{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:21:36Z","timestamp":1773886896847,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"DOI":"10.1007\/s10103-022-03605-0","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T04:02:22Z","timestamp":1658462542000},"page":"3213-3220","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of clinical outcomes of non-surgical adjunctive use of the 980-nm diode laser to conventional periodontal flap procedure\u2014a randomised controlled split-mouth clinical trial"],"prefix":"10.1007","volume":"37","author":[{"given":"Thaneshwar","family":"Patila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7616-4840","authenticated-orcid":false,"given":"Sunaina Shetty","family":"Y","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopinath","family":"Vivekanandan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghavendra M.","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betul","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saaid","family":"Al Shehadat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishir Ram","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"issue":"32","key":"3605_CR1","first-page":"11","volume":"2003","author":"ME Nunn","year":"2000","unstructured":"Nunn ME (2000) Understanding the etiology of periodontitis: an overview of periodontal risk factors. Periodontol 2003(32):11\u201323","journal-title":"Periodontol"},{"issue":"1","key":"3605_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/prd.12221","volume":"75","author":"J Slots","year":"2017","unstructured":"Slots J (2017) Periodontitis: facts, fallacies and the future. Periodontol 2000 75(1):7\u201323","journal-title":"Periodontol 2000"},{"issue":"Suppl 20","key":"3605_CR3","first-page":"S1","volume":"45","author":"JG Caton","year":"2018","unstructured":"Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS et al (2018) A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification. J Clin Periodontol 45(Suppl 20):S1\u2013S8","journal-title":"J Clin Periodontol"},{"issue":"12","key":"3605_CR4","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1902\/jop.2008.080266","volume":"79","author":"U Pagliaro","year":"2008","unstructured":"Pagliaro U, Nieri M, Rotundo R, Cairo F, Carnevale G, Esposito M et al (2008) Clinical guidelines of the Italian Society of Periodontology for the reconstructive surgical treatment of angular bony defects in periodontal patients. J Periodontol 79(12):2219\u20132232","journal-title":"J Periodontol"},{"issue":"1","key":"3605_CR5","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/prd.12008","volume":"62","author":"LJ Heitz-Mayfield","year":"2013","unstructured":"Heitz-Mayfield LJ, Lang NP (2013) Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontol 2000 62(1):218\u201331","journal-title":"Periodontol 2000"},{"issue":"10","key":"3605_CR6","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.3390\/ma11101802","volume":"11","author":"JF Lasserre","year":"2018","unstructured":"Lasserre JF, Brecx MC, Toma S (2018) Oral microbes, biofilms and their role in periodontal and peri-implant diseases. Materials (Basel) 11(10):1802","journal-title":"Materials (Basel)"},{"issue":"1","key":"3605_CR7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/prd.12156","volume":"76","author":"F Graziani","year":"2018","unstructured":"Graziani F, Karapetsa D, Mardas N, Leow N, Donos N (2018) Surgical treatment of the residual periodontal pocket. Periodontol 2000 76(1):150\u201363","journal-title":"Periodontol 2000"},{"issue":"1","key":"3605_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.4103\/0972-124X.145808","volume":"19","author":"TM Lobo","year":"2015","unstructured":"Lobo TM, Pol DG (2015) Evaluation of the use of a 940 nm diode laser as an adjunct in flap surgery for treatment of chronic periodontitis. J Indian Soc Periodontol 19(1):43\u201348","journal-title":"J Indian Soc Periodontol"},{"issue":"4","key":"3605_CR9","first-page":"206","volume":"4","author":"E Azma","year":"2013","unstructured":"Azma E, Safavi N (2013) Diode laser application in soft tissue oral surgery. J Lasers Med Sci 4(4):206\u2013211","journal-title":"J Lasers Med Sci"},{"issue":"8","key":"3605_CR10","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/medicina55080405","volume":"55","author":"HW Choung","year":"2019","unstructured":"Choung HW, Lee SH, Ham AR, Lee NR, Kim B, Pang KM et al (2019) Effectiveness of low-level laser therapy with a 915 nm wavelength diode laser on the healing of intraoral mucosal wound: an