","key":"2887_CR27","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10103-014-1635-z","volume":"30","author":"AC Bueno Filho","year":"2015","unstructured":"Bueno Filho AC, Silveira L, Yanai AL, Fernandes AB (2015) Raman spectroscopy for a rapid diagnosis of sickle cell disease in human blood samples: a preliminary study. Lasers Med Sci 30(1):247\u2013253. \nhttps:\/\/doi.org\/10.1007\/s10103-014-1635-z","journal-title":"Lasers Med Sci"},{"issue":"5","key":"2887_CR28","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1177\/0003702816686593","volume":"71","author":"CG Atkins","year":"2017","unstructured":"Atkins CG, Buckley K, Blades MW, Turner RFB (2017) Raman spectroscopy of blood and blood components. Appl Spectrosc 71(5):767\u2013793. \nhttps:\/\/doi.org\/10.1177\/0003702816686593","journal-title":"Appl Spectrosc"},{"issue":"1","key":"2887_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/jbio.201200141","volume":"6","author":"P Matousek","year":"2013","unstructured":"Matousek P, Stone N (2013) Recent advances in the development of Raman spectroscopy for deep non-invasive medical diagnosis. J Biophotonics 6(1):7\u201319. \nhttps:\/\/doi.org\/10.1002\/jbio.201200141","journal-title":"J Biophotonics"},{"issue":"11-12","key":"2887_CR30","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/jbio.201300131","volume":"6","author":"M Diem","year":"2013","unstructured":"Diem M, Mazur A, Lenau K, Schubert J, Bird B, Miljkovi\u0107 M, Krafft C, Popp J (2013) Molecular pathology via IR and Raman spectral imaging. J Biophotonics 6(11-12):855\u2013886. \nhttps:\/\/doi.org\/10.1002\/jbio.201300131","journal-title":"J Biophotonics"},{"issue":"7","key":"2887_CR31","doi-asserted-by":"publisher","first-page":"077003","DOI":"10.1117\/1.JBO.17.7.077003","volume":"17","author":"L Silveira","year":"2012","unstructured":"Silveira L, Silveira FL, Bodanese B, Z\u00e2ngaro RA, Pacheco MT (2012) Discriminating model for diagnosis of basal cell carcinoma and melanoma in vitro based on the Raman spectra of selected biochemicals. J Biomed Opt 17(7):077003. \nhttps:\/\/doi.org\/10.1117\/1.JBO.17.7.077003","journal-title":"J Biomed Opt"},{"issue":"3","key":"2887_CR32","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1097\/01.CCM.0000201898.43135.3F","volume":"34","author":"KR Ward","year":"2006","unstructured":"Ward KR, Torres Filho I, Barbee RW, Torres L, Tiba MH, Reynolds PS, Pittman RN, Ivatury RR, Terner J (2006) Resonance Raman spectroscopy: a new technology for tissue oxygenation monitoring. Crit Care Med 34(3):792\u2013799. \nhttps:\/\/doi.org\/10.1097\/01.CCM.0000201898.43135.3F","journal-title":"Crit Care Med"},{"issue":"1","key":"2887_CR33","doi-asserted-by":"publisher","first-page":"H488","DOI":"10.1152\/ajpheart.01171.2004","volume":"289","author":"IP Torres Filho","year":"2005","unstructured":"Torres Filho IP, Terner J, Pittman RN, Somera LG 3rd, Ward KR (2005) Hemoglobin oxygen saturation measurements using resonance Raman intravital microscopy. Am J Physiol Heart Circ Physiol 289(1):H488\u2013H495. \nhttps:\/\/doi.org\/10.1152\/ajpheart.01171.2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2887_CR34","unstructured":"Eigenvector Research, Eigenvector Documentation Wiki (2017) Advanced preprocessing: sample normalization. Eigenvector Research. \nhttp:\/\/wiki.eigenvector.com\/index.php?title=Advanced_Preprocessing:_Sample_Normalization\n\n. Accessed 10 June 2017"},{"key":"2887_CR35","volume-title":"Introduction to multivariate statistics","author":"C Chatfield","year":"1980","unstructured":"Chatfield C, Collins AJ (1980) Introduction to multivariate statistics. Chapman & Hall, London"},{"issue":"3","key":"2887_CR36","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/cem.785","volume":"17","author":"M Barker","year":"2003","unstructured":"Barker M, Rayens W (2003) Partial least squares for