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This retrospective observational study analyzed 118 eligible patients with de novo coronary artery disease whose only percutaneous coronary intervention was a drug-coated balloon angioplasty (i.e., no subsequent stent placement). Data related to our primary outcomes of interest\u2014incidence of major adverse cardiovascular and cerebral events (MACCE), and incidence of procedural complications (bailout stenting and minor complications)\u2014were collected and retrospectively analyzed. ELCA was used significantly more often in the cases of main branch and ostial lesions (i.e., of the circumflex, right coronary, or left anterior descending arteries, or high lateral branch), normally associated with poor treatment outcomes (55.6% vs. 14.3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0005). However, the two groups were not different in terms of cumulative incidence as estimated by the Kaplan\u2013Meier method (log-rank test, <jats:italic>p<\/jats:italic>\u2009=\u20090.603) and a causal relationship between ELCA and MACCE was not identified (OR, 2.223; 95% CI, 0.614\u20138.047; <jats:italic>p<\/jats:italic>\u2009=\u20090.223). This study confirms the safety of ELCA prior to paclitaxel DCB angioplasty to treat de novo coronary artery lesions. While difficult-to-treat lesions were significantly more prevalent in the group treated by ELCA, the study revealed similar efficiency as conventional pre-dilation methods. Our findings provide grounds for a prospective randomized trial with consistent lesion and procedural characteristics to evaluate the potential benefits of combining paclitaxel DCB angioplasty following ELCA for de novo coronary artery lesions.<\/jats:p>","DOI":"10.1007\/s10103-020-03019-w","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T01:02:30Z","timestamp":1587171750000},"page":"111-117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Excimer laser coronary atherectomy prior to paclitaxel-coated balloon angioplasty for de novo coronary artery lesions"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-5595","authenticated-orcid":false,"given":"Takashi","family":"Shibui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Tsuchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3232-8014","authenticated-orcid":false,"given":"Sho","family":"Nagamine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,18]]},"reference":[{"key":"3019_CR1","doi-asserted-by":"publisher","unstructured":"de la Torre Hernandez JM, Puri R, Alfonso F (2017) Drug-coated balloon: \u201cscoring to win.\u201d JACC Cardiovasc Interv 10:1341\u20131343. https:\/\/doi.org\/10.1016\/j.jcin.2017.05.019","DOI":"10.1016\/j.jcin.2017.05.019"},{"key":"3019_CR2","doi-asserted-by":"publisher","first-page":"620","DOI":"10.4244\/EIJV9I5A99","volume":"9","author":"M Unverdorben","year":"2013","unstructured":"Unverdorben M, Kleber FX, Heuer H et al (2013) Treatment of small coronary arteries with a paclitaxel-coated balloon catheter in the PEPCAD I study: are lesions clinically stable from 12 to 36 months? 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The study was performed with the approval of the Tokyo Metropolitan Hiroo Hospital ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All the patients provided a written informed consent to receive the ELCA treatment and have their data utilized for this study. Patients signed informed consent regarding publishing their data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}