{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:48:57Z","timestamp":1784767737796,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lasers Med Sci"],"DOI":"10.1007\/s10103-024-03986-4","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T02:04:05Z","timestamp":1705975445000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of lasers versus topical medications for acanthosis nigricans and pseudo-acanthosis nigricans treatment: a systematic review"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7309-4066","authenticated-orcid":false,"given":"Yekta","family":"Ghane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7259-4926","authenticated-orcid":false,"given":"Nazila","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-2270","authenticated-orcid":false,"given":"SeyedAyin","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4327-8814","authenticated-orcid":false,"given":"Amirhossein","family":"Heidari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0250-729X","authenticated-orcid":false,"given":"Homayoun","family":"Pishraft-sabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2809-3091","authenticated-orcid":false,"given":"Sara","family":"Eghbali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1249-4429","authenticated-orcid":false,"given":"Azadeh","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"issue":"1","key":"3986_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/jocd.14088","volume":"21","author":"F Eldeeb","year":"2022","unstructured":"Eldeeb F, Wahid RM, Alakad R (2022) Fractional carbon dioxide laser versus trichloroacetic acid peel in the treatment of pseudo-acanthosis nigricans. J Cosmet Dermatol 21(1):247\u2013253. https:\/\/doi.org\/10.1111\/jocd.14088","journal-title":"J Cosmet Dermatol"},{"issue":"9","key":"3986_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.5070\/D37MF6G290","volume":"14","author":"SP Higgins","year":"2008","unstructured":"Higgins SP, Freemark M, Prose NS (2008) Acanthosis nigricans: a practical approach to evaluation and management. Dermatol Online J 14(9):2","journal-title":"Dermatol Online J"},{"issue":"4","key":"3986_CR3","first-page":"290","volume":"7","author":"A Ehsani","year":"2016","unstructured":"Ehsani A, Noormohammadpour P, Goodarzi A, Mirshams Shahshahani M, Hejazi SP, Hosseini E et al (2016) Comparison of long-pulsed alexandrite laser and topical tretinoin-ammonium lactate in axillary acanthosis nigricans: a case series of patients in a before-after trial. Caspian J Intern Med 7(4):290\u2013293","journal-title":"Caspian J Intern Med"},{"issue":"1","key":"3986_CR4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2174\/1573396318666220429085231","volume":"19","author":"AKC Leung","year":"2022","unstructured":"Leung AKC, Lam JM, Barankin B, Leong KF, Hon KL (2022) Acanthosis nigricans: an updated review. Curr Pediatr Rev 19(1):68\u201382. https:\/\/doi.org\/10.2174\/1573396318666220429085231","journal-title":"Curr Pediatr Rev"},{"issue":"5","key":"3986_CR5","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1007\/s10103-019-02944-9","volume":"35","author":"P Leerapongnan","year":"2020","unstructured":"Leerapongnan P, Jurairattanaporn N, Kanokrungsee S, Udompataikul M (2020) Comparison of the effectiveness of fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream in the treatment of acanthosis nigricans: a prospective, randomized, controlled trial. Lasers Med Sci 35(5):1153\u20138. https:\/\/doi.org\/10.1007\/s10103-019-02944-9","journal-title":"Lasers Med Sci"},{"issue":"7","key":"3986_CR6","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1007\/s10103-018-2505-x","volume":"33","author":"NS Zaki","year":"2018","unstructured":"Zaki NS, Hilal RF, Essam RM (2018) Comparative study using fractional carbon dioxide laser versus glycolic acid peel in treatment of pseudo-acanthosis nigricans. Lasers Med Sci 33(7):1485\u20131491. https:\/\/doi.org\/10.1007\/s10103-018-2505-x","journal-title":"Lasers Med