{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:56:48Z","timestamp":1793444208311,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800673"],"award-info":[{"award-number":["81800673"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fotona d.o.o.","award":["2020005"],"award-info":[{"award-number":["2020005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"abstract":"<jats:title>Abstract\n<\/jats:title><jats:p>The purpose of this study was to investigate the morphological and histological changes in the urethra in beagle dogs after intraurethral Er:YAG laser irradiation in nonablative mode to confirm the safety of this therapy. Six 2-year-old healthy female virgin beagle dogs (13\u2009\u00b1\u20091.51\u00a0kg) were used in this study. The animals were divided into 2 groups: the sham group, which received sham treatment (<jats:italic>n<\/jats:italic>\u2009=\u20093) involving insertion of an intraurethral cannula and laser delivery handpiece into the urethra without laser irradiation, and the experimental group (<jats:italic>n<\/jats:italic>\u2009=\u20093), which received intraurethral Er:YAG laser irradiation. The laser irradiation parameters were set according to clinical criteria (4\u00a0mm spot size, 1.5\u00a0J\/cm<jats:sup>2<\/jats:sup>, 1.4\u00a0Hz, and 4 pulses) in nonablative mode. All animals received three sequential sessions at 4-week intervals. Urethrography and urethroscopy were performed in the 12th week and 13th week, respectively, after the first treatment. After urethroscopy, the animals were sacrificed, and urethral tissue was harvested for histological investigations. All procedures were performed under general anesthesia (40\u00a0mg\/kg 3% sodium pentobarbital, i.v.). Transforming growth factor \u03b21 (TGF-\u03b21) and \u03b1-smooth muscle actin (\u03b1-SMA) expression levels were measured to evaluate the biochemical characteristics of the scar. Urethral stricture was not found by urethrography or urethroscopy in either group. Urethral epithelium thickness and collagen expression under the urethral mucosa were significantly increased in the experimental group compared with the sham group. However, there were no significant differences in TGF-\u03b21 and \u03b1-SMA expression between the experimental group and sham group (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Urethral stricture is not found in beagle dogs after clinically relevant intraurethral nonablative mode Er:YAG laser irradiation. Proliferation of urethral collagen and the urethral mucosa may be one of the mechanisms by which urine leakage symptoms can be improved.<\/jats:p>","DOI":"10.1007\/s10103-022-03575-3","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:02:24Z","timestamp":1653523344000},"page":"3137-3146","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Morphological and histological changes in the urethra after intraurethral nonablative erbium YAG laser therapy: an experimental study in beagle dogs"],"prefix":"10.1007","volume":"37","author":[{"given":"Sheng-fei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuerbanjiang","family":"Abulikim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-hui","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"issue":"1","key":"3575_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/nau.20798","volume":"29","author":"BT Haylen","year":"2010","unstructured":"Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, Monga A, Petri E, Rizk DE, Sand PK, Schaer GN (2010) International Urogynecological Association, International Continence Society. An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourol Urodyn 29(1):4\u201320","journal-title":"Neurourol Urodyn"},{"issue":"3","key":"3575_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1089\/jwh.2006.0122","volume":"16","author":"KS Kinchen","year":"2007","unstructured":"Kinchen KS, Lee J, Fireman B, Hunkeler E, Nehemiah JL, Curtice TG (2007) The prevalence, burden, and treatment of urinary incontinence among women in a managed care plan. J Womens Health (Larchmt) 16(3):415\u2013422","journal-title":"J Womens Health (Larchmt)"},{"issue":"16","key":"3575_CR3","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1001\/jama.2017.12137","volume":"318","author":"ES Lukacz","year":"2017","unstructured":"Lukacz ES, Santiago-Lastra Y, Albo ME, Brubaker L (2017) Urinary incontinence in women: a review. JAMA 318(16):1592\u20131604","journal-title":"JAMA"},{"issue":"1","key":"3575_CR4","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1089\/jwh.2013.4382","volume":"23","author":"SF Ng","year":"2014","unstructured":"Ng SF, Lok MK, Pang SM, Wun YT (2014) Stress urinary incontinence in younger women in primary care: prevalence and opportunistic intervention. J Womens Health (Larchmt) 23(1):65\u201368","journal-title":"J Womens Health (Larchmt)"},{"issue":"2","key":"3575_CR5","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.juro.2011.03.114","volume":"186","author":"AD Markland","year":"2011","unstructured":"Markland AD, Richter HE, Fwu CW, Eggers P, Kusek JW (2011) Prevalence and trends of urinary incontinence in adults in the United States, 2001 to 2008. J Urol 186(2):589\u2013593","journal-title":"J Urol"},{"issue":"2","key":"3575_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1055\/s-0035-1571252","volume":"38","author":"RM Moroni","year":"2016","unstructured":"Moroni RM, Magnani PS, Haddad JM, Castro Rde A, Brito LG (2016) Conservative treatment of stress urinary incontinence: a systematic review with meta-analysis of randomized controlled trials. Rev Bras Ginecol Obstet 38(2):97\u2013111","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"1","key":"3575_CR7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1080\/09593985.2018.1482583","volume":"36","author":"C Sacomori","year":"2020","unstructured":"Sacomori C, Berghmans B, de Bie R, Mesters I, Cardoso FL (2020) Predictors for adherence to a home-based pelvic floor muscle exercise program for treating female urinary incontinence in Brazil. Physiother Theory Pract 36(1):186\u2013195","journal-title":"Physiother Theory Pract"},{"issue":"6","key":"3575_CR8","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2522\/ptj.20120072","volume":"93","author":"D Borello-France","year":"2013","unstructured":"Borello-France D, Burgio KL, Goode PS, Ye W, Weidner AC, Lukacz ES, Jelovsek JE, Bradley CS, Schaffer J, Hsu Y, Kenton K, Spino C (2013) Pelvic Floor Disorders Network. Adherence to behavioral interventions for stress incontinence: rates, barriers, and predictors. Phys Ther 93(6):757\u201373","journal-title":"Phys Ther"},{"issue":"5","key":"3575_CR9","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/nau.21104","volume":"30","author":"C Dumoulin","year":"2011","unstructured":"Dumoulin C, Glazener C, Jenkinson D (2011) Determining the optimal pelvic floor muscle training regimen for women with stress urinary incontinence. Neurourol Urodyn 30(5):746\u2013753","journal-title":"Neurourol Urodyn"},{"issue":"2","key":"3575_CR10","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/nau.23895","volume":"38","author":"A Gomelsky","year":"2019","unstructured":"Gomelsky A, Athanasiou S, Choo MS, Cosson M, Dmochowski RR, Gomes CM, Monga A, Nager CW, Ng R, Rovner ES, Sand P, Tomoe H (2019) Surgery for urinary incontinence in women: report from the 6th international consultation on incontinence. Neurourol Urodyn 38(2):825\u2013837","journal-title":"Neurourol Urodyn"},{"issue":"5","key":"3575_CR11","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00192-011-1659-x","volume":"23","author":"BT Haylen","year":"2012","unstructured":"Haylen BT, Freeman RM, Lee J, Swift SE, Cosson M, Deprest J, Dwyer PL, Fatton B, Kocjancic E, Maher C, Petri E, Rizk DE, Schaer GN, Webb R (2012) An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint terminology and classification of the complications related to native tissue female pelvic floor surgery. Int Urogynecol J 23(5):515\u2013526","journal-title":"Int Urogynecol J"},{"issue":"1","key":"3575_CR12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/nau.21036","volume":"30","author":"BT Haylen","year":"2011","unstructured":"Haylen BT, Freeman RM, Swift SE, Cosson M, Davila GW, Deprest J, Dwyer PL, Fatton B, Kocjancic E, Lee J, Maher C, Petri E, Rizk DE, Sand PK, Schaer GN, Webb R (2011) International Urogynecological Association, International Continence Society, Joint Iuga I. C. S. Working Group on Complications Terminology. An International Urogynecological Association (IUGA)\/International Continence Society (ICS) joint terminology and classification of the complications related directly to the insertion of prostheses (meshes, implants, tapes) and grafts in female pelvic floor surgery. Neurourol Urodyn 30(1):2\u201312","journal-title":"Neurourol Urodyn"},{"issue":"1","key":"3575_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/bju.15302","volume":"128","author":"R Mathieson","year":"2020","unstructured":"Mathieson R, Kippen R, Manning T, Brennan J (2020) Stress urinary incontinence in the mesh complication era: current Australian trends. BJU Int 128(1):95\u2013102","journal-title":"BJU Int"},{"issue":"2","key":"3575_CR14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00192-018-3839-4","volume":"30","author":"MM Zacche","year":"2019","unstructured":"Zacche MM, Mukhopadhyay S, Giarenis I (2019) Changing surgical trends for female stress urinary incontinence in England. Int Urogynecol J 30(2):203\u2013209","journal-title":"Int Urogynecol J"},{"issue":"8","key":"3575_CR15","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1007\/s00192-020-04597-7","volume":"32","author":"AA