{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:46:33Z","timestamp":1790462793995,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01239-14"],"award-info":[{"award-number":["APQ-01239-14"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s10103-020-03155-3","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:19:48Z","timestamp":1602289188000},"page":"1201-1208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Photobiomodulation therapy on expression of HSP70 protein and tissue repair in experimental acute Achilles tendinitis"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-5812","authenticated-orcid":false,"given":"Andr\u00e9 Nobre","family":"Evangelista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-2219","authenticated-orcid":false,"given":"Fl\u00e1via Franciele","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0300-0711","authenticated-orcid":false,"given":"Lorena Pacheco","family":"de Oliveira Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-330X","authenticated-orcid":false,"given":"Thais Peixoto","family":"Gaiad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9102-2990","authenticated-orcid":false,"given":"Alex Sander Dias","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-7237","authenticated-orcid":false,"given":"Etel","family":"Rocha-Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-3995","authenticated-orcid":false,"given":"Karine Beatriz","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0952-3249","authenticated-orcid":false,"given":"Ana Paula","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6358-4910","authenticated-orcid":false,"given":"Murilo Xavier","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"key":"3155_CR1","doi-asserted-by":"publisher","unstructured":"Li HY, Hua YH (2016) Achilles tendinopathy: current concepts about the basic science and clinical treatments. Biomed Res Int:6492597. https:\/\/doi.org\/10.1155\/2016\/6492597","DOI":"10.1155\/2016\/6492597"},{"issue":"4","key":"3155_CR2","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.fcl.2017.07.002","volume":"22","author":"AE Federer","year":"2017","unstructured":"Federer AE, Steele JR, Dekker TJ, Liles JL, Adams SB (2017) Tendonitis and tendinopathy. Foot Ankle Clin 22(4):665\u2013676. https:\/\/doi.org\/10.1016\/j.fcl.2017.07.002","journal-title":"Foot Ankle Clin"},{"issue":"2","key":"3155_CR3","first-page":"181","volume":"6","author":"P Sharma","year":"2006","unstructured":"Sharma P, Maffulli N (2006) Biology of tendon injury: healing, modeling and remodeling. J Musculoskelet Neuronal Interact 6(2):181\u2013190","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"3155_CR4","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1002\/jor.22156","volume":"30","author":"RL Marcos","year":"2012","unstructured":"Marcos RL, Leal-Junior EC, Arnold G et al (2012) Low-level laser therapy in collagenase-induced Achilles tendinitis in rats: analyses of biochemical and biomechanical aspects. J Orthop Res 30:1945\u20131951. https:\/\/doi.org\/10.1002\/jor.22156","journal-title":"J Orthop Res"},{"issue":"1","key":"3155_CR5","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1097\/jsa.0000000000000185","volume":"26","author":"UG Longo","year":"2018","unstructured":"Longo UG, Ronga M, Maffulli N (2018) Achilles tendinopathy. Sports Med Arthrosc 26(1):16\u201330. https:\/\/doi.org\/10.1097\/jsa.0000000000000185","journal-title":"Sports Med Arthrosc"},{"issue":"7","key":"3155_CR6","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1007\/s11999-008-0286-4","volume":"466","author":"Y Xu","year":"2008","unstructured":"Xu Y, Murrell GAC (2008) The basic science of tendinopathy. Clin Orthop Relat Res 466(7):1528\u20131538. https:\/\/doi.org\/10.1007\/s11999-008-0286-4","journal-title":"Clin Orthop Relat Res"},{"issue":"21","key":"3155_CR7","doi-asserted-by":"publisher","first-page":"12111","DOI":"10.1016\/S0021-9258(19)38314-0","volume":"265","author":"MJ Schlesinger","year":"1990","unstructured":"Schlesinger MJ (1990) Heat shock proteins. J Biol Chem 265(21):12111\u201312114","journal-title":"J Biol