Sci"},{"issue":"5","key":"3986_CR7","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.3892\/ol.2018.9736","volume":"17","author":"ML Popa","year":"2019","unstructured":"Popa ML, Popa AC, Tanase C, Gheorghisan-Galateanu AA (2019) Acanthosis nigricans: to be or not to be afraid. Oncol Lett 17(5):4133\u20134138. https:\/\/doi.org\/10.3892\/ol.2018.9736","journal-title":"Oncol Lett"},{"issue":"4","key":"3986_CR8","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/0030-4220(87)90259-3","volume":"63","author":"HO Sedano","year":"1987","unstructured":"Sedano HO, Gorlin RJ (1987) Acanthosis nigricans. Oral Surg Oral Med Oral Pathol 63(4):462\u2013467. https:\/\/doi.org\/10.1016\/0030-4220(87)90259-3","journal-title":"Oral Surg Oral Med Oral Pathol"},{"issue":"8","key":"3986_CR9","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1111\/jocd.13544","volume":"19","author":"A Das","year":"2020","unstructured":"Das A, Datta D, Kassir M, Wollina U, Galadari H, Lotti T et al (2020) Acanthosis nigricans: a review. J Cosmet Dermatol 19(8):1857\u20131865. https:\/\/doi.org\/10.1111\/jocd.13544","journal-title":"J Cosmet Dermatol"},{"issue":"1","key":"3986_CR10","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12902-022-01161-w","volume":"22","author":"A Oraii","year":"2022","unstructured":"Oraii A, Shafiee A, Jalali A, Alaeddini F, Saadat S, Masoudkabir F et al (2022) Prevalence, awareness, treatment, and control of type 2 diabetes mellitus among the adult residents of tehran: Tehran Cohort Study. BMC Endocr Disord 22(1):248. https:\/\/doi.org\/10.1186\/s12902-022-01161-w","journal-title":"BMC Endocr Disord"},{"issue":"11","key":"3986_CR11","doi-asserted-by":"publisher","first-page":"6890","DOI":"10.4103\/jfmpc.jfmpc_783_22","volume":"11","author":"M Roohaninasab","year":"2022","unstructured":"Roohaninasab M, Mojtabaee M, Livani F, Heidari N, Alizadeh N, Khosravi S et al (2022) Beneficial esthetic lightening effects of Cuscuta extract on skin darkness in healthy individuals: a clinical trial study. J Family Med Prim Care 11(11):6890","journal-title":"J Family Med Prim Care"},{"key":"3986_CR12","unstructured":"National Heart L, Blood Institute (2014) Quality assessment tool for Controlled Intervention Studies. https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools"},{"issue":"3","key":"3986_CR13","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/jocd.14224","volume":"21","author":"AA Abu Oun","year":"2022","unstructured":"Abu Oun AA, Ahmed NA, Hafiz HSA (2022) Comparative study between fractional carbon dioxide laser versus retinoic acid chemical peel in the treatment of acanthosis nigricans. J Cosmet Dermatol 21(3):1023\u20131030. https:\/\/doi.org\/10.1111\/jocd.14224","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"3986_CR14","doi-asserted-by":"publisher","first-page":"4173","DOI":"10.21608\/EJHM.2021.207816","volume":"85","author":"AF State","year":"2021","unstructured":"State AF, Elsayed GEM, Mohammed SEE (2021) Fractional carbon dioxide laser versus glycolic acid peel in treatment of pseudo-acanthosis nigricans. Egypt J Hosp Med 85(2):4173\u20134178. https:\/\/doi.org\/10.21608\/EJHM.2021.207816","journal-title":"Egypt J Hosp Med"},{"issue":"3","key":"3986_CR15","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/2229-5178.137765","volume":"5","author":"MM Phiske","year":"2014","unstructured":"Phiske MM (2014) An approach to acanthosis nigricans. Indian Dermatol Online J 5(3):239\u2013249. https:\/\/doi.org\/10.4103\/2229-5178.137765","journal-title":"Indian Dermatol Online J"},{"issue":"6","key":"3986_CR16","doi-asserted-by":"publisher","first-page":"678","DOI":"10.4103\/0019-5154.91828","volume":"56","author":"N Puri","year":"2011","unstructured":"Puri N (2011) A study of pathogenesis of acanthosis nigricans and its clinical implications. Indian J Dermatol 56(6):678\u2013683. https:\/\/doi.org\/10.4103\/0019-5154.91828","journal-title":"Indian J