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We performed a study in 30 women with thigh and leg varices due to major saphenous vein valve incontinence with saphenous trunk reflux causing phlebo-lymphoedema to assess the efficacy of sclerofoam-assisted laser treatment combined with nutraceutical administration. The patients underwent endovascular combination sealing of the saphenous trunk with sclerofoam-assisted laser treatment technique into the major saphenous veins under low-volume tumescent anesthesia followed by intraoperative phlebectomies. Post-operatively, the patients received capsules containing <jats:italic>Aesculus Hippocastanum<\/jats:italic>, chondroitin sulphate, proanthocyanidins from <jats:italic>Pinus pinaster Aiton<\/jats:italic>, proanthocyanidins from <jats:italic>Vitis vinifera<\/jats:italic> L., hydrolysed marine collagen and carcinine dihydrochloride for 3\u00a0weeks. We evaluated the extracellular fluid volume of the lower limbs using bioimpedance spectroscopy pre- (T0) and post-surgery (T2) (impedance is a vector which is composed of two components, resistance [RES] and reactance [REA)]). In addition, we evaluated the following parameters pre- and post-surgery: pain, heaviness, paresthesia, itching, swelling, daily urine volume output and leg volume.\u00a0Limb volume was\u00a0significantly decreased at T2 compared to T0 (<jats:italic>p<\/jats:italic> &lt; 0.01). RES and REA were\u00a0significantly increased at T2 compared to T0 (<jats:italic>p<\/jats:italic> &lt; 0.0001 and <jats:italic>p<\/jats:italic> &lt; 0.01, respectively).\u00a0A significant improvement in heaviness, paresthesia, pain, swelling and itch was also observed (all <jats:italic>p<\/jats:italic> &lt; 0.0001)\u00a0while no changes in terms of diuresis occurred. No adverse effects were observed. The present study shows a promising approach to the treatment of chronic venous insufficiency that warrants further clinical studies in larger cohorts of patients.<\/jats:p>","DOI":"10.1007\/s10103-022-03549-5","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T05:03:21Z","timestamp":1650258201000},"page":"2831-2835","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A nutraceutical formulation combined with sclerofoam-assisted laser treatment ameliorates chronic venous insufficiency"],"prefix":"10.1007","volume":"37","author":[{"given":"Beniamino","family":"Palmieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Vadal\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Ugo","family":"Urso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Ornella","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Fanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Cesar","family":"Morales-Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4758-0562","authenticated-orcid":false,"given":"Tommaso","family":"Iannitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"3549_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.ejvs.2010.09.025","volume":"41","author":"M Perrin","year":"2011","unstructured":"Perrin M, Ramelet AA (2011) Pharmacological treatment of primary chronic venous disease: rationale, results and unanswered questions. 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The patients were included voluntarily as they required a therapeutic approach to CVI treatment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}