discrimination. J Chemom 17(3):166\u2013173. \nhttps:\/\/doi.org\/10.1002\/cem.785","journal-title":"J Chemom"},{"issue":"11","key":"2887_CR37","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1590\/S0103-50532012005000073","volume":"23","author":"CA Nunes","year":"2012","unstructured":"Nunes CA, Freitas MP, Pinheiro ACM, Bastos SC (2012) Chemoface: a novel free user-friendly interface for chemometrics. J Braz Chem Soc 23(11):2003\u20132010. \nhttps:\/\/doi.org\/10.1590\/S0103-50532012005000073","journal-title":"J Braz Chem Soc"},{"issue":"4","key":"2887_CR38","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1039\/c4an02127d","volume":"140","author":"R Vanna","year":"2015","unstructured":"Vanna R, Ronchi P, Lenferink AT, Tresoldi C, Morasso C, Mehn D, Bedoni M, Picciolini S, Terstappen LW, Ciceri F, Otto C, Gramatica F (2015) Label-free imaging and identification of typical cells of acute myeloid leukaemia and myelodysplastic syndrome by Raman microspectroscopy. Analyst 140(4):1054\u20131064. \nhttps:\/\/doi.org\/10.1039\/c4an02127d","journal-title":"Analyst"},{"issue":"1","key":"2887_CR39","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.vibspec.2018.11.009","volume":"100","author":"AMF Lima","year":"2019","unstructured":"Lima AMF, Daniel CR, Navarro RS, Bodanese B, Pasqualucci CA, Pacheco MTT, Z\u00e2ngaro RA, Silveira L (2019) Discrimination of non-melanoma skin cancer and keratosis from normal skin tissue in vivo and ex vivo by Raman spectroscopy. Vib Spectrosc 100(1):131\u2013141. \nhttps:\/\/doi.org\/10.1016\/j.vibspec.2018.11.009","journal-title":"Vib Spectrosc"},{"issue":"1","key":"2887_CR40","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/0005-2795(73)90004-4","volume":"310","author":"H Brunner","year":"1973","unstructured":"Brunner H, Sussner H (1973) Resonance Raman scattering on haemoglobin. Biochim Biophys Acta 310(1):20\u201331. \nhttps:\/\/doi.org\/10.1016\/0005-2795(73)90004-4","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"2887_CR41","doi-asserted-by":"publisher","first-page":"e10427","DOI":"10.1371\/journal.pone.0010427","volume":"5","author":"A Bankapur","year":"2010","unstructured":"Bankapur A, Zachariah E, Chidangil S, Valiathan M, Mathur D (2010) Raman tweezers spectroscopy of live, single red and white blood cells. PLoS One 5(4):e10427. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0010427","journal-title":"PLoS One"},{"issue":"7","key":"2887_CR42","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/jrs.870","volume":"33","author":"BR Wood","year":"2002","unstructured":"Wood BR, McNaughton D (2002) Raman excitation wavelength investigation of single red blood cells in vivo. J Raman Spectrosc 33(7):517\u2013523. \nhttps:\/\/doi.org\/10.1002\/jrs.870","journal-title":"J Raman Spectrosc"},{"issue":"11","key":"2887_CR43","doi-asserted-by":"publisher","first-page":"7943","DOI":"10.1364\/oe.16.007943","volume":"16","author":"AC De Luca","year":"2008","unstructured":"De Luca AC, Rusciano G, Ciancia R, Martinelli V, Pesce G, Rotoli B, Selvaggi L, Sasso A (2008) Spectroscopical and mechanical characterization of normal and thalassemic red blood cells by Raman tweezers. Opt Express 16(11):7943\u20137957. \nhttps:\/\/doi.org\/10.1364\/oe.16.007943","journal-title":"Opt Express"},{"issue":"2","key":"2887_CR44","doi-asserted-by":"publisher","first-page":"e32406","DOI":"10.1371\/journal.pone.0032406","volume":"7","author":"NC Dingari","year":"2012","unstructured":"Dingari NC, Horowitz GL, Kang JW, Dasari RR, Barman I (2012) Raman spectroscopy provides a powerful diagnostic tool for accurate determination of albumin glycation. PLoS One 7(2):e32406. \nhttps:\/\/doi.org\/10.1371\/journal.pone.0032406","journal-title":"PLoS One"},{"issue":"11","key":"2887_CR45","doi-asserted-by":"publisher","first-page":"3342","DOI":"10.1002\/slct.201700190","volume":"2","author":"D