Chem"},{"key":"3155_CR8","doi-asserted-by":"publisher","unstructured":"Millar NL, Murrell GA (2012) Heat shock proteins in tendinopathy: novel molecular regulators. Mediat Inflamm 436203. https:\/\/doi.org\/10.1155\/2012\/436203","DOI":"10.1155\/2012\/436203"},{"issue":"11","key":"3155_CR9","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1002\/jor.22144","volume":"30","author":"EM Nell","year":"2012","unstructured":"Nell EM, Merwe LVD, Cook J et al (2012) The apoptosis pathway and the genetic predisposition to Achilles tendinopathy. J Orthop Res 30(11):1719\u20131724. https:\/\/doi.org\/10.1002\/jor.22144","journal-title":"J Orthop Res"},{"issue":"1","key":"3155_CR10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.4161\/pri.1.1.4059","volume":"1","author":"D Lanneau","year":"2007","unstructured":"Lanneau D, de Thonel A, Maurel S, Didelot C, Garrido C (2007) Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27. Prion 1(1):53\u201360. https:\/\/doi.org\/10.4161\/pri.1.1.4059","journal-title":"Prion"},{"key":"3155_CR11","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1379\/1466-1268(1998)003<0228:hspros>2.3.co;2","volume":"3","author":"A Samali","year":"1998","unstructured":"Samali A, Orrenius S (1998) Heat shock proteins: regulators of stress response and apoptosis. Cell Stress Chaperones 3:228\u2013236. https:\/\/doi.org\/10.1379\/1466-1268(1998)003<0228:hspros>2.3.co;2","journal-title":"Cell Stress Chaperones"},{"issue":"2","key":"3155_CR12","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1136\/ard.2011.154229","volume":"71","author":"NL Millar","year":"2012","unstructured":"Millar NL, Reilly JH, Kerr SC, Campbell AL, Little KJ, Leach WJ (2012) Hypoxia: a critical regulator of early human tendinopathy. Ann Rheum Dis 71(2):302\u2013310. https:\/\/doi.org\/10.1136\/ard.2011.154229","journal-title":"Ann Rheum Dis"},{"issue":"1\u20132","key":"3155_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0014-5793(96)00730-2","volume":"391","author":"K Bellmann","year":"1996","unstructured":"Bellmann K, J\u00e4\u00e4ttel\u00e4 M, Wissing D, Burkart V, Kolb H (1996) Heat shock protein hsp70 overexpression confers resistance against nitric oxide. FEBS Lett 391(1\u20132):185\u2013188. https:\/\/doi.org\/10.1016\/0014-5793(96)00730-2","journal-title":"FEBS Lett"},{"issue":"7","key":"3155_CR14","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1007\/s10103-014-1676-3","volume":"30","author":"R Torres-Silva","year":"2015","unstructured":"Torres-Silva R, Lopes-Martins RA, Bjordal JM et al (2015) The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis. Lasers Med Sci 30(7):1985\u20131990. https:\/\/doi.org\/10.1007\/s10103-014-1676-3","journal-title":"Lasers Med Sci"},{"issue":"1","key":"3155_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s10103-013-1280-y","volume":"29","author":"M Xavier","year":"2014","unstructured":"Xavier M, de Souza RA, Pires VA, Santos AP, Aimbire F, Silva JA Jr, Albertini R, Villaverde AB (2014) Low-level light-emitting diode therapy increases mRNA expressions of IL-10 and type I and III collagens on Achilles tendinitis in rats. Lasers Med Sci 29(1):85\u201390. https:\/\/doi.org\/10.1007\/s10103-013-1280-y","journal-title":"Lasers Med Sci"},{"issue":"1","key":"3155_CR16","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1600-0781.2006.00191.x","volume":"22","author":"EG Novoselova","year":"2006","unstructured":"Novoselova EG, Glushkova OV, Cherenkov DA, Chudnovsky VM, Fesenko EE (2006) Effects of low-power laser radiation on mice immunity. Photodermatol Photoimmunol Photomed 22(1):33\u201338. https:\/\/doi.org\/10.1111\/j.1600-0781.2006.00191.x","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"3155_CR17","first-page":"2380","volume":"18","author":"S Du","year":"2012","unstructured":"Du S, Zhang Q, Zhang S, Wang L, Lian J (2012) Heat shock protein 70 expression induced by diode laser irradiation on choroid-retinal endothelial cells in vitro. Mol Vis 18:2380\u20132387","journal-title":"Mol Vis"},{"key":"3155_CR18","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1002\/lsm.20896","volume":"42","author":"M