animal study and a double-blind randomized clinical trial. Medicina (Kaunas) 55(8):405","journal-title":"Medicina (Kaunas)"},{"issue":"8","key":"3605_CR11","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1007\/s10103-018-2492-y","volume":"33","author":"M Heidari","year":"2018","unstructured":"Heidari M, Fekrazad R, Sobouti F, Moharrami M, Azizi S, Nokhbatolfoghahaei H et al (2018) Evaluating the effect of photobiomodulation with a 940-nm diode laser on post-operative pain in periodontal flap surgery. Lasers Med Sci 33(8):1639\u20131645","journal-title":"Lasers Med Sci"},{"issue":"2","key":"3605_CR12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.4103\/ccd.ccd_810_17","volume":"9","author":"BD Jonnalagadda","year":"2018","unstructured":"Jonnalagadda BD, Gottumukkala S, Dwarakanath CD, Koneru S (2018) Effect of diode laser-assisted flap surgery on postoperative healing and clinical parameters: a randomized controlled clinical trial. Contemp Clin Dent 9(2):205\u2013212","journal-title":"Contemp Clin Dent"},{"issue":"3","key":"3605_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.4103\/jisp.jisp_252_20","volume":"25","author":"F Khan","year":"2021","unstructured":"Khan F, Chopra R, Sharma N, Agrawal E, Achom M, Sharma P (2021) Comparative evaluation of the efficacy of diode laser as an adjunct to modified Widman flap surgery for the treatment of chronic periodontitis: a randomized split-mouth clinical trial. J Indian Soc Periodontol 25(3):213\u2013219","journal-title":"J Indian Soc Periodontol"},{"issue":"3","key":"3605_CR14","doi-asserted-by":"publisher","first-page":"205","DOI":"10.15171\/jlms.2016.36","volume":"7","author":"N Derikvand","year":"2016","unstructured":"Derikvand N, Chinipardaz Z, Ghasemi S, Chiniforush N (2016) The versatility of 980 nm diode laser in dentistry: a case series. J Lasers Med Sci 7(3):205\u2013208","journal-title":"J Lasers Med Sci"},{"issue":"3","key":"3605_CR15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1089\/1549541041438597","volume":"22","author":"GE Romanos","year":"2004","unstructured":"Romanos GE, Henze M, Banihashemi S, Parsanejad HR, Winckler J, Nentwig GH (2004) Removal of epithelium in periodontal pockets following diode (980 nm) laser application in the animal model: an in vitro study. Photomed Laser Surg 22(3):177\u2013183","journal-title":"Photomed Laser Surg"},{"issue":"3","key":"3605_CR16","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jphotobiol.2006.10.002","volume":"86","author":"PC Silveira","year":"2007","unstructured":"Silveira PC, Streck EL, Pinho RA (2007) Evaluation of mitochondrial respiratory chain activity in wound healing by low-level laser therapy. J Photochem Photobiol B 86(3):279\u2013282","journal-title":"J Photochem Photobiol B"},{"issue":"1","key":"3605_CR17","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1111\/prd.12137","volume":"75","author":"CM Cobb","year":"2017","unstructured":"Cobb CM (2017) Lasers and the treatment of periodontitis: the essence and the noise. Periodontol 2000 75(1):205\u201395","journal-title":"Periodontol 2000"},{"issue":"11","key":"3605_CR18","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1902\/jop.2008.080197","volume":"79","author":"MR Karlsson","year":"2008","unstructured":"Karlsson MR, Diogo Lofgren CI, Jansson HM (2008) The effect of laser therapy as an adjunct to non-surgical periodontal treatment in subjects with chronic periodontitis: a systematic review. J Periodontol 79(11):2021\u20132028","journal-title":"J Periodontol"},{"issue":"2","key":"3605_CR19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jobcr.2020.04.014","volume":"10","author":"N Sultan","year":"2020","unstructured":"Sultan N, Jafri Z, Sawai M, Bhardwaj A (2020) Minimally invasive periodontal therapy. J Oral Biol Craniofac Res 10(2):161\u2013165","journal-title":"J Oral Biol Craniofac Res"},{"issue":"2","key":"3605_CR20","first-page":"959","volume":"8","author":"DS Kaur","year":"2021","unstructured":"Kaur DS, Siddharth DM, Gupta DR, Gupta DS (2021) The effect of low-level diode (GaAlAs) laser therapy as an adjunct to non surgical periodontal treatment in subjects with chronic periodontitis \u2013 a clinical study. J Eur J Mol Clin Med 8(2):959\u2013973","journal-title":"J Eur J Mol Clin Med"},{"issue":"2","key":"3605_CR21","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1902\/jop.2012.110660","volume":"84","author":"JD Sanz-Moliner","year":"2013","unstructured":"Sanz-Moliner JD, Nart J, Cohen RE, Ciancio SG (2013) The effect of an 810-nm diode