{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:28:33Z","timestamp":1790634513871,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s10103-021-03474-z","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:05:01Z","timestamp":1642982701000},"page":"2157-2164","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Vaginal erbium laser for treatment of stress urinary incontinence: optimization of treatment regimen for a sustained long-term effect"],"prefix":"10.1007","volume":"37","author":[{"given":"Adrian","family":"Gaspar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9671-4822","authenticated-orcid":false,"given":"Ne\u017ea","family":"Koron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"3474_CR1","unstructured":"Van Kerrebroeck PEV, ed. ICS Standards 2022. 2020th ed. ICS; 2022."},{"issue":"12","key":"3474_CR2","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1111\/j.1471-0528.2000.tb11669.x","volume":"107","author":"AH MacLennan","year":"2000","unstructured":"MacLennan AH, Taylor AW, Wilson DHD, Wilson DHD (2000) The prevalence of pelvic floor disorders and their relationship to gender, age, parity and mode of delivery. BJOG An Int J Obstet Gynaecol 107(12):1460\u20131470. https:\/\/doi.org\/10.1111\/j.1471-0528.2000.tb11669.x","journal-title":"BJOG An Int J Obstet Gynaecol"},{"issue":"8","key":"3474_CR3","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1001\/jama.291.8.986","volume":"291","author":"JM Holroyd-Leduc","year":"2004","unstructured":"Holroyd-Leduc JM, Straus SE (2004) Management of urinary incontinence in women. JAMA 291(8):986. https:\/\/doi.org\/10.1001\/jama.291.8.986","journal-title":"JAMA"},{"key":"3474_CR4","doi-asserted-by":"publisher","unstructured":"Rovner ES, Wein AJ. Treatment options for stress urinary incontinence. Rev Urol. 2004;6 Suppl 3(Table 1):S29\u201347. doi:https:\/\/doi.org\/10.1002\/nau","DOI":"10.1002\/nau"},{"issue":"5","key":"3474_CR5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/14651858.CD005654.pub3","volume":"5","author":"C Dumoulin","year":"2014","unstructured":"Dumoulin C, Hay-Smith EJC, Mac H-S\u00e9guin G (2014) Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. Cochrane database Syst Rev 5(5):119. https:\/\/doi.org\/10.1002\/14651858.CD005654.pub3","journal-title":"Cochrane database Syst Rev"},{"issue":"6","key":"3474_CR6","doi-asserted-by":"publisher","first-page":"S155","DOI":"10.5489\/cuaj.4613","volume":"11","author":"S Shamout","year":"2017","unstructured":"Shamout S, Campeau L (2017) Stress urinary incontinence in women: current and emerging therapeutic options. Can Urol Assoc J 11(6):S155\u2013S158. https:\/\/doi.org\/10.5489\/cuaj.4613","journal-title":"Can Urol Assoc J"},{"issue":"4","key":"3474_CR7","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.eururo.2013.06.045","volume":"64","author":"CR Chapple","year":"2013","unstructured":"Chapple CR, Raz S, Brubaker L, Zimmern PE (2013) Mesh sling in an era of uncertainty: lessons learned and the way forward. Eur Urol 64(4):525\u2013529. https:\/\/doi.org\/10.1016\/j.eururo.2013.06.045","journal-title":"Eur Urol"},{"issue":"4","key":"3474_CR8","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/s00192-014-2616-2","volume":"26","author":"CG Nilsson","year":"2015","unstructured":"Nilsson CG (2015) Creating a gold standard surgical procedure: the development and implementation of TVT. Int Urogynecol J Pelvic Floor Dysfunct 26(4):467\u2013469. https:\/\/doi.org\/10.1007\/s00192-014-2616-2","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"3474_CR9","doi-asserted-by":"publisher","unstructured":"El-Domyati M, Abd-El-Raheem T, Medhat W, Abdel-Wahab H, Anwer M Al. Multiple fractional erbium: yttrium\u2013aluminum\u2013garnet laser sessions for upper facial rejuvenation: clinical and histological implications and expectations. J Cosmet Dermatol. 2014;13(1):30\u201337. https:\/\/doi.org\/10.1111\/jocd.12079","DOI":"10.1111\/jocd.12079"},{"issue":"1","key":"3474_CR10","first-page":"46","volume":"2012","author":"Z Vizintin","year":"2012","unstructured":"Vizintin Z, Rivera M, Fistoni\u0107 I et al (2012) Novel minimally invasive VSP Er:YAG laser treatments in gynecology. J Laser Heal Acad 2012(1):46\u201358","journal-title":"J Laser Heal Acad"},{"issue":"4","key":"3474_CR11","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s10517-017-3650-0","volume":"162","author":"GAA Lapii","year":"2017","unstructured":"Lapii GAA, Yakovleva AYY, Neimark AII (2017) Structural reorganization of the vaginal mucosa in stress urinary incontinence under conditions of Er:YAG laser treatment. Bull Exp Biol Med 162(4):510\u2013514. https:\/\/doi.org\/10.1007\/s10517-017-3650-0","journal-title":"Bull Exp Biol