Berger","year":"2021","unstructured":"Berger AA, Tan-Kim J, Menefee SA (2021) The impact of the 2011 US Food and Drug Administration transvaginal mesh communication on utilization of synthetic mid-urethral sling procedures. Int Urogynecol J 32(8):2227\u20132231","journal-title":"Int Urogynecol J"},{"issue":"3","key":"3575_CR16","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s10103-017-2170-5","volume":"32","author":"A Gaspar","year":"2017","unstructured":"Gaspar A, Brandi H (2017) Non-ablative erbium YAG laser for the treatment of type III stress urinary incontinence (intrinsic sphincter deficiency). Lasers Med Sci 32(3):685\u2013691","journal-title":"Lasers Med Sci"},{"issue":"4","key":"3575_CR17","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s10103-016-1884-0","volume":"31","author":"N Fistonic","year":"2016","unstructured":"Fistonic N, Fistonic I, Gustek SF, Turina IS, Marton I, Vizintin Z, Kazic M, Hreljac I, Perhavec T, Lukac M (2016) Minimally invasive, non-ablative Er:YAG laser treatment of stress urinary incontinence in women\u2013a pilot study. Lasers Med Sci 31(4):635\u2013643","journal-title":"Lasers Med Sci"},{"key":"3575_CR18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ejogrb.2018.03.038","volume":"224","author":"M Blaganje","year":"2018","unstructured":"Blaganje M, \u0160\u0107epanovi\u0107 D, \u017dgur L, Verdenik I, Pajk F, Lukanovi\u0107 A (2018) Non-ablative Er:YAG laser therapy effect on stress urinary incontinence related to quality of life and sexual function: a randomized controlled trial. Eur J Obstet Gynecol Reprod Biol 224:153\u2013158","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"3575_CR19","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00192-020-04548-2","volume":"32","author":"A Alsulihem","year":"2021","unstructured":"Alsulihem A, Corcos J (2021) The use of vaginal lasers in the treatment of urinary incontinence and overactive bladder, systematic review. Int Urogynecol J 32(3):553\u2013572","journal-title":"Int Urogynecol J"},{"key":"3575_CR20","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ejogrb.2020.07.010","volume":"252","author":"CT Erel","year":"2020","unstructured":"Erel CT, Fernandez LDC, lnan D, Makul M (2020) Er:YAG laser treatment of urinary incontinence after failed TOT\/TVT procedures. Eur J Obstet Gynecol Reprod Biol 252:399\u2013403","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"3575_CR21","doi-asserted-by":"crossref","unstructured":"Elia D, Gambacciani M, Berreni N, Bohbot JM, Druckmann R, Geoffrion H, Haab F, Heiss N, Rygaloff N, Russo E (2019) Genitourinary syndrome of menopause (GSM) and laser VEL: a review. Horm Mol Biol Clin Investig 41(1)","DOI":"10.1515\/hmbci-2020-0012"},{"issue":"1","key":"3575_CR22","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/nau.24551","volume":"40","author":"A Gaspar","year":"2021","unstructured":"Gaspar A, Silva J, Silva G, Anchelerguez R, Prats J, Sagaz A, Rovere E, Alastra M, Pino J, Jauregui A, Farrugia M, Villaroel F, Guareschi J, Vega M, Biasiori E, Moyano E, La Rosa A, Hreljac I, Vizintin Z (2021) Nonablative transurethral Erbium:YAG laser treatment for chronic prostatitis\/chronic pelvic pain syndrome: a prospective comparative study. Neurourol Urodyn 40(1):278\u2013285","journal-title":"Neurourol Urodyn"},{"issue":"8","key":"3575_CR23","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/lsm.22826","volume":"50","author":"A Gaspar","year":"2018","unstructured":"Gaspar A, Maestri S, Silva J, Brandi H, Luque D, Koron N, Vizintin Z (2018) Intraurethral Erbium:YAG laser for the management of urinary symptoms of genitourinary syndrome of menopause: a pilot study. Lasers Surg Med 50(8):802\u2013807","journal-title":"Lasers Surg Med"},{"issue":"Suppl 1","key":"3575_CR24","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3109\/13697137.2015.1078668","volume":"18","author":"Z Vizintin","year":"2015","unstructured":"Vizintin Z, Lukac M, Kazic M, Tettamanti M (2015) Erbium laser in gynecology. Climacteric 18(Suppl 1):4\u20138","journal-title":"Climacteric"},{"issue":"4","key":"3575_CR25","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s10517-017-3650-0","volume":"162","author":"GA Lapii","year":"2017","unstructured":"Lapii GA, Yakovleva AY, Neimark AI (2017) Structural reorganization of the vaginal mucosa in stress urinary incontinence under conditions of Er:YAG laser treatment. Bull Exp Biol Med 162(4):510\u2013514","journal-title":"Bull Exp Biol Med"},{"issue":"sup1","key":"3575_CR26","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1080\/13697137.2020.1764525","volume":"23","author":"A Gaspar","year":"2020","unstructured":"Gaspar A, Silva J, Calderon A, Placido VDI, Vizintin Z (2020) Histological findings after non-ablative Er:YAG laser therapy in women with severe vaginal atropgy. Climacteric 