{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:24:45Z","timestamp":1790691885344,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s10103-021-03296-z","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T20:07:57Z","timestamp":1616616477000},"page":"47-59","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-4499","authenticated-orcid":false,"given":"Kelvin","family":"Truong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1247-4962","authenticated-orcid":false,"given":"Ines","family":"Prasidha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevi","family":"Wain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"issue":"1","key":"3296_CR1","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1365-4632.2007.03104.x","volume":"46","author":"N Bouzari","year":"2007","unstructured":"Bouzari N, Davis SC, Nouri K (2007) Laser treatment of keloids and hypertrophic scars. Int J Dermatol 46(1):80\u201388","journal-title":"Int J Dermatol"},{"issue":"Suppl 1","key":"3296_CR2","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1097\/DSS.0000000000000819","volume":"43","author":"B Berman","year":"2017","unstructured":"Berman B, Maderal A, Raphael B (2017) Keloids and hypertrophic scars: pathophysiology, classification, and treatment. Dermatol Surg 43(Suppl 1):S3\u2013s18","journal-title":"Dermatol Surg"},{"issue":"5","key":"3296_CR3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00403-009-1014-y","volume":"302","author":"B Shih","year":"2010","unstructured":"Shih B, Bayat A (2010) Genetics of keloid scarring. Arch Dermatol Res 302(5):319\u2013339","journal-title":"Arch Dermatol Res"},{"key":"3296_CR4","doi-asserted-by":"crossref","unstructured":"Sadiq, A., N.P. Khumalo, and A. Bayat, Genetics of Keloid Scarring, in Textbook on Scar Management: State of the Art Management and Emerging Technologies, L. T\u00e9ot, et al., Editors. 2020, Springer International Publishing: Cham. p. 61-76.","DOI":"10.1007\/978-3-030-44766-3_8"},{"key":"3296_CR5","doi-asserted-by":"crossref","unstructured":"Huang, C., et al., The Epidemiology of Keloids, in Textbook on Scar Management: State of the Art Management and Emerging Technologies, L. T\u00e9ot, et al., Editors. 2020, Springer International Publishing: Cham. p. 29-35.","DOI":"10.1007\/978-3-030-44766-3_4"},{"issue":"4S","key":"3296_CR6","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/01.prs.0000472474.17120.84","volume":"136","author":"CAE Kouwenberg","year":"2015","unstructured":"Kouwenberg CAE et al (2015) Emotional quality of life is severely affected by keloid disease: pain and itch are the main determinants of burden. Plastic and Reconstructive Surgery 136(4S):150\u2013151","journal-title":"Plastic and Reconstructive Surgery"},{"issue":"4","key":"3296_CR7","doi-asserted-by":"publisher","first-page":"368","DOI":"10.4103\/0378-6323.53132","volume":"75","author":"PB Olaitan","year":"2009","unstructured":"Olaitan PB (2009) Keloids: assessment of effects and psychosocial-impacts on subjects in a black African population. Indian J Dermatol Venereol Leprol 75(4):368\u2013372","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"2","key":"3296_CR8","first-page":"33","volume":"13","author":"U Betarbet","year":"2020","unstructured":"Betarbet U, Blalock TW (2020) Keloids: A review of etiology, prevention, and treatment. Journal of Clinical and Aesthetic Dermatology 13(2):33\u201343","journal-title":"Journal of Clinical and Aesthetic Dermatology"},{"issue":"2","key":"3296_CR9","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1097\/00006534-200208000-00031","volume":"110","author":"TA Mustoe","year":"2002","unstructured":"Mustoe TA et al (2002) International clinical recommendations on scar management. Plast Reconstr Surg 110(2):560\u2013571","journal-title":"Plast Reconstr Surg"},{"issue":"1","key":"3296_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.clindermatol.2006.09.009","volume":"25","author":"DT Robles","year":"2007","unstructured":"Robles DT, Berg D (2007) Abnormal wound healing: keloids. Clin Dermatol 25(1):26\u201332","journal-title":"Clin Dermatol"},{"key":"3296_CR11","doi-asserted-by":"crossref","unstructured":"Limmer, E.E. and D.A. Glass, 2nd, A review of current keloid management: mainstay monotherapies and emerging approaches. Dermatol Ther (Heidelb), 2020. 