Perez-Guaita","year":"2017","unstructured":"Perez-Guaita D, de Veij M, Marzec KM, Almohammedi ARD, McNaughton D, Hudson AJ, Wood BR (2017) Resonance Raman and UV-visible microscopy reveals that conditioning red blood cells with repeated doses of sodium dithionite increases haemoglobin oxygen uptake. ChemistrySelect 2(11):3342\u20133346. \nhttps:\/\/doi.org\/10.1002\/slct.201700190","journal-title":"ChemistrySelect"},{"issue":"12","key":"2887_CR46","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1039\/c7an00349h","volume":"142","author":"CG Atkins","year":"2017","unstructured":"Atkins CG, Schulze HG, Chen D, Devine DV, Blades MW, Turner RFB (2017) Using Raman spectroscopy to assess hemoglobin oxygenation in red blood cell concentrate: an objective proxy for morphological index to gauge the quality of stored blood? Analyst 142(12):2199\u20132210. \nhttps:\/\/doi.org\/10.1039\/c7an00349h","journal-title":"Analyst"},{"issue":"1-2","key":"2887_CR47","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0167-4889(01)00089-1","volume":"1539","author":"BR Wood","year":"2001","unstructured":"Wood BR, Tait B, McNaughton D (2001) Micro-Raman characterisation of the R to T state transition of haemoglobin within a single living erythrocyte. Biochim Biophys Acta 1539(1-2):58\u201370. \nhttps:\/\/doi.org\/10.1016\/S0167-4889(01)00089-1","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"2887_CR48","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1007\/s00216-006-0881-8","volume":"387","author":"BR Wood","year":"2007","unstructured":"Wood BR, Caspers P, Puppels GJ, Pandiancherri S, McNaughton D (2007) Resonance Raman spectroscopy of red blood cells using near-infrared laser excitation. Anal Bioanal Chem 387(5):1691\u20131703. \nhttps:\/\/doi.org\/10.1007\/s00216-006-0881-8","journal-title":"Anal Bioanal Chem"},{"issue":"1","key":"2887_CR49","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1529\/biophysj.108.139097","volume":"96","author":"S Rao","year":"2009","unstructured":"Rao S, B\u00e1lint S, Cossins B, Guallar V, Petrov D (2009) Raman study of mechanically induced oxygenation state transition of red blood cells using optical tweezers. Biophys J 96(1):209\u2013216. \nhttps:\/\/doi.org\/10.1529\/biophysj.108.139097","journal-title":"Biophys J"},{"issue":"4","key":"2887_CR50","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/labmed\/lmy018","volume":"49","author":"R Gautam","year":"2018","unstructured":"Gautam R, Oh JY, Marques MB, Dluhy RA, Patel RP (2018) Characterization of storage-induced red blood cell hemolysis using Raman spectroscopy. Lab Med 49(4):298\u2013310. \nhttps:\/\/doi.org\/10.1093\/labmed\/lmy018","journal-title":"Lab Med"},{"issue":"1","key":"2887_CR51","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1080\/05704928.2014.923902","volume":"50","author":"ACS Talari","year":"2015","unstructured":"Talari ACS, Movasaghi Z, Rehman S, Rehman I (2015) Raman spectroscopy of biological tissues. Appl Spectrosc Rev 50(1):46\u2013111. \nhttps:\/\/doi.org\/10.1080\/05704928.2014.923902","journal-title":"Appl Spectrosc Rev"},{"issue":"3","key":"2887_CR52","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1600-0609.2007.00818.x","volume":"78","author":"W Jelkmann","year":"2007","unstructured":"Jelkmann W (2007) Erythropoietin after a century of research: younger than ever. Eur J Haematol 78(3):183\u2013205. \nhttps:\/\/doi.org\/10.1111\/j.1600-0609.2007.00818.x","journal-title":"Eur J Haematol"},{"issue":"22","key":"2887_CR53","doi-asserted-by":"publisher","first-page":"4617","DOI":"10.1182\/blood.V114.22.4617.4617","volume":"114","author":"K Farrell","year":"2009","unstructured":"Farrell K, Dent L, Buchowski M, Aguinaga MP (2009) Sickle cell anemia as a disease of oxygen transport: possible implications for the prevention of sickle cell crises. Blood 