Med"},{"issue":"6","key":"3474_CR12","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/S0002-9378(98)70017-1","volume":"179","author":"T Rechberger","year":"2016","unstructured":"Rechberger T, Postawski K, Jakowicki JA, Gunja-Smith Z, Woessner JF Jr (2016) Role of fascial collagen in stress urinary incontinence. Am J Obstet Gynecol 179(6):1511\u20131514. https:\/\/doi.org\/10.1016\/S0002-9378(98)70017-1","journal-title":"Am J Obstet Gynecol"},{"key":"3474_CR13","doi-asserted-by":"publisher","unstructured":"Lin KL, Chou SH, Long CY. Effect of er:yag laser for women with stress urinary incontinence. Biomed Res Int. 2019;2019. doi:https:\/\/doi.org\/10.1155\/2019\/7915813","DOI":"10.1155\/2019\/7915813"},{"issue":"2","key":"3474_CR14","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/lsm.1026","volume":"28","author":"B Majaron","year":"2001","unstructured":"Majaron B, Kelly KM, Park HB, Verkruysse W, Nelson JS (2001) Er:YAG laser skin resurfacing using repetitive long-pulse exposure and cryogen spray cooling: I. Histological study. Lasers Surg Med. 28(2):121\u2013130. https:\/\/doi.org\/10.1002\/lsm.1026","journal-title":"Lasers Surg Med."},{"issue":"2","key":"3474_CR15","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/lsm.20080","volume":"35","author":"B Drnov\u0161ek-Olup","year":"2004","unstructured":"Drnov\u0161ek-Olup B, Beltram M, Pi\u017eem J et al (2004) Repetitive Er:YAG laser irradiation of human skin: a histological evaluation. Lasers Surg Med 35(2):146\u2013151. https:\/\/doi.org\/10.1002\/lsm.20080","journal-title":"Lasers Surg Med"},{"key":"3474_CR16","doi-asserted-by":"publisher","unstructured":"Lapii GA, Yakovleva AY, Neimark AI, Lushnikova EL (2017) Study of proliferative activity of vaginal epithelium in women with stress urinary incontinence treated by Er:YAG laser. Bull Exp Biol Med. 1\u20134. https:\/\/doi.org\/10.1007\/s10517-017-3784-0","DOI":"10.1007\/s10517-017-3784-0"},{"issue":"1","key":"3474_CR17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00192-007-0495-5","volume":"19","author":"G Ghoniem","year":"2008","unstructured":"Ghoniem G, Stanford E, Kenton K et al (2008) Evaluation and outcome measures in the treatment of female urinary stress incontinence: International Urogynecological Association (IUGA) guidelines for research and clinical practice. Int Urogynecol J Pelvic Floor Dysfunct 19(1):5\u201333. https:\/\/doi.org\/10.1007\/s00192-007-0495-5","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"3474_CR18","unstructured":"FDA. Guidance for Industry and Food and Drug Administration Staff: Clinical Investigations of Devices Indicated for the Treatment of Urinary Incontinence.; 2011. http:\/\/www.fda.gov\/MedicalDevices\/DeviceRegulationandGuidance\/GuidanceDocuments\/ucm07. Accessed March 7, 2018."},{"key":"3474_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ejogrb.2018.03.038","volume":"224","author":"M Blaganje","year":"2018","unstructured":"Blaganje M, \u0160\u0107epanovi\u0107 D, \u017dgur L, Verdenik I, Pajk F, Lukanovi\u0107 A (2018) Non-ablative Er:YAG laser therapy effect on stress urinary incontinence related to quality of life and sexual function: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol 224:153\u2013158. https:\/\/doi.org\/10.1016\/j.ejogrb.2018.03.038","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"9","key":"3474_CR20","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1002\/lsm.22416","volume":"47","author":"U Bizjak-Ogrinc","year":"2015","unstructured":"Bizjak-Ogrinc U, Sen\u010dar S, Lenasi H et al (2015) Novel minimally invasive laser treatment of urinary incontinence in women. Lasers Surg Med 47(9):689\u2013697. https:\/\/doi.org\/10.1002\/lsm.22416","journal-title":"Lasers Surg Med"},{"key":"3474_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejogrb.2016.06.031","volume":"204","author":"JI Pardo","year":"2016","unstructured":"Pardo JI, Sol\u00e0 VR, Morales AA (2016) Treatment of female stress urinary incontinence with Erbium-YAG laser in non-ablative mode. Eur J Obstet Gynecol Reprod Biol 204:1\u20134. https:\/\/doi.org\/10.1016\/j.ejogrb.2016.06.031","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"3474_CR22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s00192-016-3129-y","volume":"28","author":"YW Tien","year":"2017","unstructured":"Tien YW, Hsiao SM, Lee CN, Lin HH (2017) Effects of laser procedure for female urodynamic stress incontinence on pad weight, urodynamics, and sexual function. Int Urogynecol J Pelvic Floor Dysfunct 28(3):469\u2013476. https:\/\/doi.org\/10.1007\/s00192-016-3129-y","journal-title":"Int Urogynecol J Pelvic Floor Dysfunct"},{"key":"3474_CR23","doi-asserted-by":"publisher","unstructured":"Fistonic N, Fistonic I, Lukanovic A, et al. First assessment of short-term efficacy of Er:YAG laser treatment on stress urinary incontinence in women: prospective cohort study. Climacteric. 