10(5): p. 931-948.","DOI":"10.1007\/s13555-020-00427-2"},{"issue":"5","key":"3296_CR12","first-page":"480","volume":"14","author":"SA Braun","year":"2016","unstructured":"Braun SA et al (2016) Laser-assisted drug delivery: mode of action and use in daily clinical practice. J Dtsch Dermatol Ges 14(5):480\u2013488","journal-title":"J Dtsch Dermatol Ges"},{"issue":"2","key":"3296_CR13","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1097\/DSS.0000000000001171","volume":"44","author":"FR Ali","year":"2018","unstructured":"Ali FR, Al-Niaimi F (2018) Treatment of nonmelanoma skin cancers using laser-assisted drug delivery. Dermatologic Surgery 44(2):310","journal-title":"Dermatologic Surgery"},{"issue":"8","key":"3296_CR14","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1097\/DSS.0000000000000556","volume":"42","author":"LA Zaleski-Larsen","year":"2016","unstructured":"Zaleski-Larsen LA, Fabi SG (2016) Laser-assisted drug delivery. Dermatol Surg 42(8):919\u2013931","journal-title":"Dermatol Surg"},{"issue":"5","key":"3296_CR15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/lsm.20048","volume":"34","author":"D Manstein","year":"2004","unstructured":"Manstein D et al (2004) Fractional photothermolysis: a new concept for cutaneous remodeling using microscopic patterns of thermal injury. Lasers Surg Med 34(5):426\u2013438","journal-title":"Lasers Surg Med"},{"issue":"3","key":"3296_CR16","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s10103-017-2154-5","volume":"32","author":"JH Park","year":"2017","unstructured":"Park JH, Chun JY, Lee JH (2017) Laser-assisted topical corticosteroid delivery for the treatment of keloids. Lasers Med Sci 32(3):601\u2013608","journal-title":"Lasers Med Sci"},{"issue":"2","key":"3296_CR17","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/dth.12187","volume":"28","author":"M Cavali\u00e9","year":"2015","unstructured":"Cavali\u00e9 M et al (2015) Treatment of keloids with laser-assisted topical steroid delivery: a retrospective study of 23 cases. Dermatol Ther 28(2):74\u201378","journal-title":"Dermatol Ther"},{"issue":"3","key":"3296_CR18","first-page":"1545","volume":"14","author":"NH Sahib","year":"2020","unstructured":"Sahib NH et al (2020) The role of fractional co2 laser in treatment of keloid and hypertrophic scar used alone and in combination with intralesional steroids. Indian Journal of Forensic Medicine and Toxicology 14(3):1545\u20131550","journal-title":"Indian Journal of Forensic Medicine and Toxicology"},{"key":"3296_CR19","doi-asserted-by":"crossref","unstructured":"Sabry, H.H., E.A. Ibrahim, and A.M. Hamed, Assessment of laser-assisted delivery vs intralesional injection of botulinum toxin A in treatment of hypertrophic scars and keloids. Dermatologic Therapy, 2020. n\/a(n\/a): p. e13980.","DOI":"10.1111\/dth.13980"},{"key":"3296_CR20","doi-asserted-by":"crossref","unstructured":"Rahman, S.H.A., M.S. Mohamed, and A.M. Hamed, Efficacy and safety of Nd:YAG laser alone compared with combined Nd:YAG laser with intralesional steroid or botulinum toxin A in the treatment of hypertrophic scars. Lasers in Medical Science, 2020.","DOI":"10.1007\/s10103-020-03120-0"},{"issue":"2","key":"3296_CR21","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1080\/09546634.2019.1610550","volume":"31","author":"FM Khattab","year":"2020","unstructured":"Khattab FM et al (2020) Combination of pulsed dye laser and verapamil in comparison with verapamil alone in the treatment of keloid. Journal of Dermatological Treatment 31(2):186\u2013190","journal-title":"Journal of Dermatological Treatment"},{"issue":"4","key":"3296_CR22","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/DSS.0000000000001726","volume":"45","author":"HH Sabry","year":"2019","unstructured":"Sabry HH et al (2019) The efficacy of combining fractional carbon dioxide laser with verapamil hydrochloride or 5-fluorouracil in the treatment of hypertrophic scars and keloids: A clinical and immunohistochemical study. Dermatologic Surgery 45(4):536\u2013546","journal-title":"Dermatologic Surgery"},{"issue":"2","key":"3296_CR23","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1177\/1203475417739846","volume":"22","author":"TGHMHRHJ-RDHI Woo Dk","year":"2018","unstructured":"Woo Dk TGHMHRHJ-RDHI (2018) Prospective controlled trial for the treatment of acne keloidalis nuchae with a long-pulsed neodymium-doped yttrium-aluminum-garnet laser. Journal of cutaneous medicine and surgery 22(2):236","journal-title":"Journal of cutaneous medicine and surgery"},{"issue":"3","key":"3296_CR24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10103-017-2387-3","volume":"33","author":"J Alsharnoubi","year":"2018","unstructured":"Alsharnoubi J, Mohamed O (2018) Photobiomodulation effect on children\u2019s scars. Lasers in Medical Science 33(3):497\u2013501","journal-title":"Lasers in Medical