Xavier","year":"2010","unstructured":"Xavier M, David DR, de Souza RA et al (2010) Anti-inflammatory effects of low-level light emitting diode therapy on Achilles tendinitis in rats. Laser Surg Med 42:553\u2013558. https:\/\/doi.org\/10.1002\/lsm.20896","journal-title":"Laser Surg Med"},{"issue":"5","key":"3155_CR19","doi-asserted-by":"publisher","first-page":"e96801","DOI":"10.1371\/journal.pone.0096801","volume":"9","author":"F Varghese","year":"2014","unstructured":"Varghese F, Bukhari AB, Malhotra R, De A (2014) IHC profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples. PLoS One 9(5):e96801. https:\/\/doi.org\/10.1371\/journal.pone.0096801","journal-title":"PLoS One"},{"issue":"10","key":"3155_CR20","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1038\/modpathol.2008.54","volume":"21","author":"MB Flanagan","year":"2008","unstructured":"Flanagan MB, Dabbs DJ, Brufsky AM, Beriwal S, Bhargava R (2008) Histopathologic variables predict Oncotype DX recurrence score. Mod Pathol 21(10):1255\u20131261. https:\/\/doi.org\/10.1038\/modpathol.2008.54","journal-title":"Mod Pathol"},{"key":"3155_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.jembe.2015.04.024","volume":"470","author":"CM Cardoso","year":"2015","unstructured":"Cardoso CM, Sartorio PV, Machado ASD, Vignardi CP et al (2015) Hsp70 and p53 expressions and behavior of juvenile pompano, Trachinotus carolinus (Perciformes, Carangidae), at controlled temperature increase. J Exp Mar Biol Ecol 470:34\u201342. https:\/\/doi.org\/10.1016\/j.jembe.2015.04.024","journal-title":"J Exp Mar Biol Ecol"},{"key":"3155_CR22","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s10103-010-0811-z","volume":"26","author":"D Pires","year":"2011","unstructured":"Pires D, Xavier M, Ara\u00fajo T, Silva JA Jr, Aimbire F, Albertini R (2011) Low-level laser therapy (LLLT; 780 nm) acts differently on mRNA expression of anti- and pro-inflammatory mediators in an experimental model of collagenase-induced tendinitis in rat. Lasers Med Sci 26:85\u201394. https:\/\/doi.org\/10.1007\/s10103-010-0811-z","journal-title":"Lasers Med Sci"},{"issue":"1","key":"3155_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1111\/j.1751-1097.2012.01214","volume":"89","author":"FM de Lima","year":"2013","unstructured":"de Lima FM, Albertini R, Dantas Y et al (2013) Low level laser therapy restores the oxidative stress balance in acute lung injury induced by gut schemia and reperfusion. Photochem Photobiol 89(1):179\u2013188. https:\/\/doi.org\/10.1111\/j.1751-1097.2012.01214","journal-title":"Photochem Photobiol"},{"issue":"1","key":"3155_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s10103-014-1619-z","volume":"30","author":"Y Sun","year":"2015","unstructured":"Sun Y, Zhang S, Liao H et al (2015) Pre-exposure to low-power diode laser irradiation promotes cytoprotection in the rat retina. Lasers Med Sci 30(1):127\u2013133. https:\/\/doi.org\/10.1007\/s10103-014-1619-z","journal-title":"Lasers Med Sci"},{"key":"3155_CR25","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s10103-013-1468-1","volume":"29","author":"HL Casalechi","year":"2014","unstructured":"Casalechi HL, de Farias Marques AC, da Silva EAP et al (2014) Analysis of the effect of phototherapy in model with traumatic Achilles tendon injury in rats. Lasers Med Sci 29:1075. https:\/\/doi.org\/10.1007\/s10103-013-1468-1","journal-title":"Lasers Med Sci"},{"key":"3155_CR26","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1007\/s10103-016-2070-0","volume":"31","author":"AC Marques","year":"2016","unstructured":"Marques AC, Albertini R, Serra AJ et al (2016) Photobiomodulation therapy on collagen type I and III, vascular endothelial growth factor, and metalloproteinase in experimentally induced tendinopathy in aged rats. Lasers Med Sci 31:1915. https:\/\/doi.org\/10.1007\/s10103-016-2070-0","journal-title":"Lasers Med Sci"},{"issue":"3","key":"3155_CR27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1089\/pho.2017.4364","volume":"36","author":"IF Naterstad","year":"2018","unstructured":"Naterstad IF, Rossi RP, Marcos RL et al (2018) Comparison of