114(22):4617","journal-title":"Blood"},{"issue":"10","key":"2887_CR54","doi-asserted-by":"publisher","first-page":"105006","DOI":"10.1117\/1.JBO.22.10.105006","volume":"22","author":"A Chowdhury","year":"2017","unstructured":"Chowdhury A, Dasgupta R, Majumder SK (2017) Changes in hemoglobin-oxygen affinity with shape variations of red blood cells. J Biomed Opt 22(10):105006. \nhttps:\/\/doi.org\/10.1117\/1.JBO.22.10.105006","journal-title":"J Biomed Opt"},{"issue":"1","key":"2887_CR55","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0022-2836(72)90169-6","volume":"70","author":"H Brunner","year":"1972","unstructured":"Brunner H, Mayer A, Sussner H (1972) Resonance Raman scattering on the haem group of oxy-and deoxyhaemoglobin. J Mol Biol 70(1):153\u2013156. \nhttps:\/\/doi.org\/10.1016\/0022-2836(72)90169-6","journal-title":"J Mol Biol"},{"key":"2887_CR56","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.molstruc.2014.03.023","volume":"1069","author":"A Wese\u0142ucha-Birczy\u0144ska","year":"2014","unstructured":"Wese\u0142ucha-Birczy\u0144ska A, Kozicki M, Czepiel J, \u0141abanowska M, Nowak P, Kowalczyk G, Kurdziel M, Birczy\u0144ska M, Biesiada G, Mach T, Garlicki A (2014) Human erythrocytes analyzed by generalized 2D Raman correlation spectroscopy. J Mol Struct 1069:305\u2013312. \nhttps:\/\/doi.org\/10.1016\/j.molstruc.2014.03.023","journal-title":"J Mol Struct"},{"issue":"7","key":"2887_CR57","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.exphem.2013.02.012","volume":"41","author":"R Liu","year":"2013","unstructured":"Liu R, Mao Z, Matthews DL, Li CS, Chan JW, Satake N (2013) Novel single-cell functional analysis of red blood cells using laser tweezers Raman spectroscopy: application for sickle cell disease. Exp Hematol 41(7):656\u2013661. \nhttps:\/\/doi.org\/10.1016\/j.exphem.2013.02.012","journal-title":"Exp Hematol"},{"issue":"21","key":"2887_CR58","doi-asserted-by":"publisher","first-page":"6104","DOI":"10.1039\/c6an01670g","volume":"141","author":"D Yan","year":"2016","unstructured":"Yan D, Domes C, Domes R, Frosch T, Popp J, Pletz MW, Frosch T (2016) Fiber enhanced Raman spectroscopic analysis as a novel method for diagnosis and monitoring of diseases related to hyperbilirubinemia and hyperbiliverdinemia. Analyst 141(21):6104\u20136115. \nhttps:\/\/doi.org\/10.1039\/c6an01670g","journal-title":"Analyst"},{"issue":"4-5","key":"2887_CR59","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/bip.10120","volume":"67","author":"BR Wood","year":"2002","unstructured":"Wood BR, McNaughton D (2002) Micro-Raman characterization of high- and low-spin heme moieties within single living erythrocytes. Biopolymers 67(4-5):259\u2013262. \nhttps:\/\/doi.org\/10.1002\/bip.10120","journal-title":"Biopolymers"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-019-02887-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10103-019-02887-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-019-02887-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T23:32:46Z","timestamp":1603236766000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10103-019-02887-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,22]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["2887"],"URL":"https:\/\/doi.org\/10.1007\/s10103-019-02887-1","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,22]]},"assertion":[{"value":"23 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Authors declare compliance with ethical standards when using human blood samples, being the study approved by the Committee for Ethics in Research of Universidade Brasil, Protocol No. 1.578.298 (CAAE No. 53543516.4.0000.5494) following Brazilian regulations for use of human subjects or materials in research (Brazilian Ministry of Health, National Health Council, Resolution CNS No. 466\/2012) and have been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}