Science"},{"issue":"6","key":"3296_CR25","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.3892\/etm.2017.4438","volume":"13","author":"XE Chen","year":"2017","unstructured":"Chen XE et al (2017) Combined effects of long-pulsed neodymium-yttrium-aluminum-garnet laser, diprospan and 5-fluorouracil in the treatment of keloid scars. Experimental and Therapeutic Medicine 13(6):3607\u20133612","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"7","key":"3296_CR26","first-page":"907","volume":"32","author":"A Asilian","year":"2006","unstructured":"Asilian A, Darougheh A, Shariati F (2006) New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatologic Surgery 32(7):907\u2013915","journal-title":"Dermatologic Surgery"},{"issue":"1","key":"3296_CR27","first-page":"25","volume":"29","author":"T Alster","year":"2003","unstructured":"Alster T (2003) Laser scar revision: Comparison study of 585-nm pulsed dye laser with and without intralesional corticosteroids. Dermatologic Surgery 29(1):25\u201329","journal-title":"Dermatologic Surgery"},{"key":"3296_CR28","doi-asserted-by":"crossref","unstructured":"Higgins, J., et al., Cochrane Handbook for Systematic Reviews of Interventions version 6.1. 2020, Cochrane.","DOI":"10.1002\/9781119536604.ch1"},{"key":"3296_CR29","unstructured":"Review Manager (RevMan) [Computer program]. 2020, The Cochrane Collaboration."},{"issue":"173","key":"3296_CR30","first-page":"2978","volume":"29","author":"A Asilian","year":"2012","unstructured":"Asilian A, Darougheh A, Shariat F (2012) New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for the treatment of keloid and hypertrophic scars. Journal of Isfahan Medical School 29(173):2978","journal-title":"Journal of Isfahan Medical School"},{"issue":"10","key":"3296_CR31","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1097\/DSS.0000000000000873","volume":"42","author":"B Behera","year":"2016","unstructured":"Behera B et al (2016) Therapeutic efficacy of intralesional steroid with carbon dioxide laser versus with cryotherapy in treatment of Keloids: a randomized controlled trial. Dermatologic Surgery 42(10):1188\u20131198","journal-title":"Dermatologic Surgery"},{"issue":"5","key":"3296_CR32","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.phrp.2016.08.005","volume":"7","author":"SS Meymandi","year":"2016","unstructured":"Meymandi SS, Moosazadeh M, Rezazadeh A (2016) Comparing two methods of cryotherapy and intense pulsed light with triamcinolone injection in the treatment of keloid and hypertrophic scars: a clinical trial. Osong Public Health and Research Perspectives 7(5):313\u2013319","journal-title":"Osong Public Health and Research Perspectives"},{"key":"3296_CR33","unstructured":"Manuskiatti, W., et al., [ABSTRACT] A split scar comparison study of hypertrophic scar treatment with fractional laser vs fractional laserassisted topical corticosteroids delivery. Lasers in Surgery and Medicine, 2017. 49(Supplement 28): p. 23."},{"issue":"Supplement 1","key":"3296_CR34","first-page":"S43","volume":"39","author":"SA Blome-Eberwein","year":"2018","unstructured":"Blome-Eberwein SA et al (2018) [ABSTRACT] Does topical steroid after fractional CO2 laser treatment of scars make a clinical difference? Journal of Burn Care and Research 39(Supplement 1):S43","journal-title":"Journal of Burn Care and Research"},{"issue":"9","key":"3296_CR35","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1007\/s10103-018-2572-z","volume":"33","author":"J Alsharnoubi","year":"2018","unstructured":"Alsharnoubi J et al (2018) Evaluation of scars in children after treatment with low-level laser. Lasers in Medical Science 33(9):1991\u20131995","journal-title":"Lasers in Medical Science"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-021-03296-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-021-03296-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-021-03296-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T05:23:10Z","timestamp":1643692990000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-021-03296-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["3296"],"URL":"https:\/\/doi.org\/10.1007\/s10103-021-03296-z","relation":{},"ISSN":["0268-8921","1435-604X"],"issn-type":[{"value":"0268-8921","type":"print"},{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,24]]},"assertion":[{"value":"17 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare no competing interests","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Additional declarations for articles in life science journals that report the results of studies involving humans and\/or animals"}}]}}