photobiomodulation and anti-inflammatory drugs on tissue repair on collagenase-induced Achilles tendon inflammation in rats. Photomed Laser Surg 36(3):137\u2013145. https:\/\/doi.org\/10.1089\/pho.2017.4364","journal-title":"Photomed Laser Surg"},{"key":"3155_CR28","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/lsm.20533","volume":"39","author":"W Lim","year":"2007","unstructured":"Lim W, Lee S, Kim I et al (2007) The anti-inflammatory mechanism of 635 nm light-emitting-diode irradiation compared with existing cox inhibitors. Lasers Surg Med 39:614\u2013621. https:\/\/doi.org\/10.1002\/lsm.20533","journal-title":"Lasers Surg Med"},{"issue":"4","key":"3155_CR29","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1089\/pho.2005.23.355","volume":"23","author":"TI Karu","year":"2005","unstructured":"Karu TI, Kolyakov SF (2005) Exact action spectra for cellular responses relevant to phototherapy. Photomed Laser Surg 23(4):355\u2013361. https:\/\/doi.org\/10.1089\/pho.2005.23.355","journal-title":"Photomed Laser Surg"},{"key":"3155_CR30","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1089\/pho.2004.22.323","volume":"22","author":"CS Enwemeka","year":"2004","unstructured":"Enwemeka CS, Parker JC, Dowdy DS et al (2004) The efficacy of low-power lasers in tissue repair and pain control: a meta-analysis study. Photomed Laser Surg 22:323\u2013329. https:\/\/doi.org\/10.1089\/pho.2004.22.323","journal-title":"Photomed Laser Surg"},{"issue":"9","key":"3155_CR31","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1134\/s1054660x09170022","volume":"19","author":"JLN Bastos","year":"2009","unstructured":"Bastos JLN, Lizarelli RFZ, Parizotto NA (2009) Comparative study of laser and LED systems of low intensity applied to tendon healing. Laser Phys 19(9):1925\u20131931. https:\/\/doi.org\/10.1134\/s1054660x09170022","journal-title":"Laser Phys"},{"key":"3155_CR32","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s10103-008-0607-6","volume":"24","author":"HL Casalechi","year":"2009","unstructured":"Casalechi HL, Nicolau RA, Casalechi VL, Silveira-J\u00fanior L, Paula AMB, Pacheco MTT (2009) The effects of low level light emitting diode on the repair process of Achilles tendon therapy in rats. Lasers Med Sci 24:659\u2013665. https:\/\/doi.org\/10.1007\/s10103-008-0607-6","journal-title":"Lasers Med Sci"},{"key":"3155_CR33","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s10103-013-1327-0","volume":"29","author":"MD Moura J\u00fanior","year":"2014","unstructured":"Moura J\u00fanior MD, Arisawa EA, Martin AA et al (2014) Effects of low-power LED and therapeutic ultrasound in the tissue healing and inflammation in a tendinitis experimental model in rats. Lasers Med Sci 29:301\u2013311. https:\/\/doi.org\/10.1007\/s10103-013-1327-0","journal-title":"Lasers Med Sci"},{"issue":"1","key":"3155_CR34","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s10103-015-1821-7","volume":"31","author":"C Helrigle","year":"2016","unstructured":"Helrigle C, de Carvalho PD, Casalechi HL et al (2016) Effects of low-intensity non-coherent light therapy on the inflammatory process in the calcaneal tendon of ovariectomized rats. Lasers Med Sci 31(1):33\u201340. https:\/\/doi.org\/10.1007\/s10103-015-1821-7","journal-title":"Lasers Med Sci"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-020-03155-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-020-03155-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-020-03155-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T01:24:12Z","timestamp":1633915452000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-020-03155-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,10]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["3155"],"URL":"https:\/\/doi.org\/10.1007\/s10103-020-03155-3","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,10]]},"assertion":[{"value":"14 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethics Committee on Animal Use of the Federal University of Jequitinhonha and Mucuri Valleys (certificate number: 007\/2014).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}