Dermatol"},{"issue":"1","key":"3986_CR17","doi-asserted-by":"publisher","first-page":"63","DOI":"10.4274\/jcrpe.1515","volume":"7","author":"\u00d6 Pirgon","year":"2015","unstructured":"Pirgon \u00d6, Sandal G, G\u00f6k\u00e7en C, Bilgin H, D\u00fcndar B (2015) Social anxiety, depression and self-esteem in obese adolescent girls with acanthosis nigricans. J Clin Res Pediatr Endocrinol 7(1):63\u201368. https:\/\/doi.org\/10.4274\/jcrpe.1515","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"2","key":"3986_CR18","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.21608\/ejhm.2023.292768","volume":"90","author":"SAA Darhous","year":"2023","unstructured":"Darhous SAA, Eldeeb F (2023) Acanthosis nigricans, insight about management: review article. Egypt J Hospital Med 90(2):3649\u20133653. https:\/\/doi.org\/10.21608\/ejhm.2023.292768","journal-title":"Egypt J Hospital Med"},{"key":"3986_CR19","doi-asserted-by":"publisher","first-page":"407","DOI":"10.2147\/ccid.S137527","volume":"11","author":"NU Patel","year":"2018","unstructured":"Patel NU, Roach C, Alinia H, Huang WW, Feldman SR (2018) Current treatment options for acanthosis nigricans. Clin Cosmet Investig Dermatol 11:407\u2013413. https:\/\/doi.org\/10.2147\/ccid.S137527","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"3986_CR20","doi-asserted-by":"publisher","first-page":"705","DOI":"10.2147\/ccid.S401479","volume":"16","author":"MF Elmasry","year":"2023","unstructured":"Elmasry MF, Khalil MMF, Badawi A, Zaki NS, Fahim A (2023) Efficacy of fractional carbon dioxide (CO(2)) laser versus Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) and potassium-titanyl-phosphate (KTP) lasers in the treatment of acanthosis nigricans. Clin Cosmet Investig Dermatol 16:705\u2013715. https:\/\/doi.org\/10.2147\/ccid.S401479","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"1","key":"3986_CR21","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s10103-009-0734-8","volume":"25","author":"I Bogdan Allemann","year":"2010","unstructured":"Bogdan Allemann I, Kaufman J (2010) Fractional photothermolysis\u2013an update. Lasers Med Sci 25(1):137\u2013144. https:\/\/doi.org\/10.1007\/s10103-009-0734-8","journal-title":"Lasers Med Sci"},{"issue":"1","key":"3986_CR22","first-page":"33","volume":"71","author":"SH Blobstein","year":"2003","unstructured":"Blobstein SH (2003) Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity. Cutis 71(1):33\u201334","journal-title":"Cutis"},{"issue":"1","key":"3986_CR23","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1001\/archderm.1973.01620220087029","volume":"108","author":"BJ Berger","year":"1973","unstructured":"Berger BJ, Gross PR (1973) Another use for tretinoin\u2013pseudoacanthosis nigricans. Arch Dermatol 108(1):133\u2013134","journal-title":"Arch Dermatol"},{"issue":"4","key":"3986_CR24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/dth.12224","volume":"28","author":"RA Schwartz","year":"2015","unstructured":"Schwartz RA (2015) Efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. Dermatol Ther 28(4):266. https:\/\/doi.org\/10.1111\/dth.12224","journal-title":"Dermatol Ther"},{"issue":"1","key":"3986_CR25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4103\/0019-5154.147838","volume":"60","author":"A Treesirichod","year":"2015","unstructured":"Treesirichod A, Chaithirayanon S, Wongjitrat N, Wattanapan P (2015) The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study. Indian J Dermatol 60(1):103. https:\/\/doi.org\/10.4103\/0019-5154.147838","journal-title":"Indian J Dermatol"},{"issue":"3","key":"3986_CR26","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/pde.13799","volume":"36","author":"A Treesirichod","year":"2019","unstructured":"Treesirichod A, Chaithirayanon S, Wongjitrat N (2019) Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans. Pediatr Dermatol 36(3):330\u20134. https:\/\/doi.org\/10.1111\/pde.13799","journal-title":"Pediatr Dermatol"},{"key":"3986_CR27","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02472-7","author":"C