23(sup1):S11\u2013S13","journal-title":"Climacteric"},{"issue":"5","key":"3575_CR27","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/lsm.10110","volume":"31","author":"KM Sasaki","year":"2002","unstructured":"Sasaki KM, Aoki A, Ichinose S, Ishikawa I (2002) Ultrastructural analysis of bone tissue irradiated by Er:YAG Laser. Lasers Surg Med 31(5):322\u2013332","journal-title":"Lasers Surg Med"},{"issue":"6","key":"3575_CR28","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s10103-016-1983-y","volume":"31","author":"J Yang","year":"2016","unstructured":"Yang J, Wang S, Dong L, An X, Li Y, Li J, Tu Y, Tao J (2016) Skin healing and collagen changes of rats after fractional erbium:yttrium aluminum garnet laser: observation by reflectance confocal microscopy with confirmed histological evidence. Lasers Med Sci 31(6):1251\u20131260","journal-title":"Lasers Med Sci"},{"issue":"8","key":"3575_CR29","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1089\/pho.2015.4044","volume":"34","author":"T Unver","year":"2016","unstructured":"Unver T, Aytugar E, Ozturan O, Kiran T, Ademci E, Usumez A (2016) Histological effects of Er:YAG laser irradiation with snoring handpiece in the rat soft palate. Photomed Laser Surg 34(8):321\u2013325","journal-title":"Photomed Laser Surg"},{"issue":"2","key":"3575_CR30","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1067\/moe.2001.111943","volume":"91","author":"JA Jayawardena","year":"2001","unstructured":"Jayawardena JA, Kato J, Moriya K, Takagi Y (2001) Pulpal response to exposure with Er:YAG laser. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91(2):222\u2013229","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"2","key":"3575_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00266-009-9408-y","volume":"34","author":"S Serel","year":"2010","unstructured":"Serel S, Kaya B, Sara Y, Heper AO, Can Z (2010) Histopathological and electrophysiological study of CO(2), Er:YAG, and CO (2) + Er:YAG laser effect on peripheral nerve. Aesthetic Plast Surg 34(2):193\u2013199","journal-title":"Aesthetic Plast Surg"},{"issue":"5","key":"3575_CR32","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1007\/s10103-020-03149-1","volume":"36","author":"L Huth","year":"2021","unstructured":"Huth L, Huth S, Marquardt Y, Winterhalder P, Steiner T, H\u00f6lzle F, Gansel R, Baron JM, Schmitt L (2021) Deciphering the molecular effects of non-ablative Er:YAG laser treatment in an in vitro model of the non-keratinized mucous membrane. Lasers Med Sci 36(5):1117\u20131121","journal-title":"Lasers Med Sci"},{"issue":"Suppl 1","key":"3575_CR33","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1002\/nau.20888","volume":"29","author":"JO Delancey","year":"2010","unstructured":"Delancey JO (2010) Why do women have stress urinary incontinence? Neurourol Urodyn 29(Suppl 1):S13\u2013S17","journal-title":"Neurourol Urodyn"},{"issue":"4820","key":"3575_CR34","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1126\/science.2442813","volume":"237","author":"TA Mustoe","year":"1987","unstructured":"Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF (1987) Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science 237(4820):1333\u20131336","journal-title":"Science"},{"issue":"5","key":"3575_CR35","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1055\/s-0037-1605347","volume":"28","author":"XH Tan","year":"2018","unstructured":"Tan XH, Liu X, Long CL, Zhang DY, Lin T, He DW, Wei GH (2018) Histological and biochemical evaluation of urethral scar following three different hypospadias repairs: an experimental study in rabbits. Eur J Pediatr Surg 28(5):420\u2013425","journal-title":"Eur J Pediatr Surg"},{"issue":"5","key":"3575_CR36","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nrm809","volume":"3","author":"JJ Tomasek","year":"2002","unstructured":"Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA (2002) Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3(5):349\u2013363","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-022-03575-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-022-03575-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-022-03575-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T10:11:59Z","timestamp":1664532719000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-022-03575-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":36,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["3575"],"URL":"https:\/\/doi.org\/10.1007\/s10103-022-03575-3","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]},"assertion":[{"value":"9 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiment was approved by the Ethics Committee on Animal Experiments of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, P.R. China (TJH-201903001).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}