laser on postoperative pain and tissue response after modified Widman flap surgery: a pilot study in humans. J Periodontol 84(2):152\u2013158","journal-title":"J Periodontol"},{"issue":"28","key":"3605_CR22","doi-asserted-by":"publisher","first-page":"3470","DOI":"10.1002\/sim.3634","volume":"28","author":"E Lesaffre","year":"2009","unstructured":"Lesaffre E, Philstrom B, Needleman I, Worthington H (2009) The design and analysis of split-mouth studies: what statisticians and clinicians should know. Stat Med 28(28):3470\u20133482","journal-title":"Stat Med"},{"key":"3605_CR23","doi-asserted-by":"publisher","first-page":"S173","DOI":"10.1002\/JPER.17-0721","volume":"89","author":"PN Papapanou","year":"2018","unstructured":"Papapanou PN, Sanz M, Buduneli N, Dietrich T, Feres M, Fine DH, Flemmig TF, Garcia R, Giannobile WV, Graziani F, Greenwell H (2018) Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Periodontol 89:S173\u2013S182","journal-title":"J Periodontol"},{"key":"3605_CR24","first-page":"121","volume":"22","author":"J Silness","year":"1964","unstructured":"Silness J, Loe H (1964) Periodontal disease in pregnancy. II. Correlation between Oral Hyg Periodontal Cond 22:121\u201335","journal-title":"Correlation between Oral Hyg Periodontal Cond"},{"key":"3605_CR25","first-page":"533","volume":"21","author":"H Loe","year":"1963","unstructured":"Loe H, Silness J (1963) Periodontal disease in pregnancy. I Prevalence Severity 21:533\u2013551","journal-title":"I Prevalence Severity"},{"issue":"4","key":"3605_CR26","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1399-302X.1987.tb00298.x","volume":"2","author":"A Mombelli","year":"1987","unstructured":"Mombelli A, van Oosten MA, Schurch E Jr, Land NP (1987) The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol Immunol 2(4):145\u2013151","journal-title":"Oral Microbiol Immunol"},{"issue":"9","key":"3605_CR27","doi-asserted-by":"publisher","first-page":"e0238659","DOI":"10.1371\/journal.pone.0238659","volume":"15","author":"R Mikami","year":"2020","unstructured":"Mikami R, Mizutani K, Sasaki Y, Iwata T, Aoki A (2020) Patient-reported outcomes of laser-assisted pain control following non-surgical and surgical periodontal therapy: a systematic review and meta-analysis. PLoS ONE 15(9):e0238659","journal-title":"PLoS ONE"},{"issue":"1","key":"3605_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1089\/photob.2020.4818","volume":"39","author":"S Nammour","year":"2021","unstructured":"Nammour S, El Mobadder M, Maalouf E, Namour M, Namour A, Rey G et al (2021) Clinical evaluation of diode (980 nm) laser-assisted nonsurgical periodontal pocket therapy: a randomized comparative clinical trial and bacteriological study. Photobiomodul Photomed Laser Surg 39(1):10\u201322","journal-title":"Photobiomodul Photomed Laser Surg"},{"issue":"1","key":"3605_CR29","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1089\/clm.1997.15.33","volume":"15","author":"A Moritz","year":"1997","unstructured":"Moritz A, Gutknecht N, Doertbudak O, Goharkhay K, Schoop U, Schauer P et al (1997) Bacterial reduction in periodontal pockets through irradiation with a diode laser: a pilot study. J Clin Laser Med Surg 15(1):33\u201337","journal-title":"J Clin Laser Med Surg"},{"issue":"4","key":"3605_CR30","doi-asserted-by":"publisher","first-page":"384","DOI":"10.4103\/0970-9290.167626","volume":"26","author":"PJ Aena","year":"2015","unstructured":"Aena PJ, Parul A, Siddharth P, Pravesh G, Vikas D, Vandita A (2015) The clinical efficacy of laser assisted modified Widman flap: a randomized split mouth clinical trial. Indian J Dent Res 26(4):384\u2013389","journal-title":"Indian J Dent Res"},{"issue":"2","key":"3605_CR31","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1089\/photob.2018.4519","volume":"37","author":"J Karthikeyan","year":"2019","unstructured":"Karthikeyan J, Vijayalakshmi R, Mahendra J, Kanakamedala AK, Chellathurai BNK, Selvarajan S et al (2019) Diode laser as an adjunct to Kirkland flap surgery-a randomized split-mouth clinical and microbiological study. Photobiomodul Photomed Laser Surg 37(2):99\u2013109","journal-title":"Photobiomodul Photomed Laser Surg"},{"issue":"2","key":"3605_CR32","doi-asserted-by":"publisher","first-page":"133","DOI":"10.34172\/joddd.2021.023","volume":"15","author":"A Agarwal","year":"2021","unstructured":"Agarwal A, Saxena A, Gummaluri SS, Chaudhary B, Subramanyam SSK, Kumar G (2021) Clinical and microbiological evaluation of 940-nm diode laser as an adjunct to modified Widman flap for the