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This study was a prospective, randomized, sham-controlled, and home-based self-therapy trial. A total of thirty subjects with wrist pain were enrolled. All participants received low-level laser therapy on painful area at the wrist. The experimental group (<jats:italic>n<\/jats:italic>\u2009=\u200915) received laser stimulation, while the control group (<jats:italic>n<\/jats:italic>\u2009=\u200915) received sham stimulation using identical equipment that generated only a red light without the laser output. Both groups self-treated for 30\u00a0min a day, 5\u00a0days per week for 3\u00a0weeks, total of 15 sessions. The primary outcome was assessed using a visual analogue scale (VAS) for wrist pain from 0 (painless) to 10 (extreme pain). The secondary outcomes were measured with patient-rated wrist evaluation (PRWE), grip strength, lateral, palmar, and tip pinch strength. Measures were taken before and after treatment. A total of thirty participants provided outcome data. After the intervention, both groups showed a significant decrease in VAS score, from 4.93 to 3.67 in experimental group, from 5.53 to 4.00 in control group (the experiment group: <jats:italic>p<\/jats:italic>\u2009=\u20090.020, the control group: <jats:italic>p<\/jats:italic>\u2009=\u20090.003). The experimental group showed a significant improvement in function scale score (<jats:italic>p<\/jats:italic>\u2009=\u20090.012), the control group did not. Lateral and pinch strength was significantly improved in the experimental group (<jats:italic>p<\/jats:italic>\u2009=\u20090.017) and in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) respectively. There were no side effects in the patients. Medical laser irradiation is a portable and easy-to-use laser irradiator without side effects. Clinical Trial Registration number: KCT0006604.<\/jats:p>","DOI":"10.1007\/s10103-024-03975-7","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T05:01:56Z","timestamp":1706331716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic efficacy and safety of home-based portable laser irradiation on patients with wrist pain: a single-blinded randomized controlled trial"],"prefix":"10.1007","volume":"39","author":[{"given":"Young-Ji","family":"Yun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Sol","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Hui","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myoung-Hwan","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-Hwan","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-8382","authenticated-orcid":false,"given":"Gi-Wook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"3975_CR1","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12199-020-00866-5","volume":"25","author":"D Dagne","year":"2020","unstructured":"Dagne D, Abebe SM, Getachew A (2020) Work-related musculoskeletal disorders and associated factors among bank workers in Addis Ababa, Ethiopia: a cross-sectional study. 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