2015;18 Suppl 1(sup1):37\u201342. doi:https:\/\/doi.org\/10.3109\/13697137.2015.1071126","DOI":"10.3109\/13697137.2015.1071126"},{"issue":"4","key":"3474_CR24","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10103-016-1884-0","volume":"31","author":"N Fistonic","year":"2016","unstructured":"Fistonic N, Fistonic I, Gustek SF et al (2016) Minimally invasive, non-ablative Er:YAG laser treatment of stress urinary incontinence in women\u2013a pilot study. Lasers Med Sci 31(4):635\u2013643. https:\/\/doi.org\/10.1007\/s10103-016-1884-0","journal-title":"Lasers Med Sci"},{"key":"3474_CR25","doi-asserted-by":"publisher","unstructured":"Kuszka A, Gamper M, Walser C, Kociszewski J, Viereck V. Erbium:YAG laser treatment of female stress urinary incontinence: midterm data. Int Urogynecol J. December 2019. https:\/\/doi.org\/10.1007\/s00192-019-04148-9","DOI":"10.1007\/s00192-019-04148-9"},{"issue":"May","key":"3474_CR26","first-page":"1","volume":"2016","author":"JP Gaviria","year":"2016","unstructured":"Gaviria JP, Korosec B, Fernandez J et al (2016) Up to 3-year follow-up of patients with vaginal relaxation syndrome participating in laser vaginal tightening. J Laser Heal Acad 2016(May):1\u20136","journal-title":"J Laser Heal Acad"},{"key":"3474_CR27","doi-asserted-by":"publisher","unstructured":"Gonz\u00e1lez Isaza P, Jaguszewska K, Cardona JL, Lukaszuk M. Long-term effect of thermoablative fractional CO2 laser treatment as a novel approach to urinary incontinence management in women with genitourinary syndrome of menopause. Int Urogynecol J. May 2017. https:\/\/doi.org\/10.1007\/s00192-017-3352-1","DOI":"10.1007\/s00192-017-3352-1"},{"key":"3474_CR28","doi-asserted-by":"publisher","unstructured":"Hardy LA, Chang C-H, Myers EM, Kennelly MJ, Fried NM. Laser treatment of female stress urinary incontinence: optical, thermal, and tissue damage simulations. In: Choi B, Kollias N, Zeng H, et al., eds.; 2016:96891R. https:\/\/doi.org\/10.1117\/12.2208126","DOI":"10.1117\/12.2208126"},{"issue":"3","key":"3474_CR29","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ijwd.2016.05.003","volume":"2","author":"C Karcher","year":"2016","unstructured":"Karcher C, Sadick N (2016) Vaginal rejuvenation using energy-based devices. Int J Women\u2019s Dermatology 2(3):85\u201388. https:\/\/doi.org\/10.1016\/j.ijwd.2016.05.003","journal-title":"Int J Women\u2019s Dermatology"},{"issue":"5","key":"3474_CR30","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00345-018-2445-x","volume":"37","author":"N Okui","year":"2019","unstructured":"Okui N (2019) Comparison between erbium-doped yttrium aluminum garnet laser therapy and sling procedures in the treatment of stress and mixed urinary incontinence. World J Urol 37(5):885\u2013889. https:\/\/doi.org\/10.1007\/s00345-018-2445-x","journal-title":"World J Urol"},{"key":"3474_CR31","unstructured":"FDA warns against use of energy-based devices to perform vaginal \u201crejuvenation\u201d or vaginal cosmetic procedures: FDA Safety Communication | FDA. https:\/\/www.fda.gov\/medical-devices\/safety-communications\/fda-warns-against-use-energy-based-devices-perform-vaginal-rejuvenation-or-vaginal-cosmetic. Published 2018. Accessed December 13, 2019."},{"issue":"sup1","key":"3474_CR32","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1080\/13697137.2020.1813098","volume":"23","author":"M Gambacciani","year":"2020","unstructured":"Gambacciani M, Cervigni M, Gaspar A et al (2020) Safety of Vaginal Erbium Laser (VELTM): a review of 113,000 patients treated in the past eight years. Climacteric 23(sup1):S28\u2013S32. https:\/\/doi.org\/10.1080\/13697137.2020.1813098","journal-title":"Climacteric"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-021-03474-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-021-03474-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-021-03474-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T07:09:14Z","timestamp":1653721754000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-021-03474-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["3474"],"URL":"https:\/\/doi.org\/10.1007\/s10103-021-03474-z","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]},"assertion":[{"value":"20 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Study was approved by the Ethics Review Board of the Uroclinica.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"A. Gaspar has received honoraria from the manufacturer of the medical device used in this study, for speaking at symposia. N. Koron is an employee of the manufacturer of the device used in this study. Other authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}