management of chronic periodontitis: a 6-month randomized split-mouth clinical trial. J Dent Res Dent Clin Dent Prospects 15(2):133\u2013139","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"issue":"1","key":"3605_CR33","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1089\/pho.2006.24.64","volume":"24","author":"GL Castro","year":"2006","unstructured":"Castro GL, Gallas M, Nunez IR, Borrajo JL, Varela LG (2006) Histological evaluation of the use of diode laser as an adjunct to traditional periodontal treatment. Photomed Laser Surg 24(1):64\u201368","journal-title":"Photomed Laser Surg"},{"issue":"5","key":"3605_CR34","doi-asserted-by":"publisher","first-page":"490","DOI":"10.4103\/0972-124X.153471","volume":"19","author":"G Romanos","year":"2015","unstructured":"Romanos G (2015) Current concepts in the use of lasers in periodontal and implant dentistry. J Indian Soc Periodontol 19(5):490\u2013494","journal-title":"J Indian Soc Periodontol"},{"issue":"10","key":"3605_CR35","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1089\/pho.2012.3252","volume":"30","author":"SR Gokhale","year":"2012","unstructured":"Gokhale SR, Padhye AM, Byakod G, Jain SA, Padbidri V, Shivaswamy S (2012) A comparative evaluation of the efficacy of diode laser as an adjunct to mechanical debridement versus conventional mechanical debridement in periodontal flap surgery: a clinical and microbiological study. Photomed Laser Surg 30(10):598\u2013603","journal-title":"Photomed Laser Surg"},{"issue":"4","key":"3605_CR36","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s10103-008-0590-y","volume":"24","author":"NS AboElsaad","year":"2009","unstructured":"AboElsaad NS, Soory M, Gadalla LM, Ragab LI, Dunne S, Zalata KR et al (2009) Effect of soft laser and bioactive glass on bone regeneration in the treatment of bone defects (an experimental study). Lasers Med Sci 24(4):527\u2013533","journal-title":"Lasers Med Sci"},{"issue":"4","key":"3605_CR37","doi-asserted-by":"publisher","first-page":"602","DOI":"10.2203\/dose-response.11-009.Hamblin","volume":"9","author":"YY Huang","year":"2011","unstructured":"Huang YY, Sharma SK, Carroll J, Hamblin MR (2011) Biphasic dose response in low level light therapy - an update. Dose Response 9(4):602\u2013618","journal-title":"Dose Response"},{"issue":"2","key":"3605_CR38","doi-asserted-by":"publisher","first-page":"158","DOI":"10.4103\/jisp.jisp_2_18","volume":"22","author":"CP Raut","year":"2018","unstructured":"Raut CP, Sethi KS, Kohale B, Mamajiwala A, Warang A (2018) Evaluation of diode laser and stannous fluoride in the treatment of root sensitivity after access flap surgery: randomized controlled clinical trial. J Indian Soc Periodontol 22(2):158\u2013163","journal-title":"J Indian Soc Periodontol"},{"issue":"1","key":"3605_CR39","doi-asserted-by":"publisher","first-page":"72","DOI":"10.4103\/jnsbm.JNSBM_88_17","volume":"9","author":"A Bhardwaj","year":"2018","unstructured":"Bhardwaj A, Jafri Z, Sultan N, Sawai M, Daing A (2018) Periodontal flap surgery along with vestibular deepening with diode laser to increase attached gingiva in lower anterior teeth: a prospective clinical study. J Nat Sci Biol Med 9(1):72\u201376","journal-title":"J Nat Sci Biol Med"},{"issue":"4","key":"3605_CR40","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/JPER.19-0663","volume":"92","author":"M Laky","year":"2021","unstructured":"Laky M, Laky B, Arslan M, Lettner S, Muller M, Haririan H et al (2021) Effectiveness of a 655-nm InGaAsP diode laser to detect subgingival calculus in patients with periodontal disease. J Periodontol 92(4):547\u2013552","journal-title":"J Periodontol"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-022-03605-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-022-03605-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-022-03605-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T10:18:17Z","timestamp":1664533097000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-022-03605-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["3605"],"URL":"https:\/\/doi.org\/10.1007\/s10103-022-03605-0","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"assertion":[{"value":"6 October 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained by the Scientific and Ethical Committee of Chhattisgarh Dental College and Research Institute, Rajnandgaon (Chhattisgarh), India. The methods used in the present study were carried out in accordance with the relevant guidelines.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}