Kritsanaviparkporn","year":"2022","unstructured":"Kritsanaviparkporn C, Treesirichod A (2022) Comparing the efficacy and safety profiles of 0.025% and 0.05% tretinoin creams in treating acanthosis nigricans: a randomized double-blinded study. Arch Dermatol Res. https:\/\/doi.org\/10.1007\/s00403-022-02472-7","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"3986_CR28","first-page":"170","volume":"29","author":"HM Rajegowda","year":"2019","unstructured":"Rajegowda HM, Kalegowda D, Madegowda SB, Manjunath K, Thabassum A (2019) To compare the efficacy and safety of trichloroacetic acid peel with topical tretinoin in the treatment of acanthosis nigricans: a randomized controlled study. J Pak Assoc Dermatol 29(2):170\u2013175","journal-title":"J Pak Assoc Dermatol"},{"issue":"3","key":"3986_CR29","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/jdv.13580","volume":"30","author":"S Ichiyama","year":"2016","unstructured":"Ichiyama S, Funasaka Y, Otsuka Y, Takayama R, Kawana S, Saeki H et al (2016) Effective treatment by glycolic acid peeling for cutaneous manifestation of familial generalized acanthosis nigricans caused by FGFR3 mutation. J Eur Acad Dermatol Venereol 30(3):442\u2013445. https:\/\/doi.org\/10.1111\/jdv.13580","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"3986_CR30","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jaad.2021.01.065","volume":"86","author":"RL Baldissera","year":"2022","unstructured":"Baldissera RL, Yang EJ, Schmitt JV, Lin E, de Jesus FE, Wambier CG et al (2022) Trichloroacetic acid peels for the treatment of acanthosis nigricans. J Am Acad Dermatol 86(1):203\u2013204","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"3986_CR31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.25289\/ML.2014.3.1.31","volume":"3","author":"YK Kim","year":"2014","unstructured":"Kim YK, Cho S, Goo BL, Kang J-S, Cho SB (2014) Long-pulsed 755-nm alexandrite laser-induced postinflammatory hyperpigmentation treated with 1,064-nm Nd: YAG laser: time course follow-up. Medical Lasers 3(1):31\u201334","journal-title":"Medical Lasers"},{"issue":"7","key":"3986_CR32","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1080\/09546634.2019.1708855","volume":"32","author":"A Treesirichod","year":"2021","unstructured":"Treesirichod A, Chaithirayanon S, Chaikul T, Chansakulporn S (2021) The randomized trials of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis nigricans. J Dermatol Treat 32(7):837\u201342. https:\/\/doi.org\/10.1080\/09546634.2019.1708855","journal-title":"J Dermatol Treat"}],"container-title":["Lasers in Medical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-024-03986-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10103-024-03986-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10103-024-03986-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T15:40:01Z","timestamp":1738338001000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10103-024-03986-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,23]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["3986"],"URL":"https:\/\/doi.org\/10.1007\/s10103-024-03986-4","relation":{},"ISSN":["1435-604X"],"issn-type":[{"value":"1435-604X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,23]]},"assertion":[{"value":"30 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"An ethics statement is not applicable because this study is based exclusively on published literature.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that the manuscript is honest, accurate, and transparent. No important aspect of the study is omitted.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Transparency declaration"}},{"value":"Patients or the public was not involved in the design, or conduct, or reporting, or dissemination plans of our research.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Patients and public partnership"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"44"}}